Details for: BLVRA

Gene ID: 644

Symbol: BLVRA

Ensembl ID: ENSG00000106605

Description: biliverdin reductase A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.6839
    Cell Significance Index: -12.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.8759
    Cell Significance Index: -20.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.4263
    Cell Significance Index: -28.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.6697
    Cell Significance Index: -25.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.1750
    Cell Significance Index: -28.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.1326
    Cell Significance Index: -27.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.8004
    Cell Significance Index: -28.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.8973
    Cell Significance Index: -25.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2197
    Cell Significance Index: -24.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8064
    Cell Significance Index: -26.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9842
    Cell Significance Index: -27.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6834
    Cell Significance Index: -10.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6701
    Cell Significance Index: 49.3500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.8665
    Cell Significance Index: 0.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6044
    Cell Significance Index: 21.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9553
    Cell Significance Index: 71.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9497
    Cell Significance Index: 43.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8948
    Cell Significance Index: 24.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8782
    Cell Significance Index: 167.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8717
    Cell Significance Index: 25.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7842
    Cell Significance Index: 11.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5899
    Cell Significance Index: 4.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5171
    Cell Significance Index: 71.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5014
    Cell Significance Index: 26.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4432
    Cell Significance Index: 11.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4257
    Cell Significance Index: 294.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4236
    Cell Significance Index: 187.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4142
    Cell Significance Index: 83.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4135
    Cell Significance Index: 40.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4115
    Cell Significance Index: 371.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3990
    Cell Significance Index: 217.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3959
    Cell Significance Index: 48.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3868
    Cell Significance Index: 49.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3231
    Cell Significance Index: 58.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2694
    Cell Significance Index: 12.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2357
    Cell Significance Index: 84.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2275
    Cell Significance Index: 1.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2243
    Cell Significance Index: 36.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2229
    Cell Significance Index: 5.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2114
    Cell Significance Index: 27.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2107
    Cell Significance Index: 14.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2053
    Cell Significance Index: 9.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1935
    Cell Significance Index: 4.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1522
    Cell Significance Index: 17.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1113
    Cell Significance Index: 3.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1046
    Cell Significance Index: 20.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1039
    Cell Significance Index: 1.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0834
    Cell Significance Index: 14.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0644
    Cell Significance Index: 1.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0604
    Cell Significance Index: 3.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0485
    Cell Significance Index: 36.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0239
    Cell Significance Index: 0.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0126
    Cell Significance Index: 23.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0113
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0050
    Cell Significance Index: 7.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0030
    Cell Significance Index: 5.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0099
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0100
    Cell Significance Index: -6.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0243
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -16.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0290
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0384
    Cell Significance Index: -17.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0469
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0670
    Cell Significance Index: -14.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0766
    Cell Significance Index: -1.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0788
    Cell Significance Index: -22.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0824
    Cell Significance Index: -6.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0866
    Cell Significance Index: -4.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0902
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0953
    Cell Significance Index: -10.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1214
    Cell Significance Index: -17.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1284
    Cell Significance Index: -7.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1648
    Cell Significance Index: -4.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1700
    Cell Significance Index: -20.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1933
    Cell Significance Index: -22.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1980
    Cell Significance Index: -12.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2043
    Cell Significance Index: -5.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2271
    Cell Significance Index: -6.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2506
    Cell Significance Index: -19.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2544
    Cell Significance Index: -26.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2683
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3205
    Cell Significance Index: -17.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3323
    Cell Significance Index: -21.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3550
    Cell Significance Index: -11.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3682
    Cell Significance Index: -24.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3810
    Cell Significance Index: -6.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4165
    Cell Significance Index: -9.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4667
    Cell Significance Index: -9.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4737
    Cell Significance Index: -8.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4843
    Cell Significance Index: -5.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5072
    Cell Significance Index: -9.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5388
    Cell Significance Index: -19.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5469
    Cell Significance Index: -4.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5489
    Cell Significance Index: -14.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5568
    Cell Significance Index: -24.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BLVRA is a flavoprotein that catalyzes the reduction of biliverdin to bilirubin, utilizing NAD(P)H as a cofactor. This enzyme is highly specific, with a high affinity for biliverdin and a low affinity for other substrates. BLVRA is also sensitive to oxidative stress, which can inhibit its activity. The enzyme is characterized by its ability to regulate the levels of bilirubin in the body, which is essential for maintaining proper redox balance and preventing tissue damage. **Pathways and Functions** BLVRA is involved in several key pathways, including: 1. **Heme catabolic process**: BLVRA plays a critical role in the breakdown of heme, which is a byproduct of hemoglobin degradation. This process involves the conversion of heme into biliverdin, which is then further converted into bilirubin. 2. **Biliverdin reductase nad+ activity**: BLVRA uses NAD(P)H as a cofactor to reduce biliverdin to bilirubin. 3. **Biliverdin reductase (nad(p)+) activity**: BLVRA also exhibits activity with NAD(P)H, which is a crucial cofactor in the reduction of biliverdin. 4. **Cytoprotection by hmox1**: BLVRA has been shown to interact with heme oxygenase 1 (hmox1), a protein that protects cells against oxidative stress. **Clinical Significance** Dysregulation of BLVRA has been implicated in various diseases, including: 1. **Anemia**: BLVRA deficiency can lead to anemia, as the body is unable to properly break down heme. 2. **Oxidative stress**: BLVRA dysfunction can contribute to oxidative stress, which is a hallmark of various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. 3. **Heme-related disorders**: BLVRA mutations have been identified in individuals with heme-related disorders, such as hemochromatosis and porphyria. In conclusion, BLVRA is a critical enzyme involved in the catabolism of heme and plays a vital role in maintaining redox homeostasis in cells. Its dysregulation has been implicated in various diseases, highlighting the importance of BLVRA in maintaining cellular health.

Genular Protein ID: 2950998517

Symbol: BIEA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P53004 A8K747 O95019 Q86UX0 Q96QL4 Q9BRW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 19 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 4 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8950184

Title: Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase.

PubMed ID: 8950184

DOI: 10.1016/s0167-4781(96)00099-1

PubMed ID: 8631357

Title: Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes.

PubMed ID: 8631357

DOI: 10.1111/j.1432-1033.1996.00372.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8424666

Title: Purification and characterization of human biliverdin reductase.

PubMed ID: 8424666

DOI: 10.1006/abbi.1993.1044

PubMed ID: 7929092

Title: Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.

PubMed ID: 7929092

DOI: 10.1016/s0021-9258(19)51088-2

PubMed ID: 10858451

Title: Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites.

PubMed ID: 10858451

DOI: 10.1074/jbc.275.25.19009

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19580635

Title: A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice).

PubMed ID: 19580635

DOI: 10.1111/j.1478-3231.2009.02029.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 296
  • Mass: 33428
  • Checksum: 2CF2AA7F1CDDB707
  • Sequence:
    • MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE 
DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV 
LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF 
GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN 
VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.