Details for: BLVRA

Gene ID: 644

Symbol: BLVRA

Ensembl ID: ENSG00000106605

Description: biliverdin reductase A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.01
    Marker Score: 3138
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.31
    Marker Score: 2305.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.14
    Marker Score: 3744
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.14
    Marker Score: 1179
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.13
    Marker Score: 118959
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.99
    Marker Score: 50887.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.9
    Marker Score: 3703
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.84
    Marker Score: 1248
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.76
    Marker Score: 15172
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.62
    Marker Score: 18813
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.44
    Marker Score: 682
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.43
    Marker Score: 1075
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.43
    Marker Score: 7530
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.39
    Marker Score: 14031.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.39
    Marker Score: 2237
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.38
    Marker Score: 577
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 5008
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.34
    Marker Score: 2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.33
    Marker Score: 5132
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.33
    Marker Score: 3610
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.31
    Marker Score: 1504
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.31
    Marker Score: 2328
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.3
    Marker Score: 8468
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.26
    Marker Score: 3099
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.26
    Marker Score: 3042
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.25
    Marker Score: 361
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9519
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.22
    Marker Score: 390
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.19
    Marker Score: 865.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10247
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.16
    Marker Score: 7403.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.15
    Marker Score: 8590
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.15
    Marker Score: 1656
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 572
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.14
    Marker Score: 6916
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.12
    Marker Score: 749
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4699
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.08
    Marker Score: 1598
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.08
    Marker Score: 1305
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.08
    Marker Score: 2635
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.08
    Marker Score: 310
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.07
    Marker Score: 2226
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.06
    Marker Score: 766
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.04
    Marker Score: 1662
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.03
    Marker Score: 653
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.03
    Marker Score: 543
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1
    Marker Score: 6503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71667
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47894.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.99
    Marker Score: 253
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.97
    Marker Score: 2275
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.96
    Marker Score: 1022
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.95
    Marker Score: 969
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.94
    Marker Score: 1136
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.93
    Marker Score: 1090
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.93
    Marker Score: 1701
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.91
    Marker Score: 259
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.91
    Marker Score: 763
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.91
    Marker Score: 468
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.9
    Marker Score: 1695
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9
    Marker Score: 950
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.89
    Marker Score: 196
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.89
    Marker Score: 933
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.88
    Marker Score: 213
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.88
    Marker Score: 1498
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.88
    Marker Score: 500
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 430.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.87
    Marker Score: 2283
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.87
    Marker Score: 582
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.87
    Marker Score: 3606
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.87
    Marker Score: 773
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.87
    Marker Score: 594
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 358
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.86
    Marker Score: 1122
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5224
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.86
    Marker Score: 408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.86
    Marker Score: 1624.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1104
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.85
    Marker Score: 560
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.85
    Marker Score: 184
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.84
    Marker Score: 295
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.84
    Marker Score: 942
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4786
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.84
    Marker Score: 932
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.84
    Marker Score: 1591
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.84
    Marker Score: 289
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13082.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.84
    Marker Score: 2872
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.83
    Marker Score: 1143
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.83
    Marker Score: 235
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.82
    Marker Score: 2043
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8445
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1258.5

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Other Information

**Key characteristics:** - BLVRA is a protein of the cytochrome P450 family. - It is expressed in high levels in the liver and other tissues with a high metabolic demand for reduced forms of bilirubin. - It is a key regulator of bilirubin metabolism. **Pathways and functions:** - The primary pathway for bilirubin metabolism is the oxidation of bilirubin by cytochrome P450 enzymes. - BLVRA is a key enzyme in this pathway, reducing bilirubin to bilirubin-sulfoxide. - This reduced form of bilirubin can then be further metabolized by the bile acids. **Clinical significance:** - Mutations in the BLVRA gene have been linked to human diseases, including Gilbert's anemia. - In Gilbert's anemia, the lack of bilirubin reductase leads to the accumulation of bilirubin in the blood, causing jaundice. - BLVRA is a potential therapeutic target for the treatment of Gilbert's anemia. **Additional notes:** - BLVRA is a highly conserved protein with a wide expression in mammals. - It is a key regulator of the production of other bilirubin metabolites, such as bilirubin-diglucuronic acid and urobilin.

Genular Protein ID: 2950998517

Symbol: BIEA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P53004 A8K747 O95019 Q86UX0 Q96QL4 Q9BRW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 19 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8950184

Title: Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase.

PubMed ID: 8950184

DOI: 10.1016/s0167-4781(96)00099-1

PubMed ID: 8631357

Title: Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes.

PubMed ID: 8631357

DOI: 10.1111/j.1432-1033.1996.00372.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8424666

Title: Purification and characterization of human biliverdin reductase.

PubMed ID: 8424666

DOI: 10.1006/abbi.1993.1044

PubMed ID: 7929092

Title: Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.

PubMed ID: 7929092

DOI: 10.1016/s0021-9258(19)51088-2

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19580635

Title: A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice).

PubMed ID: 19580635

DOI: 10.1111/j.1478-3231.2009.02029.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 296
  • Mass: 33428
  • Checksum: 2CF2AA7F1CDDB707
  • Sequence:
    • MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE 
DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV 
LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF 
GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN 
VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.