Details for: DCLRE1C

Gene ID: 64421

Symbol: DCLRE1C

Ensembl ID: ENSG00000152457

Description: DNA cross-link repair 1C

Associated with

Other Information

Genular Protein ID: 2626567675

Symbol: DCR1C_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96SD1 D3DRT6 Q1HCL2 Q5JSR4 Q5JSR5 Q5JSR7 Q5JSR8 Q5JSR9 Q5JSS0 Q5JSS7 Q6PK14 Q8N101 Q8N132 Q8TBW9 Q9BVW9 Q9HAM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 17 EMDB 2 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 14 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 14 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11336668

Title: Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

PubMed ID: 11336668

DOI: 10.1016/s0092-8674(01)00309-9

PubMed ID: 12055248

Title: A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking native Americans.

PubMed ID: 12055248

DOI: 10.4049/jimmunol.168.12.6323

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11955432

Title: Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.

PubMed ID: 11955432

DOI: 10.1016/s0092-8674(02)00671-2

PubMed ID: 12177301

Title: Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family.

PubMed ID: 12177301

DOI: 10.1093/nar/gkf470

PubMed ID: 15071507

Title: Functional and biochemical dissection of the structure-specific nuclease ARTEMIS.

PubMed ID: 15071507

DOI: 10.1038/sj.emboj.7600206

PubMed ID: 15468306

Title: Phosphorylation of Artemis following irradiation-induced DNA damage.

PubMed ID: 15468306

DOI: 10.1002/eji.200425455

PubMed ID: 14744996

Title: The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.

PubMed ID: 14744996

DOI: 10.1084/jem.20031142

PubMed ID: 15574326

Title: A biochemically defined system for mammalian nonhomologous DNA end joining.

PubMed ID: 15574326

DOI: 10.1016/j.molcel.2004.11.017

PubMed ID: 15574327

Title: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

PubMed ID: 15574327

DOI: 10.1016/j.molcel.2004.10.029

PubMed ID: 15456891

Title: Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

PubMed ID: 15456891

DOI: 10.1128/mcb.24.20.9207-9220.2004

PubMed ID: 15723659

Title: Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

PubMed ID: 15723659

DOI: 10.1111/j.1349-7006.2005.00019.x

PubMed ID: 15811628

Title: Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.

PubMed ID: 15811628

DOI: 10.1016/j.dnarep.2005.02.001

PubMed ID: 15936993

Title: The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps.

PubMed ID: 15936993

DOI: 10.1016/j.dnarep.2005.04.013

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23219551

Title: Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.

PubMed ID: 23219551

DOI: 10.1016/j.celrep.2012.11.004

PubMed ID: 23523427

Title: Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair.

PubMed ID: 23523427

DOI: 10.1016/j.str.2013.02.014

PubMed ID: 12406895

Title: Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

PubMed ID: 12406895

DOI: 10.1182/blood-2002-01-0187

PubMed ID: 12921762

Title: Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene.

PubMed ID: 12921762

DOI: 10.1016/s1521-6616(03)00095-0

PubMed ID: 12592555

Title: Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families.

PubMed ID: 12592555

DOI: 10.1007/s00439-002-0897-x

PubMed ID: 12569164

Title: Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis.

PubMed ID: 12569164

DOI: 10.1172/jci16774

PubMed ID: 15731174

Title: Omenn syndrome due to ARTEMIS mutations.

PubMed ID: 15731174

DOI: 10.1182/blood-2004-12-4861

Sequence Information:

  • Length: 692
  • Mass: 78436
  • Checksum: 24B857F5B473637B
  • Sequence:
    • MSSFEGQMAE YPTISIDRFD RENLRARAYF LSHCHKDHMK GLRAPTLKRR LECSLKVYLY 
CSPVTKELLL TSPKYRFWKK RIISIEIETP TQISLVDEAS GEKEEIVVTL LPAGHCPGSV 
MFLFQGNNGT VLYTGDFRLA QGEAARMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE 
ECLSGVLELV RSWITRSPYH VVWLNCKAAY GYEYLFTNLS EELGVQVHVN KLDMFRNMPE 
ILHHLTTDRN TQIHACRHPK AEEYFQWSKL PCGITSRNRI PLHIISIKPS TMWFGERSRK 
TNVIVRTGES SYRACFSFHS SYSEIKDFLS YLCPVNAYPN VIPVGTTMDK VVEILKPLCR 
SSQSTEPKYK PLGKLKRART VHRDSEEEDD YLFDDPLPIP LRHKVPYPET FHPEVFSMTA 
VSEKQPEKLR QTPGCCRAEC MQSSRFTNFV DCEESNSESE EEVGIPASLQ GDLGSVLHLQ 
KADGDVPQWE VFFKRNDEIT DESLENFPSS TVAGGSQSPK LFSDSDGEST HISSQNSSQS 
THITEQGSQG WDSQSDTVLL SSQERNSGDI TSLDKADYRP TIKENIPASL MEQNVICPKD 
TYSDLKSRDK DVTIVPSTGE PTTLSSETHI PEEKSLLNLS TNADSQSSSD FEVPSTPEAE 
LPKREHLQYL YEKLATGESI AVKKRKCSLL DT

Genular Protein ID: 4017251623

Symbol: B3KMX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMX5

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 572
  • Mass: 64733
  • Checksum: 017844D077E2C779
  • Sequence:
    • MFLFQGNNGT VLYTGDFRLA QGEAARMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE 
ECLSGVLELV RSWITRSPYH VVWLNCKAAY GYEYLFTNLS EELGVRVHVN KLDMFRNMPE 
ILHHLTTDRN TQIHACRHPK AEEYFQWSKL PCGITSRNRI PLHIISIKPS TMWFGERSRK 
TNVIVRTGES SYRARFSFHS SYSEIKDFLS YLCPVNAYPN VIPVGTTMDK VVEILKPLCR 
SSQSTEPKYK PLGKLKRART VHRDSEEEDD YLFDDPLPIP LRHKVPYPET FHPEVFSMTA 
VSEKQPEKLR QTPGCCRAEC MQSSRFTNFV DCEESNSESE EEVGIPASLQ GDLGSVLHLQ 
KADGDVPQWE VFFKRNDEIT DESLENFPSS TVAGGSQSPK LFSDSDGEST HISSQNSSQS 
THITEQGSQG WDSQSDTVLL SSQERNSGDI TSLDKADYRP TIKENIPASL MEQNVICPKD 
TYSDLKSRDK DVTIVPSTGE PTTLSSETHI PEEKSLLNLS TNADSQSSSD FEVPSTPEAE 
LPKREHLQYL YEKLATGESI AVKKRKCSLL DT

Genular Protein ID: 557290436

Symbol: A0A8V8TLX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TLX1

Database IDs:

ARBA 9 CDD 1 CTD 1 EMBL 2 Ensembl 3 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 310
  • Mass: 35923
  • Checksum: 987E2C4DBFC64B43
  • Sequence:
    • MSSFEGQMAE YPTISIDRFD RENLRARAYF LSHCHKDHMK GLRAPTLKRR LECSLKVYLY 
CSPVTKELLL TSPKYRFWKK RIISIEIETP TQISLVDEAS GEKEEIVVTL LPAGHCPGSV 
MFLFQGNNGT VLYTGDFRLA QGEAARMELL HSGGRVKDIQ SVYLDTTFCD PRFYQIPSRE 
ECLSGVLELV RSWITRSPYH VVWLNCKAAY GYEYLFTNLS EELGVQVHVN KLDMFRNMPE 
ILHHLTTDRN TQIHACRHPK AEEYFQWSKL PCGITSRNRI PLHIISIKPS TMWFGERSRK 
TNVIVRLKIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.