Syt4 | ENSRNOG00000017333 | NCBI 64440

Details for: Syt4

Gene ID: 64440

Symbol: Syt4

Ensembl ID: ENSRNOG00000017333

Description: synaptotagmin 4

Associated with

Astrocyte projection
(GO:0097449)
Axon
(GO:0030424)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-ion regulated exocytosis
(GO:0017156)
Calcium ion-regulated exocytosis of neurotransmitter
(GO:0048791)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cellular response to calcium ion
(GO:0071277)
Clathrin binding
(GO:0030276)
Dendrite
(GO:0030425)
Dense core granule
(GO:0031045)
Dense core granule cytoskeletal transport
(GO:0099519)
Exocytic vesicle
(GO:0070382)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Microvesicle
(GO:1990742)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of catecholamine secretion
(GO:0033604)
Negative regulation of dense core granule exocytosis
(GO:1905414)
Negative regulation of neurotransmitter secretion
(GO:0046929)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of retrograde trans-synaptic signaling by neuropeptide
(GO:1905433)
Negative regulation of short-term neuronal synaptic plasticity
(GO:0048174)
Negative regulation of synaptic vesicle exocytosis
(GO:2000301)
Negative regulation of vesicle fusion
(GO:0031339)
Neuronal cell body
(GO:0043025)
Neuronal dense core vesicle
(GO:0098992)
Neuronal dense core vesicle membrane
(GO:0099012)
Neuron projection
(GO:0043005)
Neuron projection terminus
(GO:0044306)
Neurotransmitter secretion
(GO:0007269)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylserine binding
(GO:0001786)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of dendrite extension
(GO:1903861)
Positive regulation of dense core granule exocytosis
(GO:1905415)
Positive regulation of glutamate secretion
(GO:0014049)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of calcium ion-dependent exocytosis
(GO:0017158)
Regulation of dopamine secretion
(GO:0014059)
Regulation of endocytosis
(GO:0030100)
Regulation of postsynaptic dense core vesicle exocytosis
(GO:0150044)
Regulation of trans-synaptic signaling by bdnf, modulating synaptic transmission
(GO:0150035)
Regulation of vesicle fusion
(GO:0031338)
Secretory granule maturation
(GO:0061792)
Secretory granule membrane
(GO:0030667)
Snare binding
(GO:0000149)
Somatodendritic compartment
(GO:0036477)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Syntaxin-1 binding
(GO:0017075)
Syntaxin-3 binding
(GO:0030348)
Syntaxin binding
(GO:0019905)
Vesicle
(GO:0031982)
Vesicle fusion
(GO:0006906)
Vesicle fusion with vesicle
(GO:0061782)

Other Information

Proteins

Synaptotagmin-4

Genular Protein ID: 2543825689

Symbol: SYT4_RAT

Name: Synaptotagmin-4

UniProtKB Accession Codes:

P50232

Database IDs:

Citations:

PubMed ID: 7993622

Title: Functional properties of multiple synaptotagmins in brain.

PubMed ID: 7993622

DOI: 10.1016/0896-6273(94)90415-4

PubMed ID: 7892240

Title: Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain.

PubMed ID: 7892240

DOI: 10.1073/pnas.92.6.2164

PubMed ID: 9162066

Title: The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding.

PubMed ID: 9162066

DOI: 10.1074/jbc.272.22.14314

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 29166604

Title: Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4.

PubMed ID: 29166604

DOI: 10.1016/j.celrep.2017.10.084

PubMed ID: 30021165

Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.

PubMed ID: 30021165

DOI: 10.1016/j.celrep.2018.06.071

Sequence Information:

Length: 425
Mass: 47685
Checksum: 6AC88E00878936BB
Sequence:

MAPITTSRVE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR RSAKSNKTPP YKFVHVLKGV 
DIYPENLSSK KKFGGDDKSE AKRKAALPNL SLHLDLEKRD LNGNFPKTNP KAGSSSDLEN 
VTPKLFPETE KEAVSPESLK SSTSLTSEEK QEKLGTLFLS LEYNFEKKAF VVNIKEAQGL 
PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPVFD ETFTFYGVPY PHIQELSLHF 
TVLSFDRFSR DDVIGEVLVP LSGIELSDGK MLMTREIIKR NAKKSSGRGE LLVSLCYQST 
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 
DIPCESLEEI SVEFLVLDSE RGSRNEVIGR LVLGATAEGS GGGHWKEICD FPRRQIAKWH 
MLCDG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Syt4

Associated with

Other Information

Functional properties of multiple synaptotagmins in brain. PubMed ID: 7993622

Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. PubMed ID: 7892240

The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding. PubMed ID: 9162066

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4. PubMed ID: 29166604