Details for: Mfn2

Gene ID: 64476

Symbol: Mfn2

Description: mitofusin 2

Associated with

  • Aerobic respiration
    (GO:0009060)
  • Apoptotic process
    (GO:0006915)
  • Blastocyst formation
    (GO:0001825)
  • Camera-type eye morphogenesis
    (GO:0048593)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to ionizing radiation
    (GO:0071479)
  • Cellular response to l-glutamate
    (GO:1905232)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular response to manganese ion
    (GO:0071287)
  • Cellular response to mercaptoethanol
    (GO:0072705)
  • Cellular response to testosterone stimulus
    (GO:0071394)
  • Cytosol
    (GO:0005829)
  • Gtpase activity
    (GO:0003924)
  • Gtpase binding
    (GO:0051020)
  • Gtp binding
    (GO:0005525)
  • Identical protein binding
    (GO:0042802)
  • Intracellular distribution of mitochondria
    (GO:0048312)
  • Male gonad development
    (GO:0008584)
  • Microtubule cytoskeleton
    (GO:0015630)
  • Mitochondrial calcium ion homeostasis
    (GO:0051560)
  • Mitochondrial fusion
    (GO:0008053)
  • Mitochondrial membrane organization
    (GO:0007006)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Mitochondrion localization
    (GO:0051646)
  • Mitochondrion organization
    (GO:0007005)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cell size
    (GO:0045792)
  • Negative regulation of glial cell proliferation
    (GO:0060253)
  • Negative regulation of mitochondrial fission
    (GO:0090258)
  • Negative regulation of ras protein signal transduction
    (GO:0046580)
  • Negative regulation of reactive oxygen species biosynthetic process
    (GO:1903427)
  • Negative regulation of release of cytochrome c from mitochondria
    (GO:0090201)
  • Negative regulation of sarcomere organization
    (GO:0060299)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
    (GO:0061734)
  • Positive regulation of cellular respiration
    (GO:1901857)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of dendritic spine morphogenesis
    (GO:0061003)
  • Positive regulation of estradiol secretion
    (GO:2000866)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of hydrogen peroxide biosynthetic process
    (GO:0010729)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of ovarian follicle development
    (GO:2000386)
  • Positive regulation of progesterone secretion
    (GO:2000872)
  • Positive regulation of reactive oxygen species biosynthetic process
    (GO:1903428)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein localization to phagophore assembly site
    (GO:0034497)
  • Protein targeting to mitochondrion
    (GO:0006626)
  • Proteoglycan binding
    (GO:0043394)
  • Response to axon injury
    (GO:0048678)
  • Response to cadmium ion
    (GO:0046686)
  • Response to calcium ion
    (GO:0051592)
  • Response to d-galactose
    (GO:1905377)
  • Response to electrical stimulus
    (GO:0051602)
  • Response to fatty acid
    (GO:0070542)
  • Response to flavonoid
    (GO:1905395)
  • Response to hypobaric hypoxia
    (GO:1990910)
  • Response to l-arginine
    (GO:1903576)
  • Response to muscle activity
    (GO:0014850)
  • Response to nutrient levels
    (GO:0031667)
  • Response to testosterone
    (GO:0033574)
  • Response to unfolded protein
    (GO:0006986)
  • Small gtpase binding
    (GO:0031267)
  • Spermatogenesis
    (GO:0007283)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 4217507068

Symbol: Q6IRL2_RAT

Name: N/A

UniProtKB Accession Codes:

Q6IRL2 D4A9N3

Database IDs:

ARBA 11 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 7 ExpressionAtlas 1 GO 5 Gene3D 2 HOGENOM 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 Proteomes 1 RGD 2 RefSeq 6 SAM 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 757
  • Mass: 86181
  • Checksum: 902040E062455BC4
  • Sequence:
    • MSLLFSRCNS IVTVKKDKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI QESAGFLEDT 
HRNTELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK 
VLPSGIGHTT NCFLRVGGTD GHEAFLLTEG SEEKKSVKTV NQLAHALHQD EQLHAGSLVS 
VMWPNSKCPL LKDDLVLMDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKQF 
FHKVSERLSR PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRAQAGDR 
IFFVSAKEVL SARVQKAQGM PEGGGALAEG FQVRMFEFQN FERRFEECIS QSAVKTKFEQ 
HTVRAKQIAE AVRLIMDSLH IAAQEQRVYC LEMREERQDR LRFIDKQLEL LAQDYKLRIK 
QMTEEVERQV STAMAEEIRR LSVLVDEYQM DFHPSPVVLK VYKNELHRHI EEGLGRNMSD 
RCSTAIASSL QTMQQDMIDG LKPLLPVSVR NQIDMLVPRQ CFSLSYDLNC DKLCADFQED 
IEFHFSLGWT MLVNRFLGPK NSRRALLGYN DQVQRPLPLT PANPSMPPLP QGSLTQEELM 
VSMVTGLASL TSRTSMGILV VGGVVWKAVG WRLIALSFGL YGLLYVYERL TWTTRAKERA 
FKRQFVEYAS EKLQLIISYT GSNCSHQVQQ ELSGTFAHLC QQVDITRDNL EQEIAAMNKK 
VEALDSLQSK AKLLRNKAGW LDSELNMFIH QYLQPSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.