Details for: TPSB2

Gene ID: 64499

Symbol: TPSB2

Ensembl ID: ENSG00000197253

Description: tryptase beta 2

Associated with

Other Information

Genular Protein ID: 3655135639

Symbol: TRYB2_HUMAN

Name: Tryptase beta-2

UniProtKB Accession Codes:

P20231 D2E6S0 D2E6S2 O95827 Q15664 Q9UQI6 Q9UQI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2203827

Title: Cloning and characterization of a second complementary DNA for human tryptase.

PubMed ID: 2203827

DOI: 10.1172/jci114786

PubMed ID: 8434231

Title: Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.

PubMed ID: 8434231

DOI: 10.1111/j.1365-3083.1993.tb01757.x

PubMed ID: 9920877

Title: Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.

PubMed ID: 9920877

DOI: 10.1074/jbc.274.6.3355

PubMed ID: 19748655

Title: Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.

PubMed ID: 19748655

DOI: 10.1016/j.jaci.2009.07.026

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2187193

Title: Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

PubMed ID: 2187193

DOI: 10.1073/pnas.87.10.3811

PubMed ID: 14670919

Title: Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.

PubMed ID: 14670919

DOI: 10.1182/blood-2003-08-2981

PubMed ID: 18039527

Title: Active monomers of human beta-tryptase have expanded substrate specificities.

PubMed ID: 18039527

DOI: 10.1016/j.intimp.2007.07.007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9521329

Title: Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.

PubMed ID: 9521329

DOI: 10.1038/32703

PubMed ID: 10500112

Title: The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.

PubMed ID: 10500112

DOI: 10.1073/pnas.96.20.10984

Sequence Information:

  • Length: 275
  • Mass: 30651
  • Checksum: 2B0AE2CED3FB5112
  • Sequence:
    • MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV RDRYWMHFCG 
GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA 
DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV 
PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG 
VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.