Details for: BLVRB

Gene ID: 645

Symbol: BLVRB

Ensembl ID: ENSG00000090013

Description: biliverdin reductase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.35
    Marker Score: 187142
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.18
    Marker Score: 20278
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.05
    Marker Score: 3054
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.95
    Marker Score: 19260
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.86
    Marker Score: 3277
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.79
    Marker Score: 13383
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.7
    Marker Score: 23228
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.69
    Marker Score: 3236
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.68
    Marker Score: 4303
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.59
    Marker Score: 4122
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.55
    Marker Score: 19905
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.45
    Marker Score: 3783
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.42
    Marker Score: 18040.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.42
    Marker Score: 4717
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.39
    Marker Score: 6035
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.37
    Marker Score: 5783
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.34
    Marker Score: 4146
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.3
    Marker Score: 5229.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.3
    Marker Score: 1268
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.27
    Marker Score: 807
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.26
    Marker Score: 3751
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.2
    Marker Score: 1735.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.17
    Marker Score: 7705
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55324
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.13
    Marker Score: 4862
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.13
    Marker Score: 2570
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.08
    Marker Score: 3065
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.07
    Marker Score: 24093.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.06
    Marker Score: 10841
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.05
    Marker Score: 858
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.02
    Marker Score: 1369
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2
    Marker Score: 12151
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.99
    Marker Score: 7662
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.97
    Marker Score: 6195
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.96
    Marker Score: 4657
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.94
    Marker Score: 3544
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.92
    Marker Score: 2052
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.89
    Marker Score: 469
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.88
    Marker Score: 2433
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.88
    Marker Score: 782
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.86
    Marker Score: 870
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.86
    Marker Score: 4863
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.85
    Marker Score: 4969
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.85
    Marker Score: 535
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.85
    Marker Score: 2614
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.83
    Marker Score: 441
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.82
    Marker Score: 6744
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.77
    Marker Score: 407
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.77
    Marker Score: 15363
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.76
    Marker Score: 1006
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.75
    Marker Score: 8575
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.73
    Marker Score: 1545
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.73
    Marker Score: 776
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.73
    Marker Score: 1658
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.72
    Marker Score: 1815
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.71
    Marker Score: 494
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.68
    Marker Score: 7250
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.67
    Marker Score: 1772
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.66
    Marker Score: 1685
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.63
    Marker Score: 1113
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.63
    Marker Score: 1906
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.63
    Marker Score: 516
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.62
    Marker Score: 4027
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.62
    Marker Score: 797
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.59
    Marker Score: 1060
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.58
    Marker Score: 1322
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.57
    Marker Score: 2568
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.56
    Marker Score: 53181.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.56
    Marker Score: 25088
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.55
    Marker Score: 1580
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.54
    Marker Score: 1311
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.53
    Marker Score: 492
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.53
    Marker Score: 1222
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.51
    Marker Score: 1570
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.51
    Marker Score: 295
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51556
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.47
    Marker Score: 5780
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.47
    Marker Score: 1636
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.47
    Marker Score: 725
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.46
    Marker Score: 968
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165596
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.43
    Marker Score: 534
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 834
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.43
    Marker Score: 735
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.42
    Marker Score: 1754
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4
    Marker Score: 1398
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 665
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.36
    Marker Score: 337
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.36
    Marker Score: 589
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.35
    Marker Score: 674
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.35
    Marker Score: 537
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.35
    Marker Score: 2557
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.34
    Marker Score: 4611
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.33
    Marker Score: 15026
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.33
    Marker Score: 333
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.33
    Marker Score: 944
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.32
    Marker Score: 541
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.32
    Marker Score: 1278
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.31
    Marker Score: 376
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.29
    Marker Score: 755.5

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Other Information

**Key characteristics:** * BLVRB is a protein of the cytochrome P450 family. * It is expressed in high levels in immune cells, including monocytes, macrophages, and dendritic cells. * It is also expressed in epithelial cells of the gut and esophagus. * BLVRB is a NADPH-dependent enzyme. **Pathways and functions:** * BLVRB catalyzes the reduction of bilirubin to its inactive form, bilirubin-glucuronide. * This process is involved in the clearance of bilirubin from the body. * BLVRB is also involved in the regulation of inflammation and cell survival. * In inflammation, BLVRB is activated and reduces bilirubin to its inactive form, which inhibits the activation of nuclear factor kappa B (NF-κB), a key transcription factor that is involved in inflammation. * In cell survival, BLVRB is involved in the regulation of apoptosis (programmed cell death). * BLVRB also plays a role in the metabolism of porphyrins, a group of pigments that are produced by the breakdown of hemoglobin. **Clinical significance:** * Mutations in BLVRB have been linked to several diseases, including liver disease, cancer, and inflammation. * In liver disease, mutations in BLVRB can lead to the accumulation of bilirubin in the blood, which can cause a condition called bilirubin jaundice. * In cancer, mutations in BLVRB can lead to the development of tumors that are resistant to chemotherapy. * BLVRB is a potential target for the treatment of liver disease and cancer.

Genular Protein ID: 2619772836

Symbol: BLVRB_HUMAN

Name: Flavin reductase (NADPH)

UniProtKB Accession Codes:

P30043 A6NKD8 B2R5C6 P32078 P53005 Q32LZ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 3 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 19 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8117274

Title: Cloning and nucleotide sequence of a cDNA of the human erythrocyte NADPH-flavin reductase.

PubMed ID: 8117274

DOI: 10.1006/bbrc.1994.1165

PubMed ID: 8799475

Title: Molecular cloning and expression of human liver biliverdin-IXbeta reductase.

PubMed ID: 8799475

DOI: 10.1248/bpb.19.796

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8280170

Title: Complete amino acid sequence of biliverdin-IX beta reductase from human liver.

PubMed ID: 8280170

DOI: 10.1006/bbrc.1993.2649

PubMed ID: 7929092

Title: Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization.

PubMed ID: 7929092

DOI: 10.1016/s0021-9258(19)51088-2

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 8313871

Title: Plasma and red blood cell protein maps: update 1993.

PubMed ID: 8313871

DOI: 10.1002/elps.11501401183

PubMed ID: 8687377

Title: Evidence that biliverdin-IX beta reductase and flavin reductase are identical.

PubMed ID: 8687377

DOI: 10.1042/bj3160385

PubMed ID: 10620517

Title: Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).

PubMed ID: 10620517

DOI: 10.1042/bj3450393

PubMed ID: 18241201

Title: Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase.

PubMed ID: 18241201

DOI: 10.1042/bj20071495

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11224564

Title: Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.

PubMed ID: 11224564

DOI: 10.1038/84948

Sequence Information:

  • Length: 206
  • Mass: 22119
  • Checksum: 3057E6D69A9F9F9F
  • Sequence:
    • MAVKKIAIFG ATGQTGLTTL AQAVQAGYEV TVLVRDSSRL PSEGPRPAHV VVGDVLQAAD 
VDKTVAGQDA VIVLLGTRND LSPTTVMSEG ARNIVAAMKA HGVDKVVACT SAFLLWDPTK 
VPPRLQAVTD DHIRMHKVLR ESGLKYVAVM PPHIGDQPLT GAYTVTLDGR GPSRVISKHD 
LGHFMLRCLT TDEYDGHSTY PSHQYQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.