Details for: Il12b

Gene ID: 64546

Symbol: Il12b

Ensembl ID: ENSRNOG00000004380

Description: interleukin 12B

Associated with

  • Cytokine signaling in immune system
    (R-RNO-1280215)
  • Immune system
    (R-RNO-168256)
  • Interleukin-12 family signaling
    (R-RNO-447115)
  • Interleukin-12 signaling
    (R-RNO-9020591)
  • Interleukin-23 signaling
    (R-RNO-9020933)
  • Signaling by interleukins
    (R-RNO-449147)
  • Cell migration
    (GO:0016477)
  • Cell population proliferation
    (GO:0008283)
  • Cell surface
    (GO:0009986)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine binding
    (GO:0019955)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytokine receptor binding
    (GO:0005126)
  • Cytoplasm
    (GO:0005737)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to protozoan
    (GO:0042832)
  • Defense response to virus
    (GO:0051607)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-12 alpha subunit binding
    (GO:0042164)
  • Interleukin-12 complex
    (GO:0043514)
  • Interleukin-12-mediated signaling pathway
    (GO:0035722)
  • Interleukin-23 complex
    (GO:0070743)
  • Interleukin-23 receptor binding
    (GO:0045519)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of inflammatory response to antigenic stimulus
    (GO:0002862)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of vascular endothelial growth factor signaling pathway
    (GO:1900747)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of lymphocyte proliferation
    (GO:0050671)
  • Positive regulation of mononuclear cell proliferation
    (GO:0032946)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
    (GO:0002860)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of nk t cell activation
    (GO:0051135)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of t-helper 1 type immune response
    (GO:0002827)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein heterodimerization activity
    (GO:0046982)
  • Receptor complex
    (GO:0043235)
  • Regulation of tyrosine phosphorylation of stat protein
    (GO:0042509)
  • Response to organic substance
    (GO:0010033)
  • Response to uv-b
    (GO:0010224)
  • T-helper cell differentiation
    (GO:0042093)
  • T cell proliferation
    (GO:0042098)

Other Information

Genular Protein ID: 3010100000

Symbol: Q9R278_RAT

Name: N/A

UniProtKB Accession Codes:

Q9R278

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 CDD 1 CTD 1 EMBL 2 GO 60 Gene3D 1 Genevisible 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 3 Pfam 1 PhylomeDB 1 RGD 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 9613680

Title: Molecular cloning and sequencing of the rat interleukin-12 p40 gene.

PubMed ID: 9613680

Sequence Information:

  • Length: 335
  • Mass: 38413
  • Checksum: 39BF5B49AF191007
  • Sequence:
    • MCHQKLTFSW FAMVLLVSPL MAMWELEKDV YVVEVDWRPD APGETVTLTC DSPEEDDITW 
TSDQRRGVIG SGKTLTITVR EFLDAGQYTC HRGGETLSHS HLLLHKKENG IWSTEILKNF 
KNKTFLKCEA PNYSGRFTCS WLVHRNTDLK FNIKSSSSSP ESRAVTCGRA SLSAEKVTLN 
QRDYEKYSVA CQEDVTCPTA EETLPIELVV EAQQQNKYEN YSTSFFIRDI IKPDPPKNLQ 
VKPLKNSQVE VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK TKETEEECNQ KGAFLVEKTS 
AEVQCKGANI CVQAQDRYYN SSCSKWTCVP CRGRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.