Details for: CLEC7A

Gene ID: 64581

Symbol: CLEC7A

Ensembl ID: ENSG00000172243

Description: C-type lectin domain containing 7A

Associated with

  • C-type lectin receptors (clrs)
    (R-HSA-5621481)
  • Clec7a (dectin-1) signaling
    (R-HSA-5607764)
  • Immune system
    (R-HSA-168256)
  • Innate immune system
    (R-HSA-168249)
  • (1->3)-beta-d-glucan binding
    (GO:0001872)
  • Antifungal innate immune response
    (GO:0061760)
  • Carbohydrate binding
    (GO:0030246)
  • Carbohydrate mediated signaling
    (GO:0009756)
  • Cell activation
    (GO:0001775)
  • Cell recognition
    (GO:0008037)
  • Cell surface
    (GO:0009986)
  • Cellular response to molecule of fungal origin
    (GO:0071226)
  • Cytoplasm
    (GO:0005737)
  • Defense response to protozoan
    (GO:0042832)
  • Detection of fungus
    (GO:0016046)
  • Detection of molecule of fungal origin
    (GO:0032491)
  • Detection of yeast
    (GO:0001879)
  • Inflammatory response
    (GO:0006954)
  • Membrane
    (GO:0016020)
  • Metal ion binding
    (GO:0046872)
  • Mhc protein binding
    (GO:0042287)
  • Pattern recognition receptor activity
    (GO:0038187)
  • Phagocytosis, recognition
    (GO:0006910)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of calcium-mediated signaling
    (GO:0050850)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell maturation
    (GO:1903431)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of dendritic cell cytokine production
    (GO:0002732)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of killing of cells of another organism
    (GO:0051712)
  • Positive regulation of lymphocyte activation
    (GO:0051251)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of respiratory burst
    (GO:0060267)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of t-helper 17 type immune response
    (GO:2000318)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of wound healing
    (GO:0090303)
  • Protein binding
    (GO:0005515)
  • Regulation of calcineurin-nfat signaling cascade
    (GO:0070884)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Response to yeast
    (GO:0001878)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • T cell activation
    (GO:0042110)

Other Information

Genular Protein ID: 1503445703

Symbol: CLC7A_HUMAN

Name: C-type lectin domain family 7 member A

UniProtKB Accession Codes:

Q9BXN2 B2R861 B7Z494 B7Z5A9 B7Z5B9 Q6IPS7 Q96D32 Q96DR9 Q96LD3 Q96PA4 Q96PA5 Q96PA6 Q96PA7 Q96PA8 Q9H1K3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 31 Ensembl 10 ExpressionAtlas 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11745369

Title: A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex.

PubMed ID: 11745369

DOI: 10.1002/1521-4141(200112)31:12<3493::aid-immu3493>3.0.co;2-9

PubMed ID: 11470510

Title: Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1.

PubMed ID: 11470510

DOI: 10.1016/s0378-1119(01)00528-5

PubMed ID: 11491532

Title: Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells.

PubMed ID: 11491532

DOI: 10.1007/s002510100326

PubMed ID: 11567029

Title: Characterization of the human beta-glucan receptor and its alternatively spliced isoforms.

PubMed ID: 11567029

DOI: 10.1074/jbc.m107715200

PubMed ID: 12423684

Title: Molecular and functional characterization of human Dectin-1.

PubMed ID: 12423684

DOI: 10.1016/s0301-472x(02)00928-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16870151

Title: Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM.

PubMed ID: 16870151

DOI: 10.1016/j.bbrc.2006.07.021

PubMed ID: 17230442

Title: Dectin-1 promotes fungicidal activity of human neutrophils.

PubMed ID: 17230442

DOI: 10.1002/eji.200636653

PubMed ID: 19864674

Title: Human dectin-1 deficiency and mucocutaneous fungal infections.

PubMed ID: 19864674

DOI: 10.1056/nejmoa0901053

PubMed ID: 20807886

Title: Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.

PubMed ID: 20807886

DOI: 10.1182/blood-2010-04-279307

Sequence Information:

  • Length: 247
  • Mass: 27627
  • Checksum: 98393E36976111B9
  • Sequence:
    • MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI 
AVVLGTMAIW RSNSGSNTLE NGYFLSRNKE NHSQPTQSSL EDSVTPTKAV KTTGVLSSPC 
PPNWIIYEKS CYLFSMSLNS WDGSKRQCWQ LGSNLLKIDS SNELGFIVKQ VSSQPDNSFW 
IGLSRPQTEV PWLWEDGSTF SSNLFQIRTT ATQENPSPNC VWIHVSVIYD QLCSVPSYSI 
CEKKFSM

Genular Protein ID: 697505605

Symbol: Q68D78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D78

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 7 Ensembl 2 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 136
  • Mass: 15593
  • Checksum: 257A8E87EA88A933
  • Sequence:
    • MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI 
AVVLGTMGEY LVEEINNRQF SKQLLCARHS FKGLTCIIYF NLYIIWFYLY WVGAVNAHFT 
YKGCERLRGY FTFPGL

Genular Protein ID: 1806427214

Symbol: A0A0S2Z5Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z5Q1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 RefSeq 1 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 77
  • Mass: 8363
  • Checksum: 488D685E42698CCB
  • Sequence:
    • MEYHPDLENL DEDGYTQLHF DSQSNTRIAV VSEKGSCAAS PPWRLIAVIL GILCLVILVI 
AVVLGTMAGF KAVEFKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.