Details for: BNC1

Gene ID: 646

Symbol: BNC1

Ensembl ID: ENSG00000169594

Description: basonuclin zinc finger protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 5.89
    Marker Score: 18883
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.97
    Marker Score: 2616
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1513
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.74
    Marker Score: 726
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.52
    Marker Score: 1002.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.49
    Marker Score: 2597
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.44
    Marker Score: 3925
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.32
    Marker Score: 425
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1
    Marker Score: 2082.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7299
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2473
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.95
    Marker Score: 320
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.82
    Marker Score: 1175
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 827
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1539
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.75
    Marker Score: 833
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.71
    Marker Score: 2977
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 534
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10404
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.59
    Marker Score: 285
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.53
    Marker Score: 670.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.49
    Marker Score: 638
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.48
    Marker Score: 139
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.44
    Marker Score: 501
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 245.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.43
    Marker Score: 457
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 187
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.36
    Marker Score: 3650
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.35
    Marker Score: 652
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.35
    Marker Score: 159
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.34
    Marker Score: 287
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 692
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.33
    Marker Score: 123
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.33
    Marker Score: 2598.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.3
    Marker Score: 73
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 106
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.24
    Marker Score: 2055
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 122
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.19
    Marker Score: 455
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 98
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.18
    Marker Score: 2373
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.17
    Marker Score: 133.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.14
    Marker Score: 245.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.14
    Marker Score: 1909
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 836
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.14
    Marker Score: 197
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.12
    Marker Score: 204
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.12
    Marker Score: 460
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.12
    Marker Score: 197
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 343
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.11
    Marker Score: 268
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.11
    Marker Score: 86
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.09
    Marker Score: 677
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.09
    Marker Score: 3037
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.08
    Marker Score: 22

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Other Information

**Key characteristics:** - BNC1 is a transmembrane protein with a conserved zinc finger domain. - It is expressed in high levels in germ cells and embryonic stem cells. - It is also expressed in various cell types during development, including the embryo, placenta, and germ cells. - BNC1 is a key regulator of cell differentiation, proliferation, and survival. **Pathways and functions:** - BNC1 is involved in cell differentiation by promoting the development of neural and epithelial tissues. - It is also involved in oocyte maturation by promoting the development of mature oocyte-like cells. - BNC1 is a key regulator of spermatogenesis by promoting the development of male gametes. **Clinical significance:** - Mutations in BNC1 have been linked to several human diseases, including cancer and developmental disorders. - BNC1 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional information:** - BNC1 is a member of the Zinc finger family of proteins, which are involved in a variety of cellular processes, including cell differentiation, proliferation, and migration. - It is a highly conserved protein, with a similar protein found in mammals, birds, and fish. - BNC1 is a promising target for cancer therapy due to its role in cell differentiation and survival.

Genular Protein ID: 4229146582

Symbol: BNC1_HUMAN

Name: Zinc finger protein basonuclin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1332044

Title: Basonuclin: a keratinocyte protein with multiple paired zinc fingers.

PubMed ID: 1332044

DOI: 10.1073/pnas.89.21.10311

PubMed ID: 9099851

Title: The human basonuclin gene.

PubMed ID: 9099851

DOI: 10.1016/s0378-1119(96)00659-2

PubMed ID: 8034748

Title: Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.

PubMed ID: 8034748

DOI: 10.1083/jcb.126.2.495

PubMed ID: 9223293

Title: Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.

PubMed ID: 9223293

DOI: 10.1073/pnas.94.15.7948

PubMed ID: 9687312

Title: Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.

PubMed ID: 9687312

DOI: 10.1095/biolreprod59.2.388

PubMed ID: 16891417

Title: Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.

PubMed ID: 16891417

DOI: 10.1073/pnas.0605086103

PubMed ID: 30010909

Title: Basonuclin 1 deficiency is a cause of primary ovarian insufficiency.

PubMed ID: 30010909

DOI: 10.1093/hmg/ddy261

Sequence Information:

  • Length: 994
  • Mass: 110972
  • Checksum: 7DF13EE782E20ED5
  • Sequence:
  • MRRRPPSRGG RGAARARETR RQPRHRSGRR MAEAISCTLN CSCQSFKPGK INHRQCDQCK 
    HGWVAHALSK LRIPPMYPTS QVEIVQSNVV FDISSLMLYG TQAIPVRLKI LLDRLFSVLK 
    QDEVLQILHA LDWTLQDYIR GYVLQDASGK VLDHWSIMTS EEEVATLQQF LRFGETKSIV 
    ELMAIQEKEE QSIIIPPSTA NVDIRAFIES CSHRSSSLPT PVDKGNPSSI HPFENLISNM 
    TFMLPFQFFN PLPPALIGSL PEQYMLEQGH DQSQDPKQEV HGPFPDSSFL TSSSTPFQVE 
    KDQCLNCPDA ITKKEDSTHL SDSSSYNIVT KFERTQLSPE AKVKPERNSL GTKKGRVFCT 
    ACEKTFYDKG TLKIHYNAVH LKIKHKCTIE GCNMVFSSLR SRNRHSANPN PRLHMPMNRN 
    NRDKDLRNSL NLASSENYKC PGFTVTSPDC RPPPSYPGSG EDSKGQPAFP NIGQNGVLFP 
    NLKTVQPVLP FYRSPATPAE VANTPGILPS LPLLSSSIPE QLISNEMPFD ALPKKKSRKS 
    SMPIKIEKEA VEIANEKRHN LSSDEDMPLQ VVSEDEQEAC SPQSHRVSEE QHVQSGGLGK 
    PFPEGERPCH RESVIESSGA ISQTPEQATH NSERETEQTP ALIMVPREVE DGGHEHYFTP 
    GMEPQVPFSD YMELQQRLLA GGLFSALSNR GMAFPCLEDS KELEHVGQHA LARQIEENRF 
    QCDICKKTFK NACSVKIHHK NMHVKEMHTC TVEGCNATFP SRRSRDRHSS NLNLHQKALS 
    QEALESSEDH FRAAYLLKDV AKEAYQDVAF TQQASQTSVI FKGTSRMGSL VYPITQVHSA 
    SLESYNSGPL SEGTILDLST TSSMKSESSS HSSWDSDGVS EEGTVLMEDS DGNCEGSSLV 
    PGEDEYPICV LMEKADQSLA SLPSGLPITC HLCQKTYSNK GTFRAHYKTV HLRQLHKCKV 
    PGCNTMFSSV RSRNRHSQNP NLHKSLASSP SHLQ

Genular Protein ID: 580958758

Symbol: F5GY04_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 987
  • Mass: 109830
  • Checksum: 35C50E8B9A4844BD
  • Sequence:
  • MRCRNMFFSF KASLCGCGAA TAPSLTAISC TLNCSCQSFK PGKINHRQCD QCKHGWVAHA 
    LSKLRIPPMY PTSQVEIVQS NVVFDISSLM LYGTQAIPVR LKILLDRLFS VLKQDEVLQI 
    LHALDWTLQD YIRGYVLQDA SGKVLDHWSI MTSEEEVATL QQFLRFGETK SIVELMAIQE 
    KEEQSIIIPP STANVDIRAF IESCSHRSSS LPTPVDKGNP SSIHPFENLI SNMTFMLPFQ 
    FFNPLPPALI GSLPEQYMLE QGHDQSQDPK QEVHGPFPDS SFLTSSSTPF QVEKDQCLNC 
    PDAITKKEDS THLSDSSSYN IVTKFERTQL SPEAKVKPER NSLGTKKGRV FCTACEKTFY 
    DKGTLKIHYN AVHLKIKHKC TIEGCNMVFS SLRSRNRHSA NPNPRLHMPM NRNNRDKDLR 
    NSLNLASSEN YKCPGFTVTS PDCRPPPSYP GSGEDSKGQP AFPNIGQNGV LFPNLKTVQP 
    VLPFYRSPAT PAEVANTPGI LPSLPLLSSS IPEQLISNEM PFDALPKKKS RKSSMPIKIE 
    KEAVEIANEK RHNLSSDEDM PLQVVSEDEQ EACSPQSHRV SEEQHVQSGG LGKPFPEGER 
    PCHRESVIES SGAISQTPEQ ATHNSERETE QTPALIMVPR EVEDGGHEHY FTPGMEPQVP 
    FSDYMELQQR LLAGGLFSAL SNRGMAFPCL EDSKELEHVG QHALARQIEE NRFQCDICKK 
    TFKNACSVKI HHKNMHVKEM HTCTVEGCNA TFPSRRSRDR HSSNLNLHQK ALSQEALESS 
    EDHFRAAYLL KDVAKEAYQD VAFTQQASQT SVIFKGTSRM GSLVYPITQV HSASLESYNS 
    GPLSEGTILD LSTTSSMKSE SSSHSSWDSD GVSEEGTVLM EDSDGNCEGS SLVPGEDEYP 
    ICVLMEKADQ SLASLPSGLP ITCHLCQKTY SNKGTFRAHY KTVHLRQLHK CKVPGCNTMF 
    SSVRSRNRHS QNPNLHKSLA SSPSHLQ

Genular Protein ID: 1709001144

Symbol: B7Z885_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 987
  • Mass: 109831
  • Checksum: 02B7A394C0CD710D
  • Sequence:
  • MRCRNMFFSF KASLCGCGAA TAPSLTAISC TLNCSCQSFK PGKINHRQCD QCKHGWVAHA 
    LSKLRIPPMY PTSQVEIVQS NVVFDISSLM LYGTQAIPVR LKILLDRLFS VLKQDEVLQI 
    LHALDWTLQD YIRGYVLQDA SGKVLDHWSI MTSEEEVATL QQFLRFGETK SIVELMAIQE 
    KEEQSIIIPP STANVDIRAF IESCSHRSSS LPTPVDKGNP SSIHPFENLI SNMTFMLPFQ 
    FFNPLPPALI GSLPEQYMLE QGHDQSQDPK QEVHGPFPDS SFLTSSSTPF QVEKDQCLNC 
    PDAITKKEDS THLSDSSSYN IVTKFERTQL SPEAKVKPER NSLGTKKGRV FCTACEKTFY 
    DKGTLKIHYN AVHLKIKHKC TIEGCNMVFS SLRSRNRHSA NPNPRLHMPM NRNNRDKDLR 
    NSLNLASSEN YKCPGFTVTS PDCRPPPSYP GSGEDSKGQP AFPNIGQNGV LFPNLKTVQP 
    VLPFYRSPAT PAEVANTPGI LPSLPLLSSS IPEQLISNEM PFDALPKKKS RKSSMPIKIE 
    EEAVEIANEK RHNLSSDEDM PLQVVSEDEQ EACSPQSHRV SEEQHVQSGG LGKPFPEGER 
    PCHRESVIES SGAISQTPEQ ATHNSERETE QTPALIMVPR EVEDGGHEHY FTPGMEPQVP 
    FSDYMELQQR LLAGGLFSAL SNRGMAFPCL EDSKELEHVG QHALARQIEE NRFQCDICKK 
    TFKNACSVKI HHKNMHVKEM HTCTVEGCNA TFPSRRSRDR HSSNLNLHQK ALSQEALESS 
    EDHFRAAYLL KDVAKEAYQD VAFTQQASQT SVIFKGTSRM GSLVYPITQV HSASLESYNS 
    GPLSEGTILD LSTTSSMKSE SSSHSSWDSD GVSEEGTVLM EDSDGNCEGS SLVPGEDEYP 
    ICVLMEKADQ SLASLPSGLP ITCHLCQKTY SNKGTFRAHY KTVHLRQLHK CKVPGCNTMF 
    SSVRSRNRHS QNPNLHKSLA SSPSHLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.