VPS16 | ENSG00000215305 | NCBI 64601

Details for: VPS16

Gene ID: 64601

Symbol: VPS16

Ensembl ID: ENSG00000215305

Description: VPS16 core subunit of CORVET and HOPS complexes

Associated with

Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates autophagy
(R-HSA-9754560)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Actin binding
(GO:0003779)
Autophagosome
(GO:0005776)
Autophagosome maturation
(GO:0097352)
Clathrin-coated vesicle
(GO:0030136)
Corvet complex
(GO:0033263)
Early endosome
(GO:0005769)
Endosomal transport
(GO:0016197)
Endosomal vesicle fusion
(GO:0034058)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Hops complex
(GO:0030897)
Intracellular protein transport
(GO:0006886)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Protein binding
(GO:0005515)
Recycling endosome
(GO:0055037)
Regulation of snare complex assembly
(GO:0035542)
Vacuole fusion, non-autophagic
(GO:0042144)

Other Information

Proteins

Vacuolar protein sorting-associated protein 16 homolog

Genular Protein ID: 1575961949

Symbol: VPS16_HUMAN

Name: Vacuolar protein sorting-associated protein 16 homolog

UniProtKB Accession Codes:

Q9H269 Q5JUB1 Q8WU31 Q96EE7 Q96N92 Q9H1Q4 Q9H1Q5

Database IDs:

Citations:

PubMed ID: 11250079

Title: Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33.

PubMed ID: 11250079

DOI: 10.1016/s0378-1119(01)00333-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11382755

Title: Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.

PubMed ID: 11382755

DOI: 10.1074/jbc.m101778200

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18552835

Title: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

PubMed ID: 18552835

DOI: 10.1038/ncb1740

PubMed ID: 20434987

Title: Identification of the switch in early-to-late endosome transition.

PubMed ID: 20434987

DOI: 10.1016/j.cell.2010.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21802320

Title: Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

PubMed ID: 21802320

DOI: 10.1016/j.immuni.2011.06.009

PubMed ID: 23351085

Title: Tethering complexes in the endocytic pathway: CORVET and HOPS.

PubMed ID: 23351085

DOI: 10.1111/febs.12151

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24554770

Title: The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

PubMed ID: 24554770

DOI: 10.1091/mbc.e13-08-0447

PubMed ID: 25266290

Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.

PubMed ID: 25266290

DOI: 10.1111/tra.12232

PubMed ID: 25783203

Title: Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

PubMed ID: 25783203

DOI: 10.1111/tra.12283

PubMed ID: 27174565

Title: Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia.

PubMed ID: 27174565

DOI: 10.1038/srep25834

PubMed ID: 32808683

Title: Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities.

PubMed ID: 32808683

DOI: 10.1002/ana.25879

PubMed ID: 23901104

Title: Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

PubMed ID: 23901104

DOI: 10.1073/pnas.1307074110

Sequence Information:

Length: 839
Mass: 94694
Checksum: 9C4292D455C19A60
Sequence:

MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPWRKEKAA 
SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV QEDGAVLVYG LHGDFRRHFS 
MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW 
TVLCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT 
GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ 
FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PAASEEIFKI ASMAPGALLL EAQKEYEKES 
QKADEYLREI QELGQLTQAV QQCIEAAGHE HQPDMQKSLL RAASFGKCFL DRFPPDSFVH 
MCQDLRVLNA VRDYHIGIPL TYSQYKQLTI QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG 
VSRILAHWAC YKVQQKDVSD EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE 
YEPRSGEQVP LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA 
LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA LQTAADAFYK 
AKNEFAAKAT EDQMRLLRLQ RRLEDELGGQ FLDLSLHDTV TTLILGGHNK RAEQLARDFR 
IPDKRLWWLK LTALADLEDW EELEKFSKSK KSPIGYLPFV EICMKQHNKY EAKKYASRVG 
PEQKVKALLL VGDVAQAADV AIEHRNEAEL SLVLSHCTGA TDGATADKIQ RARAQAQKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VPS16

Associated with

Other Information

Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. PubMed ID: 11250079

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. PubMed ID: 11382755

Integral and associated lysosomal membrane proteins. PubMed ID: 17897319

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. PubMed ID: 18552835

Identification of the switch in early-to-late endosome transition. PubMed ID: 20434987

Initial characterization of the human central proteome. PubMed ID: 21269460

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. PubMed ID: 21802320

Tethering complexes in the endocytic pathway: CORVET and HOPS. PubMed ID: 23351085

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. PubMed ID: 24554770

Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. PubMed ID: 25266290

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes. PubMed ID: 25783203

Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia. PubMed ID: 27174565

Loss-of-Function Variants in HOPS Complex Genes VPS16 and VPS41 Cause Early Onset Dystonia Associated with Lysosomal Abnormalities. PubMed ID: 32808683

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. PubMed ID: 23901104