Fgf23 | ENSMUSG00000000182 | NCBI 64654

Details for: Fgf23

Gene ID: 64654

Symbol: Fgf23

Ensembl ID: ENSMUSG00000000182

Description: fibroblast growth factor 23

Associated with

Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Fgfr1 ligand binding and activation
(R-MMU-190242)
Fgfr1c and klotho ligand binding and activation
(R-MMU-190374)
Fgfr1c ligand binding and activation
(R-MMU-190373)
Fgfr2 ligand binding and activation
(R-MMU-190241)
Fgfr2c ligand binding and activation
(R-MMU-190375)
Fgfr3 ligand binding and activation
(R-MMU-190239)
Fgfr3c ligand binding and activation
(R-MMU-190372)
Fgfr4 ligand binding and activation
(R-MMU-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-MMU-5658623)
Frs-mediated fgfr1 signaling
(R-MMU-5654693)
Frs-mediated fgfr2 signaling
(R-MMU-5654700)
Frs-mediated fgfr3 signaling
(R-MMU-5654706)
Frs-mediated fgfr4 signaling
(R-MMU-5654712)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Phospholipase c-mediated cascade: fgfr1
(R-MMU-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-MMU-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-MMU-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-MMU-5654228)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signal transduction
(R-MMU-162582)
Animal organ morphogenesis
(GO:0009887)
Calcium ion homeostasis
(GO:0055074)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Intracellular phosphate ion homeostasis
(GO:0030643)
Mapk cascade
(GO:0000165)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of osteoblast differentiation
(GO:0045668)
Phosphate ion homeostasis
(GO:0055062)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapkkk cascade by fibroblast growth factor receptor signaling pathway
(GO:0090080)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vitamin d 24-hydroxylase activity
(GO:0010980)
Protein binding
(GO:0005515)
Regulation of bone mineralization
(GO:0030500)
Regulation of cell migration
(GO:0030334)
Regulation of phosphate transport
(GO:0010966)
Response to sodium phosphate
(GO:1904383)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Vitamin d catabolic process
(GO:0042369)

Other Information

Proteins

Fibroblast growth factor 23

Genular Protein ID: 1227417532

Symbol: FGF23_MOUSE

Name: Fibroblast growth factor 23

UniProtKB Accession Codes:

Q9EPC2

Database IDs:

Citations:

PubMed ID: 11032749

Title: Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.

PubMed ID: 11032749

DOI: 10.1006/bbrc.2000.3696

PubMed ID: 11062477

Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.

PubMed ID: 11062477

DOI: 10.1038/81664

PubMed ID: 17086194

Title: Klotho converts canonical FGF receptor into a specific receptor for FGF23.

PubMed ID: 17086194

DOI: 10.1038/nature05315

Sequence Information:

Length: 251
Mass: 27758
Checksum: 110C1F2C735DC360
Sequence:

MLGTCLRLLV GVLCTVCSLG TARAYPDTSP LLGSNWGSLT HLYTATARTS YHLQIHRDGH 
VDGTPHQTIY SALMITSEDA GSVVITGAMT RRFLCMDLHG NIFGSLHFSP ENCKFRQWTL 
ENGYDVYLSQ KHHYLVSLGR AKRIFQPGTN PPPFSQFLAR RNEVPLLHFY TVRPRRHTRS 
AEDPPERDPL NVLKPRPRAT PVPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARGGAGG 
ADRCRPFPRF V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.