ANAPC1 | ENSG00000153107 | NCBI 64682

Details for: ANAPC1

Gene ID: 64682

Symbol: ANAPC1

Ensembl ID: ENSG00000153107

Description: anaphase promoting complex subunit 1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Metaphase/anaphase transition of mitotic cell cycle
(GO:0007091)
Molecular adaptor activity
(GO:0060090)
Nucleoplasm
(GO:0005654)
Protein k11-linked ubiquitination
(GO:0070979)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)

Other Information

Proteins

Anaphase-promoting complex subunit 1

Genular Protein ID: 3695099921

Symbol: APC1_HUMAN

Name: Anaphase-promoting complex subunit 1

UniProtKB Accession Codes:

Q9H1A4 Q2M3H8 Q9BSE6 Q9H8D0

Database IDs:

Citations:

PubMed ID: 11179667

Title: Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex.

PubMed ID: 11179667

DOI: 10.1016/s0378-1119(00)00511-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 31303264

Title: Mutations in ANAPC1, encoding a scaffold subunit of the anaphase-promoting complex, cause Rothmund-Thomson syndrome type 1.

PubMed ID: 31303264

DOI: 10.1016/j.ajhg.2019.06.011

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 1944
Mass: 216500
Checksum: E08B1FE3FC28917E
Sequence:

MSNFYEERTT MIAARDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS SDGAAGLVGS 
LQEVTIHEKQ KESWQLRKGV SEIGEDVDYD EELYVAGNMV IWSKGSKSQA LAVYKAFTVD 
SPVQQALWCD FIISQDKSEK AYSSNEVEKC ICILQSSCIN MHSIEGKDYI ASLPFQVANV 
WPTKYGLLFE RSASSHEVPP GSPREPLPTM FSMLHPLDEI TPLVCKSGSL FGSSRVQYVV 
DHAMKIVFLN TDPSIVMTYD AVQNVHSVWT LRRVKSEEEN VVLKFSEQGG TPQNVATSSS 
LTAHLRSLSK GDSPVTSPFQ NYSSIHSQSR STSSPSLHSR SPSISNMAAL SRAHSPALGV 
HSFSGVQRFN ISSHNQSPKR HSISHSPNSN SNGSFLAPET EPIVPELCID HLWTETITNI 
REKNSQASKV FITSDLCGQK FLCFLVESQL QLRCVKFQES NDKTQLIFGS VTNIPAKDAA 
PVEKIDTMLV LEGSGNLVLY TGVVRVGKVF IPGLPAPSLT MSNTMPRPST PLDGVSTPKP 
LSKLLGSLDE VVLLSPVPEL RDSSKLHDSL YNEDCTFQQL GTYIHSIRDP VHNRVTLELS 
NGSMVRITIP EIATSELVQT CLQAIKFILP KEIAVQMLVK WYNVHSAPGG PSYHSEWNLF 
VTCLMNMMGY NTDRLAWTRN FDFEGSLSPV IAPKKARPSE TGSDDDWEYL LNSDYHQNVE 
SHLLNRSLCL SPSEASQMKD EDFSQNLSLD SSTLLFTHIP AIFFVLHLVY EELKLNTLMG 
EGICSLVELL VQLARDLKLG PYVDHYYRDY PTLVRTTGQV CTIDPGQTGF MHHPSFFTSE 
PPSIYQWVSS CLKGEGMPPY PYLPGICERS RLVVLSIALY ILGDESLVSD ESSQYLTRIT 
IAPQKLQVEQ EENRFSFRHS TSVSSLAERL VVWMTNVGFT LRDLETLPFG IALPIRDAIY 
HCREQPASDW PEAVCLLIGR QDLSKQACEG NLPKGKSVLS SDVPSGTETE EEDDGMNDMN 
HEVMSLIWSE DLRVQDVRRL LQSAHPVRVN VVQYPELSDH EFIEEKENRL LQLCQRTMAL 
PVGRGMFTLF SYHPVPTEPL PIPKLNLTGR APPRNTTVDL NSGNIDVPPN MTSWASFHNG 
VAAGLKIAPA SQIDSAWIVY NKPKHAELAN EYAGFLMALG LNGHLTKLAT LNIHDYLTKG 
HEMTSIGLLL GVSAAKLGTM DMSITRLLSI HIPALLPPTS TELDVPHNVQ VAAVVGIGLV 
YQGTAHRHTA EVLLAEIGRP PGPEMEYCTD RESYSLAAGL ALGMVCLGHG SNLIGMSDLN 
VPEQLYQYMV GGHRRFQTGM HREKHKSPSY QIKEGDTINV DVTCPGATLA LAMIYLKTNN 
RSIADWLRAP DTMYLLDFVK PEFLLLRTLA RCLILWDDIL PNSKWVDSNV PQIIRENSIS 
LSEIELPCSE DLNLETLSQA HVYIIAGACL SLGFRFAGSE NLSAFNCLHK FAKDFMTYLS 
APNASVTGPH NLETCLSVVL LSLAMVMAGS GNLKVLQLCR FLHMKTGGEM NYGFHLAHHM 
ALGLLFLGGG RYSLSTSNSS IAALLCALYP HFPAHSTDNR YHLQALRHLY VLAAEPRLLV 
PVDVDTNTPC YALLEVTYKG TQWYEQTKEE LMAPTLLPEL HLLKQIKVKG PRYWELLIDL 
SKGTQHLKSI LSKDGVLYVK LRAGQLSYKE DPMGWQSLLA QTVANRNSEA RAFKPETISA 
FTSDPALLSF AEYFCKPTVN MGQKQEILDL FSSVLYECVT QETPEMLPAY IAMDQAIRRL 
GRREMSETSE LWQIKLVLEF FSSRSHQERL QNHPKRGLFM NSEFLPVVKC TIDNTLDQWL 
QVGGDMCVHA YLSGQPLEES QLSMLACFLV YHSVPAPQHL PPIGLEGSTS FAELLFKFKQ 
LKMPVRALLR LAPLLLGNPQ PMVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANAPC1

Associated with

Other Information

Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. PubMed ID: 11179667

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Mutations in ANAPC1, encoding a scaffold subunit of the anaphase-promoting complex, cause Rothmund-Thomson syndrome type 1. PubMed ID: 31303264

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744