Details for: SMURF2
Associated with
Other Information
Genular Protein ID: 1878734203
Symbol: SMUF2_HUMAN
Name: E3 ubiquitin-protein ligase SMURF2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11163210
Title: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.
PubMed ID: 11163210
PubMed ID: 11016919
Title: Smurf2 Is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.
PubMed ID: 11016919
PubMed ID: 11158580
Title: Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
PubMed ID: 11158580
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11389444
Title: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.
PubMed ID: 11389444
DOI: 10.1038/35078562
PubMed ID: 12717440
Title: Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
PubMed ID: 12717440
DOI: 10.1038/ncb975
PubMed ID: 14562029
Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
PubMed ID: 14562029
PubMed ID: 14755250
Title: An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.
PubMed ID: 14755250
PubMed ID: 18448069
Title: AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2.
PubMed ID: 18448069
PubMed ID: 19343052
Title: Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
PubMed ID: 19343052
PubMed ID: 21572392
Title: SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
PubMed ID: 21572392
PubMed ID: 30696809
Title: TTC3 contributes to TGF-beta1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.
PubMed ID: 30696809
PubMed ID: 33673144
Title: Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs.
PubMed ID: 33673144
DOI: 10.3390/v13020288
PubMed ID: 16061177
Title: Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.
PubMed ID: 16061177
PubMed ID: 16641086
Title: An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.
PubMed ID: 16641086
PubMed ID: 21791611
Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.
PubMed ID: 21791611
DOI: 10.1128/mcb.05448-11
PubMed ID: 31076633
Title: TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2.
PubMed ID: 31076633
PubMed ID: 17719543
Title: Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.
PubMed ID: 17719543
Sequence Information:
- Length: 748
- Mass: 86196
- Checksum: 3042B443A3755762
- Sequence:
MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL GPNDNDTVRG QIVVSLQSRD RIGTGGQVVD CSRLFDNDLP DGWEERRTAS GRIQYLNHIT RTTQWERPTR PASEYSSPGR PLSCFVDENT PISGTNGATC GQSSDPRLAE RRVRSQRHRN YMSRTHLHTP PDLPEGYEQR TTQQGQVYFL HTQTGVSTWH DPRVPRDLSN INCEELGPLP PGWEIRNTAT GRVYFVDHNN RTTQFTDPRL SANLHLVLNR QNQLKDQQQQ QVVSLCPDDT ECLTVPRYKR DLVQKLKILR QELSQQQPQA GHCRIEVSRE EIFEESYRQV MKMRPKDLWK RLMIKFRGEE GLDYGGVARE WLYLLSHEML NPYYGLFQYS RDDIYTLQIN PDSAVNPEHL SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVNEENKKE YVRLYVNWRF LRGIEAQFLA LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVNDWKVN TRLKHCTPDS NIVKWFWKAV EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI DIPPYESYEK LYEKLLTAIE ETCGFAVE
Genular Protein ID: 542369907
Symbol: Q96DE7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 288
- Mass: 33255
- Checksum: FE2B43E300E66537
- Sequence:
RDDIYTLQIN PDSAVNPEHL SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVNEENKKE YVRLYVNWRF LRGIEAQFLA LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVNDWKVN TRLKHCTPDS NIVKWFWKAV EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI DIPPYESYEK LYEKLLTAIE ETCGFAVE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.