MICAL1 | ENSG00000135596 | NCBI 64780

Details for: MICAL1

Gene ID: 64780

Symbol: MICAL1

Ensembl ID: ENSG00000135596

Description: microtubule associated monooxygenase, calponin and LIM domain containing 1

Associated with

Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hemostasis
(R-HSA-109582)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament bundle assembly
(GO:0051017)
Actin filament depolymerization
(GO:0030042)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Endosome membrane
(GO:0010008)
Fad binding
(GO:0071949)
Hippocampal mossy fiber expansion
(GO:1990026)
Intercellular bridge
(GO:0045171)
Intermediate filament
(GO:0005882)
Metal ion binding
(GO:0046872)
Midbody
(GO:0030496)
Monooxygenase activity
(GO:0004497)
Nad(p)h oxidase h2o2-forming activity
(GO:0016174)
Nadph oxidase h202-forming activity
(GO:0106294)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein phosphorylation
(GO:0001933)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
(GO:0016709)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of regulated secretory pathway
(GO:1903305)
Sh3 domain binding
(GO:0017124)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Sulfur oxidation
(GO:0019417)

Other Information

Proteins

Molecule interacting with CasL protein 1

Genular Protein ID: 958377943

Symbol: MICA1_HUMAN

Name: Molecule interacting with CasL protein 1

UniProtKB Accession Codes:

Q8TDZ2 B7Z3R5 E1P5F0 Q7Z633 Q8IVS9 Q96G47 Q9H6X6 Q9H7I0 Q9HAA1 Q9UFF7

Database IDs:

Citations:

PubMed ID: 11827972

Title: MICAL, a novel CasL interacting molecule, associates with vimentin.

PubMed ID: 11827972

DOI: 10.1074/jbc.m111842200

PubMed ID: 11214971

Title: Characterization of long cDNA clones from human adult spleen.

PubMed ID: 11214971

DOI: 10.1093/dnares/7.6.357

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12110185

Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

PubMed ID: 12110185

DOI: 10.1016/s0092-8674(02)00794-8

PubMed ID: 12788069

Title: MICAL-1 isoforms, novel rab1 interacting proteins.

PubMed ID: 12788069

DOI: 10.1016/s0006-291x(03)00918-5

PubMed ID: 15694364

Title: The MICAL proteins and rab1: a possible link to the cytoskeleton?

PubMed ID: 15694364

DOI: 10.1016/j.bbrc.2004.12.182

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18305261

Title: Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein.

PubMed ID: 18305261

DOI: 10.1523/jneurosci.5646-07.2008

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21864500

Title: Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1.

PubMed ID: 21864500

DOI: 10.1016/j.abb.2011.08.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24440334

Title: Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.

PubMed ID: 24440334

DOI: 10.1016/j.cell.2013.12.035

PubMed ID: 26845023

Title: Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains.

PubMed ID: 26845023

DOI: 10.1016/j.abb.2016.01.016

PubMed ID: 29343822

Title: The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.

PubMed ID: 29343822

DOI: 10.1038/s41598-017-17943-5

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

PubMed ID: 17043746

Title: Solution structure of calponin homology domain of Human MICAL-1.

PubMed ID: 17043746

DOI: 10.1007/s10858-006-9062-5

PubMed ID: 17662518

Title: Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain.

PubMed ID: 17662518

DOI: 10.1016/j.bpc.2007.06.008

PubMed ID: 27552051

Title: bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.

PubMed ID: 27552051

DOI: 10.7554/elife.18675

PubMed ID: 28230050

Title: Oxidation of F-actin controls the terminal steps of cytokinesis.

PubMed ID: 28230050

DOI: 10.1038/ncomms14528

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1067
Mass: 117875
Checksum: 78C1BBF3E3CCD56B
Sequence:

MASPTSTNPA HAHFESFLQA QLCQDVLSSF QELCGALGLE PGGGLPQYHK IKDQLNYWSA 
KSLWTKLDKR AGQPVYQQGR ACTSTKCLVV GAGPCGLRVA VELALLGARV VLVEKRTKFS 
RHNVLHLWPF TIHDLRALGA KKFYGRFCTG TLDHISIRQL QLLLLKVALL LGVEIHWGVT 
FTGLQPPPRK GSGWRAQLQP NPPAQLANYE FDVLISAAGG KFVPEGFKVR EMRGKLAIGI 
TANFVNGRTV EETQVPEISG VARIYNQSFF QSLLKATGID LENIVYYKDD THYFVMTAKK 
QCLLRLGVLR QDWPDTNRLL GSANVVPEAL QRFTRAAADF ATHGKLGKLE FAQDAHGQPD 
VSAFDFTSMM RAESSARVQE KHGARLLLGL VGDCLVEPFW PLGTGVARGF LAAFDAAWMV 
KRWAEGAESL EVLAERESLY QLLSQTSPEN MHRNVAQYGL DPATRYPNLN LRAVTPNQVR 
DLYDVLAKEP VQRNNDKTDT GMPATGSAGT QEELLRWCQE QTAGYPGVHV SDLSSSWADG 
LALCALVYRL QPGLLEPSEL QGLGALEATA WALKVAENEL GITPVVSAQA VVAGSDPLGL 
IAYLSHFHSA FKSMAHSPGP VSQASPGTSS AVLFLSKLQR TLQRSRAKEN AEDAGGKKLR 
LEMEAETPST EVPPDPEPGV PLTPPSQHQE AGAGDLCALC GEHLYVLERL CVNGHFFHRS 
CFRCHTCEAT LWPGGYEQHP GDGHFYCLQH LPQTDHKAEG SDRGPESPEL PTPSENSMPP 
GLSTPTASQE GAGPVPDPSQ PTRRQIRLSS PERQRLSSLN LTPDPEMEPP PKPPRSCSAL 
ARHALESSFV GWGLPVQSPQ ALVAMEKEEK ESPFSSEEEE EDVPLDSDVE QALQTFAKTS 
GTMNNYPTWR RTLLRRAKEE EMKRFCKAQT IQRRLNEIEA ALRELEAEGV KLELALRRQS 
SSPEQQKKLW VGQLLQLVDK KNSLVAEEAE LMITVQELNL EEKQWQLDQE LRGYMNREEN 
LKTAADRQAE DQVLRKLVDL VNQRDALIRF QEERRLSELA LGTGAQG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MICAL1

Associated with

Other Information

MICAL, a novel CasL interacting molecule, associates with vimentin. PubMed ID: 11827972

Characterization of long cDNA clones from human adult spleen. PubMed ID: 11214971

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. PubMed ID: 12110185

MICAL-1 isoforms, novel rab1 interacting proteins. PubMed ID: 12788069

The MICAL proteins and rab1: a possible link to the cytoskeleton? PubMed ID: 15694364

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. PubMed ID: 18305261

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1. PubMed ID: 21864500

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. PubMed ID: 24440334

Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains. PubMed ID: 26845023

The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans. PubMed ID: 29343822

GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508. PubMed ID: 32344433

Solution structure of calponin homology domain of Human MICAL-1. PubMed ID: 17043746

Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. PubMed ID: 17662518

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. PubMed ID: 27552051

Oxidation of F-actin controls the terminal steps of cytokinesis. PubMed ID: 28230050

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974