Details for: CERK

Gene ID: 64781

Symbol: CERK

Ensembl ID: ENSG00000100422

Description: ceramide kinase

Associated with

Other Information

Genular Protein ID: 1061576102

Symbol: CERK1_HUMAN

Name: Ceramide kinase

UniProtKB Accession Codes:

Q8TCT0 A0JNT4 A8K611 Q6NX59 Q9BYB3 Q9UGE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 34 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 10 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11956206

Title: Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization.

PubMed ID: 11956206

DOI: 10.1074/jbc.m201535200

PubMed ID: 16269826

Title: Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.

PubMed ID: 16269826

DOI: 10.1194/jlr.m500321-jlr200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11258795

Title: Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.

PubMed ID: 11258795

DOI: 10.1093/dnares/8.1.1

PubMed ID: 16081073

Title: The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.

PubMed ID: 16081073

DOI: 10.1016/j.febslet.2005.06.079

PubMed ID: 19168031

Title: A lipid binding domain in sphingosine kinase 2.

PubMed ID: 19168031

DOI: 10.1016/j.bbrc.2009.01.075

PubMed ID: 19899769

Title: Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site.

PubMed ID: 19899769

DOI: 10.1021/pr900763z

PubMed ID: 27725450

Title: Effects of glycerophospholipids on ceramide kinase activity: cardiolipin-affected cellular formation of ceramide-1-phosphate.

PubMed ID: 27725450

DOI: 10.1248/bpb.b16-00535

Sequence Information:

  • Length: 537
  • Mass: 59977
  • Checksum: 3DBFC0ED8D679F7F
  • Sequence:
    • MGATGAAEPL QSVLWVKQQR CAVSLEPARA LLRWWRSPGP GAGAPGADAC SVPVSEIIAV 
EETDVHGKHQ GSGKWQKMEK PYAFTVHCVK RARRHRWKWA QVTFWCPEEQ LCHLWLQTLR 
EMLEKLTSRP KHLLVFINPF GGKGQGKRIY ERKVAPLFTL ASITTDIIVT EHANQAKETL 
YEINIDKYDG IVCVGGDGMF SEVLHGLIGR TQRSAGVDQN HPRAVLVPSS LRIGIIPAGS 
TDCVCYSTVG TSDAETSALH IVVGDSLAMD VSSVHHNSTL LRYSVSLLGY GFYGDIIKDS 
EKKRWLGLAR YDFSGLKTFL SHHCYEGTVS FLPAQHTVGS PRDRKPCRAG CFVCRQSKQQ 
LEEEQKKALY GLEAAEDVEE WQVVCGKFLA INATNMSCAC RRSPRGLSPA AHLGDGSSDL 
ILIRKCSRFN FLRFLIRHTN QQDQFDFTFV EVYRVKKFQF TSKHMEDEDS DLKEGGKKRF 
GHICSSHPSC CCTVSNSSWN CDGEVLHSPA IEVRVHCQLV RLFARGIEEN PKPDSHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.