Details for: DEPTOR

Gene ID: 64798

Symbol: DEPTOR

Ensembl ID: ENSG00000155792

Description: DEP domain containing MTOR interacting protein

Associated with

Other Information

Genular Protein ID: 3365355091

Symbol: DPTOR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TB45 B2RCL9 B4DN97 E7EV87 Q96EQ1 Q9H0R7 Q9H894 Q9HA07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 7 EPD 1 Ensembl 2 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 9 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19446321

Title: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

PubMed ID: 19446321

DOI: 10.1016/j.cell.2009.03.046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22017875

Title: mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

PubMed ID: 22017875

DOI: 10.1016/j.molcel.2011.08.030

PubMed ID: 22017876

Title: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

PubMed ID: 22017876

DOI: 10.1016/j.molcel.2011.08.029

PubMed ID: 22017877

Title: mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR.

PubMed ID: 22017877

DOI: 10.1016/j.molcel.2011.09.005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25936805

Title: Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.

PubMed ID: 25936805

DOI: 10.1016/j.molcel.2015.03.028

PubMed ID: 29382726

Title: OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.

PubMed ID: 29382726

DOI: 10.1074/jbc.m117.809533

PubMed ID: 30080879

Title: UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling.

PubMed ID: 30080879

DOI: 10.1371/journal.pgen.1007583

PubMed ID: 30232230

Title: The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

PubMed ID: 30232230

DOI: 10.1126/scitranslmed.aat9356

PubMed ID: 33110214

Title: Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.

PubMed ID: 33110214

DOI: 10.1038/s41418-020-00649-z

PubMed ID: 34634301

Title: Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling.

PubMed ID: 34634301

DOI: 10.1016/j.jbc.2021.101291

PubMed ID: 35216969

Title: Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.

PubMed ID: 35216969

DOI: 10.1016/j.jbc.2022.101750

PubMed ID: 33865870

Title: Structural basis of DEPTOR to recognize phosphatidic acid using its tandem DEP domains.

PubMed ID: 33865870

DOI: 10.1016/j.jmb.2021.166989

PubMed ID: 34519268

Title: Regulation of human mTOR complexes by DEPTOR.

PubMed ID: 34519268

DOI: 10.7554/elife.70871

PubMed ID: 34519269

Title: Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.

PubMed ID: 34519269

DOI: 10.7554/elife.68799

Sequence Information:

  • Length: 409
  • Mass: 46294
  • Checksum: AD132F0E9AFFB90C
  • Sequence:
    • MEEGGSTGSA GSDSSTSGSG GAQQRELERM AEVLVTGEQL RLRLHEEKVI KDRRHHLKTY 
PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH VCDEHKEFKD VKLFYRFRKD 
DGTFPLDNEV KAFMRGQRLY EKLMSPENTL LQPREEEGVK YERTFMASEF LDWLVQEGEA 
TTRKEAEQLC HRLMEHGIIQ HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNEKSPSSQE 
THDSPFCLRK QSHDNRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP 
PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC HIQAVDPSGP 
AAAAGMKVCQ FVVSVNGLNV LHVDYRTVSN LILTGPRTIV MEVMEELEC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.