BMI1 | ENSG00000168283 | NCBI 648

Details for: BMI1

Gene ID: 648

Symbol: BMI1

Ensembl ID: ENSG00000168283

Description: BMI1 proto-oncogene, polycomb ring finger

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism of proteins
(R-HSA-392499)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna methylation proteins
(R-HSA-4655427)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by runx1
(R-HSA-8878171)
Apoptotic signaling pathway
(GO:0097190)
Brain development
(GO:0007420)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Dna methylation-dependent heterochromatin formation
(GO:0006346)
Embryonic skeletal system morphogenesis
(GO:0048704)
Hemopoiesis
(GO:0030097)
Heterochromatin
(GO:0000792)
Humoral immune response
(GO:0006959)
In utero embryonic development
(GO:0001701)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of ubiquitin-protein transferase activity
(GO:0051443)
Prc1 complex
(GO:0035102)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of adaxial/abaxial pattern formation
(GO:2000011)
Regulation of gene expression
(GO:0010468)
Ring-like zinc finger domain binding
(GO:0071535)
Rostrocaudal neural tube patterning
(GO:0021903)
Segment specification
(GO:0007379)
Somatic stem cell division
(GO:0048103)
Ubiquitin-protein transferase activator activity
(GO:0097027)
Ubiquitin ligase complex
(GO:0000151)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 136.2626
Cell Significance Index: -21.2000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 78.2989
Cell Significance Index: -19.8600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 50.2835
Cell Significance Index: -23.7400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.5449
Cell Significance Index: -22.8700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.2516
Cell Significance Index: -22.1100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.5213
Cell Significance Index: -20.0300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9021
Cell Significance Index: -23.2900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.8566
Cell Significance Index: 39.5400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5106
Cell Significance Index: 149.4400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4282
Cell Significance Index: 232.2800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1918
Cell Significance Index: 1076.0600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7969
Cell Significance Index: 51.4100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6216
Cell Significance Index: 124.6900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5106
Cell Significance Index: 35.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4899
Cell Significance Index: 30.8800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4609
Cell Significance Index: 63.3000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4442
Cell Significance Index: 12.0900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3403
Cell Significance Index: 61.3500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.3073
Cell Significance Index: 88.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2849
Cell Significance Index: 35.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2800
Cell Significance Index: 100.4300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2481
Cell Significance Index: 31.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2437
Cell Significance Index: 8.4700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2391
Cell Significance Index: 11.1500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2205
Cell Significance Index: 13.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1769
Cell Significance Index: 96.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1552
Cell Significance Index: 29.5400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1512
Cell Significance Index: 66.8600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1296
Cell Significance Index: 3.2400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0955
Cell Significance Index: 2.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0801
Cell Significance Index: 15.8900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0757
Cell Significance Index: 2.1800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0634
Cell Significance Index: 0.7200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0564
Cell Significance Index: 2.6500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0439
Cell Significance Index: 2.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0432
Cell Significance Index: 1.9600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0431
Cell Significance Index: 29.7900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0007
Cell Significance Index: -0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0057
Cell Significance Index: -10.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0059
Cell Significance Index: -4.3200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0155
Cell Significance Index: -11.7600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0157
Cell Significance Index: -28.9500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0177
Cell Significance Index: -27.2200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0203
Cell Significance Index: -27.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0212
Cell Significance Index: -15.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0219
Cell Significance Index: -13.9000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0265
Cell Significance Index: -0.9300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0271
Cell Significance Index: -12.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0350
Cell Significance Index: -19.7200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0399
Cell Significance Index: -4.7000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0428
Cell Significance Index: -7.3000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0470
Cell Significance Index: -29.3600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0505
Cell Significance Index: -3.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0585
Cell Significance Index: -5.9800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0654
Cell Significance Index: -8.4600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0707
Cell Significance Index: -8.1000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0713
Cell Significance Index: -8.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0721
Cell Significance Index: -5.1000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0811
Cell Significance Index: -4.2600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1174
Cell Significance Index: -6.5900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1187
Cell Significance Index: -17.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1188
Cell Significance Index: -3.4100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1253
Cell Significance Index: -26.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1326
Cell Significance Index: -2.2200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1468
Cell Significance Index: -9.8700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1633
Cell Significance Index: -12.5300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1643
Cell Significance Index: -4.3200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1875
Cell Significance Index: -3.8900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1964
Cell Significance Index: -4.7100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2010
Cell Significance Index: -5.3900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2012
Cell Significance Index: -8.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2154
Cell Significance Index: -6.9000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2168
Cell Significance Index: -1.3100
Cell Name: peg cell (CL4033014)
Fold Change: -0.2186
Cell Significance Index: -5.0500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2208
Cell Significance Index: -6.1700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2221
Cell Significance Index: -23.1300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2260
Cell Significance Index: -17.9000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2385
Cell Significance Index: -14.6200
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.2504
Cell Significance Index: -1.9300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2536
Cell Significance Index: -3.4600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2652
Cell Significance Index: -7.7900
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2681
Cell Significance Index: -3.7600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2736
Cell Significance Index: -10.3600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2845
Cell Significance Index: -7.6100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2901
Cell Significance Index: -7.4100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3187
Cell Significance Index: -2.9400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3759
Cell Significance Index: -8.2300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4444
Cell Significance Index: -22.4600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4754
Cell Significance Index: -9.9500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4861
Cell Significance Index: -8.3300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5148
Cell Significance Index: -14.6900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5157
Cell Significance Index: -21.1300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5279
Cell Significance Index: -19.3800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5361
Cell Significance Index: -15.7900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5390
Cell Significance Index: -6.4300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5555
Cell Significance Index: -14.2800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5620
Cell Significance Index: -18.4000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.5787
Cell Significance Index: -6.3100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5860
Cell Significance Index: -20.5300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6026
Cell Significance Index: -12.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Ring-like zinc finger domain:** BMI1 contains a characteristic ring-like zinc finger domain, which is essential for its function in chromatin remodeling and gene expression regulation. 2. **Polycomb group (PcG) complex membership:** BMI1 is a core component of the PcG complex, which is responsible for silencing gene expression through chromatin remodeling and histone modification. 3. **Epigenetic regulation:** BMI1 is involved in the regulation of epigenetic marks, such as DNA methylation and histone modifications, which play a crucial role in gene expression and cellular differentiation. 4. **Cellular specificity:** BMI1 is specifically expressed in certain cell types, including proerythroblasts, male germ cells, and intestinal crypt stem cells, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Chromatin remodeling:** BMI1 is involved in the chromatin remodeling process, which allows for the regulation of gene expression and cellular differentiation. 2. **Gene expression regulation:** BMI1 regulates gene expression by modifying chromatin structure and recruiting transcriptional repressors, such as PRC1. 3. **Cell proliferation:** BMI1 promotes cell proliferation by regulating the expression of genes involved in cell cycle progression and DNA replication. 4. **Cancer development:** BMI1 is overexpressed in various types of cancer, including leukemia, lymphoma, and solid tumors, where it contributes to tumorigenesis and cancer progression. 5. **Stem cell maintenance:** BMI1 is essential for the maintenance of stem cells, particularly in the hematopoietic and gastrointestinal systems, where it regulates the expression of genes involved in stem cell self-renewal and differentiation. **Clinical Significance:** The dysregulation of BMI1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of BMI1 has been observed in several types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Hematological disorders:** BMI1 has been linked to hematological disorders, such as leukemia and lymphoma, where it contributes to tumorigenesis and disease progression. 3. **Autoimmune diseases:** BMI1 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates the expression of genes involved in immune cell function and autoimmunity. 4. **Stem cell disorders:** BMI1 is essential for the maintenance of stem cells, particularly in the hematopoietic and gastrointestinal systems, where its dysregulation can lead to stem cell disorders. In conclusion, BMI1 is a critical regulator of gene expression, cell proliferation, and cancer development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying BMI1's role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.