Gene BMI1 - ENSG00000168283 | NCBI Gene ID: 648

Details for: BMI1

Gene ID: 648

Symbol: BMI1

Ensembl ID: ENSG00000168283

Description: BMI1 proto-oncogene, polycomb ring finger

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Metabolism of proteins
(R-HSA-392499)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna methylation proteins
(R-HSA-4655427)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Transcriptional regulation by runx1
(R-HSA-8878171)
Apoptotic signaling pathway
(GO:0097190)
Brain development
(GO:0007420)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Dna methylation
(GO:0006306)
Embryonic skeletal system morphogenesis
(GO:0048704)
Hemopoiesis
(GO:0030097)
Heterochromatin
(GO:0000792)
Humoral immune response
(GO:0006959)
In utero embryonic development
(GO:0001701)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of ubiquitin-protein transferase activity
(GO:0051443)
Prc1 complex
(GO:0035102)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of adaxial/abaxial pattern formation
(GO:2000011)
Regulation of gene expression
(GO:0010468)
Ring-like zinc finger domain binding
(GO:0071535)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rostrocaudal neural tube patterning
(GO:0021903)
Segment specification
(GO:0007379)
Somatic stem cell division
(GO:0048103)
Ubiquitin-protein transferase activator activity
(GO:0097027)
Ubiquitin ligase complex
(GO:0000151)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: proerythroblast (CL0000547)
Fold Change: 1.16
Marker Score: 785
Cell Name: male germ cell (CL0000015)
Fold Change: 1.12
Marker Score: 322
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.09
Marker Score: 1361
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.03
Marker Score: 1024
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.03
Marker Score: 943
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71722
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47946
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30397
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 475
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 433
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2704
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.88
Marker Score: 8912
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.87
Marker Score: 53658
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.87
Marker Score: 13580
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5241
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4873
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 306
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.84
Marker Score: 7202
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.84
Marker Score: 892
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.79
Marker Score: 1349
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1253
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 306
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.76
Marker Score: 1601
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.75
Marker Score: 514
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.75
Marker Score: 1572
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.73
Marker Score: 1126
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 555
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.71
Marker Score: 370
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.71
Marker Score: 6733
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.71
Marker Score: 1015
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.71
Marker Score: 601
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.7
Marker Score: 421
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.7
Marker Score: 747
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.69
Marker Score: 26205
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2849
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.68
Marker Score: 202
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.68
Marker Score: 714
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.67
Marker Score: 2605
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.67
Marker Score: 249
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 603
Cell Name: keratocyte (CL0002363)
Fold Change: 0.66
Marker Score: 152
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.66
Marker Score: 1502
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.66
Marker Score: 1337
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.65
Marker Score: 5680
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.65
Marker Score: 7343
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.65
Marker Score: 675
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.64
Marker Score: 23711
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.64
Marker Score: 1274
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.63
Marker Score: 595
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.63
Marker Score: 366
Cell Name: decidual cell (CL2000002)
Fold Change: 0.62
Marker Score: 2690
Cell Name: PP cell (CL0000696)
Fold Change: 0.62
Marker Score: 139
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.61
Marker Score: 388
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.61
Marker Score: 9136
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.61
Marker Score: 179
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.61
Marker Score: 1634
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.61
Marker Score: 1454
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.6
Marker Score: 3539
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.6
Marker Score: 284
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.59
Marker Score: 505
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.59
Marker Score: 2446
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.59
Marker Score: 634
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.58
Marker Score: 1633
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.58
Marker Score: 965
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.58
Marker Score: 148
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.58
Marker Score: 651
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.58
Marker Score: 179
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.58
Marker Score: 625
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.57
Marker Score: 5407
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.57
Marker Score: 385
Cell Name: neural cell (CL0002319)
Fold Change: 0.57
Marker Score: 274
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.56
Marker Score: 372
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.56
Marker Score: 643
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.55
Marker Score: 130
Cell Name: granulocyte (CL0000094)
Fold Change: 0.55
Marker Score: 247
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.55
Marker Score: 268
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.55
Marker Score: 577
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.55
Marker Score: 135
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.54
Marker Score: 1028
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.54
Marker Score: 156
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.54
Marker Score: 226
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.53
Marker Score: 425
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.53
Marker Score: 242
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.53
Marker Score: 17886
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.52
Marker Score: 1236
Cell Name: kidney cell (CL1000497)
Fold Change: 0.52
Marker Score: 349.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.52
Marker Score: 163
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.52
Marker Score: 10300
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.52
Marker Score: 3963
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.52
Marker Score: 166
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.51
Marker Score: 136
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.51
Marker Score: 519
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.51
Marker Score: 383
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.51
Marker Score: 363
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.5
Marker Score: 252
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.5
Marker Score: 278
Cell Name: supporting cell (CL0000630)
Fold Change: 0.5
Marker Score: 943
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.5
Marker Score: 531

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Other Information

Description

**Key characteristics:** * BMI1 is a ubiquitin-dependent protein that is degraded by the proteasome. * It is highly expressed in normal cells and is downregulated in many cancer cells. * In cancer cells, BMI1 is mutated or deleted, leading to uncontrolled cell growth and proliferation. **Pathways and functions:** * BMI1 inhibits the PI3K/Akt signaling pathway, a key pathway involved in cell growth and survival. * It also regulates the expression of genes involved in cell cycle arrest, DNA repair, and apoptosis. * BMI1 plays a role in maintaining genomic integrity by regulating the expression of genes involved in DNA repair and damage response. * It also regulates the differentiation of pluripotent stem cells into different cell types, including cancer cells. **Clinical significance:** * Mutations in the BMI1 gene are frequently found in human cancers. * Targeting BMI1 has emerged as a promising therapeutic strategy for cancer treatment. * Several BMI1 inhibitors are currently being evaluated in clinical trials to inhibit cancer growth and metastasis. **Additional notes:** * BMI1 is a highly conserved gene, with a similar gene found in mice and humans. * It is a key tumor suppressor gene that plays a crucial role in preventing cancer development. * Dysregulation of BMI1 has been linked to various human cancers, including breast cancer, lung cancer, and leukemia.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.