YTHDC2 | ENSG00000047188 | NCBI 64848

Details for: YTHDC2

Gene ID: 64848

Symbol: YTHDC2

Ensembl ID: ENSG00000047188

Description: YTH N6-methyladenosine RNA binding protein C2

Associated with

3'-5' rna helicase activity
(GO:0034458)
Atp-dependent activity, acting on rna
(GO:0008186)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Endoplasmic reticulum
(GO:0005783)
Germline cell cycle switching, mitotic to meiotic cell cycle
(GO:0051729)
Helicase activity
(GO:0004386)
Intracellular anatomical structure
(GO:0005622)
Meiotic cell cycle
(GO:0051321)
N6-methyladenosine-containing rna reader activity
(GO:1990247)
Oocyte development
(GO:0048599)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation by host of viral genome replication
(GO:0044829)
Protein binding
(GO:0005515)
Response to interleukin-1
(GO:0070555)
Response to tumor necrosis factor
(GO:0034612)
Ribonucleoprotein granule
(GO:0035770)
Rna binding
(GO:0003723)
Rna polymerase binding
(GO:0070063)
Spermatid development
(GO:0007286)

Other Information

Proteins

YTDC2_HUMAN

Genular Protein ID: 1462044182

Symbol: YTDC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H6S0 B2RP66

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26318451

Title: structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins.

PubMed ID: 26318451

DOI: 10.1074/jbc.m115.680389

PubMed ID: 29033321

Title: Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline.

PubMed ID: 29033321

DOI: 10.1016/j.molcel.2017.09.021

PubMed ID: 29087293

Title: The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.

PubMed ID: 29087293

DOI: 10.7554/elife.26116

PubMed ID: 29970596

Title: The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.

PubMed ID: 29970596

DOI: 10.1261/rna.064238.117

PubMed ID: 31799605

Title: The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.

PubMed ID: 31799605

DOI: 10.1093/nar/gkz1147

PubMed ID: 31472957

Title: Crystal structure of human YTHDC2 YTH domain.

PubMed ID: 31472957

DOI: 10.1016/j.bbrc.2019.08.107

Sequence Information:

Length: 1430
Mass: 160248
Checksum: A0C3B45771A3DE16
Sequence:

MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN IALERFRYGD 
QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL TVKKKDGSET AHAMMTCNLT 
HNTKHAVRSL IQRFPVTNKE RTELLPKTER GNVFAVEAEN REMSKTSGRL NNGIPQIPVK 
RGESEFDSFR QSLPVFEKQE EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP 
CRIFCTQPRR LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL 
MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA LDVNLFIRYF 
GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE KQQEEKQQTT LTEWYSAQEN 
SFKPESQRQR TVLNVTDEYD LLDDGGDAVF SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK 
DIDAFAQVFH LILTENVSVD YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG 
WMALDWAKHF GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD 
DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA DSTHRYQVFM 
LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV VFVIDSGKVK EKSFDALNFV 
TMLKMVWISK ASAIQRKGRA GRCRPGICFR LFSRLRFQNM LEFQTPELLR MPLQELCLHT 
KLLAPVNCPI ADFLMKAPEP PPALIVRNAV QMLKTIDAMD TWEDLTELGY HLADLPVEPH 
LGKMVLCAVV LKCLDPILTI ACTLAYRDPF VLPTQASQKR AAMLCRKRFT AGAFSDHMAL 
LRAFQAWQKA RSDGWERAFC EKNFLSQATM EIIIGMRTQL LGQLRASGFV RARGGGDIRD 
VNTNSENWAV VKAALVAGMY PNLVHVDREN LVLTGPKEKK VRFHPASVLS QPQYKKIPPA 
NGQAAAIKAL PTDWLIYDEM TRAHRIANIR CCSAVTPVTI LVFCGPARLA SNALQEPSSF 
RVDGIPNDSS DSEMEDKTTA NLAALKLDEW LHFTLEPEAA SLLLQLRQKW HSLFLRRMRA 
PSKPWSQVDE ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK 
SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ SSLKSTDSSS 
YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN LEISQQKGIW STTPSNERKL 
NRAFWESSIV YLVFSVQGSG HFQGFSRMSS EIGREKSQDW GSAGLGGVFK VEWIRKESLP 
FQFAHHLLNP WNDNKKVQIS RDGQELEPLV GEQLLQLWER LPLGEKNTTD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YTHDC2

Associated with

Other Information

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins. PubMed ID: 26318451

Regulation of m6A transcripts by the 3'-5' RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline. PubMed ID: 29033321

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. PubMed ID: 29087293

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1. PubMed ID: 29970596

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. PubMed ID: 31799605

Crystal structure of human YTHDC2 YTH domain. PubMed ID: 31472957