Details for: USP46

Gene ID: 64854

Symbol: USP46

Ensembl ID: ENSG00000109189

Description: ubiquitin specific peptidase 46

Associated with

Other Information

Genular Protein ID: 2256525631

Symbol: UBP46_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 46

UniProtKB Accession Codes:

P62068 B7Z3Y7 B7Z675 B7Z7S3 G8ACC7 Q80V95 Q9H7U4 Q9H9T8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 5 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 22043315

Title: Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.

PubMed ID: 22043315

DOI: 10.1371/journal.pone.0026297

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14715245

Title: Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

PubMed ID: 14715245

DOI: 10.1016/j.bbrc.2003.12.050

PubMed ID: 19075014

Title: UAF1 is a subunit of multiple deubiquitinating enzyme complexes.

PubMed ID: 19075014

DOI: 10.1074/jbc.m808430200

PubMed ID: 20147737

Title: WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.

PubMed ID: 20147737

DOI: 10.1074/jbc.m109.095141

PubMed ID: 30466959

Title: WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.

PubMed ID: 30466959

DOI: 10.1016/j.ejcb.2018.10.003

PubMed ID: 33844468

Title: The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.

PubMed ID: 33844468

DOI: 10.1111/febs.15875

PubMed ID: 26388029

Title: Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46.

PubMed ID: 26388029

DOI: 10.1016/j.str.2015.08.010

PubMed ID: 27650958

Title: A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

PubMed ID: 27650958

DOI: 10.1016/j.jsb.2016.09.011

Sequence Information:

  • Length: 366
  • Mass: 42442
  • Checksum: 67BB113FC4081C46
  • Sequence:
    • MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 
AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET 
RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK 
RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 
VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL 
FYQSRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.