Details for: BMP1

Gene ID: 649

Symbol: BMP1

Ensembl ID: ENSG00000168487

Description: bone morphogenetic protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.82
    Marker Score: 667
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.56
    Marker Score: 442
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.22
    Marker Score: 1469
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.22
    Marker Score: 1671
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.21
    Marker Score: 5236
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2
    Marker Score: 19258
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.19
    Marker Score: 13441
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2568
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.08
    Marker Score: 7003
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.04
    Marker Score: 1122
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.04
    Marker Score: 234
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251773
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15445
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.94
    Marker Score: 6146
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.94
    Marker Score: 524
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.91
    Marker Score: 3782.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5094
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.86
    Marker Score: 545.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1742
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.82
    Marker Score: 2243
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.82
    Marker Score: 3051
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.82
    Marker Score: 906
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 849
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4558
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 358
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.74
    Marker Score: 9801
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3107
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.74
    Marker Score: 25100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.72
    Marker Score: 829
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.7
    Marker Score: 1355
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.68
    Marker Score: 157
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.67
    Marker Score: 827
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 644
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.65
    Marker Score: 1230
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.65
    Marker Score: 1002.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.65
    Marker Score: 1689
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.64
    Marker Score: 164
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.63
    Marker Score: 853
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.6
    Marker Score: 326
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.59
    Marker Score: 399
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 182
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 187
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 366
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.57
    Marker Score: 307
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.57
    Marker Score: 5697
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.56
    Marker Score: 3614
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.56
    Marker Score: 1761
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.55
    Marker Score: 221
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.55
    Marker Score: 207
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.55
    Marker Score: 199
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.54
    Marker Score: 263
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.52
    Marker Score: 193
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 125
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 303
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.5
    Marker Score: 121
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.49
    Marker Score: 127
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.49
    Marker Score: 459
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.48
    Marker Score: 233
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.48
    Marker Score: 432
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.47
    Marker Score: 571
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.47
    Marker Score: 584
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.46
    Marker Score: 1093
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.46
    Marker Score: 106
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.45
    Marker Score: 895
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.43
    Marker Score: 1848
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.42
    Marker Score: 405
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.42
    Marker Score: 288
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.42
    Marker Score: 675
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.42
    Marker Score: 725.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 184
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 623
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 361
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4
    Marker Score: 8532
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.39
    Marker Score: 87
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.39
    Marker Score: 227
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.39
    Marker Score: 93
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.39
    Marker Score: 177

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Other Information

**Key characteristics:** - BMP1 is a secreted protein that is produced by a variety of cell types, including bone cells, fibroblasts, and endothelial cells. - It is a member of the BMP family of growth factors, which are known for their ability to regulate cell proliferation, differentiation, and survival. - BMP1 is a potent activator of the BMP receptor type 1 (BMP1R1). - It is also a negative regulator of the TGF-β signaling pathway, which is involved in suppressing the production of TGF-β, a cytokine that inhibits collagen synthesis. **Pathways and functions:** - BMP1 plays a crucial role in the formation and remodeling of bone. - It is essential for the assembly of collagen fibrils, which are the main structural components of bones. - BMP1 also regulates the production of other extracellular matrix proteins, such as proteoglycans and fibronectin. - It is involved in the regulation of bone remodeling, including the formation of new bone and the repair of damaged tissue. - BMP1 also has a role in inflammation and tissue repair. **Clinical significance:** - Mutations in BMP1 have been linked to osteoporosis and other bone disorders. - BMP1 inhibitors are being investigated as a treatment for these disorders. - BMP1 is a promising target for the treatment of osteoporosis and other bone disorders.

Genular Protein ID: 2099296242

Symbol: BMP1_HUMAN

Name: Bone morphogenetic protein 1

UniProtKB Accession Codes:

P13497 A8K6F5 B2RN46 D3DSR0 Q13292 Q13872 Q14874 Q99421 Q99422 Q99423 Q9UL38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 12 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 5 RefSeq 4 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8643539

Title: The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

PubMed ID: 8643539

DOI: 10.1073/pnas.93.10.5127

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 9500680

Title: Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.

PubMed ID: 9500680

DOI: 10.1007/s001090050202

PubMed ID: 7798260

Title: Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.

PubMed ID: 7798260

DOI: 10.1016/s0021-9258(18)31672-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11283002

Title: Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.

PubMed ID: 11283002

DOI: 10.1074/jbc.m010814200

PubMed ID: 12637569

Title: Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.

PubMed ID: 12637569

DOI: 10.1074/jbc.m213021200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 21453682

Title: Bone morphogenetic protein (BMP)1-3 enhances bone repair.

PubMed ID: 21453682

DOI: 10.1016/j.bbrc.2011.03.109

PubMed ID: 31152061

Title: Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.

PubMed ID: 31152061

DOI: 10.1074/jbc.ra119.007806

PubMed ID: 32636307

Title: BMP-1 disrupts cell adhesion and enhances TGF-beta activation through cleavage of the matricellular protein thrombospondin-1.

PubMed ID: 32636307

DOI: 10.1126/scisignal.aba3880

PubMed ID: 33169406

Title: Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.

PubMed ID: 33169406

DOI: 10.1002/jper.20-0354

PubMed ID: 33206546

Title: Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.

PubMed ID: 33206546

DOI: 10.1152/ajpcell.00012.2020

PubMed ID: 18824173

Title: Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

PubMed ID: 18824173

DOI: 10.1016/j.jmb.2008.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22482805

Title: Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish.

PubMed ID: 22482805

DOI: 10.1016/j.ajhg.2012.02.026

PubMed ID: 22052668

Title: Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta.

PubMed ID: 22052668

DOI: 10.1002/humu.21647

PubMed ID: 25402547

Title: Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta.

PubMed ID: 25402547

DOI: 10.1002/humu.22731

Sequence Information:

  • Length: 986
  • Mass: 111249
  • Checksum: F89201913AC3CBEA
  • Sequence:
    • MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE 
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR 
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY 
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN 
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG 
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI 
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS 
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF 
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF 
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG 
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK 
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN 
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST 
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR 
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY 
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS 
DDTITKKGFH LRYTSTKFQD TLHSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.