BMP1 | ENSG00000168487 | NCBI 649

Details for: BMP1

Gene ID: 649

Symbol: BMP1

Ensembl ID: ENSG00000168487

Description: bone morphogenetic protein 1

Associated with

Anchoring fibril formation
(R-HSA-2214320)
Assembly of collagen fibrils and other multimeric structures
(R-HSA-2022090)
Collagen biosynthesis and modifying enzymes
(R-HSA-1650814)
Collagen formation
(R-HSA-1474290)
Crosslinking of collagen fibrils
(R-HSA-2243919)
Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Hdl assembly
(R-HSA-8963896)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Transport of small molecules
(R-HSA-382551)
Calcium ion binding
(GO:0005509)
Cartilage condensation
(GO:0001502)
Cell differentiation
(GO:0030154)
Collagen fibril organization
(GO:0030199)
Cytokine activity
(GO:0005125)
Dorsal/ventral pattern formation
(GO:0009953)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Growth factor activity
(GO:0008083)
Identical protein binding
(GO:0042802)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Ossification
(GO:0001503)
Peptidase activity
(GO:0008233)
Positive regulation of cartilage development
(GO:0061036)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Serine-type endopeptidase activity
(GO:0004252)
Signal transduction
(GO:0007165)
Skeletal system development
(GO:0001501)
Vesicle
(GO:0031982)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Bone morphogenetic protein 1

Genular Protein ID: 2099296242

Symbol: BMP1_HUMAN

Name: Bone morphogenetic protein 1

UniProtKB Accession Codes:

P13497 A8K6F5 B2RN46 D3DSR0 Q13292 Q13872 Q14874 Q99421 Q99422 Q99423 Q9UL38

Database IDs:

Citations:

PubMed ID: 8643539

Title: The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

PubMed ID: 8643539

DOI: 10.1073/pnas.93.10.5127

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 9500680

Title: Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.

PubMed ID: 9500680

DOI: 10.1007/s001090050202

PubMed ID: 7798260

Title: Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.

PubMed ID: 7798260

DOI: 10.1016/s0021-9258(18)31672-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11283002

Title: Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.

PubMed ID: 11283002

DOI: 10.1074/jbc.m010814200

PubMed ID: 12637569

Title: Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.

PubMed ID: 12637569

DOI: 10.1074/jbc.m213021200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 21453682

Title: Bone morphogenetic protein (BMP)1-3 enhances bone repair.

PubMed ID: 21453682

DOI: 10.1016/j.bbrc.2011.03.109

PubMed ID: 31152061

Title: Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.

PubMed ID: 31152061

DOI: 10.1074/jbc.ra119.007806

PubMed ID: 32636307

Title: BMP-1 disrupts cell adhesion and enhances TGF-beta activation through cleavage of the matricellular protein thrombospondin-1.

PubMed ID: 32636307

DOI: 10.1126/scisignal.aba3880

PubMed ID: 33169406

Title: Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.

PubMed ID: 33169406

DOI: 10.1002/jper.20-0354

PubMed ID: 33206546

Title: Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts.

PubMed ID: 33206546

DOI: 10.1152/ajpcell.00012.2020

PubMed ID: 18824173

Title: Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

PubMed ID: 18824173

DOI: 10.1016/j.jmb.2008.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22482805

Title: Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish.

PubMed ID: 22482805

DOI: 10.1016/j.ajhg.2012.02.026

PubMed ID: 22052668

Title: Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta.

PubMed ID: 22052668

DOI: 10.1002/humu.21647

PubMed ID: 25402547

Title: Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta.

PubMed ID: 25402547

DOI: 10.1002/humu.22731

Sequence Information:

Length: 986
Mass: 111249
Checksum: F89201913AC3CBEA
Sequence:

MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE 
EDLRAFQVQQ AVDLRRHTAR KSSIKAAVPG NTSTPSCQST NGQPQRGACG RWRGRSRSRR 
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY 
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN 
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG 
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI 
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS 
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF 
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF 
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG 
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK 
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN 
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST 
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR 
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY 
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS 
DDTITKKGFH LRYTSTKFQD TLHSRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BMP1

Associated with

Other Information

The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. PubMed ID: 8643539

Novel regulators of bone formation: molecular clones and activities. PubMed ID: 3201241

Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1. PubMed ID: 9500680

Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. PubMed ID: 7798260

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. PubMed ID: 11283002

Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. PubMed ID: 12637569

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Bone morphogenetic protein (BMP)1-3 enhances bone repair. PubMed ID: 21453682

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. PubMed ID: 31152061

BMP-1 disrupts cell adhesion and enhances TGF-beta activation through cleavage of the matricellular protein thrombospondin-1. PubMed ID: 32636307

Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis. PubMed ID: 33169406

Extracellular BMP1 is the major proteinase for COOH-terminal proteolysis of type I procollagen in lung fibroblasts. PubMed ID: 33206546

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. PubMed ID: 18824173

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish. PubMed ID: 22482805

Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta. PubMed ID: 22052668

Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta. PubMed ID: 25402547