Details for: BCL11B

Gene ID: 64919

Symbol: BCL11B

Ensembl ID: ENSG00000127152

Description: BCL11 transcription factor B

Associated with

  • Alpha-beta t cell differentiation
    (GO:0046632)
  • Commitment of neuronal cell to specific neuron type in forebrain
    (GO:0021902)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Epithelial cell morphogenesis
    (GO:0003382)
  • Hematopoietic stem cell migration
    (GO:0035701)
  • Keratinocyte development
    (GO:0003334)
  • Lymphoid lineage cell migration into thymus
    (GO:0097535)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of thymocyte apoptotic process
    (GO:0070244)
  • Neuron projection
    (GO:0043005)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Olfactory bulb axon guidance
    (GO:0071678)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive t cell selection
    (GO:0043368)
  • Post-embryonic camera-type eye development
    (GO:0031077)
  • Protein binding
    (GO:0005515)
  • Regulation of keratinocyte proliferation
    (GO:0010837)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Regulation of neuron differentiation
    (GO:0045664)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Striatal medium spiny neuron differentiation
    (GO:0021773)
  • Swi/snf complex
    (GO:0016514)
  • T cell differentiation in thymus
    (GO:0033077)
  • T cell receptor v(d)j recombination
    (GO:0033153)
  • Thymocyte apoptotic process
    (GO:0070242)
  • Thymus development
    (GO:0048538)
  • Transcription by rna polymerase ii
    (GO:0006366)

Other Information

Genular Protein ID: 689600467

Symbol: BC11B_HUMAN

Name: B-cell lymphoma/leukemia 11B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11719382

Title: The BCL11 gene family: involvement of BCL11A in lymphoid malignancies.

PubMed ID: 11719382

DOI: 10.1182/blood.v98.12.3413

PubMed ID: 12565905

Title: Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas.

PubMed ID: 12565905

DOI: 10.1016/s0006-291x(02)03069-3

PubMed ID: 16809611

Title: BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.

PubMed ID: 16809611

DOI: 10.1182/blood-2006-05-021790

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

PubMed ID: 27959755

Title: Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B.

PubMed ID: 27959755

DOI: 10.1056/nejmoa1509164

PubMed ID: 29985992

Title: BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells.

PubMed ID: 29985992

DOI: 10.1093/brain/awy173

Sequence Information:

  • Length: 894
  • Mass: 95519
  • Checksum: DF6C467AE2EEC122
  • Sequence:
  • MSRRKQGNPQ HLSQRELITP EADHVEAAIL EEDEGLEIEE PSGLGLMVGG PDPDLLTCGQ 
    CQMNFPLGDI LVFIEHKRKQ CGGSLGACYD KALDKDSPPP SSRSELRKVS EPVEIGIQVT 
    PDEDDHLLSP TKGICPKQEN IAGPCRPAQL PAVAPIAASS HPHSSVITSP LRALGALPPC 
    LPLPCCSARP VSGDGTQGEG QTEAPFGCQC QLSGKDEPSS YICTTCKQPF NSAWFLLQHA 
    QNTHGFRIYL EPGPASSSLT PRLTIPPPLG PEAVAQSPLM NFLGDSNPFN LLRMTGPILR 
    DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR LNPMAIDSPA 
    MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK SPFLSTPPLP PMPPGGTPPP 
    QPPAKSKSCE FCGKTFKFQS NLIVHRRSHT GEKPYKCQLC DHACSQASKL KRHMKTHMHK 
    AGSLAGRSDD GLSAASSPEP GTSELAGEGL KAADGDFRHH ESDPSLGHEP EEEDEEEEEE 
    EEELLLENES RPESSFSMDS ELSRNRENGG GGVPGVPGAG GGAAKALADE KALVLGKVME 
    NVGLGALPQY GELLADKQKR GAFLKRAAGG GDAGDDDDAG GCGDAGAGGA VNGRGGGFAP 
    GTEPFPGLFP RKPAPLPSPG LNSAAKRIKV EKDLELPPAA LIPSENVYSQ WLVGYAASRH 
    FMKDPFLGFT DARQSPFATS SEHSSENGSL RFSTPPGDLL DGGLSGRSGT ASGGSTPHLG 
    GPGPGRPSSK EGRRSDTCEY CGKVFKNCSN LTVHRRSHTG ERPYKCELCN YACAQSSKLT 
    RHMKTHGQIG KEVYRCDICQ MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS

Genular Protein ID: 2215900870

Symbol: L8B567_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 823
  • Mass: 88476
  • Checksum: 589266E55A4C367E
  • Sequence:
  • MSRRKQGNPQ HLSQRELITP EADHVEAAIL EEDEGLEIEE PSGLGLMVGG PDPDLLTCGQ 
    CQMNFPLGDI LVFIEHKRKQ CGGSLGACYD KALDKDSPPP SSRSELRKVS EPVEIGIQVT 
    PDEDDHLLSP TKGICPKQEN IAGKDEPSSY ICTTCKQPFN SAWFLLQHAQ NTHGFRIYLE 
    PGPASSSLTP RLTIPPPLGP EAVAQSPLMN FLGDSNPFNL LRMTGPILRD HPGFGEGRLP 
    GTPPLFSPPP RHHLDPHRLS AEEMGLVAQH PSAFDRVMRL NPMAIDSPAM DFSRRLRELA 
    GNSSTPPPVS PGRGNPMHRL LNPFQPSPKS PFLSTPPLPP MPPGGTPPPQ PPAKSKSCEF 
    CGKTFKFQSN LIVHRRSHTG EKPYKCQLCD HACSQASKLK RHMKTHMHKA GSLAGRSDDG 
    LSAASSPEPG TSELAGEGLK AADGDFRHHE SDPSLGHEPE EEDEEEEEEE EELLLENESR 
    PESSFSMDSE LSRNRENGGG GVPGVPGAGG GAAKALADEK ALVLGKVMEN VGLGALPQYG 
    ELLADKQKRG AFLKRAAGGG DAGDDDDAGG CGDAGAGGAV NGRGGGFAPG TEPFPGLFPR 
    KPAPLPSPGL NSAAKRIKVE KDLELPPAAL IPSENVYSQW LVGYAASRHF MKDPFLGFTD 
    ARQSPFATSS EHSSENGSLR FSTPPGDLLD GGLSGRSGTA SGGSTPHLGG PGPGRPSSKE 
    GRRSDTCEYC GKVFKNCSNL TVHRRSHTGE RPYKCELCNY ACAQSSKLTR HMKTHGQIGK 
    EVYRCDICQM PFSVYSTLEK HMKKWHGEHL LTNDVKIEQA ERS

Genular Protein ID: 3732923174

Symbol: L8B862_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 822
  • Mass: 88378
  • Checksum: 7E91064476C479E3
  • Sequence:
  • MSRRKQGNPQ HLSQRELITQ ADHVEAAILE EDEGLEIEEP SGLGLMVGGP DPDLLTCGQC 
    QMNFPLGDIL VFIEHKRKQC GGSLGACYDK ALDKDSPPPS SRSELRKVSE PVEIGIQVTP 
    DEDDHLLSPT KGICPKQENI AGKDEPSSYI CTTCKQPFNS AWFLLQHAQN THGFRIYLEP 
    GPASSSLTPR LTIPPPLGPE AVAQSPLMNF LGDSNPFNLL RMTGPILRDH PGFGEGRLPG 
    TPPLFSPPPR HHLDPHRLSA EEMGLVAQHP SAFDRVMRLN PMAIDSPAMD FSRRLRELAG 
    NSSTPPPVSP GRGNPMHRLL NPFQPSPKSP FLSTPPLPPM PPGGTPPPQP PAKSKSCEFC 
    GKTFKFQSNL IVHRRSHTGE KPYKCQLCDH ACSQASKLKR HMKTHMHKAG SLAGRSDDGL 
    SAASSPEPGT SELAGEGLKA ADGDFRHHES DPSLGHEPEE EDEEEEEEEE ELLLENESRP 
    ESSFSMDSEL SRNRENGGGG VPGVPGAGGG AAKALADEKA LVLGKVMENV GLGALPQYGE 
    LLADKQKRGA FLKRAAGGGD AGDDDDAGGC GDAGAGGAVN GRGGGFAPGT EPFPGLFPRK 
    PAPLPSPGLN SAAKRIKVEK DLELPPAALI PSENVYSQWL VGYAASRHFM KDPFLGFTDA 
    RQSPFATSSE HSSENGSLRF STPPGDLLDG GLSGRSGTAS GGSTPHLGGP GPGRPSSKEG 
    RRSDTCEYCG KVFKNCSNLT VHRRSHTGER PYKCELCNYA CAQSSKLTRH MKTHGQIGKE 
    VYRCDICQMP FSVYSTLEKH MKKWHGEHLL TNDVKIEQAE RS

Genular Protein ID: 2165039940

Symbol: L8B8F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 893
  • Mass: 95421
  • Checksum: 36BAB220D2FB1FB5
  • Sequence:
  • MSRRKQGNPQ HLSQRELITQ ADHVEAAILE EDEGLEIEEP SGLGLMVGGP DPDLLTCGQC 
    QMNFPLGDIL VFIEHKRKQC GGSLGACYDK ALDKDSPPPS SRSELRKVSE PVEIGIQVTP 
    DEDDHLLSPT KGICPKQENI AGPCRPAQLP AVAPIAASSH PHSSVITSPL RALGALPPCL 
    PLPCCSARPV SGDGTQGEGQ TEAPFGCQCQ LSGKDEPSSY ICTTCKQPFN SAWFLLQHAQ 
    NTHGFRIYLE PGPASSSLTP RLTIPPPLGP EAVAQSPLMN FLGDSNPFNL LRMTGPILRD 
    HPGFGEGRLP GTPPLFSPPP RHHLDPHRLS AEEMGLVAQH PSAFDRVMRL NPMAIDSPAM 
    DFSRRLRELA GNSSTPPPVS PGRGNPMHRL LNPFQPSPKS PFLSTPPLPP MPPGGTPPPQ 
    PPAKSKSCEF CGKTFKFQSN LIVHRRSHTG EKPYKCQLCD HACSQASKLK RHMKTHMHKA 
    GSLAGRSDDG LSAASSPEPG TSELAGEGLK AADGDFRHHE SDPSLGHEPE EEDEEEEEEE 
    EELLLENESR PESSFSMDSE LSRNRENGGG GVPGVPGAGG GAAKALADEK ALVLGKVMEN 
    VGLGALPQYG ELLADKQKRG AFLKRAAGGG DAGDDDDAGG CGDAGAGGAV NGRGGGFAPG 
    TEPFPGLFPR KPAPLPSPGL NSAAKRIKVE KDLELPPAAL IPSENVYSQW LVGYAASRHF 
    MKDPFLGFTD ARQSPFATSS EHSSENGSLR FSTPPGDLLD GGLSGRSGTA SGGSTPHLGG 
    PGPGRPSSKE GRRSDTCEYC GKVFKNCSNL TVHRRSHTGE RPYKCELCNY ACAQSSKLTR 
    HMKTHGQIGK EVYRCDICQM PFSVYSTLEK HMKKWHGEHL LTNDVKIEQA ERS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.