Details for: BMP2

Gene ID: 650

Symbol: BMP2

Ensembl ID: ENSG00000125845

Description: bone morphogenetic protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.7412
    Cell Significance Index: -12.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.1742
    Cell Significance Index: -12.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5194
    Cell Significance Index: -12.9700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 5.5346
    Cell Significance Index: 16.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.8699
    Cell Significance Index: 252.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2691
    Cell Significance Index: -12.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.8161
    Cell Significance Index: 328.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8336
    Cell Significance Index: 83.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5211
    Cell Significance Index: 105.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1750
    Cell Significance Index: 9.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0757
    Cell Significance Index: 29.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0058
    Cell Significance Index: 21.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7762
    Cell Significance Index: 46.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6892
    Cell Significance Index: 622.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6447
    Cell Significance Index: 9.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5987
    Cell Significance Index: 59.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5678
    Cell Significance Index: 61.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4942
    Cell Significance Index: 60.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4531
    Cell Significance Index: 81.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4410
    Cell Significance Index: 56.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4338
    Cell Significance Index: 12.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4197
    Cell Significance Index: 68.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2783
    Cell Significance Index: 31.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2711
    Cell Significance Index: 51.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2561
    Cell Significance Index: 7.3400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1863
    Cell Significance Index: 0.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1689
    Cell Significance Index: 0.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1629
    Cell Significance Index: 1.1700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1603
    Cell Significance Index: 1.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1523
    Cell Significance Index: 1.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1204
    Cell Significance Index: 43.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0892
    Cell Significance Index: 48.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0814
    Cell Significance Index: 36.0100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.0773
    Cell Significance Index: 0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0771
    Cell Significance Index: 48.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0610
    Cell Significance Index: 10.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0484
    Cell Significance Index: 1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0356
    Cell Significance Index: 1.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0242
    Cell Significance Index: 16.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0202
    Cell Significance Index: 4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0198
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0103
    Cell Significance Index: 7.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0027
    Cell Significance Index: 0.0500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0024
    Cell Significance Index: 0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0014
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0104
    Cell Significance Index: -19.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0125
    Cell Significance Index: -19.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0202
    Cell Significance Index: -4.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0215
    Cell Significance Index: -6.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0225
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0240
    Cell Significance Index: -2.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0272
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0645
    Cell Significance Index: -6.5900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0725
    Cell Significance Index: -0.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0780
    Cell Significance Index: -5.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0866
    Cell Significance Index: -2.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0879
    Cell Significance Index: -0.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0920
    Cell Significance Index: -11.8900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0991
    Cell Significance Index: -1.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1019
    Cell Significance Index: -1.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1019
    Cell Significance Index: -5.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1113
    Cell Significance Index: -2.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1147
    Cell Significance Index: -2.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1161
    Cell Significance Index: -7.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1252
    Cell Significance Index: -13.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1344
    Cell Significance Index: -5.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1353
    Cell Significance Index: -9.1000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1360
    Cell Significance Index: -1.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1369
    Cell Significance Index: -3.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1510
    Cell Significance Index: -2.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1790
    Cell Significance Index: -11.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1860
    Cell Significance Index: -14.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1899
    Cell Significance Index: -14.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2007
    Cell Significance Index: -12.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2149
    Cell Significance Index: -10.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2183
    Cell Significance Index: -12.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2325
    Cell Significance Index: -10.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2508
    Cell Significance Index: -13.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2858
    Cell Significance Index: -9.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2919
    Cell Significance Index: -12.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3011
    Cell Significance Index: -2.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3029
    Cell Significance Index: -5.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3219
    Cell Significance Index: -11.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3248
    Cell Significance Index: -10.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3375
    Cell Significance Index: -8.4300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3384
    Cell Significance Index: -3.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3415
    Cell Significance Index: -12.9300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3555
    Cell Significance Index: -3.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3688
    Cell Significance Index: -12.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP2 is a secreted protein that belongs to the TGF-β superfamily, which consists of 18 members. BMP2 is encoded by the BMP2 gene, which is located on chromosome 4q11.13 in humans. The BMP2 protein is a dimeric molecule composed of two identical subunits, each consisting of 139 amino acids. BMP2 is produced by various cell types, including osteoblasts, chondrocytes, and fibroblasts, and plays a crucial role in regulating cell proliferation, differentiation, and migration. **Pathways and Functions** BMP2 signaling pathways involve the activation of specific receptors, which triggers a cascade of downstream signaling events. The BMP2 receptor complex is composed of two types of receptors: type I (BMPR1A and BMPR1B) and type II (BMPR2). The binding of BMP2 to its receptors triggers the activation of Smad proteins, which are transcription factors that regulate gene expression. BMP2 signaling pathways are involved in various biological processes, including: 1. **Bone and cartilage development**: BMP2 promotes the differentiation of osteoblasts and chondrocytes, which are essential for bone and cartilage development. 2. **Tissue repair**: BMP2 regulates the proliferation and differentiation of fibroblasts, which are involved in wound healing and tissue repair. 3. **Immune responses**: BMP2 modulates the activity of immune cells, such as T cells and macrophages, which are involved in immune responses. 4. **Angiogenesis**: BMP2 promotes the formation of new blood vessels, which is essential for tissue development and repair. **Clinical Significance** BMP2 has been implicated in various diseases, including: 1. **Bone disorders**: BMP2 has been used as a therapeutic agent to promote bone healing and repair in patients with bone fractures and osteoporosis. 2. **Cancer**: BMP2 has been shown to promote tumor growth and metastasis in certain types of cancer, such as breast and prostate cancer. 3. **Cardiovascular disease**: BMP2 has been implicated in the development of atherosclerosis and cardiac fibrosis. 4. **Immune disorders**: BMP2 has been shown to modulate the activity of immune cells, which is essential for the development of autoimmune diseases, such as rheumatoid arthritis. In conclusion, BMP2 is a crucial regulator of various biological processes, including embryonic development, tissue repair, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its potential therapeutic applications. **References:** 1. [Insert references to studies on BMP2 and its role in various diseases] 2. [Insert references to studies on BMP2 signaling pathways and its regulation of gene expression] **Future Directions** 1. **Investigating the role of BMP2 in immune disorders**: Further research is needed to understand the mechanisms by which BMP2 regulates immune responses and its potential implications in autoimmune diseases. 2. **Developing BMP2-based therapeutic agents**: Researchers should explore the development of BMP2-based therapeutic agents for the treatment of bone disorders, cancer, and cardiovascular disease. 3. **Understanding the mechanisms of BMP2 dysregulation**: Further research is needed to understand the mechanisms by which BMP2 dysregulation contributes to various diseases. By continuing to investigate the role of BMP2 in various biological processes, we can gain a deeper understanding of its importance in maintaining tissue homeostasis and its potential implications in various diseases.

Genular Protein ID: 3889770483

Symbol: BMP2_HUMAN

Name: Bone morphogenetic protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 7791754

Title: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

PubMed ID: 7791754

DOI: 10.1128/mcb.15.7.3479

PubMed ID: 9265423

Title: Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry.

PubMed ID: 9265423

DOI: 10.1021/ac9611172

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 16771708

Title: Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.

PubMed ID: 16771708

DOI: 10.1042/bj20060027

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 18436533

Title: BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.

PubMed ID: 18436533

DOI: 10.1074/jbc.m800850200

PubMed ID: 20555025

Title: Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment.

PubMed ID: 20555025

DOI: 10.1210/en.2010-0326

PubMed ID: 20851880

Title: BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

PubMed ID: 20851880

DOI: 10.1074/jbc.m110.142307

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

PubMed ID: 24362451

Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

PubMed ID: 24362451

DOI: 10.1007/s00223-013-9828-1

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 10074410

Title: Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.

PubMed ID: 10074410

DOI: 10.1006/jmbi.1999.2590

PubMed ID: 15064755

Title: Molecular recognition of BMP-2 and BMP receptor IA.

PubMed ID: 15064755

DOI: 10.1038/nsmb756

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 31019025

Title: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.

PubMed ID: 31019025

DOI: 10.1126/scitranslmed.aar4953

PubMed ID: 19327734

Title: Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.

PubMed ID: 19327734

DOI: 10.1016/j.ajhg.2009.03.001

PubMed ID: 21357617

Title: A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family.

PubMed ID: 21357617

DOI: 10.1136/jmg.2010.084814

PubMed ID: 29198724

Title: Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions.

PubMed ID: 29198724

DOI: 10.1016/j.ajhg.2017.10.006

Sequence Information:

  • Length: 396
  • Mass: 44702
  • Checksum: 20653A3987B25E60
  • Sequence:
  • MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM 
    FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE 
    LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA 
    TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS 
    KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP 
    LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC 
    CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.