BMP2 | ENSG00000125845 | NCBI 650

Details for: BMP2

Gene ID: 650

Symbol: BMP2

Ensembl ID: ENSG00000125845

Description: bone morphogenetic protein 2

Associated with

Elastic fibre formation
(R-HSA-1566948)
Extracellular matrix organization
(R-HSA-1474244)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Molecules associated with elastic fibres
(R-HSA-2129379)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by bmp
(R-HSA-201451)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Ameloblast differentiation
(GO:0036305)
Animal organ morphogenesis
(GO:0009887)
Aortic valve development
(GO:0003176)
Atrioventricular valve morphogenesis
(GO:0003181)
Bmp receptor binding
(GO:0070700)
Bmp signaling pathway
(GO:0030509)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac atrium formation
(GO:0003210)
Cardiocyte differentiation
(GO:0035051)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Chondrocyte differentiation
(GO:0002062)
Co-receptor binding
(GO:0039706)
Cytokine activity
(GO:0005125)
Embryonic heart tube anterior/posterior pattern specification
(GO:0035054)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion morphogenesis
(GO:0003203)
Endodermal-mesodermal cell signaling
(GO:0003133)
Epithelial to mesenchymal transition
(GO:0001837)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart induction
(GO:0003129)
Inflammatory response
(GO:0006954)
In utero embryonic development
(GO:0001701)
Negative regulation of aldosterone biosynthetic process
(GO:0032348)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin-like growth factor receptor signaling pathway
(GO:0043569)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of steroid biosynthetic process
(GO:0010894)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Notch signaling pathway
(GO:0007219)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Osteoblast differentiation
(GO:0001649)
Osteoclast differentiation
(GO:0030316)
Phosphatase activator activity
(GO:0019211)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of extracellular matrix constituent secretion
(GO:0003331)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of phosphatase activity
(GO:0010922)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein serine/threonine kinase activator activity
(GO:0043539)
Proteoglycan metabolic process
(GO:0006029)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of odontogenesis of dentin-containing tooth
(GO:0042487)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Signaling receptor binding
(GO:0005102)
Skeletal system development
(GO:0001501)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Bone morphogenetic protein 2

Genular Protein ID: 3889770483

Symbol: BMP2_HUMAN

Name: Bone morphogenetic protein 2

UniProtKB Accession Codes:

P12643

Database IDs:

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 7791754

Title: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

PubMed ID: 7791754

DOI: 10.1128/mcb.15.7.3479

PubMed ID: 9265423

Title: Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry.

PubMed ID: 9265423

DOI: 10.1021/ac9611172

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 16771708

Title: Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.

PubMed ID: 16771708

DOI: 10.1042/bj20060027

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 18436533

Title: BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.

PubMed ID: 18436533

DOI: 10.1074/jbc.m800850200

PubMed ID: 20555025

Title: Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment.

PubMed ID: 20555025

DOI: 10.1210/en.2010-0326

PubMed ID: 20851880

Title: BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

PubMed ID: 20851880

DOI: 10.1074/jbc.m110.142307

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

PubMed ID: 24362451

Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

PubMed ID: 24362451

DOI: 10.1007/s00223-013-9828-1

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 10074410

Title: Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.

PubMed ID: 10074410

DOI: 10.1006/jmbi.1999.2590

PubMed ID: 15064755

Title: Molecular recognition of BMP-2 and BMP receptor IA.

PubMed ID: 15064755

DOI: 10.1038/nsmb756

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 31019025

Title: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.

PubMed ID: 31019025

DOI: 10.1126/scitranslmed.aar4953

PubMed ID: 19327734

Title: Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.

PubMed ID: 19327734

DOI: 10.1016/j.ajhg.2009.03.001

PubMed ID: 21357617

Title: A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family.

PubMed ID: 21357617

DOI: 10.1136/jmg.2010.084814

PubMed ID: 29198724

Title: Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions.

PubMed ID: 29198724

DOI: 10.1016/j.ajhg.2017.10.006

Sequence Information:

Length: 396
Mass: 44702
Checksum: 20653A3987B25E60
Sequence:

MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM 
FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE 
LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA 
TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS 
KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP 
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC 
CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BMP2

Associated with

Other Information

Novel regulators of bone formation: molecular clones and activities. PubMed ID: 3201241

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. PubMed ID: 7791754

Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry. PubMed ID: 9265423

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. PubMed ID: 15020244

Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2. PubMed ID: 16771708

Targeting of bone morphogenetic protein growth factor complexes to fibrillin. PubMed ID: 18339631

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. PubMed ID: 18436533

Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. PubMed ID: 20555025

BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. PubMed ID: 20851880

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. PubMed ID: 31800957

Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. PubMed ID: 24362451

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. PubMed ID: 33308444

Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. PubMed ID: 10074410

Molecular recognition of BMP-2 and BMP receptor IA. PubMed ID: 15064755

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. PubMed ID: 17295905

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. PubMed ID: 31019025

Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2. PubMed ID: 19327734

A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family. PubMed ID: 21357617

Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions. PubMed ID: 29198724