Gene BMP2 - ENSG00000125845 | NCBI Gene ID: 650

Details for: BMP2

Gene ID: 650

Symbol: BMP2

Ensembl ID: ENSG00000125845

Description: bone morphogenetic protein 2

Associated with

Elastic fibre formation
(R-HSA-1566948)
Extracellular matrix organization
(R-HSA-1474244)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Molecules associated with elastic fibres
(R-HSA-2129379)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by bmp
(R-HSA-201451)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Ameloblast differentiation
(GO:0036305)
Animal organ morphogenesis
(GO:0009887)
Aortic valve development
(GO:0003176)
Atrioventricular valve morphogenesis
(GO:0003181)
Bmp receptor binding
(GO:0070700)
Bmp signaling pathway
(GO:0030509)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac atrium formation
(GO:0003210)
Cardiocyte differentiation
(GO:0035051)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Chondrocyte differentiation
(GO:0002062)
Co-receptor binding
(GO:0039706)
Cytokine activity
(GO:0005125)
Embryonic heart tube anterior/posterior pattern specification
(GO:0035054)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion morphogenesis
(GO:0003203)
Endodermal-mesodermal cell signaling
(GO:0003133)
Epithelial to mesenchymal transition
(GO:0001837)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart induction
(GO:0003129)
Inflammatory response
(GO:0006954)
In utero embryonic development
(GO:0001701)
Negative regulation of aldosterone biosynthetic process
(GO:0032348)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin-like growth factor receptor signaling pathway
(GO:0043569)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of steroid biosynthetic process
(GO:0010894)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Notch signaling pathway
(GO:0007219)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Osteoblast differentiation
(GO:0001649)
Osteoclast differentiation
(GO:0030316)
Phosphatase activator activity
(GO:0019211)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of extracellular matrix constituent secretion
(GO:0003331)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of phosphatase activity
(GO:0010922)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein serine/threonine kinase activator activity
(GO:0043539)
Proteoglycan metabolic process
(GO:0006029)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of odontogenesis of dentin-containing tooth
(GO:0042487)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Signaling receptor binding
(GO:0005102)
Skeletal system development
(GO:0001501)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.88
Marker Score: 2771
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.52
Marker Score: 2887
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169086
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.42
Marker Score: 482
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.38
Marker Score: 1472
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.36
Marker Score: 1161
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.24
Marker Score: 2528
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.23
Marker Score: 1479
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.17
Marker Score: 918
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.13
Marker Score: 7347
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.06
Marker Score: 1102
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.01
Marker Score: 1004
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71801
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48026
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.99
Marker Score: 3113
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Marker Score: 1034
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5262
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2733
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.91
Marker Score: 378
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.9
Marker Score: 5723
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5277
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.86
Marker Score: 13531
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.86
Marker Score: 1957
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 299
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 561.5
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.73
Marker Score: 329
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.72
Marker Score: 1751.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 642
Cell Name: ionocyte (CL0005006)
Fold Change: 0.7
Marker Score: 212
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.7
Marker Score: 197
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2898
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.67
Marker Score: 168
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.67
Marker Score: 168
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.66
Marker Score: 317
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.66
Marker Score: 163
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.66
Marker Score: 394
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.65
Marker Score: 1502
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.63
Marker Score: 3772
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.56
Marker Score: 5682
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.56
Marker Score: 164
Cell Name: enterocyte (CL0000584)
Fold Change: 0.56
Marker Score: 2667
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: osteoblast (CL0000062)
Fold Change: 0.56
Marker Score: 298
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.55
Marker Score: 133
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.55
Marker Score: 877.5
Cell Name: lactocyte (CL0002325)
Fold Change: 0.54
Marker Score: 8703
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.53
Marker Score: 417
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5
Marker Score: 16975
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.49
Marker Score: 592
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.48
Marker Score: 123
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.47
Marker Score: 113
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.47
Marker Score: 193
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.46
Marker Score: 1076
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.46
Marker Score: 177
Cell Name: granule cell (CL0000120)
Fold Change: 0.45
Marker Score: 3384.5
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.45
Marker Score: 129
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.45
Marker Score: 1218
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.45
Marker Score: 283
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.44
Marker Score: 204
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.44
Marker Score: 4927
Cell Name: peptic cell (CL0000155)
Fold Change: 0.43
Marker Score: 182
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.43
Marker Score: 251
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.42
Marker Score: 265
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.42
Marker Score: 675
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.42
Marker Score: 1766
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.42
Marker Score: 2196
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.42
Marker Score: 480
Cell Name: malignant cell (CL0001064)
Fold Change: 0.41
Marker Score: 5445
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.4
Marker Score: 119
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.4
Marker Score: 168
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.39
Marker Score: 383
Cell Name: tendon cell (CL0000388)
Fold Change: 0.38
Marker Score: 94
Cell Name: pericyte (CL0000669)
Fold Change: 0.37
Marker Score: 215
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.36
Marker Score: 161
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 363
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.36
Marker Score: 144
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.36
Marker Score: 514
Cell Name: stem cell (CL0000034)
Fold Change: 0.35
Marker Score: 840
Cell Name: fibroblast (CL0000057)
Fold Change: 0.35
Marker Score: 337
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.35
Marker Score: 76
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.35
Marker Score: 219
Cell Name: stromal cell (CL0000499)
Fold Change: 0.34
Marker Score: 402
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.34
Marker Score: 109
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.34
Marker Score: 303
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.34
Marker Score: 324
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.34
Marker Score: 105
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.33
Marker Score: 127.5
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.33
Marker Score: 350
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.33
Marker Score: 502
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.32
Marker Score: 84

Hover over a box to see details here...

**Key characteristics:** - BMP2 is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the BMP receptor family. - BMP2 is produced by various cell types, including endothelial cells, fibroblasts, and stem cells. - It is known to interact with other BMPs and signaling molecules, such as TGF-beta, TGF-beta receptor, and other extracellular matrix proteins. **Pathways and functions:** - BMP2 signaling is initiated by the binding of BMP2 to its receptor, BMP receptor type 2 (BMPR2). - This binding triggers a cascade of intracellular events that lead to the activation of downstream signaling pathways, including the Smad signaling pathway. - BMP2 also regulates the expression of various target genes through transcriptional and post-translational mechanisms. - It plays a critical role in embryonic development, cardiovascular homeostasis, tissue repair, and cancer progression. **Clinical significance:** - Mutations in BMP2 have been linked to various human diseases, including cardiovascular diseases, cancer, and osteoporosis. - BMP2 inhibitors are being investigated as potential therapeutics for these diseases. - Understanding the role of BMP2 in various physiological and pathological processes has important implications for developing new therapeutic strategies. **Additional information:** - BMP2 is a key regulator of cardiovascular development and function. - It is also involved in tissue repair, cell migration, and angiogenesis. - BMP2 signaling is essential for the survival and differentiation of various cell types.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bone morphogenetic protein 2

Genular Protein ID: 3889770483

Symbol: BMP2_HUMAN

Name: Bone morphogenetic protein 2

UniProtKB Accession Codes:

P12643

Database IDs:

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 7791754

Title: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

PubMed ID: 7791754

DOI: 10.1128/mcb.15.7.3479

PubMed ID: 9265423

Title: Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry.

PubMed ID: 9265423

DOI: 10.1021/ac9611172

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 16771708

Title: Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.

PubMed ID: 16771708

DOI: 10.1042/bj20060027

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 18436533

Title: BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.

PubMed ID: 18436533

DOI: 10.1074/jbc.m800850200

PubMed ID: 20555025

Title: Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment.

PubMed ID: 20555025

DOI: 10.1210/en.2010-0326

PubMed ID: 20851880

Title: BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

PubMed ID: 20851880

DOI: 10.1074/jbc.m110.142307

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

PubMed ID: 24362451

Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

PubMed ID: 24362451

DOI: 10.1007/s00223-013-9828-1

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 10074410

Title: Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.

PubMed ID: 10074410

DOI: 10.1006/jmbi.1999.2590

PubMed ID: 15064755

Title: Molecular recognition of BMP-2 and BMP receptor IA.

PubMed ID: 15064755

DOI: 10.1038/nsmb756

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 31019025

Title: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.

PubMed ID: 31019025

DOI: 10.1126/scitranslmed.aar4953

PubMed ID: 19327734

Title: Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.

PubMed ID: 19327734

DOI: 10.1016/j.ajhg.2009.03.001

PubMed ID: 21357617

Title: A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family.

PubMed ID: 21357617

DOI: 10.1136/jmg.2010.084814

PubMed ID: 29198724

Title: Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions.

PubMed ID: 29198724

DOI: 10.1016/j.ajhg.2017.10.006

Sequence Information:

Length: 396
Mass: 44702
Checksum: 20653A3987B25E60
Sequence:

MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM 
FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE 
LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA 
TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS 
KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP 
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC 
CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BMP2

Associated with

Cells (max top 100)

Other Information

Novel regulators of bone formation: molecular clones and activities. PubMed ID: 3201241

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. PubMed ID: 7791754

Direct isoform analysis of high-mannose-containing glycoproteins by on-line capillary electrophoresis electrospray mass spectrometry. PubMed ID: 9265423

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. PubMed ID: 15020244

Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2. PubMed ID: 16771708

Targeting of bone morphogenetic protein growth factor complexes to fibrillin. PubMed ID: 18339631

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. PubMed ID: 18436533

Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. PubMed ID: 20555025

BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. PubMed ID: 20851880

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. PubMed ID: 31800957

Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. PubMed ID: 24362451

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. PubMed ID: 33308444

Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. PubMed ID: 10074410

Molecular recognition of BMP-2 and BMP receptor IA. PubMed ID: 15064755

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. PubMed ID: 17295905

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. PubMed ID: 31019025

Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2. PubMed ID: 19327734

A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family. PubMed ID: 21357617

Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions. PubMed ID: 29198724