Details for: PINK1

Gene ID: 65018

Symbol: PINK1

Ensembl ID: ENSG00000158828

Description: PTEN induced kinase 1

Associated with

Other Information

Genular Protein ID: 2909675069

Symbol: PINK1_HUMAN

Name: Serine/threonine-protein kinase PINK1, mitochondrial

UniProtKB Accession Codes:

Q9BXM7 Q8N6T9 Q8NBU3 Q96DE4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 1 GO 100 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11494141

Title: Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

PubMed ID: 11494141

DOI: 10.1038/sj.onc.1204608

PubMed ID: 14607334

Title: BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential.

PubMed ID: 14607334

DOI: 10.1016/s0304-3835(03)00443-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16672980

Title: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.

PubMed ID: 16672980

DOI: 10.1038/nature04788

PubMed ID: 18957282

Title: PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.

PubMed ID: 18957282

DOI: 10.1016/j.bbrc.2008.10.104

PubMed ID: 18443288

Title: Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.

PubMed ID: 18443288

DOI: 10.1073/pnas.0711845105

PubMed ID: 18687899

Title: The kinase domain of mitochondrial PINK1 faces the cytoplasm.

PubMed ID: 18687899

DOI: 10.1073/pnas.0802814105

PubMed ID: 19229105

Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

PubMed ID: 19229105

DOI: 10.1172/jci37617

PubMed ID: 20798600

Title: The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.

PubMed ID: 20798600

DOI: 10.4161/auto.6.7.13286

PubMed ID: 20547144

Title: R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress.

PubMed ID: 20547144

DOI: 10.1016/j.brainres.2010.06.005

PubMed ID: 20404107

Title: PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.

PubMed ID: 20404107

DOI: 10.1083/jcb.200910140

PubMed ID: 19966284

Title: PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.

PubMed ID: 19966284

DOI: 10.1073/pnas.0911187107

PubMed ID: 22043288

Title: Bioenergetic consequences of PINK1 mutations in Parkinson disease.

PubMed ID: 22043288

DOI: 10.1371/journal.pone.0025622

PubMed ID: 22354088

Title: Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

PubMed ID: 22354088

DOI: 10.1038/embor.2012.14

PubMed ID: 22910362

Title: PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.

PubMed ID: 22910362

DOI: 10.1038/ncomms2016

PubMed ID: 22396657

Title: Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.

PubMed ID: 22396657

DOI: 10.1371/journal.pgen.1002537

PubMed ID: 23754282

Title: Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

PubMed ID: 23754282

DOI: 10.1074/jbc.m113.467530

PubMed ID: 23933751

Title: The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

PubMed ID: 23933751

DOI: 10.1038/nn.3489

PubMed ID: 23620051

Title: PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.

PubMed ID: 23620051

DOI: 10.1126/science.1231031

PubMed ID: 24660806

Title: Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

PubMed ID: 24660806

DOI: 10.1042/bj20140334

PubMed ID: 24898855

Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.

PubMed ID: 24898855

DOI: 10.7554/elife.01958

PubMed ID: 24751536

Title: PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.

PubMed ID: 24751536

DOI: 10.1083/jcb.201402104

PubMed ID: 24784582

Title: Ubiquitin is phosphorylated by PINK1 to activate parkin.

PubMed ID: 24784582

DOI: 10.1038/nature13392

PubMed ID: 24896179

Title: The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.

PubMed ID: 24896179

DOI: 10.1038/nature13418

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 24652937

Title: PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

PubMed ID: 24652937

DOI: 10.1126/science.1249161

PubMed ID: 25527291

Title: Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

PubMed ID: 25527291

DOI: 10.15252/embj.201489847

PubMed ID: 30733118

Title: Reciprocal roles of Tom7 and OMA1 during mitochondrial import and activation of PINK1.

PubMed ID: 30733118

DOI: 10.1016/j.molcel.2019.01.002

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 32047033

Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.

PubMed ID: 32047033

DOI: 10.1073/pnas.1909814117

PubMed ID: 32484300

Title: PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics.

PubMed ID: 32484300

DOI: 10.15252/embr.201948686

PubMed ID: 29123128

Title: PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.

PubMed ID: 29123128

DOI: 10.1038/s41467-017-01435-1

PubMed ID: 15349860

Title: PINK1 mutations are associated with sporadic early-onset parkinsonism.

PubMed ID: 15349860

DOI: 10.1002/ana.20256

PubMed ID: 15349870

Title: Novel PINK1 mutations in early-onset parkinsonism.

PubMed ID: 15349870

DOI: 10.1002/ana.20251

PubMed ID: 15596610

Title: Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.

PubMed ID: 15596610

DOI: 10.1001/archneur.61.12.1898

PubMed ID: 15505171

Title: PINK1 (PARK6) associated Parkinson disease in Ireland.

PubMed ID: 15505171

DOI: 10.1212/01.wnl.0000142089.38301.8e

PubMed ID: 15087508

Title: Hereditary early-onset Parkinson's disease caused by mutations in PINK1.

PubMed ID: 15087508

DOI: 10.1126/science.1096284

PubMed ID: 16207217

Title: Analysis of PINK1 in Asian patients with familial parkinsonism.

PubMed ID: 16207217

DOI: 10.1111/j.1399-0004.2005.00500.x

PubMed ID: 15970950

Title: PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism.

PubMed ID: 15970950

DOI: 10.1038/sj.ejhg.5201455

PubMed ID: 16207731

Title: Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

PubMed ID: 16207731

DOI: 10.1093/hmg/ddi377

PubMed ID: 15955953

Title: Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism.

PubMed ID: 15955953

DOI: 10.1212/01.wnl.0000164009.36740.4e

PubMed ID: 16009891

Title: Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

PubMed ID: 16009891

DOI: 10.1212/01.wnl.0000167546.39375.82

PubMed ID: 16969854

Title: A heterozygous effect for PINK1 mutations in Parkinson's disease?

PubMed ID: 16969854

DOI: 10.1002/ana.20960

PubMed ID: 16966503

Title: Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1.

PubMed ID: 16966503

DOI: 10.1001/archneur.63.9.1257

PubMed ID: 17030667

Title: T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease.

PubMed ID: 17030667

DOI: 10.1001/archneur.63.10.1483

PubMed ID: 16401616

Title: Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa.

PubMed ID: 16401616

DOI: 10.1093/brain/awl005

PubMed ID: 16632486

Title: Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.

PubMed ID: 16632486

DOI: 10.1093/hmg/ddl104

PubMed ID: 16482571

Title: PINK1 mutations in sporadic early-onset Parkinson's disease.

PubMed ID: 16482571

DOI: 10.1002/mds.20810

PubMed ID: 16257123

Title: Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan.

PubMed ID: 16257123

DOI: 10.1016/j.neulet.2005.10.005

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18330912

Title: PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum.

PubMed ID: 18330912

DOI: 10.1002/humu.20719

PubMed ID: 18286320

Title: Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation.

PubMed ID: 18286320

DOI: 10.1007/s00415-008-0763-4

PubMed ID: 18785233

Title: Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism.

PubMed ID: 18785233

DOI: 10.1002/mds.22156

PubMed ID: 22956510

Title: Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.

PubMed ID: 22956510

DOI: 10.1002/mds.25132

Sequence Information:

  • Length: 581
  • Mass: 62769
  • Checksum: 721FE01F63263A64
  • Sequence:
    • MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 
LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 
AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 
NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 
LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH 
RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 
ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP 
DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 
ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.