Inppl1 | ENSRNOG00000019730 | NCBI 65038

Details for: Inppl1

Gene ID: 65038

Symbol: Inppl1

Ensembl ID: ENSRNOG00000019730

Description: inositol polyphosphate phosphatase-like 1

Associated with

Cytokine signaling in immune system
(R-RNO-1280215)
Immune system
(R-RNO-168256)
Inositol phosphate metabolism
(R-RNO-1483249)
Interleukin-2 family signaling
(R-RNO-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-RNO-512988)
Interleukin receptor shc signaling
(R-RNO-912526)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Phospholipid metabolism
(R-RNO-1483257)
Pi metabolism
(R-RNO-1483255)
Signaling by interleukins
(R-RNO-449147)
Synthesis of ip3 and ip4 in the cytosol
(R-RNO-1855204)
Synthesis of pips at the plasma membrane
(R-RNO-1660499)
Actin binding
(GO:0003779)
Actin filament organization
(GO:0007015)
Apoptotic process
(GO:0006915)
Basal plasma membrane
(GO:0009925)
Cell adhesion
(GO:0007155)
Cellular lipid metabolic process
(GO:0044255)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endochondral ossification
(GO:0001958)
Endocytosis
(GO:0006897)
Erk1 and erk2 cascade
(GO:0070371)
Filopodium
(GO:0030175)
Gene expression
(GO:0010467)
Glucose metabolic process
(GO:0006006)
Golgi apparatus
(GO:0005794)
Immune system process
(GO:0002376)
Inositol-polyphosphate 5-phosphatase activity
(GO:0004445)
Inositol phosphate phosphatase activity
(GO:0052745)
Inositol trisphosphate metabolic process
(GO:0032957)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna replication
(GO:0008156)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin-like growth factor receptor signaling pathway
(GO:0043569)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
(GO:0034485)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol dephosphorylation
(GO:0046856)
Plasma membrane
(GO:0005886)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Regulation of immune response
(GO:0050776)
Response to insulin
(GO:0032868)
Response to xenobiotic stimulus
(GO:0009410)
Ruffle assembly
(GO:0097178)
Sh2 domain binding
(GO:0042169)
Sh3 domain binding
(GO:0017124)
Spindle pole
(GO:0000922)

Other Information

Proteins

SHIP2_RAT

Genular Protein ID: 2860954109

Symbol: SHIP2_RAT

Name: N/A

UniProtKB Accession Codes:

Q9WVR3 Q9R1V2

Database IDs:

Citations:

PubMed ID: 10381377

Title: Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.

PubMed ID: 10381377

DOI: 10.1006/bbrc.1999.0888

PubMed ID: 10648902

Title: Localization of mRNA for SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase, in the brain of developing and mature rats.

PubMed ID: 10648902

DOI: 10.1016/s0169-328x(99)00311-3

PubMed ID: 11238900

Title: Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

PubMed ID: 11238900

DOI: 10.1128/mcb.21.5.1633-1646.2001

PubMed ID: 12351701

Title: Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.

PubMed ID: 12351701

DOI: 10.1210/me.2002-0083

PubMed ID: 17535963

Title: An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells.

PubMed ID: 17535963

DOI: 10.1083/jcb.200609017

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 12086927

Title: The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.

PubMed ID: 12086927

DOI: 10.2337/diabetes.51.7.2012

Sequence Information:

Length: 1257
Mass: 139143
Checksum: 3A994C8E52940083
Sequence:

MASVCGAPSP GGALGSQAPA WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV 
LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE 
REPDPPDDRD ASDVEDEKPP LPPRSGSTSI SVPAGPSSPL PAPETPTTPA AESTPNGLST 
VSHEYLKGSY GLDLEAVRGG ASNLPHLTRT LVTSCRRLHS EVDKVLSGLE ILSKVFDQQS 
SPMVTRLLQQ QSLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPLQP 
SIRKAKTIPV QAFEVKLDVT LGDLTKIGKS QKFTLSVDVE GGRLVLLRRQ RDSQEDWTTF 
THDRIRQLIK SQRVQNKLGV VFEKEKDRTQ RKDFIFVSAR KREAFCQLLQ LMKNKHSKQD 
EPDMISVFIG TWNMGSVPPP KNVTSWFTSK GLGKALDEVT VTIPHDIYVF GTQENSVGDR 
EWLDLLRGGL KELTDLDYRP IAMQSLWNIK VAVLVKPEHE NRISHVSTSS VKTGIANTLG 
NKGAVGVSFM FNGTSFGFVN CHLTSGNEKT TRRNQNYLDI LRLLSLGDRQ LSAFDISLRF 
THLFWFGDLN YRLDMDIQEI LNYISRREFE PLLRVDQLNL EREKHKVFLR FSEEEISFPP 
TYRYERGSRD TYAWHKQKPT GVRTNVPSWC DRILWKSYPE THIICNSYGC TDDIVTSDHS 
PVFGTFEVGV TSQFISKKGL SKTSDQAYIE FESIEAIVKT ASRTKFFIEF YSTCLEEYKK 
SFENDAQSSD NINFLKVQWS SRQLPTLKPI LADIEYLQDQ HLLLTVKSMD GYESYGECVV 
ALKSMIGSTA QQFLTFLSHR GEETGNIRGS MKVRVPTERL GTRERLYEWI SIDKDDTGAK 
SKAPSVLRGS QEHRSGSRKP TSTEASCPLS KLFEEPEKPP PTGRPPAPPR AVPREESLNP 
RLKSEGTPEQ EGVAAPPPKN SFNNPAYYVL EGVPHQLLPL EPTSFARAPI PPTTKNKVAI 
TVPAPQLGRH RTPRVGEGSS SDEDSGGTLP PPDFPPPPLP DSAIFLPPNL DPLSMPVVRG 
RSVGEARGPP PPKAHPRPPL PPGTSPASTF LEEVASADDR SCSVLQMAKT LSEVDYSPGP 
GRSALLPNPL ELQLPRGPSD YGRPLSFPPP RIRESIQEDL AEEAPCPQGG RASGLGEAGM 
GAWLRAIGLE RYEEGLVHNG WDDLEFLSDI TEEDLEEAGV QDPAHKRLLL DTLQLSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Inppl1

Associated with

Other Information

Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling. PubMed ID: 10381377

Localization of mRNA for SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase, in the brain of developing and mature rats. PubMed ID: 10648902

Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. PubMed ID: 11238900

Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors. PubMed ID: 12351701

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. PubMed ID: 17535963

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. PubMed ID: 12086927