RTN4R | ENSG00000040608 | NCBI 65078

Details for: RTN4R

Gene ID: 65078

Symbol: RTN4R

Ensembl ID: ENSG00000040608

Description: reticulon 4 receptor

Associated with

Axonal growth inhibition (rhoa activation)
(R-HSA-193634)
Death receptor signaling
(R-HSA-73887)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr regulates axonogenesis
(R-HSA-193697)
Signal transduction
(R-HSA-162582)
Axonal growth cone
(GO:0044295)
Axonogenesis
(GO:0007409)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Chondroitin sulfate binding
(GO:0035374)
Corpus callosum development
(GO:0022038)
Dendritic shaft
(GO:0043198)
Endoplasmic reticulum
(GO:0005783)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Ganglioside gm1 binding
(GO:1905573)
Ganglioside gt1b binding
(GO:1905576)
Glutamatergic synapse
(GO:0098978)
Heparin binding
(GO:0008201)
Membrane raft
(GO:0045121)
Negative regulation of axon extension
(GO:0030517)
Negative regulation of axon regeneration
(GO:0048681)
Negative regulation of neuron projection development
(GO:0010977)
Neuregulin receptor activity
(GO:0038131)
Neuronal cell body
(GO:0043025)
Neuronal signal transduction
(GO:0023041)
Neuron projection
(GO:0043005)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of rho protein signal transduction
(GO:0035025)
Presynapse
(GO:0098793)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Signaling receptor activity
(GO:0038023)

Other Information

Proteins

Reticulon-4 receptor

Genular Protein ID: 2847184655

Symbol: RTN4R_HUMAN

Name: Reticulon-4 receptor

UniProtKB Accession Codes:

Q9BZR6 D3DX28

Database IDs:

Citations:

PubMed ID: 11201742

Title: Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.

PubMed ID: 11201742

DOI: 10.1038/35053072

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12426574

Title: A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.

PubMed ID: 12426574

DOI: 10.1038/nn975

PubMed ID: 12037567

Title: Nogo-66 receptor antagonist peptide promotes axonal regeneration.

PubMed ID: 12037567

DOI: 10.1038/417547a

PubMed ID: 12068310

Title: Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.

PubMed ID: 12068310

DOI: 10.1038/nature00867

PubMed ID: 12089450

Title: Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.

PubMed ID: 12089450

DOI: 10.1126/science.1073031

PubMed ID: 12694398

Title: Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor.

PubMed ID: 12694398

DOI: 10.1046/j.1471-4159.2003.01710.x

PubMed ID: 15532024

Title: Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia.

PubMed ID: 15532024

DOI: 10.1002/humu.9292

PubMed ID: 14966521

Title: LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

PubMed ID: 14966521

DOI: 10.1038/nn1188

PubMed ID: 12183616

Title: It takes more than two to Nogo.

PubMed ID: 12183616

DOI: 10.1126/science.1076247

PubMed ID: 11891768

Title: Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration.

PubMed ID: 11891768

DOI: 10.1002/jnr.10134

PubMed ID: 16712417

Title: A high-content screening assay for the Nogo receptor based on cellular Rho activation.

PubMed ID: 16712417

DOI: 10.1089/adt.2006.4.133

PubMed ID: 18411262

Title: Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.

PubMed ID: 18411262

DOI: 10.1074/jbc.m802067200

PubMed ID: 19052207

Title: Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.

PubMed ID: 19052207

DOI: 10.1523/jneurosci.3828-08.2008

PubMed ID: 20697954

Title: Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1.

PubMed ID: 20697954

DOI: 10.1007/s10571-010-9549-1

PubMed ID: 22325200

Title: The Nogo receptor family restricts synapse number in the developing hippocampus.

PubMed ID: 22325200

DOI: 10.1016/j.neuron.2011.11.029

PubMed ID: 28892071

Title: A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility.

PubMed ID: 28892071

DOI: 10.1038/tp.2017.170

PubMed ID: 12839991

Title: Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.

PubMed ID: 12839991

DOI: 10.1093/emboj/cdg325

PubMed ID: 12718853

Title: Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition.

PubMed ID: 12718853

DOI: 10.1016/s0896-6273(03)00232-0

Sequence Information:

Length: 473
Mass: 50708
Checksum: CA5624B24C584702
Sequence:

MKRASAGGSR LLAWVLWLQA WQVAAPCPGA CVCYNEPKVT TSCPQQGLQA VPVGIPAASQ 
RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FTGLALLEQL DLSDNAQLRS 
VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL 
THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA 
LPTEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR 
LAANDLQGCA VATGPYHPIW TGRATDEEPL GLPKCCQPDA ADKASVLEPG RPASAGNALK 
GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP EGSEPPGFPT SGPRRRPGCS 
RKNRTRSHCR LGQAGSGGGG TGDSEGSGAL PSLTCSLTPL GLALVLWTVL GPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RTN4R

Associated with

Other Information

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. PubMed ID: 11201742

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. PubMed ID: 12426574

Nogo-66 receptor antagonist peptide promotes axonal regeneration. PubMed ID: 12037567

Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. PubMed ID: 12068310

Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. PubMed ID: 12089450

Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. PubMed ID: 12694398

Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. PubMed ID: 15532024

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. PubMed ID: 14966521

It takes more than two to Nogo. PubMed ID: 12183616

Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. PubMed ID: 11891768

A high-content screening assay for the Nogo receptor based on cellular Rho activation. PubMed ID: 16712417

Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. PubMed ID: 18411262

Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. PubMed ID: 19052207

Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. PubMed ID: 20697954

The Nogo receptor family restricts synapse number in the developing hippocampus. PubMed ID: 22325200

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility. PubMed ID: 28892071

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. PubMed ID: 12839991

Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. PubMed ID: 12718853