Details for: VPS33A

Gene ID: 65082

Symbol: VPS33A

Ensembl ID: ENSG00000139719

Description: VPS33A core subunit of CORVET and HOPS complexes

Associated with

Other Information

Genular Protein ID: 3004065676

Symbol: VP33A_HUMAN

Name: Vacuolar protein sorting-associated protein 33A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12538872

Title: The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation.

PubMed ID: 12538872

DOI: 10.1073/pnas.0237292100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18552835

Title: Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

PubMed ID: 18552835

DOI: 10.1038/ncb1740

PubMed ID: 19109425

Title: SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.

PubMed ID: 19109425

DOI: 10.1091/mbc.e08-07-0728

PubMed ID: 20434987

Title: Identification of the switch in early-to-late endosome transition.

PubMed ID: 20434987

DOI: 10.1016/j.cell.2010.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21411634

Title: Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

PubMed ID: 21411634

DOI: 10.1091/mbc.e10-10-0799

PubMed ID: 23351085

Title: Tethering complexes in the endocytic pathway: CORVET and HOPS.

PubMed ID: 23351085

DOI: 10.1111/febs.12151

PubMed ID: 24554770

Title: The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

PubMed ID: 24554770

DOI: 10.1091/mbc.e13-08-0447

PubMed ID: 25266290

Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.

PubMed ID: 25266290

DOI: 10.1111/tra.12232

PubMed ID: 25783203

Title: Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

PubMed ID: 25783203

DOI: 10.1111/tra.12283

PubMed ID: 28325809

Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed ID: 28325809

DOI: 10.1083/jcb.201607085

PubMed ID: 23901104

Title: Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

PubMed ID: 23901104

DOI: 10.1073/pnas.1307074110

PubMed ID: 28013294

Title: Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms.

PubMed ID: 28013294

DOI: 10.1093/hmg/ddw377

PubMed ID: 27547915

Title: A probable new syndrome with the storage disease phenotype caused by the VPS33A gene mutation.

PubMed ID: 27547915

DOI: 10.1097/mcd.0000000000000149

Sequence Information:

  • Length: 596
  • Mass: 67611
  • Checksum: 12442A1D9A223F56
  • Sequence:
  • MAAHLSYGRV NLNVLREAVR RELREFLDKC AGSKAIVWDE YLTGPFGLIA QYSLLKEHEV 
    EKMFTLKGNR LPAADVKNII FFVRPRLELM DIIAENVLSE DRRGPTRDFH ILFVPRRSLL 
    CEQRLKDLGV LGSFIHREEY SLDLIPFDGD LLSMESEGAF KECYLEGDQT SLYHAAKGLM 
    TLQALYGTIP QIFGKGECAR QVANMMIRMK REFTGSQNSI FPVFDNLLLL DRNVDLLTPL 
    ATQLTYEGLI DEIYGIQNSY VKLPPEKFAP KKQGDGGKDL PTEAKKLQLN SAEELYAEIR 
    DKNFNAVGSV LSKKAKIISA AFEERHNAKT VGEIKQFVSQ LPHMQAARGS LANHTSIAEL 
    IKDVTTSEDF FDKLTVEQEF MSGIDTDKVN NYIEDCIAQK HSLIKVLRLV CLQSVCNSGL 
    KQKVLDYYKR EILQTYGYEH ILTLHNLEKA GLLKPQTGGR NNYPTIRKTL RLWMDDVNEQ 
    NPTDISYVYS GYAPLSVRLA QLLSRPGWRS IEEVLRILPG PHFEERQPLP TGLQKKRQPG 
    ENRVTLIFFL GGVTFAEIAA LRFLSQLEDG GTEYVIATTK LMNGTSWIEA LMEKPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.