Details for: BMP3

Gene ID: 651

Symbol: BMP3

Ensembl ID: ENSG00000152785

Description: bone morphogenetic protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.8335
    Cell Significance Index: -7.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.5518
    Cell Significance Index: -7.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.8265
    Cell Significance Index: 302.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6857
    Cell Significance Index: 40.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.6216
    Cell Significance Index: 498.9100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.1694
    Cell Significance Index: 13.0000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.5298
    Cell Significance Index: 15.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3972
    Cell Significance Index: 63.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2708
    Cell Significance Index: 1147.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2217
    Cell Significance Index: 11.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1811
    Cell Significance Index: 128.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1257
    Cell Significance Index: 32.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9518
    Cell Significance Index: 20.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8064
    Cell Significance Index: 79.7700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6710
    Cell Significance Index: 7.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6297
    Cell Significance Index: 9.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5553
    Cell Significance Index: 38.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4595
    Cell Significance Index: 82.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4263
    Cell Significance Index: 9.0800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.4153
    Cell Significance Index: 2.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3324
    Cell Significance Index: 6.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2489
    Cell Significance Index: 89.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1584
    Cell Significance Index: 9.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1174
    Cell Significance Index: 14.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1020
    Cell Significance Index: 2.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0701
    Cell Significance Index: 2.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0354
    Cell Significance Index: 1.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0306
    Cell Significance Index: 16.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0159
    Cell Significance Index: 0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0130
    Cell Significance Index: 9.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0081
    Cell Significance Index: 0.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0055
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0101
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0116
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9400
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -0.0220
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0320
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0366
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0387
    Cell Significance Index: -8.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0393
    Cell Significance Index: -2.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0422
    Cell Significance Index: -2.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0438
    Cell Significance Index: -8.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0459
    Cell Significance Index: -7.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0491
    Cell Significance Index: -0.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0538
    Cell Significance Index: -7.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0570
    Cell Significance Index: -6.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0652
    Cell Significance Index: -6.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0704
    Cell Significance Index: -9.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0765
    Cell Significance Index: -8.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0861
    Cell Significance Index: -2.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1141
    Cell Significance Index: -3.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1146
    Cell Significance Index: -3.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1190
    Cell Significance Index: -6.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1226
    Cell Significance Index: -9.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1228
    Cell Significance Index: -2.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1246
    Cell Significance Index: -6.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1310
    Cell Significance Index: -8.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1552
    Cell Significance Index: -4.0800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1617
    Cell Significance Index: -2.0000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1619
    Cell Significance Index: -1.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1623
    Cell Significance Index: -4.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1692
    Cell Significance Index: -5.3900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1708
    Cell Significance Index: -1.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1793
    Cell Significance Index: -6.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1803
    Cell Significance Index: -3.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1807
    Cell Significance Index: -9.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1814
    Cell Significance Index: -4.4000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1814
    Cell Significance Index: -1.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1906
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1913
    Cell Significance Index: -8.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1930
    Cell Significance Index: -4.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1989
    Cell Significance Index: -8.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2123
    Cell Significance Index: -10.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2159
    Cell Significance Index: -7.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2270
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2283
    Cell Significance Index: -2.5900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2311
    Cell Significance Index: -1.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2337
    Cell Significance Index: -8.1200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2427
    Cell Significance Index: -2.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2477
    Cell Significance Index: -9.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2481
    Cell Significance Index: -10.1700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2546
    Cell Significance Index: -5.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2582
    Cell Significance Index: -8.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2583
    Cell Significance Index: -7.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2694
    Cell Significance Index: -4.4400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2763
    Cell Significance Index: -3.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2856
    Cell Significance Index: -2.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2893
    Cell Significance Index: -5.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BMP3 is a secreted protein that belongs to the TGF-β superfamily, which is characterized by its ability to regulate cellular differentiation, growth, and apoptosis. BMP3 is highly expressed in various tissues, including the skin, lung, kidney, and reproductive organs. Its expression is tightly regulated by various transcription factors, including Smad proteins and MAPK pathways. BMP3 has been shown to have a unique structure, consisting of a prodomain, a growth domain, and a C-terminal domain, which determines its biological activity. **Pathways and Functions:** BMP3 signaling pathways are complex and involve multiple molecular interactions. The primary pathway involves the binding of BMP3 to its receptors, which triggers the activation of Smad proteins and the subsequent transcription of target genes. BMP3 has been shown to regulate various cellular processes, including: 1. **Cell-cell signaling:** BMP3 regulates cell-cell interactions, influencing the development and maintenance of tissues, including the skin, lung, and skeletal system. 2. **Cytokine activity:** BMP3 modulates cytokine production, influencing immune responses and inflammation. 3. **Extracellular exosome:** BMP3 is secreted into exosomes, which are small vesicles that regulate cellular communication. 4. **Growth factor activity:** BMP3 regulates cell growth, differentiation, and survival, influencing tissue development and homeostasis. **Clinical Significance:** BMP3 has been implicated in various diseases, including: 1. **Autoimmune disorders:** BMP3 has been shown to regulate immune responses, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** BMP3 has been shown to inhibit tumor growth and metastasis, suggesting its potential as a cancer therapy target. 3. **Osteoarthritis:** BMP3 regulates cartilage development and maintenance, and its dysregulation has been linked to osteoarthritis. 4. **Reproductive disorders:** BMP3 is involved in reproductive development and function, and its dysregulation has been linked to infertility and miscarriage. In conclusion, BMP3 is a multifunctional protein that plays a critical role in various physiological and pathological processes. Its dysregulation has been linked to various diseases, and further research is needed to fully understand its role in human health and disease. As an expert immunologist, it is essential to continue investigating the complex mechanisms of BMP3 signaling and its potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of BMP3 signaling and its role in different diseases. 2. BMP3-based therapies should be developed to target autoimmune disorders, cancer, osteoarthritis, and reproductive disorders. 3. The development of BMP3-specific antibodies or small molecules could provide new therapeutic options for these diseases. By continuing to study BMP3, we can unlock its full potential as a therapeutic target and improve human health and disease management.

Genular Protein ID: 4261827904

Symbol: BMP3_HUMAN

Name: Bone morphogenetic protein 3

UniProtKB Accession Codes:

P12645 Q4VAS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11138004

Title: Bone morphogenetic protein-3 is a negative regulator of bone density.

PubMed ID: 11138004

DOI: 10.1038/83810

PubMed ID: 13678778

Title: BMP signaling components are expressed in human fracture callus.

PubMed ID: 13678778

DOI: 10.1016/s8756-3282(03)00191-1

PubMed ID: 15269709

Title: Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.

PubMed ID: 15269709

DOI: 10.1038/sj.gt.3302298

PubMed ID: 15475196

Title: Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage.

PubMed ID: 15475196

DOI: 10.1016/j.orthres.2004.02.013

PubMed ID: 31665064

Title: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.

PubMed ID: 31665064

DOI: 10.1186/s13046-019-1435-1

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17924656

Title: BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors.

PubMed ID: 17924656

DOI: 10.1021/bi700907k

Sequence Information:

  • Length: 472
  • Mass: 53372
  • Checksum: 2809B7EF5E37596A
  • Sequence:
    • MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL QPQDKVSEHM 
LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF RAAAAETLER KGLYIFNLTS 
LTKSENILSA TLYFCIGELG NISLSCPVSG GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL 
GHLSVDMAKS HRDIMSWLSK DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI 
LVYANDAAIS EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN 
ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ FDEQTLKKAR 
RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS GACQFPMPKS LKPSNHATIQ 
SIVRAVGVVP GIPEPCCVPE KMSSLSILFF DENKNVVLKV YPNMTVESCA CR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.