Details for: BMP3

Gene ID: 651

Symbol: BMP3

Ensembl ID: ENSG00000152785

Description: bone morphogenetic protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.18
    Marker Score: 1505
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.82
    Marker Score: 7597
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.58
    Marker Score: 868
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.37
    Marker Score: 2839
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1966
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 664
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251793
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1
    Marker Score: 864
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.96
    Marker Score: 641
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.94
    Marker Score: 184
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.93
    Marker Score: 238
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.88
    Marker Score: 923
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.86
    Marker Score: 1034.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1616
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.78
    Marker Score: 365
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.77
    Marker Score: 247
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.77
    Marker Score: 195
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.76
    Marker Score: 376
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.73
    Marker Score: 210
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2873.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.63
    Marker Score: 161
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1282
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.63
    Marker Score: 127
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.61
    Marker Score: 3221
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.61
    Marker Score: 142
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9410
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.59
    Marker Score: 1837
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.58
    Marker Score: 3772
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 448
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.54
    Marker Score: 5169
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.53
    Marker Score: 200
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.52
    Marker Score: 837
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.52
    Marker Score: 2003
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.51
    Marker Score: 509
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5
    Marker Score: 1013
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 445
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.42
    Marker Score: 6216
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.42
    Marker Score: 1731
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.41
    Marker Score: 214
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 265
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4
    Marker Score: 498
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.4
    Marker Score: 758
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.39
    Marker Score: 136
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.39
    Marker Score: 452
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.39
    Marker Score: 613
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.38
    Marker Score: 1306
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.37
    Marker Score: 3218
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.36
    Marker Score: 1028
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.36
    Marker Score: 103
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 810
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.33
    Marker Score: 238
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.32
    Marker Score: 89
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3
    Marker Score: 4858
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 506
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.29
    Marker Score: 191
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.29
    Marker Score: 2133
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.27
    Marker Score: 352
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 489.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.27
    Marker Score: 605
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 126
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 198.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.26
    Marker Score: 62
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.25
    Marker Score: 90
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.25
    Marker Score: 134.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.25
    Marker Score: 381
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 689
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 107
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.23
    Marker Score: 147

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Other Information

**Key characteristics**: * BMP3 is a secreted protein that is expressed in high levels in cartilage tissues. * It is a member of the BMP family of growth factors. * BMP3 is a key regulator of chondrocyte differentiation, proliferation, and survival. * It is also involved in cell-cell signaling, cytokine activity, and extracellular matrix remodeling. **Pathways and functions**: * BMP3 signaling is initiated by the binding of BMP3 to its receptor, BMP1 and BMP2. * BMP3 signaling is essential for the differentiation of mesenchymal stem cells into chondrocytes. * BMP3 also promotes the survival and migration of chondrocytes. * BMP3 plays a role in cartilage development, remodeling, and homeostasis. **Clinical significance**: * Mutations in BMP3 have been linked to several human diseases, including rheumatoid arthritis, osteoarthritis, and cartilage defects. * BMP3 inhibitors are being investigated as potential treatments for these diseases. * Understanding the role of BMP3 in cartilage development and disease is important for developing new therapeutic strategies. **Additional information**: * BMP3 is a highly conserved protein that is found in vertebrates. * It is produced by a variety of cell types, including chondrocytes, epithelial cells, and immune cells. * BMP3 is a potent activator of the BMP receptor type I. * It is a key regulator of the development and function of cartilage tissues.

Genular Protein ID: 4261827904

Symbol: BMP3_HUMAN

Name: Bone morphogenetic protein 3

UniProtKB Accession Codes:

P12645 Q4VAS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11138004

Title: Bone morphogenetic protein-3 is a negative regulator of bone density.

PubMed ID: 11138004

DOI: 10.1038/83810

PubMed ID: 13678778

Title: BMP signaling components are expressed in human fracture callus.

PubMed ID: 13678778

DOI: 10.1016/s8756-3282(03)00191-1

PubMed ID: 15269709

Title: Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.

PubMed ID: 15269709

DOI: 10.1038/sj.gt.3302298

PubMed ID: 15475196

Title: Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage.

PubMed ID: 15475196

DOI: 10.1016/j.orthres.2004.02.013

PubMed ID: 31665064

Title: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.

PubMed ID: 31665064

DOI: 10.1186/s13046-019-1435-1

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17924656

Title: BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors.

PubMed ID: 17924656

DOI: 10.1021/bi700907k

Sequence Information:

  • Length: 472
  • Mass: 53372
  • Checksum: 2809B7EF5E37596A
  • Sequence:
    • MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL QPQDKVSEHM 
LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF RAAAAETLER KGLYIFNLTS 
LTKSENILSA TLYFCIGELG NISLSCPVSG GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL 
GHLSVDMAKS HRDIMSWLSK DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI 
LVYANDAAIS EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN 
ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ FDEQTLKKAR 
RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS GACQFPMPKS LKPSNHATIQ 
SIVRAVGVVP GIPEPCCVPE KMSSLSILFF DENKNVVLKV YPNMTVESCA CR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.