UPF3B | ENSG00000125351 | NCBI 65109

Details for: UPF3B

Gene ID: 65109

Symbol: UPF3B

Ensembl ID: ENSG00000125351

Description: UPF3B regulator of nonsense mediated mRNA decay

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Gene expression (transcription)
(R-HSA-74160)
Metabolism of rna
(R-HSA-8953854)
Mrna 3'-end processing
(R-HSA-72187)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of expression of slits and robos
(R-HSA-9010553)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription termination
(R-HSA-73856)
Signaling by robo receptors
(R-HSA-376176)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Brain development
(GO:0007420)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Exon-exon junction complex
(GO:0035145)
Mrna binding
(GO:0003729)
Mrna transport
(GO:0051028)
Neuronal cell body
(GO:0043025)
Neuron projection development
(GO:0031175)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mrna cis splicing, via spliceosome
(GO:1905746)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)

Other Information

Proteins

Up-frameshift suppressor 3 homolog on chromosome X

Genular Protein ID: 2488230908

Symbol: REN3B_HUMAN

Name: Up-frameshift suppressor 3 homolog on chromosome X

UniProtKB Accession Codes:

Q9BZI7 D3DWI3 D3DWI4 Q0VAK8 Q9H1J0

Database IDs:

Citations:

PubMed ID: 11163187

Title: Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.

PubMed ID: 11163187

DOI: 10.1016/s0092-8674(00)00214-2

PubMed ID: 11113196

Title: Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).

PubMed ID: 11113196

DOI: 10.1128/mcb.21.1.209-223.2001

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11546873

Title: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.

PubMed ID: 11546873

DOI: 10.1126/science.1062829

PubMed ID: 11546874

Title: Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.

PubMed ID: 11546874

DOI: 10.1126/science.1062786

PubMed ID: 12718880

Title: Y14 and hUpf3b form an NMD-activating complex.

PubMed ID: 12718880

DOI: 10.1016/s1097-2765(03)00142-4

PubMed ID: 12554878

Title: Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

PubMed ID: 12554878

DOI: 10.1261/rna.2137903

PubMed ID: 16209946

Title: Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.

PubMed ID: 16209946

DOI: 10.1016/j.molcel.2005.08.012

PubMed ID: 16601204

Title: Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.

PubMed ID: 16601204

DOI: 10.1261/rna.12506

PubMed ID: 18066079

Title: NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.

PubMed ID: 18066079

DOI: 10.1038/nsmb1330

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19864460

Title: Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.

PubMed ID: 19864460

DOI: 10.1091/mbc.e09-05-0389

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23917022

Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

PubMed ID: 23917022

DOI: 10.4161/rna.25827

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 15004547

Title: The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.

PubMed ID: 15004547

DOI: 10.1038/nsmb741

PubMed ID: 20479275

Title: Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

PubMed ID: 20479275

DOI: 10.1073/pnas.1000993107

PubMed ID: 17704778

Title: Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

PubMed ID: 17704778

DOI: 10.1038/ng2100

Sequence Information:

Length: 483
Mass: 57762
Checksum: F5A8A395783D1A69
Sequence:

MKEEKEHRPK EKRVTLLTPA GATGSGGGTS GDSSKGEDKQ DRNKEKKEAL SKVVIRRLPP 
TLTKEQLQEH LQPMPEHDYF EFFSNDTSLY PHMYARAYIN FKNQEDIILF RDRFDGYVFL 
DNKGQEYPAI VEFAPFQKAA KKKTKKRDTK VGTIDDDPEY RKFLESYATD NEKMTSTPET 
LLEEIEAKNR ELIAKKTTPL LSFLKNKQRM REEKREERRR REIERKRQRE EERRKWKEEE 
KRKRKDIEKL KKIDRIPERD KLKDEPKIKV HRFLLQAVNQ KNLLKKPEKG DEKELDKREK 
AKKLDKENLS DERASGQSCT LPKRSDSELK DEKPKRPEDE SGRDYRERER EYERDQERIL 
RERERLKRQE EERRRQKERY EKEKTFKRKE EEMKKEKDTL RDKGKKAEST ESIGSSEKTE 
KKEEVVKRDR IRNKDRPAMQ LYQPGARSRN RLCPPDDSTK SGDSAAERKQ ESGISHRKEG 
GEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UPF3B

Associated with

Other Information

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. PubMed ID: 11163187

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). PubMed ID: 11113196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. PubMed ID: 11546873

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. PubMed ID: 11546874

Y14 and hUpf3b form an NMD-activating complex. PubMed ID: 12718880

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. PubMed ID: 12554878

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. PubMed ID: 16209946

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. PubMed ID: 16601204

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. PubMed ID: 18066079

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export. PubMed ID: 19864460

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. PubMed ID: 23917022

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. PubMed ID: 25220460

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. PubMed ID: 15004547

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. PubMed ID: 20479275

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. PubMed ID: 17704778