Vps35 | ENSMUSG00000031696 | NCBI 65114

Details for: Vps35

Gene ID: 65114

Symbol: Vps35

Ensembl ID: ENSMUSG00000031696

Description: VPS35 retromer complex component

Associated with

Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Wnt ligand biogenesis and trafficking
(R-MMU-3238698)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
D1 dopamine receptor binding
(GO:0031748)
Dopaminergic synapse
(GO:0098691)
Early endosome
(GO:0005769)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Glutamatergic synapse
(GO:0098978)
Intracellular protein transport
(GO:0006886)
Late endosome
(GO:0005770)
Lysosome
(GO:0005764)
Lysosome organization
(GO:0007040)
Membrane
(GO:0016020)
Mitochondrial fragmentation involved in apoptotic process
(GO:0043653)
Mitochondrion
(GO:0005739)
Mitochondrion-derived vesicle
(GO:0099073)
Mitochondrion to lysosome vesicle-mediated transport
(GO:0099074)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of late endosome to lysosome transport
(GO:1902823)
Negative regulation of lysosomal protein catabolic process
(GO:1905166)
Negative regulation of protein homooligomerization
(GO:0032463)
Negative regulation of protein localization
(GO:1903828)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Neurotransmitter receptor transport, endosome to plasma membrane
(GO:0099639)
Neurotransmitter receptor transport, endosome to postsynaptic membrane
(GO:0098887)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of dopamine biosynthetic process
(GO:1903181)
Positive regulation of dopamine receptor signaling pathway
(GO:0060161)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of locomotion involved in locomotory behavior
(GO:0090326)
Positive regulation of mitochondrial fission
(GO:0090141)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein localization to cell periphery
(GO:1904377)
Positive regulation of wnt protein secretion
(GO:0061357)
Postsynapse
(GO:0098794)
Postsynaptic density
(GO:0014069)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein localization to endosome
(GO:0036010)
Protein localization to organelle
(GO:0033365)
Protein transport
(GO:0015031)
Regulation of dendritic spine maintenance
(GO:1902950)
Regulation of mitochondrion organization
(GO:0010821)
Regulation of postsynapse assembly
(GO:0150052)
Regulation of protein metabolic process
(GO:0051246)
Regulation of protein stability
(GO:0031647)
Regulation of synapse maturation
(GO:0090128)
Regulation of terminal button organization
(GO:2000331)
Retrograde transport, endosome to golgi
(GO:0042147)
Retromer, cargo-selective complex
(GO:0030906)
Retromer complex
(GO:0030904)
Synapse
(GO:0045202)
Transcytosis
(GO:0045056)
Tubular endosome
(GO:0097422)
Vacuolar protein processing
(GO:0006624)
Vesicle-mediated transport in synapse
(GO:0099003)
Voluntary musculoskeletal movement
(GO:0050882)

Other Information

Proteins

Vacuolar protein sorting-associated protein 35

Genular Protein ID: 286152309

Symbol: VPS35_MOUSE

Name: Vacuolar protein sorting-associated protein 35

UniProtKB Accession Codes:

Q9EQH3 Q61123

Database IDs:

Citations:

PubMed ID: 8678978

Title: Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3.

PubMed ID: 8678978

DOI: 10.1007/s003359900174

PubMed ID: 11112353

Title: Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21.

PubMed ID: 11112353

DOI: 10.1006/geno.2000.6380

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16190980

Title: A novel mammalian retromer component, Vps26B.

PubMed ID: 16190980

DOI: 10.1111/j.1600-0854.2005.00328.x

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21040701

Title: Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.

PubMed ID: 21040701

DOI: 10.1016/j.bbrc.2010.10.121

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20875039

Title: Assembly and solution structure of the core retromer protein complex.

PubMed ID: 20875039

DOI: 10.1111/j.1600-0854.2010.01124.x

PubMed ID: 21920005

Title: Vps26A and Vps26B subunits define distinct retromer complexes.

PubMed ID: 21920005

DOI: 10.1111/j.1600-0854.2011.01284.x

PubMed ID: 23395371

Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

PubMed ID: 23395371

DOI: 10.1016/j.neuron.2012.11.033

PubMed ID: 28469074

Title: SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.

PubMed ID: 28469074

DOI: 10.1172/jci.insight.88995

Sequence Information:

Length: 796
Mass: 91713
Checksum: 2ABD338111D641CC
Sequence:

MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML GELRTSMLSP 
KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY AGNIIPRLYL LITVGVVYVK 
SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR NYLLQCTRNI LPDEGEPTDE ETTGDISDSM 
DFVLLNFAEM NKLWVRMQHQ GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ 
IVLTGILEQV VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII 
ALIDRLALFA HREDGPGIPA EIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL QVSLINLAMK 
CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR LLKIPVDTYN NILTVLKLKH 
FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD 
PEDFADEQSL VGRFIHLLRS DDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA 
FRYKENSQMD DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE 
TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR TQCALAASKL 
LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL KKALKIANQC MDPSLQVQLF 
IEILNRYIYF YEKENDAVTI QVLNQLIQKI REDLPNLESS EETEQINKHF HNTLEHLRSR 
RESPESEGPI YEGLIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vps35

Associated with

Other Information

Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3. PubMed ID: 8678978

Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. PubMed ID: 11112353

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel mammalian retromer component, Vps26B. PubMed ID: 16190980

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. PubMed ID: 21040701

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Assembly and solution structure of the core retromer protein complex. PubMed ID: 20875039

Vps26A and Vps26B subunits define distinct retromer complexes. PubMed ID: 21920005

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. PubMed ID: 23395371

SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. PubMed ID: 28469074