Details for: Kcnd2

Gene ID: 65180

Symbol: Kcnd2

Ensembl ID: ENSRNOG00000067416

Description: potassium voltage-gated channel subfamily D member 2

Associated with

Other Information

Genular Protein ID: 258963000

Symbol: KCND2_RAT

Name: Potassium voltage-gated channel subfamily D member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1840649

Title: Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel.

PubMed ID: 1840649

DOI: 10.1016/0896-6273(91)90299-f

PubMed ID: 1705709

Title: Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart.

PubMed ID: 1705709

DOI: 10.1073/pnas.88.5.1798

PubMed ID: 1722463

Title: Functional characterization of RK5, a voltage-gated K+ channel cloned from the rat cardiovascular system.

PubMed ID: 1722463

DOI: 10.1016/0014-5793(91)81420-d

PubMed ID: 9093524

Title: Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current.

PubMed ID: 9093524

DOI: 10.1016/s0008-6363(96)00221-0

PubMed ID: 9058605

Title: Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels.

PubMed ID: 9058605

PubMed ID: 9070739

Title: Clustering of KV4.2 potassium channels in postsynaptic membrane of rat supraoptic neurons: an ultrastructural study.

PubMed ID: 9070739

DOI: 10.1016/s0306-4522(96)00561-1

PubMed ID: 10681507

Title: Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase.

PubMed ID: 10681507

DOI: 10.1074/jbc.275.8.5337

PubMed ID: 10860776

Title: Voltage-gated K(+)Channel, Kv4.2, localizes predominantly to the transverse-axial tubular system of the rat myocyte.

PubMed ID: 10860776

DOI: 10.1006/jmcc.2000.1172

PubMed ID: 11080179

Title: The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK.

PubMed ID: 11080179

DOI: 10.1046/j.1471-4159.2000.0752277.x

PubMed ID: 11102480

Title: Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.

PubMed ID: 11102480

DOI: 10.1523/jneurosci.20-23-08736.2000

PubMed ID: 10676964

Title: Modulation of A-type potassium channels by a family of calcium sensors.

PubMed ID: 10676964

DOI: 10.1038/35000592

PubMed ID: 12451113

Title: PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex.

PubMed ID: 12451113

DOI: 10.1523/jneurosci.22-23-10123.2002

PubMed ID: 11847232

Title: Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.

PubMed ID: 11847232

DOI: 10.1074/jbc.m200897200

PubMed ID: 11923279

Title: Cell surface targeting and clustering interactions between heterologously expressed PSD-95 and the Shal voltage-gated potassium channel, Kv4.2.

PubMed ID: 11923279

DOI: 10.1074/jbc.m109412200

PubMed ID: 11805342

Title: Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.

PubMed ID: 11805342

DOI: 10.1073/pnas.022509299

PubMed ID: 12829703

Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.

PubMed ID: 12829703

DOI: 10.1074/jbc.m306142200

PubMed ID: 12592409

Title: An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting.

PubMed ID: 12592409

DOI: 10.1038/nn1020

PubMed ID: 12575952

Title: The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.

PubMed ID: 12575952

DOI: 10.1016/s0896-6273(02)01185-6

PubMed ID: 12754210

Title: The role of Zn2+ in Shal voltage-gated potassium channel formation.

PubMed ID: 12754210

DOI: 10.1074/jbc.m304268200

PubMed ID: 14559911

Title: Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95.

PubMed ID: 14559911

DOI: 10.1074/jbc.m304675200

PubMed ID: 15485870

Title: KChIP3 rescues the functional expression of Shal channel tetramerization mutants.

PubMed ID: 15485870

DOI: 10.1074/jbc.m409721200

PubMed ID: 15356203

Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.

PubMed ID: 15356203

DOI: 10.1523/jneurosci.0776-04.2004

PubMed ID: 14980207

Title: Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

PubMed ID: 14980207

DOI: 10.1016/s0896-6273(04)00049-2

PubMed ID: 15452711

Title: The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels.

PubMed ID: 15452711

DOI: 10.1007/s00424-004-1328-8

PubMed ID: 15858231

Title: Molecular determinants of voltage-gated potassium currents in vascular smooth muscle.

PubMed ID: 15858231

DOI: 10.1385/cbb:42:2:167

PubMed ID: 15671030

Title: DPP10 modulates Kv4-mediated A-type potassium channels.

PubMed ID: 15671030

DOI: 10.1074/jbc.m410613200

PubMed ID: 15736227

Title: Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells.

PubMed ID: 15736227

DOI: 10.1002/cne.20443

PubMed ID: 16207878

Title: Functional role of the fast transient outward K+ current IA in pyramidal neurons in (rat) primary visual cortex.

PubMed ID: 16207878

DOI: 10.1523/jneurosci.2858-05.2005

PubMed ID: 16123112

Title: Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties.

PubMed ID: 16123112

DOI: 10.1113/jphysiol.2005.087858

PubMed ID: 16820361

Title: C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2.

PubMed ID: 16820361

DOI: 10.1074/jbc.m604843200

PubMed ID: 17026528

Title: Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression.

PubMed ID: 17026528

DOI: 10.1111/j.1471-4159.2006.04185.x

PubMed ID: 17917103

Title: Ionic channel function in action potential generation: current perspective.

PubMed ID: 17917103

DOI: 10.1007/s12035-007-8001-0

PubMed ID: 17582333

Title: Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.

PubMed ID: 17582333

DOI: 10.1016/j.neuron.2007.05.026

PubMed ID: 18371079

Title: Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.

PubMed ID: 18371079

DOI: 10.1111/j.1460-9568.2008.06141.x

PubMed ID: 18650329

Title: Protein kinase A mediates activity-dependent Kv4.2 channel trafficking.

PubMed ID: 18650329

DOI: 10.1523/jneurosci.1951-08.2008

PubMed ID: 18276729

Title: Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.

PubMed ID: 18276729

DOI: 10.1113/jphysiol.2007.150540

PubMed ID: 18357523

Title: The neuronal Kv4 channel complex.

PubMed ID: 18357523

DOI: 10.1007/s11064-008-9650-8

PubMed ID: 19441798

Title: Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits.

PubMed ID: 19441798

DOI: 10.1021/bi802316m

PubMed ID: 19901547

Title: A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.

PubMed ID: 19901547

DOI: 10.4161/chan.3.6.10216

PubMed ID: 19213956

Title: Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

PubMed ID: 19213956

DOI: 10.1161/circresaha.108.191007

PubMed ID: 19279261

Title: The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.

PubMed ID: 19279261

DOI: 10.1523/jneurosci.4767-08.2009

PubMed ID: 20224290

Title: Alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels.

PubMed ID: 20224290

DOI: 10.4161/chan.4.3.11479

PubMed ID: 20045463

Title: KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.

PubMed ID: 20045463

DOI: 10.1016/j.mcn.2009.12.005

PubMed ID: 22098631

Title: Unique somato-dendritic distribution pattern of Kv4.2 channels on hippocampal CA1 pyramidal cells.

PubMed ID: 22098631

DOI: 10.1111/j.1460-9568.2011.07907.x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 25352783

Title: Regulation of Kv4.2 A-type potassium channels in HEK-293 cells by hypoxia.

PubMed ID: 25352783

DOI: 10.3389/fncel.2014.00329

PubMed ID: 24037673

Title: Distribution and functional expression of Kv4 family alpha subunits and associated KChIP beta subunits in the bed nucleus of the stria terminalis.

PubMed ID: 24037673

DOI: 10.1002/cne.23435

PubMed ID: 24811166

Title: The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.

PubMed ID: 24811166

DOI: 10.1074/jbc.m114.563452

PubMed ID: 24793047

Title: Localization of Kv4.2 and KChIP2 in lipid rafts and modulation of outward K(+) currents by membrane cholesterol content in rat left ventricular myocytes.

PubMed ID: 24793047

DOI: 10.1007/s00424-014-1521-3

PubMed ID: 24404150

Title: Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2.

PubMed ID: 24404150

DOI: 10.1371/journal.pone.0084086

PubMed ID: 27346450

Title: Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo.

PubMed ID: 27346450

DOI: 10.1016/j.toxicon.2016.06.014

PubMed ID: 12835418

Title: Determining the basis of channel-tetramerization specificity by X-ray crystallography and a sequence-comparison algorithm: family values (FamVal).

PubMed ID: 12835418

DOI: 10.1073/pnas.1432840100

PubMed ID: 14980206

Title: Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels.

PubMed ID: 14980206

DOI: 10.1016/s0896-6273(04)00045-5

Sequence Information:

  • Length: 630
  • Mass: 70549
  • Checksum: FDE57E8A5113BABF
  • Sequence:
  • MAAGVAAWLP FARAAAIGWM PVASGPMPAP PRQERKRTQD ALIVLNVSGT RFQTWQDTLE 
    RYPDTLLGSS ERDFFYHPET QQYFFDRDPD IFRHILNFYR TGKLHYPRHE CISAYDEELA 
    FFGLIPEIIG DCCYEEYKDR RRENAERLQD DADTDNTGES ALPTMTARQR VWRAFENPHT 
    STMALVFYYV TGFFIAVSVI ANVVETVPCG SSPGHIKELP CGERYAVAFF CLDTACVMIF 
    TVEYLLRLAA APSRYRFVRS VMSIIDVVAI LPYYIGLVMT DNEDVSGAFV TLRVFRVFRI 
    FKFSRHSQGL RILGYTLKSC ASELGFLLFS LTMAIIIFAT VMFYAEKGSS ASKFTSIPAA 
    FWYTIVTMTT LGYGDMVPKT IAGKIFGSIC SLSGVLVIAL PVPVIVSNFS RIYHQNQRAD 
    KRRAQKKARL ARIRAAKSGS ANAYMQSKRN GLLSNQLQSS EDEPAFVSKS GSSFETQHHH 
    LLHCLEKTTN HEFVDEQVFE ESCMEVATVN RPSSHSPSLS SQQGVTSTCC SRRHKKSFRI 
    PNANVSGSHR GSVQELSTIQ IRCVERTPLS NSRSSLNAKM EECVKLNCEQ PYVTTAIISI 
    PTPPVTTPEG DDRPESPEYS GGNIVRVSAL

Genular Protein ID: 3904728203

Symbol: A6IE48_RAT

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 630
  • Mass: 70563
  • Checksum: BCA06ADF4114CDB8
  • Sequence:
  • MAAGVAAWLP FARAAAIGWM PVASGPMPAP PRQERKRTQD ALIVLNVSGT RFQTWQDTLE 
    RYPDTLLGSS ERDFFYHPET QQYFFDRDPD IFRHILNFYR TGKLHYPRHE CISAYDEELA 
    FFGLIPEIIG DCCYEEYKDR RRENAERLQD DADTDNTGES ALPTMTARQR VWRAFENPHT 
    STMALVFYYV TGFFIAVSVI ANVVETVPCG SSPGHIKELP CGERYAVAFF CLDTACVMIF 
    TVEYLLRLAA APSRYRFVRS VMSIIDVVAI LPYYIGLVMT DNEDVSGAFV TLRVFRVFRI 
    FKFSRHSQGL RILGYTLKSC ASELGFLLFS LTMAIIIFAT VMFYAEKGSS ASKFTSIPAA 
    FWYTIVTMTT LGYGDMVPKT IAGKIFGSIC SLSGVLVIAL PVPVIVSNFS RIYHQNQRAD 
    KRRAQKKARL ARIRAAKSGS ANAYMQSKRN GLLSNQLQSS EDEPAFVSKS GSSFETQHHH 
    LLHCLEKTTN HEFVDEQVFE ESCMEVATVN RPSSHSPSLS SQQGVTSTCC SRRHKKTFRI 
    PNANVSGSHR GSVQELSTIQ IRCVERTPLS NSRSSLNAKM EECVKLNCEQ PYVTTAIISI 
    PTPPVTTPEG DDRPESPEYS GGNIVRVSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.