BMP4 | ENSG00000125378 | NCBI 652

Details for: BMP4

Gene ID: 652

Symbol: BMP4

Ensembl ID: ENSG00000125378

Description: bone morphogenetic protein 4

Associated with

Developmental biology
(R-HSA-1266738)
Elastic fibre formation
(R-HSA-1566948)
Extracellular matrix organization
(R-HSA-1474244)
Formation of intermediate mesoderm
(R-HSA-9761174)
Formation of lateral plate mesoderm
(R-HSA-9758920)
Formation of paraxial mesoderm
(R-HSA-9793380)
Formation of the nephric duct
(R-HSA-9830364)
Formation of the ureteric bud
(R-HSA-9830674)
Gastrulation
(R-HSA-9758941)
Germ layer formation at gastrulation
(R-HSA-9754189)
Metabolism of proteins
(R-HSA-392499)
Molecules associated with elastic fibres
(R-HSA-2129379)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Reproduction
(R-HSA-1474165)
Specification of primordial germ cells
(R-HSA-9827857)
Specification of the neural plate border
(R-HSA-9834899)
Ameloblast differentiation
(GO:0036305)
Anterior/posterior axis specification
(GO:0009948)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process involved in endocardial cushion morphogenesis
(GO:0003277)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Bmp receptor binding
(GO:0070700)
Bmp signaling pathway
(GO:0030509)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cardiac septum development
(GO:0003279)
Chemoattractant activity
(GO:0042056)
Chondrocyte differentiation
(GO:0002062)
Co-receptor binding
(GO:0039706)
Cytokine activity
(GO:0005125)
Deltoid tuberosity development
(GO:0035993)
Dorsal/ventral neural tube patterning
(GO:0021904)
Embryonic hindlimb morphogenesis
(GO:0035116)
Endocardial cushion development
(GO:0003197)
Endochondral ossification
(GO:0001958)
Endoderm development
(GO:0007492)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Erythrocyte differentiation
(GO:0030218)
Germ cell development
(GO:0007281)
Growth factor activity
(GO:0008083)
Heart induction
(GO:0003129)
Heart morphogenesis
(GO:0003007)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Heparin binding
(GO:0008201)
Kidney development
(GO:0001822)
Lymphoid progenitor cell differentiation
(GO:0002320)
Macrophage differentiation
(GO:0030225)
Membranous septum morphogenesis
(GO:0003149)
Mesodermal cell fate determination
(GO:0007500)
Mesonephros development
(GO:0001823)
Metanephros development
(GO:0001656)
Monocyte differentiation
(GO:0030224)
Muscular septum morphogenesis
(GO:0003150)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of chondrocyte differentiation
(GO:0032331)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of immature t cell proliferation in thymus
(GO:0033088)
Negative regulation of t cell differentiation in thymus
(GO:0033085)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Odontogenesis
(GO:0042476)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Osteoblast differentiation
(GO:0001649)
Outflow tract septum morphogenesis
(GO:0003148)
Pituitary gland development
(GO:0021983)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of cell fate commitment
(GO:0010453)
Regulation of protein import into nucleus
(GO:0042306)
Renal system process
(GO:0003014)
Secondary heart field specification
(GO:0003139)
Sinoatrial node development
(GO:0003163)
Specification of animal organ position
(GO:0010159)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Tendon cell differentiation
(GO:0035990)
Transcription by rna polymerase ii
(GO:0006366)
Type b pancreatic cell development
(GO:0003323)
Ureteric bud development
(GO:0001657)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.3533
Cell Significance Index: -14.0400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 28.9226
Cell Significance Index: -11.7500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 27.7470
Cell Significance Index: -13.1000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.3593
Cell Significance Index: -11.8000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 7.3949
Cell Significance Index: 45.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.4949
Cell Significance Index: -14.7200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.5580
Cell Significance Index: -14.0400
Cell Name: kidney cell (CL1000497)
Fold Change: 3.0999
Cell Significance Index: 24.7500
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 2.9677
Cell Significance Index: 2.2700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.9489
Cell Significance Index: 19.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4695
Cell Significance Index: 279.6500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1700
Cell Significance Index: 24.4900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0426
Cell Significance Index: 103.1400
Cell Name: keratocyte (CL0002363)
Fold Change: 0.9360
Cell Significance Index: 14.8500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8472
Cell Significance Index: 168.1300
Cell Name: decidual cell (CL2000002)
Fold Change: 0.7604
Cell Significance Index: 12.2000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7492
Cell Significance Index: 676.5200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5793
Cell Significance Index: 63.0100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5489
Cell Significance Index: 89.2700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5197
Cell Significance Index: 31.2000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4424
Cell Significance Index: 56.7100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3476
Cell Significance Index: 12.0800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3047
Cell Significance Index: 41.8400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2905
Cell Significance Index: 20.0900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1346
Cell Significance Index: 73.5100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1305
Cell Significance Index: 3.7600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1225
Cell Significance Index: 2.1700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1219
Cell Significance Index: 6.1600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1076
Cell Significance Index: 6.7800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1061
Cell Significance Index: 2.0700
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.1025
Cell Significance Index: 1.0700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0989
Cell Significance Index: 5.1500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0974
Cell Significance Index: 2.1100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0714
Cell Significance Index: 1.2000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0569
Cell Significance Index: 1.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0461
Cell Significance Index: 1.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0416
Cell Significance Index: 1.0400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0297
Cell Significance Index: 0.4600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0230
Cell Significance Index: 0.3300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0207
Cell Significance Index: 39.0700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0197
Cell Significance Index: 0.4200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0154
Cell Significance Index: 0.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0149
Cell Significance Index: 9.4700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0120
Cell Significance Index: 22.1200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0067
Cell Significance Index: 2.9600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0009
Cell Significance Index: -0.0100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0013
Cell Significance Index: -2.0500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0062
Cell Significance Index: -0.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0063
Cell Significance Index: -4.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0065
Cell Significance Index: -4.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0071
Cell Significance Index: -1.4300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0125
Cell Significance Index: -17.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0128
Cell Significance Index: -2.3100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0212
Cell Significance Index: -15.6900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0225
Cell Significance Index: -10.2000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0262
Cell Significance Index: -0.7000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0263
Cell Significance Index: -14.8300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0318
Cell Significance Index: -0.6600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0319
Cell Significance Index: -11.4300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0320
Cell Significance Index: -20.0000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0370
Cell Significance Index: -5.3900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0381
Cell Significance Index: -1.2200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0394
Cell Significance Index: -11.3300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0453
Cell Significance Index: -5.2800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0550
Cell Significance Index: -0.7500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0628
Cell Significance Index: -3.8500
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0659
Cell Significance Index: -0.5600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0680
Cell Significance Index: -8.3600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0757
Cell Significance Index: -15.9500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0849
Cell Significance Index: -14.5000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0871
Cell Significance Index: -6.4900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0876
Cell Significance Index: -10.0400
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.0942
Cell Significance Index: -0.5900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0992
Cell Significance Index: -12.8200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1038
Cell Significance Index: -10.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1198
Cell Significance Index: -12.4800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1257
Cell Significance Index: -5.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1263
Cell Significance Index: -3.5300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1319
Cell Significance Index: -1.3700
Cell Name: chondroblast (CL0000058)
Fold Change: -0.1346
Cell Significance Index: -0.7900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1578
Cell Significance Index: -6.8600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1586
Cell Significance Index: -12.5600
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1597
Cell Significance Index: -1.5400
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.1701
Cell Significance Index: -1.8300
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.1923
Cell Significance Index: -0.9200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1930
Cell Significance Index: -5.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1931
Cell Significance Index: -14.8200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2058
Cell Significance Index: -13.8400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2189
Cell Significance Index: -2.3800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2210
Cell Significance Index: -12.4000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2243
Cell Significance Index: -14.4700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2260
Cell Significance Index: -10.6200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2271
Cell Significance Index: -4.8600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2469
Cell Significance Index: -3.7200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2491
Cell Significance Index: -6.7800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2746
Cell Significance Index: -7.2200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2874
Cell Significance Index: -13.4000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2920
Cell Significance Index: -10.2300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2958
Cell Significance Index: -15.5300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3151
Cell Significance Index: -8.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure and Expression:** BMP4 is a secreted protein encoded by the BMP4 gene, with a predicted molecular weight of approximately 17 kDa. It is highly expressed in embryonic tissues, including the heart, lungs, kidneys, and limbs, and plays a crucial role in their development. 2. **Cellular Expression:** BMP4 is expressed in various cell types, including pulmonary interstitial fibroblasts, mesodermal cells, granulocyte-monocyte progenitor cells, leptomeningeal cells, kidney cells, skeletal muscle fibroblasts, epithelial cells of the nephron, fallopian tube secretory epithelial cells, early T lineage precursors, and cerebral cortex GABAergic interneurons. 3. **Protein-Protein Interactions:** BMP4 interacts with several receptors, including the type II receptor (BMPR2) and the type I receptor (BMPR1A), facilitating its downstream signaling pathways. **Pathways and Functions:** 1. **Developmental Biology:** BMP4 plays a crucial role in embryonic development, regulating the specification of anterior/posterior axis, anterior/posterior axis specification, and cardiac right ventricle morphogenesis. 2. **Apoptotic Process:** BMP4 is involved in the regulation of apoptotic processes, particularly in endocardial cushion morphogenesis and cardiac septum development. 3. **Blood Vessel Endothelial Cell Proliferation:** BMP4 promotes endothelial cell proliferation, involved in sprouting angiogenesis. 4. **Chondrocyte Differentiation:** BMP4 regulates chondrocyte differentiation, essential for endochondral ossification. 5. **Endoderm Development:** BMP4 is involved in the development of the endoderm, a critical organ system in embryonic development. **Clinical Significance:** 1. **Congenital Heart Defects:** BMP4 has been implicated in the development of congenital heart defects, such as atrial septal defects and ventricular septal defects. 2. **Bone Development:** BMP4 is involved in bone development, and alterations in BMP4 expression have been linked to bone disorders, including osteoporosis and osteogenesis imperfecta. 3. **Cancer:** BMP4 has been implicated in cancer development and progression, particularly in the context of bone metastasis. 4. **Neurological Disorders:** BMP4 has been linked to neurological disorders, including cerebral cortical development and cognitive function. In conclusion, BMP4 is a multifunctional gene that plays a crucial role in embryonic development, tissue homeostasis, and adult tissue regeneration. Its dysregulation has been implicated in various diseases, including congenital heart defects, bone disorders, cancer, and neurological disorders. Further research is needed to elucidate the complex mechanisms underlying BMP4's functions and to explore its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

BMP4_HUMAN

Genular Protein ID: 2580404692

Symbol: BMP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P12644 Q9UM80

Database IDs:

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 9701626

Title: The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation.

PubMed ID: 9701626

DOI: 10.1007/s002239900518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7579580

Title: Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library.

PubMed ID: 7579580

DOI: 10.3109/10425179509030980

PubMed ID: 8006002

Title: Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

PubMed ID: 8006002

DOI: 10.1016/s0021-9258(17)32506-1

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25868050

Title: Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis.

PubMed ID: 25868050

DOI: 10.1210/en.2014-1942

PubMed ID: 29212066

Title: Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway.

PubMed ID: 29212066

DOI: 10.1159/000485759

PubMed ID: 31363885

Title: VEGFR2 activation mediates the pro-angiogenic activity of BMP4.

PubMed ID: 31363885

DOI: 10.1007/s10456-019-09676-y

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 12404109

Title: Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs).

PubMed ID: 12404109

DOI: 10.1038/sj.ejhg.5200875

PubMed ID: 18252212

Title: Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.

PubMed ID: 18252212

DOI: 10.1016/j.ajhg.2007.09.023

PubMed ID: 18305125

Title: SIX2 and BMP4 mutations associate with anomalous kidney development.

PubMed ID: 18305125

DOI: 10.1681/asn.2006111282

PubMed ID: 19249007

Title: Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.

PubMed ID: 19249007

DOI: 10.1016/j.ajhg.2009.02.002

Sequence Information:

Length: 408
Mass: 46555
Checksum: 79B01179DBB98204
Sequence:

MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF 
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI 
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH 
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BMP4

Associated with

Cells (max top 100)

Other Information

Novel regulators of bone formation: molecular clones and activities. PubMed ID: 3201241

The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation. PubMed ID: 9701626

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. PubMed ID: 7579580

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. PubMed ID: 8006002

USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. PubMed ID: 15020244

Targeting of bone morphogenetic protein growth factor complexes to fibrillin. PubMed ID: 18339631

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis. PubMed ID: 25868050

Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway. PubMed ID: 29212066

VEGFR2 activation mediates the pro-angiogenic activity of BMP4. PubMed ID: 31363885

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. PubMed ID: 33308444

Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). PubMed ID: 12404109

Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. PubMed ID: 18252212

SIX2 and BMP4 mutations associate with anomalous kidney development. PubMed ID: 18305125

Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. PubMed ID: 19249007