Details for: BMP4

Gene ID: 652

Symbol: BMP4

Ensembl ID: ENSG00000125378

Description: bone morphogenetic protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.61
    Marker Score: 3689
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.69
    Marker Score: 22310
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.27
    Marker Score: 627
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.21
    Marker Score: 806
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.13
    Marker Score: 746
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.12
    Marker Score: 2347
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251790
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1
    Marker Score: 4151.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.98
    Marker Score: 1512
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5279
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.85
    Marker Score: 196
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.81
    Marker Score: 1249
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 701.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.76
    Marker Score: 2066
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.76
    Marker Score: 534
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.75
    Marker Score: 724
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4498
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.72
    Marker Score: 2811
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 445
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2899
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.69
    Marker Score: 946
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.68
    Marker Score: 217
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.63
    Marker Score: 758.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 402
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.6
    Marker Score: 1581
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1204
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.59
    Marker Score: 151
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.58
    Marker Score: 612
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8881
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 268
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1317
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.56
    Marker Score: 595
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.55
    Marker Score: 931
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.54
    Marker Score: 133
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 127
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.51
    Marker Score: 172
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.49
    Marker Score: 143
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.48
    Marker Score: 233
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.47
    Marker Score: 586
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.47
    Marker Score: 821
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 694
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 231
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.43
    Marker Score: 4862
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 259
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.43
    Marker Score: 241
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1002
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.42
    Marker Score: 142
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 373
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 408
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4
    Marker Score: 673
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.39
    Marker Score: 333
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.39
    Marker Score: 91
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.38
    Marker Score: 13075
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.38
    Marker Score: 210
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.37
    Marker Score: 160
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.37
    Marker Score: 1539
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.37
    Marker Score: 441.5
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.36
    Marker Score: 193.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.36
    Marker Score: 105
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.36
    Marker Score: 101
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.34
    Marker Score: 73
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.34
    Marker Score: 290
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.34
    Marker Score: 452
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.33
    Marker Score: 392
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 132
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.33
    Marker Score: 468
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.31
    Marker Score: 360
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.31
    Marker Score: 68
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.31
    Marker Score: 307
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.31
    Marker Score: 74
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3
    Marker Score: 268
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3
    Marker Score: 1282
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.3
    Marker Score: 210
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.29
    Marker Score: 2883

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Other Information

**Key characteristics:** - BMP4 is a secreted protein that is highly expressed in embryonic and fetal tissues. - It is a transmembrane protein that is localized to the cell surface. - BMP4 is a key regulator of epithelial-mesenchymal transition. - It is involved in the formation of various tissues and organs, including the kidney, skin, and eye. **Pathways and functions:** - BMP4 signaling is involved in cell migration, proliferation, and differentiation. - It promotes epithelial cell migration and invasion. - It inhibits mesenchymal cell migration and proliferation. - It plays a role in the formation of the neural plate border. - It is involved in the specification of primordial germ cells. - It is involved in the specification of the neural plate border. **Clinical significance:** - Mutations in BMP4 genes have been linked to several human diseases, including kidney diseases, skin disorders, and eye disorders. - BMP4 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - BMP4 is a highly conserved protein, with a similar sequence in mammals and humans. - It is a key regulator of cell migration and differentiation. - It is a target for therapeutic intervention in a variety of human diseases.

Genular Protein ID: 2580404692

Symbol: BMP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P12644 Q9UM80

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 100 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 8 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3201241

Title: Novel regulators of bone formation: molecular clones and activities.

PubMed ID: 3201241

DOI: 10.1126/science.3201241

PubMed ID: 9701626

Title: The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation.

PubMed ID: 9701626

DOI: 10.1007/s002239900518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7579580

Title: Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library.

PubMed ID: 7579580

DOI: 10.3109/10425179509030980

PubMed ID: 8006002

Title: Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

PubMed ID: 8006002

DOI: 10.1016/s0021-9258(17)32506-1

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25868050

Title: Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis.

PubMed ID: 25868050

DOI: 10.1210/en.2014-1942

PubMed ID: 29212066

Title: Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway.

PubMed ID: 29212066

DOI: 10.1159/000485759

PubMed ID: 31363885

Title: VEGFR2 activation mediates the pro-angiogenic activity of BMP4.

PubMed ID: 31363885

DOI: 10.1007/s10456-019-09676-y

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 12404109

Title: Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs).

PubMed ID: 12404109

DOI: 10.1038/sj.ejhg.5200875

PubMed ID: 18252212

Title: Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.

PubMed ID: 18252212

DOI: 10.1016/j.ajhg.2007.09.023

PubMed ID: 18305125

Title: SIX2 and BMP4 mutations associate with anomalous kidney development.

PubMed ID: 18305125

DOI: 10.1681/asn.2006111282

PubMed ID: 19249007

Title: Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.

PubMed ID: 19249007

DOI: 10.1016/j.ajhg.2009.02.002

Sequence Information:

  • Length: 408
  • Mass: 46555
  • Checksum: 79B01179DBB98204
  • Sequence:
    • MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF 
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI 
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH 
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.