Prkaa1 | ENSRNOG00000012799 | NCBI 65248

Details for: Prkaa1

Gene ID: 65248

Symbol: Prkaa1

Ensembl ID: ENSRNOG00000012799

Description: protein kinase AMP-activated catalytic subunit alpha 1

Associated with

Energy dependent regulation of mtor by lkb1-ampk
(R-RNO-380972)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Macroautophagy
(R-RNO-1632852)
Mtor signalling
(R-RNO-165159)
Regulation of tp53 activity
(R-RNO-5633007)
Regulation of tp53 activity through phosphorylation
(R-RNO-6804756)
Rna polymerase ii transcription
(R-RNO-73857)
Signal transduction
(R-RNO-162582)
Tp53 regulates metabolic genes
(R-RNO-5628897)
Transcriptional regulation by tp53
(R-RNO-3700989)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Bile acid and bile salt transport
(GO:0015721)
Bile acid signaling pathway
(GO:0038183)
Camkk-ampk signaling cascade
(GO:0061762)
Cellular response to calcium ion
(GO:0071277)
Cellular response to ethanol
(GO:0071361)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nutrient levels
(GO:0031669)
Cellular response to organonitrogen compound
(GO:0071417)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cholesterol biosynthetic process
(GO:0006695)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cold acclimation
(GO:0009631)
Energy homeostasis
(GO:0097009)
Eukaryotic elongation factor-2 kinase activator activity
(GO:0042557)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid homeostasis
(GO:0055089)
Fatty acid oxidation
(GO:0019395)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Histone h2bs36 kinase activity
(GO:0140823)
Kinase binding
(GO:0019900)
Lipid biosynthetic process
(GO:0008610)
Lipid droplet disassembly
(GO:1905691)
Metal ion binding
(GO:0046872)
Motor behavior
(GO:0061744)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of tor signaling
(GO:0032007)
Negative regulation of translation
(GO:0017148)
Negative regulation of tubulin deacetylation
(GO:1904428)
Neuron cellular homeostasis
(GO:0070050)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cellular catabolic process
(GO:0031331)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of mitochondrial transcription
(GO:1903109)
Positive regulation of protein localization
(GO:1903829)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Positive regulation of skeletal muscle tissue development
(GO:0048643)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of bile acid secretion
(GO:0120188)
Regulation of circadian rhythm
(GO:0042752)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of peptidyl-serine phosphorylation
(GO:0033135)
Regulation of stress granule assembly
(GO:0062028)
Regulation of vesicle-mediated transport
(GO:0060627)
Response to activity
(GO:0014823)
Response to caffeine
(GO:0031000)
Response to estrogen
(GO:0043627)
Response to gamma radiation
(GO:0010332)
Response to hydrogen peroxide
(GO:0042542)
Response to uv
(GO:0009411)
Response to xenobiotic stimulus
(GO:0009410)
Rhythmic process
(GO:0048511)
Tau-protein kinase activity
(GO:0050321)
Wnt signaling pathway
(GO:0016055)
[acetyl-coa carboxylase] kinase activity
(GO:0050405)
[hydroxymethylglutaryl-coa reductase (nadph)] kinase activity
(GO:0047322)

Other Information

Proteins

5'-AMP-activated protein kinase catalytic subunit alpha-1

Genular Protein ID: 3591611322

Symbol: AAPK1_RAT

Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1

UniProtKB Accession Codes:

P54645

Database IDs:

Citations:

PubMed ID: 8557660

Title: Mammalian AMP-activated protein kinase subfamily.

PubMed ID: 8557660

DOI: 10.1074/jbc.271.2.611

PubMed ID: 2369897

Title: Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

PubMed ID: 2369897

DOI: 10.1002/j.1460-2075.1990.tb07420.x

PubMed ID: 7961907

Title: Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.

PubMed ID: 7961907

DOI: 10.1016/s0021-9258(18)43879-3

PubMed ID: 8910387

Title: Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.

PubMed ID: 8910387

DOI: 10.1074/jbc.271.44.27879

PubMed ID: 9029219

Title: Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A.

PubMed ID: 9029219

DOI: 10.1152/jappl.1997.82.1.219

PubMed ID: 10025949

Title: AMP-activated protein kinase phosphorylation of endothelial NO synthase.

PubMed ID: 10025949

DOI: 10.1016/s0014-5793(98)01705-0

PubMed ID: 11069105

Title: Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.

PubMed ID: 11069105

DOI: 10.1016/s0960-9822(00)00742-9

PubMed ID: 11598104

Title: 5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside.

PubMed ID: 11598104

DOI: 10.1074/jbc.c100483200

PubMed ID: 11724780

Title: Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase.

PubMed ID: 11724780

DOI: 10.1074/jbc.m107895200

PubMed ID: 12065600

Title: The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase.

PubMed ID: 12065600

DOI: 10.1074/jbc.m205213200

PubMed ID: 14614828

Title: LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.

PubMed ID: 14614828

DOI: 10.1016/j.cub.2003.10.031

PubMed ID: 14511394

Title: Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

PubMed ID: 14511394

DOI: 10.1186/1475-4924-2-28

PubMed ID: 12740371

Title: AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.

PubMed ID: 12740371

DOI: 10.1074/jbc.m304112200

PubMed ID: 12764152

Title: Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.

PubMed ID: 12764152

DOI: 10.1074/jbc.m303946200

PubMed ID: 14709557

Title: Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.

PubMed ID: 14709557

DOI: 10.1074/jbc.m309773200

PubMed ID: 16054095

Title: Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

PubMed ID: 16054095

DOI: 10.1016/j.cmet.2005.05.009

PubMed ID: 16054096

Title: Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

PubMed ID: 16054096

DOI: 10.1016/j.cmet.2005.06.005

PubMed ID: 17341212

Title: Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK).

PubMed ID: 17341212

DOI: 10.1042/bj20061850

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21204788

Title: AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure.

PubMed ID: 21204788

DOI: 10.1042/bj20101485

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 17851531

Title: Structural basis for AMP binding to mammalian AMP-activated protein kinase.

PubMed ID: 17851531

DOI: 10.1038/nature06161

PubMed ID: 21399626

Title: Structure of mammalian AMPK and its regulation by ADP.

PubMed ID: 21399626

DOI: 10.1038/nature09932

Sequence Information:

Length: 559
Mass: 63973
Checksum: A869C340A85785ED
Sequence:

MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 
IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTFSKMSL QLYQVDSRTY LLDFRSIDDE 
ITEAKSGTAT PQRSGSISNY RSCQRSDSDA EAQGKPSEVS LTSSVTSLDS SPVDVAPRPG 
SHTIEFFEMC ANLIKILAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkaa1

Associated with

Other Information

Mammalian AMP-activated protein kinase subfamily. PubMed ID: 8557660

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. PubMed ID: 2369897

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. PubMed ID: 7961907

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. PubMed ID: 8910387

Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. PubMed ID: 9029219

AMP-activated protein kinase phosphorylation of endothelial NO synthase. PubMed ID: 10025949

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. PubMed ID: 11069105

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. PubMed ID: 11598104

Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. PubMed ID: 11724780

The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. PubMed ID: 12065600

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. PubMed ID: 14614828

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. PubMed ID: 14511394

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability. PubMed ID: 12740371

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis. PubMed ID: 12764152

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. PubMed ID: 14709557

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. PubMed ID: 16054095

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. PubMed ID: 16054096

Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK). PubMed ID: 17341212

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. PubMed ID: 21460634

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure. PubMed ID: 21204788

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Structural basis for AMP binding to mammalian AMP-activated protein kinase. PubMed ID: 17851531

Structure of mammalian AMPK and its regulation by ADP. PubMed ID: 21399626