Details for: Asb2

Gene ID: 65256

Symbol: Asb2

Ensembl ID: ENSMUSG00000021200

Description: ankyrin repeat and SOCS box-containing 2

Associated with

Other Information

Genular Protein ID: 1441266434

Symbol: ASB2_MOUSE

Name: Ankyrin repeat and SOCS box protein 2

UniProtKB Accession Codes:

Q8K0L0 Q9CTH4 Q9WV73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CTD 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 GO 17 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 Pfam 5 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 2 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 11111040

Title: Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

PubMed ID: 11111040

DOI: 10.1016/s0378-1119(00)00402-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19300455

Title: The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

PubMed ID: 19300455

DOI: 10.1038/cdd.2009.27

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23632887

Title: ASB2alpha regulates migration of immature dendritic cells.

PubMed ID: 23632887

DOI: 10.1182/blood-2012-11-466649

PubMed ID: 26343497

Title: The E3 ubiquitin ligase Asb2beta is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.

PubMed ID: 26343497

DOI: 10.1016/j.yjmcc.2015.08.020

PubMed ID: 27182554

Title: Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass.

PubMed ID: 27182554

DOI: 10.1172/jci.insight.85477

PubMed ID: 29374072

Title: Asb2alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.

PubMed ID: 29374072

DOI: 10.1161/circresaha.117.312015

PubMed ID: 31175139

Title: The E3 Ubiquitin Ligase Asb2alpha in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer.

PubMed ID: 31175139

DOI: 10.1158/2326-6066.cir-18-0562

PubMed ID: 32179481

Title: Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle.

PubMed ID: 32179481

DOI: 10.1016/j.isci.2020.100959

Sequence Information:

  • Length: 634
  • Mass: 70221
  • Checksum: E320CEBD39891D41
  • Sequence:
    • MATEISTRGR QRAIGHEEYS LYSSLSEEEL LQMAIEQSLA DKTRGPTPAE ASASSQTNHQ 
PGHFHPWTRS PSSPENPPAR APLGLFQGVM QKYSSNLFKT SQMAAMDPVL KAIKEGDEEA 
LKIMIQDGKN LAEPNKEGWL PLHEAAYYGQ LGCLKVLQQA YPGTIDQRTL QEETALYLAT 
CREHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VRILVRYNAD ANHRCNRGWT 
ALHESVSRND LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ 
ASDSASALYE ASKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY RIVQMLLPVT 
SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNAPLA PERARLYEDR RSSALYFAVV 
NNNVYATELL LLAGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA 
TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPR PGRFHDAPVD DKAPSVVQFC 
EFLSAPEVSR WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR 
LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.