WNK4 | ENSG00000126562 | NCBI 65266

Details for: WNK4

Gene ID: 65266

Symbol: WNK4

Ensembl ID: ENSG00000126562

Description: WNK lysine deficient protein kinase 4

Associated with

Ion channel transport
(R-HSA-983712)
Stimuli-sensing channels
(R-HSA-2672351)
Transport of small molecules
(R-HSA-382551)
Aldosterone secretion
(GO:0035932)
Atp binding
(GO:0005524)
Bicellular tight junction
(GO:0005923)
Calcium ion homeostasis
(GO:0055074)
Cell body
(GO:0044297)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chloride ion binding
(GO:0031404)
Chloride transport
(GO:0006821)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Distal tubule morphogenesis
(GO:0072156)
Erk1 and erk2 cascade
(GO:0070371)
Gene expression
(GO:0010467)
Inflammatory response
(GO:0006954)
Intracellular chloride ion homeostasis
(GO:0030644)
Intracellular signal transduction
(GO:0035556)
Ion channel inhibitor activity
(GO:0008200)
Macrophage activation
(GO:0042116)
Membrane
(GO:0016020)
Monoatomic ion homeostasis
(GO:0050801)
Negative regulation of pancreatic juice secretion
(GO:0090188)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of sodium ion transport
(GO:0010766)
Potassium ion transmembrane transport
(GO:0071805)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase c signaling
(GO:0070528)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of blood pressure
(GO:0008217)
Regulation of potassium ion export across plasma membrane
(GO:1903764)
Renal sodium ion absorption
(GO:0070294)
Renal sodium ion transport
(GO:0003096)
Response to dietary excess
(GO:0002021)
Signal transduction
(GO:0007165)
Sodium ion transmembrane transport
(GO:0035725)

Other Information

Proteins

WNK4_HUMAN

Genular Protein ID: 5862941

Symbol: WNK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96J92 B0LPI0 Q8N8X3 Q8N8Z2 Q96DT8 Q9BYS5

Database IDs:

Citations:

PubMed ID: 11498583

Title: Human hypertension caused by mutations in WNK kinases.

PubMed ID: 11498583

DOI: 10.1126/science.1062844

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11571656

Title: WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.

PubMed ID: 11571656

DOI: 10.1038/sj.onc.1204726

PubMed ID: 16669787

Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

PubMed ID: 16669787

DOI: 10.1042/bj20060220

PubMed ID: 16832045

Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

PubMed ID: 16832045

DOI: 10.1073/pnas.0604607103

PubMed ID: 20525693

Title: Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

PubMed ID: 20525693

DOI: 10.1074/jbc.m110.103432

PubMed ID: 22989884

Title: Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

PubMed ID: 22989884

DOI: 10.1074/jbc.m112.398750

PubMed ID: 23838290

Title: KLHL2 interacts with and ubiquitinates WNK kinases.

PubMed ID: 23838290

DOI: 10.1016/j.bbrc.2013.06.104

PubMed ID: 23387299

Title: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

PubMed ID: 23387299

DOI: 10.1042/bj20121903

PubMed ID: 23453970

Title: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

PubMed ID: 23453970

DOI: 10.1016/j.celrep.2013.02.024

PubMed ID: 23665031

Title: Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.

PubMed ID: 23665031

DOI: 10.1016/j.febslet.2013.04.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23576762

Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.

PubMed ID: 23576762

DOI: 10.1073/pnas.1304592110

PubMed ID: 26435498

Title: Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

PubMed ID: 26435498

DOI: 10.1016/j.bbrc.2015.09.184

PubMed ID: 26732173

Title: Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.

PubMed ID: 26732173

DOI: 10.1038/srep18710

PubMed ID: 27727489

Title: Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study.

PubMed ID: 27727489

DOI: 10.1002/pro.3063

PubMed ID: 17721439

Title: Structural insights into the recognition of substrates and activators by the OSR1 kinase.

PubMed ID: 17721439

DOI: 10.1038/sj.embor.7401048

PubMed ID: 24641320

Title: Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

PubMed ID: 24641320

DOI: 10.1042/bj20140153

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1243
Mass: 134739
Checksum: BAC35F0098BA3391
Sequence:

MLASPATETT VLMSQTEADL ALRPPPPLGT AGQPRLGPPP RRARRFSGKA EPRPRSSRLS 
RRSSVDLGLL SSWSLPASPA PDPPDPPDSA GPGPARSPPP SSKEPPEGTW TEGAPVKAAE 
DSARPELPDS AVGPGSREPL RVPEAVALER RREQEEKEDM ETQAVATSPD GRYLKFDIEI 
GRGSFKTVYR GLDTDTTVEV AWCELQTRKL SRAERQRFSE EVEMLKGLQH PNIVRFYDSW 
KSVLRGQVCI VLVTELMTSG TLKTYLRRFR EMKPRVLQRW SRQILRGLHF LHSRVPPILH 
RDLKCDNVFI TGPTGSVKIG DLGLATLKRA SFAKSVIGTP EFMAPEMYEE KYDEAVDVYA 
FGMCMLEMAT SEYPYSECQN AAQIYRKVTS GRKPNSFHKV KIPEVKEIIE GCIRTDKNER 
FTIQDLLAHA FFREERGVHV ELAEEDDGEK PGLKLWLRME DARRGGRPRD NQAIEFLFQL 
GRDAAEEVAQ EMVALGLVCE ADYQPVARAV RERVAAIQRK REKLRKAREL EALPPEPGPP 
PATVPMAPGP PSVFPPEPEE PEADQHQPFL FRHASYSSTT SDCETDGYLS SSGFLDASDP 
ALQPPGGVPS SLAESHLCLP SAFALSIPRS GPGSDFSPGD SYASDAASGL SDVGEGMGQM 
RRPPGRNLRR RPRSRLRVTS VSDQNDRVVE CQLQTHNSKM VTFRFDLDGD SPEEIAAAMV 
YNEFILPSER DGFLRRIREI IQRVETLLKR DTGPMEAAED TLSPQEEPAP LPALPVPLPD 
PSNEELQSST SLEHRSWTAF STSSSSPGTP LSPGNPFSPG TPISPGPIFP ITSPPCHPSP 
SPFSPISSQV SSNPSPHPTS SPLPFSSSTP EFPVPLSQCP WSSLPTTSPP TFSPTCSQVT 
LSSPFFPPCP STSSFPSTTA APLLSLASAF SLAVMTVAQS LLSPSPGLLS QSPPAPPSPL 
PSLPLPPPVA PGGQESPSPH TAEVESEASP PPARPLPGEA RLAPISEEGK PQLVGRFQVT 
SSKEPAEPLP LQPTSPTLSG SPKPSTPQLT SESSDTEDSA GGGPETREAL AESDRAAEGL 
GAGVEEEGDD GKEPQVGGSP QPLSHPSPVW MNYSYSSLCL SSEESESSGE DEEFWAELQS 
LRQKHLSEVE TLQTLQKKEI EDLYSRLGKQ PPPGIVAPAA MLSSRQRRLS KGSFPTSRRN 
SLQRSEPPGP GIMRRNSLSG SSTGSQEQRA SKGVTFAGDV GRM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WNK4

Associated with

Other Information

Human hypertension caused by mutations in WNK kinases. PubMed ID: 11498583

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. PubMed ID: 11571656

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. PubMed ID: 16669787

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. PubMed ID: 16832045

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. PubMed ID: 20525693

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. PubMed ID: 22989884

KLHL2 interacts with and ubiquitinates WNK kinases. PubMed ID: 23838290

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. PubMed ID: 23387299

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. PubMed ID: 23453970

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. PubMed ID: 23665031

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. PubMed ID: 23576762

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3. PubMed ID: 26435498

Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway. PubMed ID: 26732173

Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study. PubMed ID: 27727489

Structural insights into the recognition of substrates and activators by the OSR1 kinase. PubMed ID: 17721439

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. PubMed ID: 24641320

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846