Details for: BMP5

Gene ID: 653

Symbol: BMP5

Ensembl ID: ENSG00000112175

Description: bone morphogenetic protein 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.3
    Marker Score: 5,043
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.61
    Marker Score: 1,450
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.48
    Marker Score: 5,694
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.46
    Marker Score: 14,792
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.29
    Marker Score: 1,510
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.48
    Marker Score: 733
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,017
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.4
    Marker Score: 757
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.36
    Marker Score: 1,157
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.29
    Marker Score: 335
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2,339
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 681
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1,980
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 283
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,045
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.98
    Marker Score: 1,515
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.91
    Marker Score: 480
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13,708
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.8
    Marker Score: 264
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 361
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.73
    Marker Score: 12,904
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.73
    Marker Score: 302
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.71
    Marker Score: 1,856
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.69
    Marker Score: 673
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.68
    Marker Score: 306
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.67
    Marker Score: 833
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.63
    Marker Score: 607
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.63
    Marker Score: 272
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.61
    Marker Score: 229
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.61
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.57
    Marker Score: 1,173
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.54
    Marker Score: 537
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.53
    Marker Score: 186
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.49
    Marker Score: 273
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.46
    Marker Score: 6,085
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.45
    Marker Score: 861
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.45
    Marker Score: 1,864
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.41
    Marker Score: 1,266
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 413
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.41
    Marker Score: 236
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.41
    Marker Score: 625
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 178
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.4
    Marker Score: 480
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 216
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.37
    Marker Score: 200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.33
    Marker Score: 1,720
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.32
    Marker Score: 80
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.32
    Marker Score: 80
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.32
    Marker Score: 5,059
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.31
    Marker Score: 425
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.3
    Marker Score: 2,283
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.29
    Marker Score: 1,043
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 199
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.27
    Marker Score: 314
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.27
    Marker Score: 328
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 300
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.24
    Marker Score: 55
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.24
    Marker Score: 59
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.24
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 211
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.23
    Marker Score: 52
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.23
    Marker Score: 504
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.23
    Marker Score: 188
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 522
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.22
    Marker Score: 78
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.22
    Marker Score: 121
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 75
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 84
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.2
    Marker Score: 1,002
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.2
    Marker Score: 92
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.19
    Marker Score: 66

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP5 is a secreted growth factor that belongs to the bone morphogenetic protein (BMP) family. It is encoded by the BMP5 gene, which is located on chromosome 1 in humans. BMP5 is a heterodimeric protein composed of two distinct domains: the BMP domain and the TGF-β type II receptor (TβRII) domain. This unique structure enables BMP5 to interact with both BMP receptors and TGF-β receptors, facilitating its signaling pathways. **Pathways and Functions** BMP5 signaling pathways are involved in various cellular processes, including: 1. **Developmental processes**: BMP5 plays a crucial role in the development of various organs and tissues, such as the heart, skeletal system, and nervous system. It regulates the formation of cardiac muscle tissue, cardiac septum morphogenesis, and neural fold elevation. 2. **Cell proliferation and differentiation**: BMP5 promotes cell proliferation and inhibits cell death, particularly in the context of cancer. It also regulates the differentiation of various cell types, including cardiac muscle cells and granulocyte monocyte progenitor cells. 3. **Inflammation and immune response**: BMP5 has anti-inflammatory properties and modulates the immune response by regulating the activity of immune cells, such as macrophages and granulocytes. 4. **Metabolic processes**: BMP5 influences metabolic processes, including glucose and lipid metabolism, by regulating the expression of genes involved in these pathways. **Clinical Significance** Dysregulation of BMP5 signaling has been implicated in various diseases and disorders, including: 1. **Cardiovascular disease**: BMP5 has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 2. **Cancer**: BMP5 has been identified as a tumor suppressor gene, and its dysregulation has been linked to various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: BMP5 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: BMP5 has been linked to metabolic disorders, including obesity and type 2 diabetes. In conclusion, BMP5 is a multifunctional protein that plays a crucial role in various developmental and physiological processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of BMP5 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms of BMP5 signaling and its clinical significance. **References** * [Insert references to relevant studies on BMP5] As an expert immunologist, I would like to emphasize that BMP5 is an important protein that has implications for our understanding of immune regulation and disease. Further research is needed to fully elucidate the mechanisms of BMP5 signaling and its clinical significance.

Genular Protein ID: 442893888

Symbol: BMP5_HUMAN

Name: Bone morphogenetic protein 5

UniProtKB Accession Codes:

P22003 B4E0Y4 Q9H547 Q9NTM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2263636

Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

PubMed ID: 2263636

DOI: 10.1073/pnas.87.24.9843

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11580864

Title: Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.

PubMed ID: 11580864

DOI: 10.1186/1471-2202-2-12

PubMed ID: 20402566

Title: BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model.

PubMed ID: 20402566

DOI: 10.3109/08977191003752296

PubMed ID: 30097509

Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

PubMed ID: 30097509

DOI: 10.1182/blood-2018-06-857995

PubMed ID: 29321139

Title: BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.

PubMed ID: 29321139

DOI: 10.1523/jneurosci.1540-17.2018

Sequence Information:

  • Length: 454
  • Mass: 51737
  • Checksum: 631277413CCC22EE
  • Sequence:
    • MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 
LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 
NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 
RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 
QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 
SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

Genular Protein ID: 3962479880

Symbol: A8K694_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K694

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 454
  • Mass: 51751
  • Checksum: 22B8A64A3CBCF3EE
  • Sequence:
    • MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 
LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 
NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 
RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 
QALDLGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 
SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.