Details for: BMP5

Gene ID: 653

Symbol: BMP5

Ensembl ID: ENSG00000112175

Description: bone morphogenetic protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 12.8113
    Cell Significance Index: 79.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.6767
    Cell Significance Index: -5.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.5436
    Cell Significance Index: -5.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.8393
    Cell Significance Index: 46.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.3836
    Cell Significance Index: -5.1400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 4.0374
    Cell Significance Index: 86.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4221
    Cell Significance Index: 38.1100
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.1093
    Cell Significance Index: 4.9100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8605
    Cell Significance Index: 7.8100
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.6467
    Cell Significance Index: 3.0800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.5043
    Cell Significance Index: 2.9600
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.4606
    Cell Significance Index: 1.3200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.4453
    Cell Significance Index: 2.1300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3976
    Cell Significance Index: 5.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3798
    Cell Significance Index: 3.1900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1689
    Cell Significance Index: 0.3900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1408
    Cell Significance Index: 0.6500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1260
    Cell Significance Index: 1.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1059
    Cell Significance Index: 1.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0317
    Cell Significance Index: 0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0215
    Cell Significance Index: 3.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0193
    Cell Significance Index: 13.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0134
    Cell Significance Index: 1.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0015
    Cell Significance Index: 0.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0049
    Cell Significance Index: -0.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0050
    Cell Significance Index: -2.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0075
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0112
    Cell Significance Index: -2.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0130
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0149
    Cell Significance Index: -3.1300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0193
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0261
    Cell Significance Index: -4.4500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0314
    Cell Significance Index: -3.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0359
    Cell Significance Index: -0.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0391
    Cell Significance Index: -0.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0404
    Cell Significance Index: -5.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0430
    Cell Significance Index: -5.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0487
    Cell Significance Index: -5.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0494
    Cell Significance Index: -0.7300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0534
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0538
    Cell Significance Index: -5.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0542
    Cell Significance Index: -5.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0689
    Cell Significance Index: -3.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0702
    Cell Significance Index: -4.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0731
    Cell Significance Index: -1.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0757
    Cell Significance Index: -5.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0844
    Cell Significance Index: -5.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0884
    Cell Significance Index: -5.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0923
    Cell Significance Index: -4.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0939
    Cell Significance Index: -5.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0995
    Cell Significance Index: -4.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1102
    Cell Significance Index: -6.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1162
    Cell Significance Index: -5.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1184
    Cell Significance Index: -6.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1282
    Cell Significance Index: -4.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1293
    Cell Significance Index: -5.7200
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.1298
    Cell Significance Index: -1.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1311
    Cell Significance Index: -3.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1326
    Cell Significance Index: -4.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1406
    Cell Significance Index: -5.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1413
    Cell Significance Index: -4.5000
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1444
    Cell Significance Index: -1.3400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1483
    Cell Significance Index: -1.5300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1499
    Cell Significance Index: -1.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1500
    Cell Significance Index: -3.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1505
    Cell Significance Index: -5.7000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1574
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1591
    Cell Significance Index: -4.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1619
    Cell Significance Index: -5.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1628
    Cell Significance Index: -5.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1628
    Cell Significance Index: -4.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1652
    Cell Significance Index: -4.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1667
    Cell Significance Index: -4.9100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1673
    Cell Significance Index: -1.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1727
    Cell Significance Index: -6.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1758
    Cell Significance Index: -5.0400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1843
    Cell Significance Index: -3.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1874
    Cell Significance Index: -1.9400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1876
    Cell Significance Index: -2.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1886
    Cell Significance Index: -2.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1891
    Cell Significance Index: -5.4000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1906
    Cell Significance Index: -2.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1912
    Cell Significance Index: -1.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1921
    Cell Significance Index: -5.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP5 is a secreted growth factor that belongs to the bone morphogenetic protein (BMP) family. It is encoded by the BMP5 gene, which is located on chromosome 1 in humans. BMP5 is a heterodimeric protein composed of two distinct domains: the BMP domain and the TGF-β type II receptor (TβRII) domain. This unique structure enables BMP5 to interact with both BMP receptors and TGF-β receptors, facilitating its signaling pathways. **Pathways and Functions** BMP5 signaling pathways are involved in various cellular processes, including: 1. **Developmental processes**: BMP5 plays a crucial role in the development of various organs and tissues, such as the heart, skeletal system, and nervous system. It regulates the formation of cardiac muscle tissue, cardiac septum morphogenesis, and neural fold elevation. 2. **Cell proliferation and differentiation**: BMP5 promotes cell proliferation and inhibits cell death, particularly in the context of cancer. It also regulates the differentiation of various cell types, including cardiac muscle cells and granulocyte monocyte progenitor cells. 3. **Inflammation and immune response**: BMP5 has anti-inflammatory properties and modulates the immune response by regulating the activity of immune cells, such as macrophages and granulocytes. 4. **Metabolic processes**: BMP5 influences metabolic processes, including glucose and lipid metabolism, by regulating the expression of genes involved in these pathways. **Clinical Significance** Dysregulation of BMP5 signaling has been implicated in various diseases and disorders, including: 1. **Cardiovascular disease**: BMP5 has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 2. **Cancer**: BMP5 has been identified as a tumor suppressor gene, and its dysregulation has been linked to various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: BMP5 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: BMP5 has been linked to metabolic disorders, including obesity and type 2 diabetes. In conclusion, BMP5 is a multifunctional protein that plays a crucial role in various developmental and physiological processes. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of BMP5 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms of BMP5 signaling and its clinical significance. **References** * [Insert references to relevant studies on BMP5] As an expert immunologist, I would like to emphasize that BMP5 is an important protein that has implications for our understanding of immune regulation and disease. Further research is needed to fully elucidate the mechanisms of BMP5 signaling and its clinical significance.

Genular Protein ID: 442893888

Symbol: BMP5_HUMAN

Name: Bone morphogenetic protein 5

UniProtKB Accession Codes:

P22003 B4E0Y4 Q9H547 Q9NTM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2263636

Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

PubMed ID: 2263636

DOI: 10.1073/pnas.87.24.9843

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11580864

Title: Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.

PubMed ID: 11580864

DOI: 10.1186/1471-2202-2-12

PubMed ID: 20402566

Title: BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model.

PubMed ID: 20402566

DOI: 10.3109/08977191003752296

PubMed ID: 30097509

Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

PubMed ID: 30097509

DOI: 10.1182/blood-2018-06-857995

PubMed ID: 29321139

Title: BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.

PubMed ID: 29321139

DOI: 10.1523/jneurosci.1540-17.2018

Sequence Information:

  • Length: 454
  • Mass: 51737
  • Checksum: 631277413CCC22EE
  • Sequence:
    • MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 
LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 
NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 
RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 
QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 
SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

Genular Protein ID: 3962479880

Symbol: A8K694_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K694

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 454
  • Mass: 51751
  • Checksum: 22B8A64A3CBCF3EE
  • Sequence:
    • MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 
LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 
NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 
RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 
QALDLGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 
MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 
SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 
PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.