Details for: BMP6
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.3
Marker Score: 1,135 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.65
Marker Score: 24,606 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1,165 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169,112 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.4
Marker Score: 837 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.37
Marker Score: 1,368 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 851 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.19
Marker Score: 2,418 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.18
Marker Score: 1,429 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.17
Marker Score: 1,350 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 485 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,804 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 501 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.08
Marker Score: 11,197 - Cell Name: interneuron (CL0000099)
Fold Change: 1.04
Marker Score: 473 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.01
Marker Score: 1,472 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,814 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,038 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.95
Marker Score: 298 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.95
Marker Score: 14,787 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,325 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.91
Marker Score: 5,445 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,289 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.82
Marker Score: 6,307 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 599 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 460 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.7
Marker Score: 422 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.7
Marker Score: 222 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.67
Marker Score: 302 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.62
Marker Score: 10,926 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1,442 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.55
Marker Score: 176 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.54
Marker Score: 152 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.53
Marker Score: 254 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.52
Marker Score: 558 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.48
Marker Score: 124 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.47
Marker Score: 114 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.45
Marker Score: 199 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.44
Marker Score: 1,712 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.42
Marker Score: 473 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.4
Marker Score: 117 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.4
Marker Score: 105 - Cell Name: Unknown (CL0000003)
Fold Change: 0.39
Marker Score: 1,201 - Cell Name: oocyte (CL0000023)
Fold Change: 0.38
Marker Score: 95 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.38
Marker Score: 3,276 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.38
Marker Score: 338 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.38
Marker Score: 7,475 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.37
Marker Score: 90 - Cell Name: endocardial cell (CL0002350)
Fold Change: 0.37
Marker Score: 209 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 370 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.32
Marker Score: 12,212 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.3
Marker Score: 796 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.29
Marker Score: 167 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.28
Marker Score: 193 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.28
Marker Score: 9,608 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.28
Marker Score: 117 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.28
Marker Score: 299 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.27
Marker Score: 939 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.27
Marker Score: 77 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.27
Marker Score: 97 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.26
Marker Score: 467 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.26
Marker Score: 422 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.26
Marker Score: 69 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.26
Marker Score: 132 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.26
Marker Score: 1,205 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.26
Marker Score: 235 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.26
Marker Score: 89 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.25
Marker Score: 272 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.24
Marker Score: 286 - Cell Name: platelet (CL0000233)
Fold Change: 0.24
Marker Score: 109 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.24
Marker Score: 205 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.23
Marker Score: 211 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.23
Marker Score: 447 - Cell Name: macroglial cell (CL0000126)
Fold Change: 0.23
Marker Score: 528 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.23
Marker Score: 96 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.23
Marker Score: 428 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.22
Marker Score: 297 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.22
Marker Score: 410 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.21
Marker Score: 56 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.21
Marker Score: 212 - Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.21
Marker Score: 58 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.21
Marker Score: 213 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 116 - Cell Name: chondrocyte (CL0000138)
Fold Change: 0.2
Marker Score: 89
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3180919326
Symbol: BMP6_HUMAN
Name: Bone morphogenetic protein 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2263636
Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
PubMed ID: 2263636
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 33021694
Title: BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
PubMed ID: 33021694
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 30097509
Title: Erythroferrone inhibits the induction of hepcidin by BMP6.
PubMed ID: 30097509
PubMed ID: 31800957
Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
PubMed ID: 31800957
PubMed ID: 17924656
Title: BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors.
PubMed ID: 17924656
DOI: 10.1021/bi700907k
PubMed ID: 18070108
Title: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
PubMed ID: 18070108
PubMed ID: 31019025
Title: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
PubMed ID: 31019025
PubMed ID: 26582087
Title: Heterozygous Mutations in BMP6 pro-peptide lead to inappropriate hepcidin synthesis and moderate iron overload in humans.
PubMed ID: 26582087
PubMed ID: 27591421
Title: Heterozygous BMP6 variants coupled with HFE variants.
PubMed ID: 27591421
PubMed ID: 27590690
Title: The p.Leu96Pro missense mutation in the BMP6 gene is repeatedly associated with hyperferritinemia in patients of French origin.
PubMed ID: 27590690
PubMed ID: 28335084
Title: Identification of new BMP6 pro-peptide mutations in patients with iron overload.
PubMed ID: 28335084
DOI: 10.1002/ajh.24730
PubMed ID: 32464486
Title: Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.
PubMed ID: 32464486
PubMed ID: 31640930
Title: Mutations and polymorphisms associated with iron overload in a series of 91 non-HFE haemochromatosis patients.
PubMed ID: 31640930
PubMed ID: 34037557
Title: Novel BMP6 gene mutation in patient with iron overload.
PubMed ID: 34037557
Sequence Information:
- Length: 513
- Mass: 57226
- Checksum: 3F19155B36049278
- Sequence:
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH
Genular Protein ID: 1669008987
Symbol: Q4VBA3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 428
- Mass: 47993
- Checksum: 0D5F8FBC738462AE
- Sequence:
DCSRQGPQRP RSGLAPPQPP ALRQQEEQQQ QQQLPRGEPP PGRLKSAPLF MLDLYNALSA DNDEDGASEG ERQQSWPHEA ASSSQRRQPP PGAAHPLNRK SLLAPGSGSG GASPLTSAQD SAFLNDADMV MSFVNLVEYD KEFSPRQRHH KEFKFNLSQI PEGEVVTAAE FRIYKDCVMG SFKNQTFLIS IYQVLQEHQH RDSDLFLLDT RVVWASEEGW LEFDITATSN LWVVTPQHNM GLQLSVVTRD GVHVHPRAAG LVGRDGPYDK QPFMVAFFKV SEVHVRTTRS ASSRRRQQSR NRSTQSQDVA RVSSASDYNS SELKTACRKH ELYVSFQDLG WQDWIIAPKG YAANYCDGEC SFPLNAHMNA TNHAIVQTLV HLMNPEYVPK PCCAPTKLNA ISVLYFDDNS NVILKKYRNM VVRACGCH
Genular Protein ID: 367785251
Symbol: B4DUF7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 435
- Mass: 48916
- Checksum: AA775335CFFF2924
- Sequence:
MQKEILSVLG LPHRPRPLHG LQQPQPPALR QQEEQQQQQQ LPRGEPPPGR LKSAPLFMLD LYNALSADND EDGASEGERQ QSWPHEAASS SQRRQPPPGA AHPLNRKSLL APGSGSGGAS PLTSAQDSAF LNDADMVMSF VNLVEYDKEF SPRQRHHKEF KFNLSQIPEG EVVTAAEFRI YKDCVMGSFK NQTFLISIYQ VLQEHQHRDS DLFLLDTRVV WASEEGWLEF DITATSNLWV VTPQHNMGLQ LSVVTRDGVH VHPRAAGLVG RDGPYDKQPF MVAFFKVSEV HVRTTRSASS RRRQQSRNRS TQSQDVARVS SASDYNSSEL KTACRKHELY VSFQDLGWQD WIIAPKGYAA NYCDGECSFP LNAHMNATNH AIVQTLVHLM NPEYVPKPCC APTKLNAISV LYFDDNSNVI LKKYRNMVVR ACGCH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.