Details for: BMP6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.5995
Cell Significance Index: -8.0200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 17.8077
Cell Significance Index: -9.1600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 6.5080
Cell Significance Index: 39.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.5047
Cell Significance Index: -8.0200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 4.4095
Cell Significance Index: 94.2600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.4105
Cell Significance Index: 64.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.2496
Cell Significance Index: 47.3200 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.0833
Cell Significance Index: 11.2200 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.0355
Cell Significance Index: 8.1800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9895
Cell Significance Index: 43.7700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.7175
Cell Significance Index: 10.3200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5408
Cell Significance Index: 102.9300 - Cell Name: endothelial stalk cell (CL0002671)
Fold Change: 0.5408
Cell Significance Index: 6.0600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4014
Cell Significance Index: 39.7100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3190
Cell Significance Index: 288.0400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2819
Cell Significance Index: 101.1000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2637
Cell Significance Index: 33.8100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2340
Cell Significance Index: 7.5000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1985
Cell Significance Index: 32.2900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1444
Cell Significance Index: 222.2400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1416
Cell Significance Index: 15.4100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0805
Cell Significance Index: 1.7200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0635
Cell Significance Index: 4.3900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0597
Cell Significance Index: 1.7100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0319
Cell Significance Index: 6.3400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0293
Cell Significance Index: 5.8800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0184
Cell Significance Index: 1.1100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0154
Cell Significance Index: 28.4700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0054
Cell Significance Index: 0.1900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0003
Cell Significance Index: 0.0100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0007
Cell Significance Index: -0.0100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0015
Cell Significance Index: -2.0000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0018
Cell Significance Index: -3.4400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0046
Cell Significance Index: -0.3100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0062
Cell Significance Index: -4.5700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0070
Cell Significance Index: -0.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0072
Cell Significance Index: -1.3000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0080
Cell Significance Index: -0.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0086
Cell Significance Index: -0.3900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0091
Cell Significance Index: -4.9500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0105
Cell Significance Index: -7.7700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0107
Cell Significance Index: -8.1300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0108
Cell Significance Index: -0.6600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0113
Cell Significance Index: -7.1700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0131
Cell Significance Index: -8.2000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0132
Cell Significance Index: -7.4200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0157
Cell Significance Index: -0.3400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0160
Cell Significance Index: -7.0900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0167
Cell Significance Index: -7.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0206
Cell Significance Index: -5.9200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0216
Cell Significance Index: -0.3700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0222
Cell Significance Index: -0.4800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0255
Cell Significance Index: -0.5300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0335
Cell Significance Index: -2.0600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0347
Cell Significance Index: -5.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0363
Cell Significance Index: -4.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0366
Cell Significance Index: -5.0300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0379
Cell Significance Index: -7.9800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0409
Cell Significance Index: -5.9400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0487
Cell Significance Index: -0.6500 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0534
Cell Significance Index: -0.8800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0535
Cell Significance Index: -6.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0647
Cell Significance Index: -7.4200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0695
Cell Significance Index: -8.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0719
Cell Significance Index: -5.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0764
Cell Significance Index: -7.9500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0798
Cell Significance Index: -9.4100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0833
Cell Significance Index: -1.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0840
Cell Significance Index: -8.5800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0934
Cell Significance Index: -2.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1026
Cell Significance Index: -1.4000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1048
Cell Significance Index: -3.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1051
Cell Significance Index: -8.3200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1086
Cell Significance Index: -2.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1110
Cell Significance Index: -5.7800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1217
Cell Significance Index: -6.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1221
Cell Significance Index: -9.1000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1264
Cell Significance Index: -2.5000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1276
Cell Significance Index: -5.5500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1321
Cell Significance Index: -2.6000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1403
Cell Significance Index: -9.0500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1465
Cell Significance Index: -6.8300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1467
Cell Significance Index: -2.9500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1482
Cell Significance Index: -3.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1567
Cell Significance Index: -8.1400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1624
Cell Significance Index: -5.6900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1692
Cell Significance Index: -2.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1698
Cell Significance Index: -7.9800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1780
Cell Significance Index: -5.6700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1797
Cell Significance Index: -3.8200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1839
Cell Significance Index: -1.5000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1944
Cell Significance Index: -5.1900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2040
Cell Significance Index: -2.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2158
Cell Significance Index: -7.5000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2178
Cell Significance Index: -8.0000 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.2194
Cell Significance Index: -2.2900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2232
Cell Significance Index: -6.3700 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2295
Cell Significance Index: -4.6700 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: -0.2394
Cell Significance Index: -1.7600 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.2446
Cell Significance Index: -3.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3180919326
Symbol: BMP6_HUMAN
Name: Bone morphogenetic protein 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2263636
Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
PubMed ID: 2263636
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 33021694
Title: BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
PubMed ID: 33021694
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 30097509
Title: Erythroferrone inhibits the induction of hepcidin by BMP6.
PubMed ID: 30097509
PubMed ID: 31800957
Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
PubMed ID: 31800957
PubMed ID: 17924656
Title: BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors.
PubMed ID: 17924656
DOI: 10.1021/bi700907k
PubMed ID: 18070108
Title: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
PubMed ID: 18070108
PubMed ID: 31019025
Title: A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
PubMed ID: 31019025
PubMed ID: 26582087
Title: Heterozygous Mutations in BMP6 pro-peptide lead to inappropriate hepcidin synthesis and moderate iron overload in humans.
PubMed ID: 26582087
PubMed ID: 27591421
Title: Heterozygous BMP6 variants coupled with HFE variants.
PubMed ID: 27591421
PubMed ID: 27590690
Title: The p.Leu96Pro missense mutation in the BMP6 gene is repeatedly associated with hyperferritinemia in patients of French origin.
PubMed ID: 27590690
PubMed ID: 28335084
Title: Identification of new BMP6 pro-peptide mutations in patients with iron overload.
PubMed ID: 28335084
DOI: 10.1002/ajh.24730
PubMed ID: 32464486
Title: Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.
PubMed ID: 32464486
PubMed ID: 31640930
Title: Mutations and polymorphisms associated with iron overload in a series of 91 non-HFE haemochromatosis patients.
PubMed ID: 31640930
PubMed ID: 34037557
Title: Novel BMP6 gene mutation in patient with iron overload.
PubMed ID: 34037557
Sequence Information:
- Length: 513
- Mass: 57226
- Checksum: 3F19155B36049278
- Sequence:
MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH
Genular Protein ID: 367785251
Symbol: B4DUF7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 435
- Mass: 48916
- Checksum: AA775335CFFF2924
- Sequence:
MQKEILSVLG LPHRPRPLHG LQQPQPPALR QQEEQQQQQQ LPRGEPPPGR LKSAPLFMLD LYNALSADND EDGASEGERQ QSWPHEAASS SQRRQPPPGA AHPLNRKSLL APGSGSGGAS PLTSAQDSAF LNDADMVMSF VNLVEYDKEF SPRQRHHKEF KFNLSQIPEG EVVTAAEFRI YKDCVMGSFK NQTFLISIYQ VLQEHQHRDS DLFLLDTRVV WASEEGWLEF DITATSNLWV VTPQHNMGLQ LSVVTRDGVH VHPRAAGLVG RDGPYDKQPF MVAFFKVSEV HVRTTRSASS RRRQQSRNRS TQSQDVARVS SASDYNSSEL KTACRKHELY VSFQDLGWQD WIIAPKGYAA NYCDGECSFP LNAHMNATNH AIVQTLVHLM NPEYVPKPCC APTKLNAISV LYFDDNSNVI LKKYRNMVVR ACGCH
Genular Protein ID: 1669008987
Symbol: Q4VBA3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 428
- Mass: 47993
- Checksum: 0D5F8FBC738462AE
- Sequence:
DCSRQGPQRP RSGLAPPQPP ALRQQEEQQQ QQQLPRGEPP PGRLKSAPLF MLDLYNALSA DNDEDGASEG ERQQSWPHEA ASSSQRRQPP PGAAHPLNRK SLLAPGSGSG GASPLTSAQD SAFLNDADMV MSFVNLVEYD KEFSPRQRHH KEFKFNLSQI PEGEVVTAAE FRIYKDCVMG SFKNQTFLIS IYQVLQEHQH RDSDLFLLDT RVVWASEEGW LEFDITATSN LWVVTPQHNM GLQLSVVTRD GVHVHPRAAG LVGRDGPYDK QPFMVAFFKV SEVHVRTTRS ASSRRRQQSR NRSTQSQDVA RVSSASDYNS SELKTACRKH ELYVSFQDLG WQDWIIAPKG YAANYCDGEC SFPLNAHMNA TNHAIVQTLV HLMNPEYVPK PCCAPTKLNA ISVLYFDDNS NVILKKYRNM VVRACGCH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.