Details for: BMP7

Gene ID: 655

Symbol: BMP7

Ensembl ID: ENSG00000101144

Description: bone morphogenetic protein 7

Associated with

  • Adipogenesis
    (R-HSA-9843745)
  • Developmental biology
    (R-HSA-1266738)
  • Elastic fibre formation
    (R-HSA-1566948)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Molecules associated with elastic fibres
    (R-HSA-2129379)
  • Transcriptional regulation of brown and beige adipocyte differentiation
    (R-HSA-9843743)
  • Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
    (R-HSA-9844594)
  • Allantois development
    (GO:1905069)
  • Ameloblast differentiation
    (GO:0036305)
  • Axon guidance
    (GO:0007411)
  • Bmp receptor binding
    (GO:0070700)
  • Bmp signaling pathway
    (GO:0030509)
  • Branching involved in salivary gland morphogenesis
    (GO:0060445)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cardiac muscle tissue development
    (GO:0048738)
  • Cardiac septum morphogenesis
    (GO:0060411)
  • Cartilage development
    (GO:0051216)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Cellular response to hypoxia
    (GO:0071456)
  • Chorio-allantoic fusion
    (GO:0060710)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytokine activity
    (GO:0005125)
  • Dendrite development
    (GO:0016358)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Embryonic pattern specification
    (GO:0009880)
  • Embryonic skeletal joint morphogenesis
    (GO:0060272)
  • Endocardial cushion formation
    (GO:0003272)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Heart trabecula morphogenesis
    (GO:0061384)
  • Heparin binding
    (GO:0008201)
  • Hindbrain development
    (GO:0030902)
  • Mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:1901145)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Mesenchyme development
    (GO:0060485)
  • Mesoderm formation
    (GO:0001707)
  • Mesonephros development
    (GO:0001823)
  • Metanephric mesenchymal cell proliferation involved in metanephros development
    (GO:0072136)
  • Metanephric mesenchyme morphogenesis
    (GO:0072133)
  • Metanephros development
    (GO:0001656)
  • Monocyte aggregation
    (GO:0070487)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of glomerular mesangial cell proliferation
    (GO:0072125)
  • Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:0072040)
  • Negative regulation of mitotic nuclear division
    (GO:0045839)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of non-canonical nf-kappab signal transduction
    (GO:1901223)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of prostatic bud formation
    (GO:0060686)
  • Negative regulation of striated muscle cell apoptotic process
    (GO:0010664)
  • Nephrogenic mesenchyme morphogenesis
    (GO:0072134)
  • Neural fold elevation formation
    (GO:0021502)
  • Neuron projection morphogenesis
    (GO:0048812)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Ossification
    (GO:0001503)
  • Pericardium morphogenesis
    (GO:0003344)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of bone mineralization
    (GO:0030501)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:1905312)
  • Positive regulation of dendrite development
    (GO:1900006)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of hyaluranon cable assembly
    (GO:1900106)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of branching involved in prostate gland morphogenesis
    (GO:0060687)
  • Regulation of removal of superoxide radicals
    (GO:2000121)
  • Response to estradiol
    (GO:0032355)
  • Response to peptide hormone
    (GO:0043434)
  • Response to vitamin d
    (GO:0033280)
  • Skeletal system development
    (GO:0001501)
  • Ureteric bud development
    (GO:0001657)
  • Vesicle
    (GO:0031982)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.6129
    Cell Significance Index: 139.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.8579
    Cell Significance Index: 66.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9990
    Cell Significance Index: 122.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7425
    Cell Significance Index: 90.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5645
    Cell Significance Index: 41.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4252
    Cell Significance Index: 39.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7762
    Cell Significance Index: 11.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7029
    Cell Significance Index: 383.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5963
    Cell Significance Index: 73.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5794
    Cell Significance Index: 110.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4615
    Cell Significance Index: 83.2000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3969
    Cell Significance Index: 5.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3862
    Cell Significance Index: 49.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3398
    Cell Significance Index: 3.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3355
    Cell Significance Index: 148.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3204
    Cell Significance Index: 289.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3177
    Cell Significance Index: 31.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2481
    Cell Significance Index: 8.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1916
    Cell Significance Index: 1.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1839
    Cell Significance Index: 5.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1629
    Cell Significance Index: 18.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1500
    Cell Significance Index: 24.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1152
    Cell Significance Index: 73.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0496
    Cell Significance Index: 17.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0429
    Cell Significance Index: 8.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0421
    Cell Significance Index: 29.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0382
    Cell Significance Index: 71.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0269
    Cell Significance Index: 2.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0218
    Cell Significance Index: 40.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0066
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0174
    Cell Significance Index: -26.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0233
    Cell Significance Index: -3.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0244
    Cell Significance Index: -33.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0259
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0261
    Cell Significance Index: -14.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0318
    Cell Significance Index: -23.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0337
    Cell Significance Index: -25.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0345
    Cell Significance Index: -7.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0370
    Cell Significance Index: -1.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0388
    Cell Significance Index: -0.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0468
    Cell Significance Index: -9.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0524
    Cell Significance Index: -23.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0578
    Cell Significance Index: -2.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0604
    Cell Significance Index: -17.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0786
    Cell Significance Index: -1.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0902
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1064
    Cell Significance Index: -18.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1214
    Cell Significance Index: -16.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1313
    Cell Significance Index: -15.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1477
    Cell Significance Index: -3.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1528
    Cell Significance Index: -10.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1779
    Cell Significance Index: -10.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1818
    Cell Significance Index: -23.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1907
    Cell Significance Index: -21.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2018
    Cell Significance Index: -13.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2171
    Cell Significance Index: -22.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2213
    Cell Significance Index: -13.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2252
    Cell Significance Index: -17.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2267
    Cell Significance Index: -23.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2361
    Cell Significance Index: -27.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2465
    Cell Significance Index: -13.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3300
    Cell Significance Index: -16.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3384
    Cell Significance Index: -25.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3462
    Cell Significance Index: -23.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3584
    Cell Significance Index: -22.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3877
    Cell Significance Index: -25.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3879
    Cell Significance Index: -11.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4005
    Cell Significance Index: -20.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4180
    Cell Significance Index: -8.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4208
    Cell Significance Index: -9.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4344
    Cell Significance Index: -22.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4777
    Cell Significance Index: -22.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5015
    Cell Significance Index: -10.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5255
    Cell Significance Index: -10.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5458
    Cell Significance Index: -24.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5571
    Cell Significance Index: -14.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5622
    Cell Significance Index: -6.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6353
    Cell Significance Index: -23.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6353
    Cell Significance Index: -29.6200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6387
    Cell Significance Index: -7.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6391
    Cell Significance Index: -24.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6448
    Cell Significance Index: -10.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6557
    Cell Significance Index: -22.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6960
    Cell Significance Index: -20.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7047
    Cell Significance Index: -15.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7104
    Cell Significance Index: -29.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7219
    Cell Significance Index: -14.0900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.7407
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7410
    Cell Significance Index: -21.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7651
    Cell Significance Index: -25.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7944
    Cell Significance Index: -25.3000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.8508
    Cell Significance Index: -5.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.8765
    Cell Significance Index: -7.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8818
    Cell Significance Index: -27.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9025
    Cell Significance Index: -13.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.9156
    Cell Significance Index: -13.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9170
    Cell Significance Index: -24.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9193
    Cell Significance Index: -13.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP7 exhibits several key characteristics that distinguish it from other BMP family members. These include: 1. **Receptor binding**: BMP7 binds to specific receptors, including the BMP type II receptor and the type I receptor, which triggers the activation of downstream signaling pathways. 2. **Signaling pathways**: BMP7 activates various signaling pathways, including the Smad-dependent and Smad-independent pathways, which regulate gene expression, cell differentiation, and proliferation. 3. **Cellular responses**: BMP7 regulates cellular responses to hypoxia, estradiol, peptide hormones, and vitamin D, among other stimuli. 4. **Tissue development**: BMP7 is involved in the development of various tissues, including the skeletal system, cardiovascular system, and nervous system. **Pathways and Functions** BMP7's signaling pathways and functions can be broadly categorized into several key areas: 1. **Cellular differentiation and proliferation**: BMP7 regulates the differentiation and proliferation of various cell types, including osteoblasts, chondrocytes, and neural cells. 2. **Tissue morphogenesis**: BMP7 plays a crucial role in the morphogenesis of various tissues, including the development of the skeletal system, cardiovascular system, and nervous system. 3. **Apoptosis regulation**: BMP7 regulates the apoptotic process, influencing cell survival and death in response to various stimuli. 4. **Gene expression regulation**: BMP7 regulates gene expression by activating or repressing the expression of specific genes involved in cellular differentiation, proliferation, and survival. **Clinical Significance** BMP7 has significant implications for various clinical conditions, including: 1. **Bone disorders**: BMP7 is involved in the regulation of bone mineralization and density, making it a potential therapeutic target for bone disorders, such as osteoporosis. 2. **Cardiovascular disease**: BMP7 plays a role in the development and function of the cardiovascular system, making it a potential therapeutic target for cardiovascular disease. 3. **Neurological disorders**: BMP7 is involved in the development and function of the nervous system, making it a potential therapeutic target for neurological disorders, such as Alzheimer's disease. 4. **Cancer**: BMP7 has been shown to regulate the proliferation and differentiation of cancer cells, making it a potential therapeutic target for cancer treatment. In conclusion, BMP7 is a multifunctional protein that plays a crucial role in various developmental and physiological processes. Its dysregulation has been implicated in various clinical conditions, making it a potential therapeutic target for the treatment of bone disorders, cardiovascular disease, neurological disorders, and cancer.

Genular Protein ID: 2817769699

Symbol: BMP7_HUMAN

Name: Bone morphogenetic protein 7

UniProtKB Accession Codes:

P18075 Q9H512 Q9NTQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2357959

Title: OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.

PubMed ID: 2357959

DOI: 10.1002/j.1460-2075.1990.tb07376.x

PubMed ID: 2263636

Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

PubMed ID: 2263636

DOI: 10.1073/pnas.87.24.9843

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17977014

Title: Expression and characterization of a human BMP-7 variant with improved biochemical properties.

PubMed ID: 17977014

DOI: 10.1016/j.pep.2007.09.016

PubMed ID: 9748228

Title: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.

PubMed ID: 9748228

DOI: 10.1074/jbc.273.40.25628

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 20506283

Title: Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies.

PubMed ID: 20506283

DOI: 10.1002/humu.21280

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 30097509

Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

PubMed ID: 30097509

DOI: 10.1182/blood-2018-06-857995

PubMed ID: 31208997

Title: Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA.

PubMed ID: 31208997

DOI: 10.1242/bio.042283

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 8570652

Title: Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.

PubMed ID: 8570652

DOI: 10.1073/pnas.93.2.878

PubMed ID: 12478285

Title: Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

PubMed ID: 12478285

DOI: 10.1038/nature01245

PubMed ID: 12667445

Title: The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

PubMed ID: 12667445

DOI: 10.1016/s1097-2765(03)00094-7

Sequence Information:

  • Length: 431
  • Mass: 49313
  • Checksum: 47A05E45C6815F8A
  • Sequence:
    • MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 
RNMVVRACGC H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.