Details for: BMP7

Gene ID: 655

Symbol: BMP7

Ensembl ID: ENSG00000101144

Description: bone morphogenetic protein 7

Associated with

  • Elastic fibre formation
    (R-HSA-1566948)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Molecules associated with elastic fibres
    (R-HSA-2129379)
  • Allantois development
    (GO:1905069)
  • Ameloblast differentiation
    (GO:0036305)
  • Axon guidance
    (GO:0007411)
  • Bmp receptor binding
    (GO:0070700)
  • Bmp signaling pathway
    (GO:0030509)
  • Branching involved in salivary gland morphogenesis
    (GO:0060445)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cardiac muscle tissue development
    (GO:0048738)
  • Cardiac septum morphogenesis
    (GO:0060411)
  • Cartilage development
    (GO:0051216)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Cellular response to hypoxia
    (GO:0071456)
  • Chorio-allantoic fusion
    (GO:0060710)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytokine activity
    (GO:0005125)
  • Dendrite development
    (GO:0016358)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Embryonic pattern specification
    (GO:0009880)
  • Embryonic skeletal joint morphogenesis
    (GO:0060272)
  • Endocardial cushion formation
    (GO:0003272)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Heart trabecula morphogenesis
    (GO:0061384)
  • Heparin binding
    (GO:0008201)
  • Hindbrain development
    (GO:0030902)
  • Mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:1901145)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Mesenchyme development
    (GO:0060485)
  • Mesoderm formation
    (GO:0001707)
  • Mesonephros development
    (GO:0001823)
  • Metanephric mesenchymal cell proliferation involved in metanephros development
    (GO:0072136)
  • Metanephric mesenchyme morphogenesis
    (GO:0072133)
  • Metanephros development
    (GO:0001656)
  • Monocyte aggregation
    (GO:0070487)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of glomerular mesangial cell proliferation
    (GO:0072125)
  • Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:0072040)
  • Negative regulation of mitotic nuclear division
    (GO:0045839)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of non-canonical nf-kappab signal transduction
    (GO:1901223)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of prostatic bud formation
    (GO:0060686)
  • Negative regulation of striated muscle cell apoptotic process
    (GO:0010664)
  • Nephrogenic mesenchyme morphogenesis
    (GO:0072134)
  • Neural fold elevation formation
    (GO:0021502)
  • Neuron projection morphogenesis
    (GO:0048812)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Ossification
    (GO:0001503)
  • Pericardium morphogenesis
    (GO:0003344)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of bone mineralization
    (GO:0030501)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:1905312)
  • Positive regulation of dendrite development
    (GO:1900006)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of hyaluranon cable assembly
    (GO:1900106)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of branching involved in prostate gland morphogenesis
    (GO:0060687)
  • Regulation of phosphorylation
    (GO:0042325)
  • Regulation of removal of superoxide radicals
    (GO:2000121)
  • Response to estradiol
    (GO:0032355)
  • Response to peptide hormone
    (GO:0043434)
  • Response to vitamin d
    (GO:0033280)
  • Skeletal system development
    (GO:0001501)
  • Ureteric bud development
    (GO:0001657)
  • Vesicle
    (GO:0031982)

Other Information

Genular Protein ID: 2817769699

Symbol: BMP7_HUMAN

Name: Bone morphogenetic protein 7

UniProtKB Accession Codes:

P18075 Q9H512 Q9NTQ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2357959

Title: OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.

PubMed ID: 2357959

DOI: 10.1002/j.1460-2075.1990.tb07376.x

PubMed ID: 2263636

Title: Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

PubMed ID: 2263636

DOI: 10.1073/pnas.87.24.9843

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17977014

Title: Expression and characterization of a human BMP-7 variant with improved biochemical properties.

PubMed ID: 17977014

DOI: 10.1016/j.pep.2007.09.016

PubMed ID: 9748228

Title: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.

PubMed ID: 9748228

DOI: 10.1074/jbc.273.40.25628

PubMed ID: 15020244

Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.

PubMed ID: 15020244

DOI: 10.1016/j.bbrc.2004.02.075

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 20506283

Title: Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies.

PubMed ID: 20506283

DOI: 10.1002/humu.21280

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 30097509

Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

PubMed ID: 30097509

DOI: 10.1182/blood-2018-06-857995

PubMed ID: 31208997

Title: Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA.

PubMed ID: 31208997

DOI: 10.1242/bio.042283

PubMed ID: 33308444

Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

PubMed ID: 33308444

DOI: 10.1016/j.ajhg.2020.11.015

PubMed ID: 8570652

Title: Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.

PubMed ID: 8570652

DOI: 10.1073/pnas.93.2.878

PubMed ID: 12478285

Title: Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

PubMed ID: 12478285

DOI: 10.1038/nature01245

PubMed ID: 12667445

Title: The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.

PubMed ID: 12667445

DOI: 10.1016/s1097-2765(03)00094-7

Sequence Information:

  • Length: 431
  • Mass: 49313
  • Checksum: 47A05E45C6815F8A
  • Sequence:
    • MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 
RNMVVRACGC H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.