Details for: BMP7

Gene ID: 655

Symbol: BMP7

Ensembl ID: ENSG00000101144

Description: bone morphogenetic protein 7

Associated with

  • Adipogenesis
    (R-HSA-9843745)
  • Developmental biology
    (R-HSA-1266738)
  • Elastic fibre formation
    (R-HSA-1566948)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Molecules associated with elastic fibres
    (R-HSA-2129379)
  • Transcriptional regulation of brown and beige adipocyte differentiation
    (R-HSA-9843743)
  • Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
    (R-HSA-9844594)
  • Allantois development
    (GO:1905069)
  • Ameloblast differentiation
    (GO:0036305)
  • Axon guidance
    (GO:0007411)
  • Bmp receptor binding
    (GO:0070700)
  • Bmp signaling pathway
    (GO:0030509)
  • Branching involved in salivary gland morphogenesis
    (GO:0060445)
  • Branching morphogenesis of an epithelial tube
    (GO:0048754)
  • Cardiac muscle tissue development
    (GO:0048738)
  • Cardiac septum morphogenesis
    (GO:0060411)
  • Cartilage development
    (GO:0051216)
  • Cellular response to bmp stimulus
    (GO:0071773)
  • Cellular response to hypoxia
    (GO:0071456)
  • Chorio-allantoic fusion
    (GO:0060710)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytokine activity
    (GO:0005125)
  • Dendrite development
    (GO:0016358)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Embryonic pattern specification
    (GO:0009880)
  • Embryonic skeletal joint morphogenesis
    (GO:0060272)
  • Endocardial cushion formation
    (GO:0003272)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Growth factor activity
    (GO:0008083)
  • Heart trabecula morphogenesis
    (GO:0061384)
  • Heparin binding
    (GO:0008201)
  • Hindbrain development
    (GO:0030902)
  • Mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:1901145)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Mesenchyme development
    (GO:0060485)
  • Mesoderm formation
    (GO:0001707)
  • Mesonephros development
    (GO:0001823)
  • Metanephric mesenchymal cell proliferation involved in metanephros development
    (GO:0072136)
  • Metanephric mesenchyme morphogenesis
    (GO:0072133)
  • Metanephros development
    (GO:0001656)
  • Monocyte aggregation
    (GO:0070487)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of glomerular mesangial cell proliferation
    (GO:0072125)
  • Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
    (GO:0072040)
  • Negative regulation of mitotic nuclear division
    (GO:0045839)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of non-canonical nf-kappab signal transduction
    (GO:1901223)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of prostatic bud formation
    (GO:0060686)
  • Negative regulation of striated muscle cell apoptotic process
    (GO:0010664)
  • Nephrogenic mesenchyme morphogenesis
    (GO:0072134)
  • Neural fold elevation formation
    (GO:0021502)
  • Neuron projection morphogenesis
    (GO:0048812)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Ossification
    (GO:0001503)
  • Pericardium morphogenesis
    (GO:0003344)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of bone mineralization
    (GO:0030501)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:1905312)
  • Positive regulation of dendrite development
    (GO:1900006)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of hyaluranon cable assembly
    (GO:1900106)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of branching involved in prostate gland morphogenesis
    (GO:0060687)
  • Regulation of removal of superoxide radicals
    (GO:2000121)
  • Response to estradiol
    (GO:0032355)
  • Response to peptide hormone
    (GO:0043434)
  • Response to vitamin d
    (GO:0033280)
  • Skeletal system development
    (GO:0001501)
  • Ureteric bud development
    (GO:0001657)
  • Vesicle
    (GO:0031982)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell (CL0000000)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.99
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP7 exhibits several key characteristics that distinguish it from other BMP family members. These include: 1. **Receptor binding**: BMP7 binds to specific receptors, including the BMP type II receptor and the type I receptor, which triggers the activation of downstream signaling pathways. 2. **Signaling pathways**: BMP7 activates various signaling pathways, including the Smad-dependent and Smad-independent pathways, which regulate gene expression, cell differentiation, and proliferation. 3. **Cellular responses**: BMP7 regulates cellular responses to hypoxia, estradiol, peptide hormones, and vitamin D, among other stimuli. 4. **Tissue development**: BMP7 is involved in the development of various tissues, including the skeletal system, cardiovascular system, and nervous system. **Pathways and Functions** BMP7's signaling pathways and functions can be broadly categorized into several key areas: 1. **Cellular differentiation and proliferation**: BMP7 regulates the differentiation and proliferation of various cell types, including osteoblasts, chondrocytes, and neural cells. 2. **Tissue morphogenesis**: BMP7 plays a crucial role in the morphogenesis of various tissues, including the development of the skeletal system, cardiovascular system, and nervous system. 3. **Apoptosis regulation**: BMP7 regulates the apoptotic process, influencing cell survival and death in response to various stimuli. 4. **Gene expression regulation**: BMP7 regulates gene expression by activating or repressing the expression of specific genes involved in cellular differentiation, proliferation, and survival. **Clinical Significance** BMP7 has significant implications for various clinical conditions, including: 1. **Bone disorders**: BMP7 is involved in the regulation of bone mineralization and density, making it a potential therapeutic target for bone disorders, such as osteoporosis. 2. **Cardiovascular disease**: BMP7 plays a role in the development and function of the cardiovascular system, making it a potential therapeutic target for cardiovascular disease. 3. **Neurological disorders**: BMP7 is involved in the development and function of the nervous system, making it a potential therapeutic target for neurological disorders, such as Alzheimer's disease. 4. **Cancer**: BMP7 has been shown to regulate the proliferation and differentiation of cancer cells, making it a potential therapeutic target for cancer treatment. In conclusion, BMP7 is a multifunctional protein that plays a crucial role in various developmental and physiological processes. Its dysregulation has been implicated in various clinical conditions, making it a potential therapeutic target for the treatment of bone disorders, cardiovascular disease, neurological disorders, and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.