Details for: BMP8B

Gene ID: 656

Symbol: BMP8B

Ensembl ID: ENSG00000116985

Description: bone morphogenetic protein 8b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 17.8083
    Cell Significance Index: -2.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.0785
    Cell Significance Index: -2.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.2466
    Cell Significance Index: -2.7700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.3801
    Cell Significance Index: 12.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8404
    Cell Significance Index: 159.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.7121
    Cell Significance Index: -2.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4501
    Cell Significance Index: 27.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4285
    Cell Significance Index: 42.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3765
    Cell Significance Index: 339.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3295
    Cell Significance Index: 35.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2616
    Cell Significance Index: 4.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2391
    Cell Significance Index: 12.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2260
    Cell Significance Index: 36.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1904
    Cell Significance Index: 13.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1569
    Cell Significance Index: 4.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1527
    Cell Significance Index: 6.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0957
    Cell Significance Index: 1.3700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0642
    Cell Significance Index: 0.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0541
    Cell Significance Index: 0.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0357
    Cell Significance Index: 0.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0340
    Cell Significance Index: 6.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0332
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0324
    Cell Significance Index: 5.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0322
    Cell Significance Index: 2.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0233
    Cell Significance Index: 0.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0229
    Cell Significance Index: 4.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0221
    Cell Significance Index: 12.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0195
    Cell Significance Index: 0.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0188
    Cell Significance Index: 0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0112
    Cell Significance Index: 1.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0106
    Cell Significance Index: 1.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0106
    Cell Significance Index: 0.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0051
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0041
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0015
    Cell Significance Index: -0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0023
    Cell Significance Index: -1.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.7000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0066
    Cell Significance Index: -0.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0067
    Cell Significance Index: -0.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0082
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0084
    Cell Significance Index: -0.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0118
    Cell Significance Index: -1.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0134
    Cell Significance Index: -2.8200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0137
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0146
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0157
    Cell Significance Index: -2.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0165
    Cell Significance Index: -0.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0171
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0220
    Cell Significance Index: -0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0233
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0266
    Cell Significance Index: -2.7700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0275
    Cell Significance Index: -0.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0282
    Cell Significance Index: -2.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0310
    Cell Significance Index: -1.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0348
    Cell Significance Index: -2.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0349
    Cell Significance Index: -0.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0391
    Cell Significance Index: -2.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0391
    Cell Significance Index: -2.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0392
    Cell Significance Index: -1.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0399
    Cell Significance Index: -1.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0433
    Cell Significance Index: -2.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0493
    Cell Significance Index: -2.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0514
    Cell Significance Index: -0.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0545
    Cell Significance Index: -1.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0557
    Cell Significance Index: -1.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0579
    Cell Significance Index: -1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0580
    Cell Significance Index: -1.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0590
    Cell Significance Index: -1.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0622
    Cell Significance Index: -1.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0643
    Cell Significance Index: -2.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0656
    Cell Significance Index: -2.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0682
    Cell Significance Index: -0.9300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0691
    Cell Significance Index: -0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0719
    Cell Significance Index: -2.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0726
    Cell Significance Index: -0.9500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0733
    Cell Significance Index: -1.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0755
    Cell Significance Index: -2.7700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0797
    Cell Significance Index: -0.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0806
    Cell Significance Index: -2.0100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0821
    Cell Significance Index: -0.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0844
    Cell Significance Index: -0.9100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0861
    Cell Significance Index: -0.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0868
    Cell Significance Index: -1.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMP8B exhibits a unique expression profile, primarily found in specific cell types such as early T lineage precursors, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. These cells are essential for the development and maintenance of the central nervous system and the regulation of the immune system. BMP8B's expression is also observed in intestinal epithelial cells, goblet cells, and stem cells, highlighting its role in maintaining tissue homeostasis and immune function. **Pathways and Functions** BMP8B is involved in various signaling pathways, including cartilage development, cell differentiation, cytokine activity, and growth factor activity. Its signaling pathways regulate the expression of genes involved in these processes, ultimately influencing the development and maintenance of tissues, including the skeletal system. BMP8B also interacts with other growth factors and cytokines to modulate immune responses and tissue repair. In particular, BMP8B has been shown to: 1. Regulate the development and maintenance of the central nervous system, including the cerebral cortex and spinal cord. 2. Inhibit the differentiation of T cells and promote the development of regulatory T cells, which play a crucial role in immune tolerance. 3. Modulate the expression of genes involved in inflammation and tissue repair. 4. Interact with other growth factors, such as BMP4 and BMP7, to regulate the development and differentiation of cells in the skeletal system. **Clinical Significance** The dysregulation of BMP8B has been implicated in various diseases, including: 1. Autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where BMP8B's role in immune tolerance and tissue repair is disrupted. 2. Neurological disorders, such as Alzheimer's disease and Parkinson's disease, where BMP8B's involvement in brain development and maintenance is compromised. 3. Cancer, where BMP8B's role in regulating cell growth and differentiation is altered. 4. Tissue engineering and regenerative medicine, where BMP8B's ability to promote tissue repair and regeneration is exploited. In conclusion, BMP8B is a critical regulator of immune function and tissue development, and its dysregulation has significant implications for various diseases. Further research is needed to fully elucidate the mechanisms by which BMP8B exerts its effects and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 3563277605

Symbol: BMP8B_HUMAN

Name: Bone morphogenetic protein 8B

UniProtKB Accession Codes:

P34820 E7EMY8 Q32NE5 Q53ZM7 Q9NUF0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1460021

Title: Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.

PubMed ID: 1460021

DOI: 10.1016/s0021-9258(19)74028-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 402
  • Mass: 44768
  • Checksum: AE2330F1547E83A7
  • Sequence:
    • MTALPGPLWL LGLALCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA VLGLPGRPRP 
RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAERRLG RADLVMSFVN MVERDRALGH 
QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF 
FLDLQTLRAG DEGWLVLDVT AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA 
PRSQQPFVVT FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV 
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD 
AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.