Details for: BMPR2
Associated with
Other Information
Genular Protein ID: 2996767760
Symbol: BMPR2_HUMAN
Name: Bone morphogenetic protein receptor type-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7791754
Title: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
PubMed ID: 7791754
PubMed ID: 7644468
Title: Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
PubMed ID: 7644468
PubMed ID: 7673243
Title: Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors.
PubMed ID: 7673243
PubMed ID: 7890683
Title: Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor.
PubMed ID: 7890683
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21791611
Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.
PubMed ID: 21791611
DOI: 10.1128/mcb.05448-11
PubMed ID: 21976273
Title: New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.
PubMed ID: 21976273
DOI: 10.1002/jbmr.532
PubMed ID: 29212066
Title: Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway.
PubMed ID: 29212066
DOI: 10.1159/000485759
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33308444
Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.
PubMed ID: 33308444
PubMed ID: 17094948
Title: High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding.
PubMed ID: 17094948
PubMed ID: 10903931
Title: Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
PubMed ID: 10903931
DOI: 10.1086/303059
PubMed ID: 11015450
Title: Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.
PubMed ID: 11015450
PubMed ID: 10973254
Title: Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension.
PubMed ID: 10973254
DOI: 10.1038/79226
PubMed ID: 11115378
Title: BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.
PubMed ID: 11115378
DOI: 10.1086/316947
PubMed ID: 12358323
Title: BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives.
PubMed ID: 12358323
PubMed ID: 12045205
Title: Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.
PubMed ID: 12045205
PubMed ID: 12446270
Title: Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II.
PubMed ID: 12446270
PubMed ID: 15965979
Title: BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension.
PubMed ID: 15965979
DOI: 10.1002/humu.20200
PubMed ID: 16429395
Title: Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.
PubMed ID: 16429395
DOI: 10.1002/humu.20285
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 24936649
Title: Novel mutations in BMPR2, ACVRL1 and KCNA5 genes and hemodynamic parameters in patients with pulmonary arterial hypertension.
PubMed ID: 24936649
PubMed ID: 25187962
Title: Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations.
PubMed ID: 25187962
PubMed ID: 28507310
Title: Molecular and functional characterization of the BMPR2 gene in Pulmonary Arterial Hypertension.
PubMed ID: 28507310
Sequence Information:
- Length: 1038
- Mass: 115201
- Checksum: 1389923CE574B913
- Sequence:
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEATGQ QDFTQTANGQ ACLIPDVLPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT HRAQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT NSNNNNSNPC SEQDVLAQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD GSSIQIGEST QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV NNNGSNRAVH SKSSTAVYLA EGGTATTMVS KDIGMNCL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.