Details for: BMPR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 694.3318
Cell Significance Index: -108.0000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 424.7696
Cell Significance Index: -107.7400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 226.8902
Cell Significance Index: -107.1200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 209.7932
Cell Significance Index: -85.2300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 89.3225
Cell Significance Index: -85.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 88.0324
Cell Significance Index: -108.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 37.0568
Cell Significance Index: -99.2700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 34.9038
Cell Significance Index: -76.3900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.5161
Cell Significance Index: -108.5800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 26.7561
Cell Significance Index: -82.1800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 6.2670
Cell Significance Index: 90.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.3369
Cell Significance Index: 225.9100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.3431
Cell Significance Index: 187.6000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8554
Cell Significance Index: 572.8000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.7380
Cell Significance Index: 168.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.6924
Cell Significance Index: 965.7300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.5525
Cell Significance Index: 65.6100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3910
Cell Significance Index: 474.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.3634
Cell Significance Index: 181.3600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.8174
Cell Significance Index: 43.5900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.7935
Cell Significance Index: 1240.4200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.5602
Cell Significance Index: 30.4500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2235
Cell Significance Index: 82.2700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.1125
Cell Significance Index: 49.2100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0227
Cell Significance Index: 125.7600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9855
Cell Significance Index: 177.6600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8688
Cell Significance Index: 32.9000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7229
Cell Significance Index: 652.7100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6342
Cell Significance Index: 68.9900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4151
Cell Significance Index: 183.5400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3478
Cell Significance Index: 654.8500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3149
Cell Significance Index: 8.8000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2511
Cell Significance Index: 137.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2314
Cell Significance Index: 5.7900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2304
Cell Significance Index: 104.5900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2066
Cell Significance Index: 318.0300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1829
Cell Significance Index: 5.2200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1634
Cell Significance Index: 2.8000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1563
Cell Significance Index: 288.3100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1540
Cell Significance Index: 97.8200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1310
Cell Significance Index: 178.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1137
Cell Significance Index: 15.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0654
Cell Significance Index: 10.6400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0430
Cell Significance Index: 0.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0347
Cell Significance Index: 6.6100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0307
Cell Significance Index: 3.0400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0301
Cell Significance Index: -3.8600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0485
Cell Significance Index: -1.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0642
Cell Significance Index: -47.5600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0724
Cell Significance Index: -45.2100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0956
Cell Significance Index: -70.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1235
Cell Significance Index: -5.6000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1330
Cell Significance Index: -3.5500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1439
Cell Significance Index: -108.9100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1467
Cell Significance Index: -82.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1815
Cell Significance Index: -5.2300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2467
Cell Significance Index: -42.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3284
Cell Significance Index: -94.4800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3365
Cell Significance Index: -48.9200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3728
Cell Significance Index: -78.5300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3960
Cell Significance Index: -8.4700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5060
Cell Significance Index: -11.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.5356
Cell Significance Index: -54.7200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5412
Cell Significance Index: -63.0700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6194
Cell Significance Index: -43.8100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6265
Cell Significance Index: -29.2100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.6536
Cell Significance Index: -84.4400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.6614
Cell Significance Index: -45.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6646
Cell Significance Index: -69.2000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6668
Cell Significance Index: -23.4300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7282
Cell Significance Index: -45.9000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8154
Cell Significance Index: -93.4200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.8155
Cell Significance Index: -96.1700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8430
Cell Significance Index: -96.2300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9774
Cell Significance Index: -26.1900 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.9881
Cell Significance Index: -14.0400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.1036
Cell Significance Index: -82.2500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.1173
Cell Significance Index: -58.0400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1606
Cell Significance Index: -91.9200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.1660
Cell Significance Index: -54.8000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3493
Cell Significance Index: -82.7300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.3952
Cell Significance Index: -15.8500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.4732
Cell Significance Index: -21.7500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.4883
Cell Significance Index: -96.0200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.5278
Cell Significance Index: -21.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.5883
Cell Significance Index: -83.3900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.7760
Cell Significance Index: -18.5000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.8194
Cell Significance Index: -30.4500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.8222
Cell Significance Index: -59.6600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.8993
Cell Significance Index: -60.4900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.9192
Cell Significance Index: -50.4700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.9943
Cell Significance Index: -69.3000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -2.1484
Cell Significance Index: -26.7900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -2.1509
Cell Significance Index: -42.5300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -2.2225
Cell Significance Index: -47.1700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -2.2225
Cell Significance Index: -47.3300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.2610
Cell Significance Index: -72.4200 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -2.3424
Cell Significance Index: -25.5200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -2.3667
Cell Significance Index: -64.4200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.3895
Cell Significance Index: -83.7100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2996767760
Symbol: BMPR2_HUMAN
Name: Bone morphogenetic protein receptor type-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7791754
Title: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
PubMed ID: 7791754
PubMed ID: 7644468
Title: Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
PubMed ID: 7644468
PubMed ID: 7673243
Title: Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors.
PubMed ID: 7673243
PubMed ID: 7890683
Title: Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor.
PubMed ID: 7890683
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21791611
Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.
PubMed ID: 21791611
DOI: 10.1128/mcb.05448-11
PubMed ID: 21976273
Title: New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.
PubMed ID: 21976273
DOI: 10.1002/jbmr.532
PubMed ID: 29212066
Title: Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway.
PubMed ID: 29212066
DOI: 10.1159/000485759
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33308444
Title: SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.
PubMed ID: 33308444
PubMed ID: 17094948
Title: High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding.
PubMed ID: 17094948
PubMed ID: 10903931
Title: Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
PubMed ID: 10903931
DOI: 10.1086/303059
PubMed ID: 11015450
Title: Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.
PubMed ID: 11015450
PubMed ID: 10973254
Title: Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension.
PubMed ID: 10973254
DOI: 10.1038/79226
PubMed ID: 11115378
Title: BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.
PubMed ID: 11115378
DOI: 10.1086/316947
PubMed ID: 12358323
Title: BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives.
PubMed ID: 12358323
PubMed ID: 12045205
Title: Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.
PubMed ID: 12045205
PubMed ID: 12446270
Title: Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II.
PubMed ID: 12446270
PubMed ID: 15965979
Title: BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension.
PubMed ID: 15965979
DOI: 10.1002/humu.20200
PubMed ID: 16429395
Title: Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.
PubMed ID: 16429395
DOI: 10.1002/humu.20285
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 24936649
Title: Novel mutations in BMPR2, ACVRL1 and KCNA5 genes and hemodynamic parameters in patients with pulmonary arterial hypertension.
PubMed ID: 24936649
PubMed ID: 25187962
Title: Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations.
PubMed ID: 25187962
PubMed ID: 28507310
Title: Molecular and functional characterization of the BMPR2 gene in Pulmonary Arterial Hypertension.
PubMed ID: 28507310
Sequence Information:
- Length: 1038
- Mass: 115201
- Checksum: 1389923CE574B913
- Sequence:
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEATGQ QDFTQTANGQ ACLIPDVLPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT HRAQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT NSNNNNSNPC SEQDVLAQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD GSSIQIGEST QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV NNNGSNRAVH SKSSTAVYLA EGGTATTMVS KDIGMNCL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.