Details for: BMPR2

Gene ID: 659

Symbol: BMPR2

Ensembl ID: ENSG00000204217

Description: bone morphogenetic protein receptor type 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.54
    Cell Significance Index: 2
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.37
    Cell Significance Index: 2
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.22
    Cell Significance Index: 2
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: hypertrophic chondrocyte (CL0000743)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.98
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMPR2 is a transmembrane receptor serine/threonine kinase, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. The receptor is characterized by its high degree of homology with other TGF-β receptors, but possesses distinct differences in its extracellular and intracellular domains. BMPR2 is a ligand-independent kinase, meaning it can phosphorylate and activate Smad proteins without the presence of its ligand, BMPs. **Pathways and Functions** BMPR2 signaling pathways are crucial for the regulation of various cellular processes, including: 1. **Cell growth and differentiation**: BMPR2 signaling regulates the proliferation and differentiation of cells in various tissues, including the cardiovascular system, lung, and bone. 2. **Cell migration and adhesion**: BMPR2 signaling influences cell migration and adhesion, which are essential for tissue development and repair. 3. **Angiogenesis**: BMPR2 signaling promotes angiogenesis, the formation of new blood vessels, which is critical for tissue growth and development. 4. **Apoptosis**: BMPR2 signaling regulates apoptosis, or programmed cell death, which is essential for maintaining tissue homeostasis. 5. **Inflammation**: BMPR2 signaling modulates inflammatory responses, which are critical for protecting against tissue damage. **Clinical Significance** Mutations in the BMPR2 gene have been identified as a primary cause of: 1. **Pulmonary Arterial Hypertension (PAH)**: A severe and life-threatening disease characterized by high blood pressure in the arteries that supply blood to the lungs. 2. **Idiopathic Pulmonary Arterial Hypertension (IPAH)**: A subtype of PAH with no identifiable underlying cause. 3. **Heritable PAH**: A subtype of PAH caused by genetic mutations in the BMPR2 gene or other genes involved in TGF-β signaling. In addition to its role in PAH, BMPR2 signaling has been implicated in other diseases, including: 1. **Cardiovascular disease**: BMPR2 signaling regulates cardiovascular development and function, and mutations in the BMPR2 gene have been associated with cardiovascular disease. 2. **Osteoporosis**: BMPR2 signaling regulates bone metabolism, and mutations in the BMPR2 gene have been associated with osteoporosis. 3. **Fibrosis**: BMPR2 signaling regulates fibrosis, or excessive scarring, which is a hallmark of various diseases, including PAH and cardiovascular disease. In conclusion, BMPR2 is a critical receptor in the TGF-β superfamily, playing a pivotal role in various cellular processes, including cell growth, differentiation, and development. Mutations in the BMPR2 gene have been identified as a primary cause of PAH, and the receptor's signaling pathways have been implicated in other diseases, including cardiovascular disease, osteoporosis, and fibrosis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.