Map3k20 | ENSMUSG00000004085 | NCBI 65964

Details for: Map3k20

Gene ID: 65964

Symbol: Map3k20

Ensembl ID: ENSMUSG00000004085

Description: mitogen-activated protein kinase kinase kinase 20

Associated with

Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to uv-b
(GO:0071493)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Dna damage checkpoint signaling
(GO:0000077)
Embryonic digit morphogenesis
(GO:0042733)
Gcn2-mediated signaling
(GO:0140469)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Kinase activity
(GO:0016301)
Limb development
(GO:0060173)
Magnesium ion binding
(GO:0000287)
Mapk cascade
(GO:0000165)
Map kinase kinase kinase activity
(GO:0004709)
Metal ion binding
(GO:0046872)
Negative regulation of stress-activated protein kinase signaling cascade
(GO:0070303)
Negative regulation of translation in response to endoplasmic reticulum stress
(GO:1902010)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
P38mapk cascade
(GO:0038066)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mitotic dna damage checkpoint
(GO:1904291)
Positive regulation of programmed cell death
(GO:0043068)
Protein autophosphorylation
(GO:0046777)
Protein kinase activator activity
(GO:0030295)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Pyroptosis
(GO:0070269)
Ribosome binding
(GO:0043022)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Small ribosomal subunit rrna binding
(GO:0070181)
Stalled ribosome sensor activity
(GO:0170011)
Stress-activated mapk cascade
(GO:0051403)
Stress-activated protein kinase signaling cascade
(GO:0031098)
Transferase activity
(GO:0016740)

Other Information

Proteins

Mitogen-activated protein kinase kinase kinase 20
Q3TRG2_MOUSE

Genular Protein ID: 4172908480

Symbol: M3K20_MOUSE

Name: Mitogen-activated protein kinase kinase kinase 20

UniProtKB Accession Codes:

Q9ESL4 Q3V1X8 Q8BR73 Q9ESL3

Database IDs:

Citations:

PubMed ID: 11042189

Title: Identification and characterization of a novel MAP kinase kinase kinase, MLTK.

PubMed ID: 11042189

DOI: 10.1074/jbc.m008595200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26755636

Title: Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.

PubMed ID: 26755636

DOI: 10.1101/gr.199430.115

PubMed ID: 27598200

Title: A novel Zak knockout mouse with a defective ribotoxic stress response.

PubMed ID: 27598200

DOI: 10.3390/toxins8090259

PubMed ID: 32289254

Title: ZAKalpha recognizes stalled ribosomes through partially redundant sensor domains.

PubMed ID: 32289254

DOI: 10.1016/j.molcel.2020.03.021

Sequence Information:

Length: 802
Mass: 91720
Checksum: D431DF8F312A43CC
Sequence:

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 
SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMEHIMTW ATDVAKGMHY 
LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 
LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 
QCWEADAKKR PSFKQIISIL ESMSNDTNLP DQCNSFLHNK AEWRCEIEAT LERLKKLERD 
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYFWVQQ LVRKGESSVE 
MSGYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF KSAIEKLTHD YLNLFHFPPL 
IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT GPQDCKWKMY MEMDGDEVAI TYIKDVTFNT 
SLPDAEILKM TKPPFVMEKW IVGIAEDQTV ECTVTYENDV RTPKLTKHVH SIQWDRTKPQ 
DEVKAVQLAI QTLFSSSEGN PGSRSDSSAD CQWLDTLRMR QIASHTSLQR SQSNPILGSP 
FFPYFANQDS YAAAVRRTQT PVKYQQITPS INPSRSSSPT QYGLSRNFSS LNLSSRDSGF 
SSLNDSSSER GRYSDRSRNK YYRGSVSLNS SPKGRYGGKS QHSTPSRERY SGKFYRLPQS 
ALNTHQSPDF KRSPNDHDRR VPRTIPGMPL HPETASKAGE EESRVSEGGW TKVEYRKKTH 
RQLSAKTSKE RTRGNYRGRR NF

Genular Protein ID: 233353404

Symbol: Q3TRG2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TRG2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 454
Mass: 51366
Checksum: 35C2FC0D729D9395
Sequence:

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 
SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMEHIMTW ATDVAKGMHY 
LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 
LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 
QCWEADAKKR PSFKQIISIL ESMSNDTNLP DQCNSFLHNK AEWRCEIEAT LERLKKLERD 
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LLPLSARMSE ESYFESKTEE SNSAEMSCQI 
TAASNGEGHG MNPGLQAMML MGFGDVFSMN KAGAVLHSGM QINMQAKQNS SKTTCKRRGK 
KVNMALGFSD FDLSEGDDDD HDGDDAENDV DNSE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map3k20

Associated with

Other Information

Identification and characterization of a novel MAP kinase kinase kinase, MLTK. PubMed ID: 11042189

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice. PubMed ID: 26755636

A novel Zak knockout mouse with a defective ribotoxic stress response. PubMed ID: 27598200

ZAKalpha recognizes stalled ribosomes through partially redundant sensor domains. PubMed ID: 32289254

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073