Details for: DDRGK1

Gene ID: 65992

Symbol: DDRGK1

Ensembl ID: ENSG00000198171

Description: DDRGK domain containing 1

Associated with

  • Rhoa gtpase cycle
    (R-HSA-8980692)
  • Rho gtpase cycle
    (R-HSA-9012999)
  • Signaling by rho gtpases
    (R-HSA-194315)
  • Signaling by rho gtpases, miro gtpases and rhobtb3
    (R-HSA-9716542)
  • Signal transduction
    (R-HSA-162582)
  • Cartilage development
    (GO:0051216)
  • Cytoplasm
    (GO:0005737)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of ire1-mediated unfolded protein response
    (GO:1903895)
  • Negative regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032435)
  • Nucleolus
    (GO:0005730)
  • Positive regulation of cell cycle g1/s phase transition
    (GO:1902808)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of i-kappab phosphorylation
    (GO:1903721)
  • Positive regulation of metallopeptidase activity
    (GO:1905050)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of proteasomal protein catabolic process
    (GO:1901800)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of protein localization to endoplasmic reticulum
    (GO:1905552)
  • Positive regulation of rna polymerase ii regulatory region sequence-specific dna binding
    (GO:1905636)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein k69-linked ufmylation
    (GO:1990592)
  • Protein localization to endoplasmic reticulum
    (GO:0070972)
  • Protein ufmylation
    (GO:0071569)
  • Regulation of intracellular estrogen receptor signaling pathway
    (GO:0033146)
  • Regulation of protein stability
    (GO:0031647)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Reticulophagy
    (GO:0061709)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Ubiquitin-like protein ligase binding
    (GO:0044389)

Other Information

Genular Protein ID: 1133366331

Symbol: DDRGK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96HY6 A6NIU5 C9JSZ5 Q9BW47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20036718

Title: Cloning and molecular characterization of Dashurin encoded by C20orf116, a PCI-domain containing protein.

PubMed ID: 20036718

DOI: 10.1016/j.bbagen.2009.12.004

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20018847

Title: A novel type of E3 ligase for the Ufm1 conjugation system.

PubMed ID: 20018847

DOI: 10.1074/jbc.m109.036814

PubMed ID: 20228063

Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.

PubMed ID: 20228063

DOI: 10.1074/jbc.m110.110619

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23675531

Title: DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability.

PubMed ID: 23675531

DOI: 10.1371/journal.pone.0064231

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28263186

Title: Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.

PubMed ID: 28263186

DOI: 10.1172/jci90193

PubMed ID: 28128204

Title: A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability.

PubMed ID: 28128204

DOI: 10.1038/ncomms14186

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

Sequence Information:

  • Length: 314
  • Mass: 35611
  • Checksum: 2190D30B0D6D674A
  • Sequence:
    • MVAPVWYLVA AALLVGFILF LTRSRGRAAS AGQEPLHNEE LAGAGRVAQP GPLEPEEPRA 
GGRPRRRRDL GSRLQAQRRA QRVAWAEADE NEEEAVILAQ EEEGVEKPAE THLSGKIGAK 
KLRKLEEKQA RKAQREAEEA EREERKRLES QREAEWKKEE ERLRLEEEQK EEEERKAREE 
QAQREHEEYL KLKEAFVVEE EGVGETMTEE QSQSFLTEFI NYIKQSKVVL LEDLASQVGL 
RTQDTINRIQ DLLAEGTITG VIDDRGKFIY ITPEELAAVA NFIRQRGRVS IAELAQASNS 
LIAWGRESPA QAPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.