Details for: BMX

Gene ID: 660

Symbol: BMX

Ensembl ID: ENSG00000102010

Description: BMX non-receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.0106
    Cell Significance Index: -8.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.1317
    Cell Significance Index: -8.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.7904
    Cell Significance Index: -8.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6101
    Cell Significance Index: -8.1500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 6.4503
    Cell Significance Index: 65.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8701
    Cell Significance Index: -8.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.6732
    Cell Significance Index: 699.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3895
    Cell Significance Index: -9.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1626
    Cell Significance Index: 101.3000
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.7981
    Cell Significance Index: 16.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5130
    Cell Significance Index: 248.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3275
    Cell Significance Index: 215.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2442
    Cell Significance Index: 135.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.1261
    Cell Significance Index: 16.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7685
    Cell Significance Index: 53.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6485
    Cell Significance Index: 38.9300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.6217
    Cell Significance Index: 7.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5150
    Cell Significance Index: 9.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4629
    Cell Significance Index: 91.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2859
    Cell Significance Index: 4.9000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2715
    Cell Significance Index: 1.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1164
    Cell Significance Index: 3.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1035
    Cell Significance Index: 7.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0877
    Cell Significance Index: 0.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0859
    Cell Significance Index: 2.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0831
    Cell Significance Index: 1.2000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0661
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0480
    Cell Significance Index: 5.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0451
    Cell Significance Index: 0.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0428
    Cell Significance Index: 1.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0422
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0341
    Cell Significance Index: 6.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0300
    Cell Significance Index: 0.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0277
    Cell Significance Index: 3.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0081
    Cell Significance Index: 12.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0054
    Cell Significance Index: 0.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0028
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0004
    Cell Significance Index: 0.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0023
    Cell Significance Index: -0.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0024
    Cell Significance Index: -0.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0043
    Cell Significance Index: -1.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0051
    Cell Significance Index: -0.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0095
    Cell Significance Index: -6.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0106
    Cell Significance Index: -1.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0110
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0171
    Cell Significance Index: -0.8900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0369
    Cell Significance Index: -4.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0380
    Cell Significance Index: -4.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0457
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0517
    Cell Significance Index: -5.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0623
    Cell Significance Index: -8.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0668
    Cell Significance Index: -2.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0687
    Cell Significance Index: -3.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0707
    Cell Significance Index: -9.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0719
    Cell Significance Index: -7.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0830
    Cell Significance Index: -1.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0875
    Cell Significance Index: -8.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0935
    Cell Significance Index: -1.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1075
    Cell Significance Index: -6.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1079
    Cell Significance Index: -2.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1161
    Cell Significance Index: -3.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1206
    Cell Significance Index: -8.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1344
    Cell Significance Index: -8.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1346
    Cell Significance Index: -6.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1483
    Cell Significance Index: -8.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1491
    Cell Significance Index: -6.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1521
    Cell Significance Index: -4.2500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1543
    Cell Significance Index: -2.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1671
    Cell Significance Index: -8.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1727
    Cell Significance Index: -6.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1817
    Cell Significance Index: -8.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1849
    Cell Significance Index: -5.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1889
    Cell Significance Index: -4.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1914
    Cell Significance Index: -4.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1957
    Cell Significance Index: -2.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2025
    Cell Significance Index: -6.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2072
    Cell Significance Index: -2.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2073
    Cell Significance Index: -5.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2221
    Cell Significance Index: -5.9400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.2275
    Cell Significance Index: -1.9300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2277
    Cell Significance Index: -2.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2367
    Cell Significance Index: -8.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2487
    Cell Significance Index: -5.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2563
    Cell Significance Index: -3.6800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2700
    Cell Significance Index: -3.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2794
    Cell Significance Index: -6.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BMX is a non-receptor tyrosine kinase, meaning it does not require the presence of a ligand to activate its tyrosine kinase activity. Unlike receptor tyrosine kinases, BMX is a cytoplasmic enzyme, which allows it to interact with a wide range of signaling molecules. BMX has a unique structure, consisting of an N-terminal domain, a kinase domain, and a C-terminal domain. The kinase domain is responsible for the phosphorylation of tyrosine residues on target proteins. **Pathways and Functions** BMX is involved in various signaling pathways, including: 1. **Apoptosis**: BMX regulates the pro-apoptotic and anti-apoptotic signaling pathways, influencing the survival and death of immune cells. 2. **Cell Adhesion**: BMX interacts with adhesion molecules, regulating the interaction between immune cells and the extracellular matrix. 3. **Metabolism**: BMX is involved in lipid and glucose metabolism, influencing the energy homeostasis of immune cells. 4. **Adaptive Immune Response**: BMX regulates the activation and proliferation of immune cells, including T cells and B cells. BMX also interacts with various signaling molecules, including: 1. **Phosphatidylinositol 3-kinase (PI3K)**: BMX phosphorylates and activates PI3K, leading to the activation of downstream signaling pathways. 2. **Protein kinase C (PKC)**: BMX interacts with PKC, regulating its activity and influencing the immune response. 3. **Nuclear factor kappa B (NF-κB)**: BMX phosphorylates and activates NF-κB, a transcription factor involved in immune regulation. **Clinical Significance** BMX has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: BMX dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: BMX is overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: BMX has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, BMX is a unique non-receptor tyrosine kinase that plays a critical role in the adaptive immune response. Its dysregulation has been linked to various immune-related disorders, highlighting the importance of further research into the functions and clinical significance of BMX.

Genular Protein ID: 1072173694

Symbol: BMX_HUMAN

Name: Cytoplasmic tyrosine-protein kinase BMX

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7970727

Title: BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

PubMed ID: 7970727

PubMed ID: 9520419

Title: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.

PubMed ID: 9520419

DOI: 10.1073/pnas.95.7.3644

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12573241

Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

PubMed ID: 12573241

DOI: 10.1016/s1570-9639(02)00524-1

PubMed ID: 10688651

Title: Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.

PubMed ID: 10688651

DOI: 10.1128/mcb.20.6.2043-2054.2000

PubMed ID: 11331870

Title: Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

PubMed ID: 11331870

DOI: 10.1038/35074500

PubMed ID: 11751885

Title: Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.

PubMed ID: 11751885

DOI: 10.1074/jbc.m108537200

PubMed ID: 11877430

Title: Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking.

PubMed ID: 11877430

DOI: 10.1074/jbc.m111933200

PubMed ID: 12370298

Title: Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis.

PubMed ID: 12370298

DOI: 10.1128/mcb.22.21.7512-7523.2002

PubMed ID: 12832404

Title: p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.

PubMed ID: 12832404

DOI: 10.1074/jbc.m306438200

PubMed ID: 15788485

Title: Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.

PubMed ID: 15788485

DOI: 10.1152/ajpcell.00410.2004

PubMed ID: 18292575

Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.

PubMed ID: 18292575

DOI: 10.4049/jimmunol.180.5.3485

PubMed ID: 11114746

Title: Signaling network of the Btk family kinases.

PubMed ID: 11114746

DOI: 10.1038/sj.onc.1203958

PubMed ID: 11340625

Title: The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.

PubMed ID: 11340625

DOI: 10.1002/bies.1062

PubMed ID: 17624943

Title: Tec kinases, actin, and cell adhesion.

PubMed ID: 17624943

DOI: 10.1111/j.1600-065x.2007.00534.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 675
  • Mass: 78011
  • Checksum: CB22382A3BD02599
  • Sequence:
  • MDTKSILEEL LLKRSQQKKK MSPNNYKERL FVLTKTNLSY YEYDKMKRGS RKGSIEIKKI 
    RCVEKVNLEE QTPVERQYPF QIVYKDGLLY VYASNEESRS QWLKALQKEI RGNPHLLVKY 
    HSGFFVDGKF LCCQQSCKAA PGCTLWEAYA NLHTAVNEEK HRVPTFPDRV LKIPRAVPVL 
    KMDAPSSSTT LAQYDNESKK NYGSQPPSSS TSLAQYDSNS KKIYGSQPNF NMQYIPREDF 
    PDWWQVRKLK SSSSSEDVAS SNQKERNVNH TTSKISWEFP ESSSSEEEEN LDDYDWFAGN 
    ISRSQSEQLL RQKGKEGAFM VRNSSQVGMY TVSLFSKAVN DKKGTVKHYH VHTNAENKLY 
    LAENYCFDSI PKLIHYHQHN SAGMITRLRH PVSTKANKVP DSVSLGNGIW ELKREEITLL 
    KELGSGQFGV VQLGKWKGQY DVAVKMIKEG SMSEDEFFQE AQTMMKLSHP KLVKFYGVCS 
    KEYPIYIVTE YISNGCLLNY LRSHGKGLEP SQLLEMCYDV CEGMAFLESH QFIHRDLAAR 
    NCLVDRDLCV KVSDFGMTRY VLDDQYVSSV GTKFPVKWSA PEVFHYFKYS SKSDVWAFGI 
    LMWEVFSLGK QPYDLYDNSQ VVLKVSQGHR LYRPHLASDT IYQIMYSCWH ELPEKRPTFQ 
    QLLSSIEPLR EKDKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.