BMX | ENSG00000102010 | NCBI 660

Details for: BMX

Gene ID: 660

Symbol: BMX

Ensembl ID: ENSG00000102010

Description: BMX non-receptor tyrosine kinase

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Programmed cell death
(R-HSA-5357801)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
B cell receptor signaling pathway
(GO:0050853)
Cell adhesion
(GO:0007155)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleoplasm
(GO:0005654)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Plasma membrane
(GO:0005886)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Ruffle membrane
(GO:0032587)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cytoplasmic tyrosine-protein kinase BMX

Genular Protein ID: 1072173694

Symbol: BMX_HUMAN

Name: Cytoplasmic tyrosine-protein kinase BMX

UniProtKB Accession Codes:

P51813 A6NIH9 O60564 Q12871

Database IDs:

Citations:

PubMed ID: 7970727

Title: BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

PubMed ID: 7970727

PubMed ID: 9520419

Title: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.

PubMed ID: 9520419

DOI: 10.1073/pnas.95.7.3644

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12573241

Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

PubMed ID: 12573241

DOI: 10.1016/s1570-9639(02)00524-1

PubMed ID: 10688651

Title: Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.

PubMed ID: 10688651

DOI: 10.1128/mcb.20.6.2043-2054.2000

PubMed ID: 11331870

Title: Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

PubMed ID: 11331870

DOI: 10.1038/35074500

PubMed ID: 11751885

Title: Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.

PubMed ID: 11751885

DOI: 10.1074/jbc.m108537200

PubMed ID: 11877430

Title: Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking.

PubMed ID: 11877430

DOI: 10.1074/jbc.m111933200

PubMed ID: 12370298

Title: Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis.

PubMed ID: 12370298

DOI: 10.1128/mcb.22.21.7512-7523.2002

PubMed ID: 12832404

Title: p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.

PubMed ID: 12832404

DOI: 10.1074/jbc.m306438200

PubMed ID: 15788485

Title: Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.

PubMed ID: 15788485

DOI: 10.1152/ajpcell.00410.2004

PubMed ID: 18292575

Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.

PubMed ID: 18292575

DOI: 10.4049/jimmunol.180.5.3485

PubMed ID: 11114746

Title: Signaling network of the Btk family kinases.

PubMed ID: 11114746

DOI: 10.1038/sj.onc.1203958

PubMed ID: 11340625

Title: The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.

PubMed ID: 11340625

DOI: 10.1002/bies.1062

PubMed ID: 17624943

Title: Tec kinases, actin, and cell adhesion.

PubMed ID: 17624943

DOI: 10.1111/j.1600-065x.2007.00534.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 675
Mass: 78011
Checksum: CB22382A3BD02599
Sequence:

MDTKSILEEL LLKRSQQKKK MSPNNYKERL FVLTKTNLSY YEYDKMKRGS RKGSIEIKKI 
RCVEKVNLEE QTPVERQYPF QIVYKDGLLY VYASNEESRS QWLKALQKEI RGNPHLLVKY 
HSGFFVDGKF LCCQQSCKAA PGCTLWEAYA NLHTAVNEEK HRVPTFPDRV LKIPRAVPVL 
KMDAPSSSTT LAQYDNESKK NYGSQPPSSS TSLAQYDSNS KKIYGSQPNF NMQYIPREDF 
PDWWQVRKLK SSSSSEDVAS SNQKERNVNH TTSKISWEFP ESSSSEEEEN LDDYDWFAGN 
ISRSQSEQLL RQKGKEGAFM VRNSSQVGMY TVSLFSKAVN DKKGTVKHYH VHTNAENKLY 
LAENYCFDSI PKLIHYHQHN SAGMITRLRH PVSTKANKVP DSVSLGNGIW ELKREEITLL 
KELGSGQFGV VQLGKWKGQY DVAVKMIKEG SMSEDEFFQE AQTMMKLSHP KLVKFYGVCS 
KEYPIYIVTE YISNGCLLNY LRSHGKGLEP SQLLEMCYDV CEGMAFLESH QFIHRDLAAR 
NCLVDRDLCV KVSDFGMTRY VLDDQYVSSV GTKFPVKWSA PEVFHYFKYS SKSDVWAFGI 
LMWEVFSLGK QPYDLYDNSQ VVLKVSQGHR LYRPHLASDT IYQIMYSCWH ELPEKRPTFQ 
QLLSSIEPLR EKDKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BMX

Associated with

Other Information

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. PubMed ID: 7970727

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. PubMed ID: 9520419

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. PubMed ID: 12573241

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. PubMed ID: 10688651

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. PubMed ID: 11331870

Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. PubMed ID: 11751885

Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. PubMed ID: 11877430

Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. PubMed ID: 12370298

p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. PubMed ID: 12832404

Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems. PubMed ID: 15788485

Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. PubMed ID: 18292575

Signaling network of the Btk family kinases. PubMed ID: 11114746

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. PubMed ID: 11340625

Tec kinases, actin, and cell adhesion. PubMed ID: 17624943

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846