Details for: BMX
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 52.0106
Cell Significance Index: -8.0900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 32.1317
Cell Significance Index: -8.1500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 19.7904
Cell Significance Index: -8.0400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.6101
Cell Significance Index: -8.1500 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 6.4503
Cell Significance Index: 65.0700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.8701
Cell Significance Index: -8.4700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 3.6732
Cell Significance Index: 699.0200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.3895
Cell Significance Index: -9.0800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 3.1626
Cell Significance Index: 101.3000 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.7981
Cell Significance Index: 16.5200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.5130
Cell Significance Index: 248.5900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3275
Cell Significance Index: 215.9000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2442
Cell Significance Index: 135.3400 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.1261
Cell Significance Index: 16.3500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7685
Cell Significance Index: 53.1500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6485
Cell Significance Index: 38.9300 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.6217
Cell Significance Index: 7.8600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.5150
Cell Significance Index: 9.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4629
Cell Significance Index: 91.8700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2859
Cell Significance Index: 4.9000 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.2715
Cell Significance Index: 1.9500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.1164
Cell Significance Index: 3.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1035
Cell Significance Index: 7.9500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0877
Cell Significance Index: 0.5300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.0859
Cell Significance Index: 2.0800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0831
Cell Significance Index: 1.2000 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.0661
Cell Significance Index: 0.2300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0480
Cell Significance Index: 5.9000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0451
Cell Significance Index: 0.6800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0428
Cell Significance Index: 1.0700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0422
Cell Significance Index: 0.6100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0341
Cell Significance Index: 6.8500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0300
Cell Significance Index: 0.6500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0277
Cell Significance Index: 3.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0115
Cell Significance Index: 0.3300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0081
Cell Significance Index: 12.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0054
Cell Significance Index: 0.9700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0051
Cell Significance Index: 0.1800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0028
Cell Significance Index: 0.1900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0022
Cell Significance Index: 4.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0015
Cell Significance Index: 2.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0004
Cell Significance Index: 0.2200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0001
Cell Significance Index: -0.0500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0005
Cell Significance Index: -0.0200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0007
Cell Significance Index: -0.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0007
Cell Significance Index: -0.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0023
Cell Significance Index: -0.4900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0024
Cell Significance Index: -0.6800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0043
Cell Significance Index: -1.5400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0044
Cell Significance Index: -2.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0051
Cell Significance Index: -0.8700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0095
Cell Significance Index: -6.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0105
Cell Significance Index: -7.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0106
Cell Significance Index: -1.5400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0110
Cell Significance Index: -0.1700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0120
Cell Significance Index: -5.4500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0150
Cell Significance Index: -0.3200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0171
Cell Significance Index: -0.8900 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0223
Cell Significance Index: -0.3200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0369
Cell Significance Index: -4.2200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0380
Cell Significance Index: -4.8700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0457
Cell Significance Index: -0.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0517
Cell Significance Index: -5.9300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0623
Cell Significance Index: -8.5600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0668
Cell Significance Index: -2.5300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0687
Cell Significance Index: -3.0400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0707
Cell Significance Index: -9.1300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0719
Cell Significance Index: -7.4900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0830
Cell Significance Index: -1.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0875
Cell Significance Index: -8.9400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0935
Cell Significance Index: -1.3800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1075
Cell Significance Index: -6.5900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1079
Cell Significance Index: -2.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1161
Cell Significance Index: -3.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1206
Cell Significance Index: -8.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1344
Cell Significance Index: -8.2600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1346
Cell Significance Index: -6.9900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1483
Cell Significance Index: -8.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1491
Cell Significance Index: -6.9500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1521
Cell Significance Index: -4.2500 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1543
Cell Significance Index: -2.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1671
Cell Significance Index: -8.7800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1727
Cell Significance Index: -6.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1817
Cell Significance Index: -8.5400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1849
Cell Significance Index: -5.8900 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1889
Cell Significance Index: -4.6100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1914
Cell Significance Index: -4.9200 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1957
Cell Significance Index: -2.4400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2025
Cell Significance Index: -6.6300 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2072
Cell Significance Index: -2.6200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2073
Cell Significance Index: -5.1700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2221
Cell Significance Index: -5.9400 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: -0.2275
Cell Significance Index: -1.9300 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2277
Cell Significance Index: -2.9200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2367
Cell Significance Index: -8.6900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2487
Cell Significance Index: -5.2100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2563
Cell Significance Index: -3.6800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2700
Cell Significance Index: -3.4000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2794
Cell Significance Index: -6.9700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1072173694
Symbol: BMX_HUMAN
Name: Cytoplasmic tyrosine-protein kinase BMX
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7970727
Title: BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
PubMed ID: 7970727
PubMed ID: 9520419
Title: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.
PubMed ID: 9520419
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12573241
Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
PubMed ID: 12573241
PubMed ID: 10688651
Title: Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
PubMed ID: 10688651
PubMed ID: 11331870
Title: Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
PubMed ID: 11331870
DOI: 10.1038/35074500
PubMed ID: 11751885
Title: Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.
PubMed ID: 11751885
PubMed ID: 11877430
Title: Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking.
PubMed ID: 11877430
PubMed ID: 12370298
Title: Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis.
PubMed ID: 12370298
PubMed ID: 12832404
Title: p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.
PubMed ID: 12832404
PubMed ID: 15788485
Title: Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems.
PubMed ID: 15788485
PubMed ID: 18292575
Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.
PubMed ID: 18292575
PubMed ID: 11114746
PubMed ID: 11340625
Title: The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.
PubMed ID: 11340625
DOI: 10.1002/bies.1062
PubMed ID: 17624943
Title: Tec kinases, actin, and cell adhesion.
PubMed ID: 17624943
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 675
- Mass: 78011
- Checksum: CB22382A3BD02599
- Sequence:
MDTKSILEEL LLKRSQQKKK MSPNNYKERL FVLTKTNLSY YEYDKMKRGS RKGSIEIKKI RCVEKVNLEE QTPVERQYPF QIVYKDGLLY VYASNEESRS QWLKALQKEI RGNPHLLVKY HSGFFVDGKF LCCQQSCKAA PGCTLWEAYA NLHTAVNEEK HRVPTFPDRV LKIPRAVPVL KMDAPSSSTT LAQYDNESKK NYGSQPPSSS TSLAQYDSNS KKIYGSQPNF NMQYIPREDF PDWWQVRKLK SSSSSEDVAS SNQKERNVNH TTSKISWEFP ESSSSEEEEN LDDYDWFAGN ISRSQSEQLL RQKGKEGAFM VRNSSQVGMY TVSLFSKAVN DKKGTVKHYH VHTNAENKLY LAENYCFDSI PKLIHYHQHN SAGMITRLRH PVSTKANKVP DSVSLGNGIW ELKREEITLL KELGSGQFGV VQLGKWKGQY DVAVKMIKEG SMSEDEFFQE AQTMMKLSHP KLVKFYGVCS KEYPIYIVTE YISNGCLLNY LRSHGKGLEP SQLLEMCYDV CEGMAFLESH QFIHRDLAAR NCLVDRDLCV KVSDFGMTRY VLDDQYVSSV GTKFPVKWSA PEVFHYFKYS SKSDVWAFGI LMWEVFSLGK QPYDLYDNSQ VVLKVSQGHR LYRPHLASDT IYQIMYSCWH ELPEKRPTFQ QLLSSIEPLR EKDKH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.