Details for: POLR3D

Gene ID: 661

Symbol: POLR3D

Ensembl ID: ENSG00000168495

Description: RNA polymerase III subunit D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.7553
    Cell Significance Index: -20.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.6039
    Cell Significance Index: -16.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.4877
    Cell Significance Index: -22.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.4792
    Cell Significance Index: -18.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.6000
    Cell Significance Index: -21.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4808
    Cell Significance Index: -20.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5600
    Cell Significance Index: -21.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2748
    Cell Significance Index: -13.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.5906
    Cell Significance Index: 57.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6730
    Cell Significance Index: -5.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6798
    Cell Significance Index: 116.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4266
    Cell Significance Index: 38.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2418
    Cell Significance Index: 13.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2146
    Cell Significance Index: 120.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8920
    Cell Significance Index: 12.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8458
    Cell Significance Index: 92.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7954
    Cell Significance Index: 16.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6715
    Cell Significance Index: 109.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6618
    Cell Significance Index: 30.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5947
    Cell Significance Index: 17.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4784
    Cell Significance Index: 24.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4082
    Cell Significance Index: 56.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3813
    Cell Significance Index: 10.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3455
    Cell Significance Index: 68.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3182
    Cell Significance Index: 39.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3002
    Cell Significance Index: 163.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2557
    Cell Significance Index: 16.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2519
    Cell Significance Index: 45.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2454
    Cell Significance Index: 169.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2381
    Cell Significance Index: 11.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2368
    Cell Significance Index: 5.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2248
    Cell Significance Index: 29.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2224
    Cell Significance Index: 10.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2178
    Cell Significance Index: 41.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2084
    Cell Significance Index: 92.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1564
    Cell Significance Index: 9.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1339
    Cell Significance Index: 3.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1157
    Cell Significance Index: 8.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0999
    Cell Significance Index: 3.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0925
    Cell Significance Index: 18.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0874
    Cell Significance Index: 78.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0582
    Cell Significance Index: 20.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0416
    Cell Significance Index: 5.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0264
    Cell Significance Index: 1.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0202
    Cell Significance Index: -0.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0226
    Cell Significance Index: -14.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0343
    Cell Significance Index: -1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0369
    Cell Significance Index: -16.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0399
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0423
    Cell Significance Index: -26.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0512
    Cell Significance Index: -14.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0544
    Cell Significance Index: -1.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0588
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0590
    Cell Significance Index: -10.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0662
    Cell Significance Index: -7.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0795
    Cell Significance Index: -1.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0850
    Cell Significance Index: -6.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0883
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0940
    Cell Significance Index: -13.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0973
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1206
    Cell Significance Index: -25.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1291
    Cell Significance Index: -0.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1363
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1363
    Cell Significance Index: -15.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1479
    Cell Significance Index: -1.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1522
    Cell Significance Index: -1.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1616
    Cell Significance Index: -9.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1628
    Cell Significance Index: -8.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1637
    Cell Significance Index: -5.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2009
    Cell Significance Index: -2.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2072
    Cell Significance Index: -21.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2297
    Cell Significance Index: -12.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2327
    Cell Significance Index: -18.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2330
    Cell Significance Index: -4.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2377
    Cell Significance Index: -6.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2492
    Cell Significance Index: -15.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2678
    Cell Significance Index: -3.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2875
    Cell Significance Index: -19.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3160
    Cell Significance Index: -4.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3178
    Cell Significance Index: -8.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3289
    Cell Significance Index: -14.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3993
    Cell Significance Index: -15.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4237
    Cell Significance Index: -8.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4339
    Cell Significance Index: -17.7800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4615
    Cell Significance Index: -3.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4841
    Cell Significance Index: -14.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5025
    Cell Significance Index: -11.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5075
    Cell Significance Index: -18.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of RNA Polymerase III:** The POLR3D gene is a subunit of the RNA polymerase III complex, which is responsible for transcribing genes involved in ribosomal RNA synthesis, transfer RNA production, and some small nuclear RNAs. 2. **Significant Expression in Immune Cells:** POLR3D is expressed in various immune cells, including male germ cells, proerythroblasts, and intestinal crypt stem cells, suggesting its involvement in immune response and development. 3. **Cellular Localization:** The gene is localized in the cytosol, where it interacts with other transcription factors and chromatin components to regulate gene expression. 4. **Regulation of Innate Immune Response:** POLR3D is involved in the positive regulation of innate immune response and interferon-beta production, highlighting its role in initiating an immune response against pathogens. **Pathways and Functions:** 1. **Chromatin Binding:** POLR3D interacts with histone proteins and other chromatin components to regulate gene expression and maintain chromatin structure. 2. **Cytosol:** The gene is localized in the cytosol, where it interacts with other transcription factors and signaling molecules to regulate gene expression. 3. **Innate Immune Response:** POLR3D is involved in the positive regulation of innate immune response and interferon-beta production, highlighting its role in initiating an immune response against pathogens. 4. **Transcriptional Regulation:** The gene plays a critical role in regulating the expression of genes involved in ribosomal RNA synthesis, transfer RNA production, and small nuclear RNA synthesis. **Clinical Significance:** 1. **Immune System Disorders:** Abnormalities in the POLR3D gene have been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer:** The gene's role in regulating gene expression and maintaining cellular homeostasis makes it a potential target for cancer therapy. 3. **Neurological Disorders:** POLR3D's involvement in the regulation of gene expression in the nervous system makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental Disorders:** The gene's role in regulating gene expression during development makes it a potential target for the treatment of developmental disorders, such as birth defects and genetic disorders. In conclusion, the POLR3D gene plays a critical role in regulating gene expression and maintaining cellular homeostasis, particularly in the context of immune response and development. Further studies are needed to fully elucidate the functions and clinical significance of this gene.

Genular Protein ID: 3468025987

Symbol: RPC4_HUMAN

Name: DNA-directed RNA polymerase III subunit RPC4

UniProtKB Accession Codes:

P05423 Q6FI28 Q9BPV7 Q9BPZ1 Q9BXB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 14 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3683386

Title: Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.

PubMed ID: 3683386

DOI: 10.1128/mcb.7.10.3386-3393.1987

PubMed ID: 12391170

Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.

PubMed ID: 12391170

DOI: 10.1128/mcb.22.22.8044-8055.2002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279001

Title: Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex.

PubMed ID: 11279001

DOI: 10.1074/jbc.m100088200

PubMed ID: 19631370

Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

PubMed ID: 19631370

DOI: 10.1016/j.cell.2009.06.015

PubMed ID: 19609254

Title: RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

PubMed ID: 19609254

DOI: 10.1038/ni.1779

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35637192

Title: A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A non-coding RNA.

PubMed ID: 35637192

DOI: 10.1038/s41467-022-30323-6

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

Sequence Information:

  • Length: 398
  • Mass: 44396
  • Checksum: CD8AFF3257B78410
  • Sequence:
    • MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP 
NIISRKIKEE PKEEVTVKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK 
GNWDKTVDVS DMGPSHIINI KKEKRETDEE TKQILRMLEK DDFLDDPGLR NDTRNMPVQL 
PLAHSGWLFK EENDEPDVKP WLAGPKEEDM EVDIPAVKVK EEPRDEEEEA KMKAPPKAAR 
KTPGLPKDVS VAELLRELSL TKEEELLFLQ LPDTLPGQPP TQDIKPIKTE VQGEDGQVVL 
IKQEKDREAK LAENACTLAD LTEGQVGKLL IRKSGRVQLL LGKVTLDVTM GTACSFLQEL 
VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.