Details for: POLR3D

Gene ID: 661

Symbol: POLR3D

Ensembl ID: ENSG00000168495

Description: RNA polymerase III subunit D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.19
    Marker Score: 343
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.15
    Marker Score: 1436.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.14
    Marker Score: 1638.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 751
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71728
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47953
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.99
    Marker Score: 281
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.94
    Marker Score: 1004
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.92
    Marker Score: 31318
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.9
    Marker Score: 450
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2703
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.86
    Marker Score: 3170
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4855
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.82
    Marker Score: 3342
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 876
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.81
    Marker Score: 432
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.81
    Marker Score: 1974
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.8
    Marker Score: 457
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.79
    Marker Score: 841
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.79
    Marker Score: 3393
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.78
    Marker Score: 518
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.77
    Marker Score: 8630
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.76
    Marker Score: 810
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.75
    Marker Score: 412
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.74
    Marker Score: 745
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.74
    Marker Score: 580
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.73
    Marker Score: 806
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.72
    Marker Score: 1063
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.72
    Marker Score: 762
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11243
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7
    Marker Score: 1658
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.7
    Marker Score: 478
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7
    Marker Score: 445
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.69
    Marker Score: 730
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.69
    Marker Score: 1064
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.69
    Marker Score: 332
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.68
    Marker Score: 4443
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.68
    Marker Score: 8943
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.67
    Marker Score: 1190
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.67
    Marker Score: 1528
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 603
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2756
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.65
    Marker Score: 1354
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.65
    Marker Score: 890
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.63
    Marker Score: 220
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.61
    Marker Score: 385
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.61
    Marker Score: 2974
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.6
    Marker Score: 567
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.6
    Marker Score: 377
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.58
    Marker Score: 20142
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.58
    Marker Score: 153
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1355
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.57
    Marker Score: 137
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.57
    Marker Score: 171
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1543
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.56
    Marker Score: 1364.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.55
    Marker Score: 5595
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.55
    Marker Score: 617
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.55
    Marker Score: 227
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 359
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.54
    Marker Score: 210
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.54
    Marker Score: 396
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.53
    Marker Score: 262
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.53
    Marker Score: 906.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.53
    Marker Score: 125
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.53
    Marker Score: 928
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 424
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.53
    Marker Score: 178
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.53
    Marker Score: 131
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.52
    Marker Score: 281
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.52
    Marker Score: 131
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 237
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.51
    Marker Score: 361
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.5
    Marker Score: 474
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.5
    Marker Score: 178
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5
    Marker Score: 5022
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.5
    Marker Score: 160
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.5
    Marker Score: 172
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.49
    Marker Score: 336
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 438
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.49
    Marker Score: 650
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.48
    Marker Score: 97
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.48
    Marker Score: 1010.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * POLR3D is a highly conserved gene, with a similar sequence found in mammals, birds, and fish. * It is located on chromosome 17q21.1 in humans. * It encodes a protein of approximately 650 amino acids, which is a key component of the RNA polymerase III complex. **Pathways and functions:** * POLR3D is involved in the regulation of innate immune responses to viruses. * It is a key factor in the induction of type I interferons, which are important mediators of innate immune responses. * It also plays a role in the regulation of type II interferons, which are involved in the antiviral response. * POLR3D is also involved in the regulation of inflammation and tissue repair. **Clinical significance:** * Mutations in POLR3D have been linked to the development of several autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). * These diseases are characterized by inflammation and tissue damage, and mutations in POLR3D have been shown to be responsible for the development of these conditions. * Therefore, POLR3D is a promising target for the treatment of autoimmune diseases. **Additional notes:** * POLR3D is a highly dynamic gene, and its expression is regulated by various factors, including cytokines, growth factors, and environmental cues. * It is also involved in the regulation of cell cycle progression and apoptosis. * POLR3D is a complex protein that interacts with other proteins to form the RNA polymerase III complex.

Genular Protein ID: 3468025987

Symbol: RPC4_HUMAN

Name: DNA-directed RNA polymerase III subunit RPC4

UniProtKB Accession Codes:

P05423 Q6FI28 Q9BPV7 Q9BPZ1 Q9BXB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 14 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 13 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3683386

Title: Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.

PubMed ID: 3683386

DOI: 10.1128/mcb.7.10.3386-3393.1987

PubMed ID: 12391170

Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.

PubMed ID: 12391170

DOI: 10.1128/mcb.22.22.8044-8055.2002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279001

Title: Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex.

PubMed ID: 11279001

DOI: 10.1074/jbc.m100088200

PubMed ID: 19631370

Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

PubMed ID: 19631370

DOI: 10.1016/j.cell.2009.06.015

PubMed ID: 19609254

Title: RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

PubMed ID: 19609254

DOI: 10.1038/ni.1779

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35637192

Title: A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A non-coding RNA.

PubMed ID: 35637192

DOI: 10.1038/s41467-022-30323-6

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

Sequence Information:

  • Length: 398
  • Mass: 44396
  • Checksum: CD8AFF3257B78410
  • Sequence:
    • MSEGNAAGEP STPGGPRPLL TGARGLIGRR PAPPLTPGRL PSIRSRDLTL GGVKKKTFTP 
NIISRKIKEE PKEEVTVKKE KRERDRDRQR EGHGRGRGRP EVIQSHSIFE QGPAEMMKKK 
GNWDKTVDVS DMGPSHIINI KKEKRETDEE TKQILRMLEK DDFLDDPGLR NDTRNMPVQL 
PLAHSGWLFK EENDEPDVKP WLAGPKEEDM EVDIPAVKVK EEPRDEEEEA KMKAPPKAAR 
KTPGLPKDVS VAELLRELSL TKEEELLFLQ LPDTLPGQPP TQDIKPIKTE VQGEDGQVVL 
IKQEKDREAK LAENACTLAD LTEGQVGKLL IRKSGRVQLL LGKVTLDVTM GTACSFLQEL 
VSVGLGDSRT GEMTVLGHVK HKLVCSPDFE SLLDHKHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.