Details for: BNIP1

Gene ID: 662

Symbol: BNIP1

Ensembl ID: ENSG00000113734

Description: BCL2 interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.7903
    Cell Significance Index: -10.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.7084
    Cell Significance Index: -11.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 31.3875
    Cell Significance Index: -12.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.3318
    Cell Significance Index: -11.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2546
    Cell Significance Index: -11.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1869
    Cell Significance Index: -12.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3675
    Cell Significance Index: -11.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2919
    Cell Significance Index: -12.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8618
    Cell Significance Index: -8.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7686
    Cell Significance Index: 273.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2387
    Cell Significance Index: 36.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1019
    Cell Significance Index: 994.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0172
    Cell Significance Index: 61.0700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8643
    Cell Significance Index: 12.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8044
    Cell Significance Index: 130.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5626
    Cell Significance Index: 35.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5537
    Cell Significance Index: 64.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3819
    Cell Significance Index: 26.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3588
    Cell Significance Index: 7.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3282
    Cell Significance Index: 17.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3137
    Cell Significance Index: 3.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2935
    Cell Significance Index: 8.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2715
    Cell Significance Index: 7.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2119
    Cell Significance Index: 9.8800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1903
    Cell Significance Index: 2.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1888
    Cell Significance Index: 12.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1810
    Cell Significance Index: 80.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1772
    Cell Significance Index: 8.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1651
    Cell Significance Index: 32.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1608
    Cell Significance Index: 87.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1456
    Cell Significance Index: 19.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1449
    Cell Significance Index: 29.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1431
    Cell Significance Index: 10.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1329
    Cell Significance Index: 10.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1218
    Cell Significance Index: 21.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1150
    Cell Significance Index: 3.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1126
    Cell Significance Index: 13.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1045
    Cell Significance Index: 13.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1004
    Cell Significance Index: 4.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0966
    Cell Significance Index: 18.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0962
    Cell Significance Index: 3.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0922
    Cell Significance Index: 6.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0922
    Cell Significance Index: 33.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0918
    Cell Significance Index: 11.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0841
    Cell Significance Index: 2.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0727
    Cell Significance Index: 1.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0586
    Cell Significance Index: 1.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0573
    Cell Significance Index: 2.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0521
    Cell Significance Index: 1.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0381
    Cell Significance Index: 2.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0380
    Cell Significance Index: 0.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0342
    Cell Significance Index: 23.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0286
    Cell Significance Index: 4.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0272
    Cell Significance Index: 0.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0168
    Cell Significance Index: 2.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0104
    Cell Significance Index: 0.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0034
    Cell Significance Index: 2.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0118
    Cell Significance Index: -7.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0214
    Cell Significance Index: -12.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0230
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0247
    Cell Significance Index: -15.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0288
    Cell Significance Index: -8.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0394
    Cell Significance Index: -5.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0515
    Cell Significance Index: -1.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0631
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0680
    Cell Significance Index: -14.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0711
    Cell Significance Index: -1.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0712
    Cell Significance Index: -0.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1049
    Cell Significance Index: -2.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1116
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1151
    Cell Significance Index: -3.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1173
    Cell Significance Index: -1.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1203
    Cell Significance Index: -12.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1217
    Cell Significance Index: -7.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1246
    Cell Significance Index: -1.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1286
    Cell Significance Index: -8.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1368
    Cell Significance Index: -8.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1393
    Cell Significance Index: -11.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1459
    Cell Significance Index: -3.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1568
    Cell Significance Index: -2.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1758
    Cell Significance Index: -3.8500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1839
    Cell Significance Index: -1.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1847
    Cell Significance Index: -8.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2194
    Cell Significance Index: -3.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2287
    Cell Significance Index: -8.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2776
    Cell Significance Index: -10.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2866
    Cell Significance Index: -10.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2996
    Cell Significance Index: -9.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3042
    Cell Significance Index: -9.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BNIP1 is a pro-apoptotic gene that belongs to the BCL2 family of proteins. It is characterized by its ability to interact with BCL2, inhibiting its anti-apoptotic activity and promoting cell death. BNIP1 is also involved in regulating cellular stress responses, including endoplasmic reticulum (ER) stress and mitochondrial membrane fragmentation. Its expression is tightly regulated by various signaling pathways, including calcium-mediated signaling and the unfolded protein response (UPR). **Pathways and Functions:** BNIP1 plays a crucial role in various cellular pathways, including: 1. **Apoptotic Process:** BNIP1 interacts with BCL2 to modulate its activity, promoting cell death in response to various cellular stresses. 2. **Calcium-Mediated Signaling:** BNIP1 is involved in calcium-induced calcium release activity, regulating intracellular calcium levels and modulating cellular responses. 3. **Membrane Trafficking:** BNIP1 is involved in vesicle-mediated transport, regulating the movement of vesicles between the Golgi apparatus and the ER. 4. **Organelle Organization:** BNIP1 regulates the organization of ER and Golgi apparatus, maintaining cellular homeostasis. 5. **Endoplasmic Reticulum Stress:** BNIP1 is involved in regulating ER stress responses, including the unfolded protein response (UPR). **Clinical Significance:** BNIP1 dysregulation has been implicated in various diseases, including: 1. **Cancer:** BNIP1 is often downregulated in cancer cells, leading to increased cell survival and tumor progression. 2. **Cardiovascular Disorders:** BNIP1 has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 3. **Neurodegenerative Diseases:** BNIP1 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Gastrointestinal Disorders:** BNIP1 has been implicated in gastrointestinal disorders, including inflammatory bowel disease and colon cancer. In conclusion, BNIP1 is a critical regulator of apoptosis, cellular stress, and membrane trafficking. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying BNIP1 function and its role in human disease.

Genular Protein ID: 4151554329

Symbol: SEC20_HUMAN

Name: Vesicle transport protein SEC20

UniProtKB Accession Codes:

Q12981 D3DQM3 D3DQM4 D3DQM5 D3DQM6 O75622 O75623 O75624 Q6K044 Q96FG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 10217402

Title: Novel BNIP1 variants and their interaction with BCL2 family members.

PubMed ID: 10217402

DOI: 10.1016/s0014-5793(99)00335-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15272311

Title: Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.

PubMed ID: 15272311

DOI: 10.1038/sj.emboj.7600333

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21931693

Title: RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.

PubMed ID: 21931693

DOI: 10.1371/journal.pone.0024367

PubMed ID: 23896122

Title: A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1.

PubMed ID: 23896122

DOI: 10.1016/j.cellsig.2013.07.016

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 228
  • Mass: 26132
  • Checksum: 23F4C21E7327DE3D
  • Sequence:
    • MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSAL TELNTKVKEK FQQLRHRIQD 
LEQLAKEQDK ESEKQLLLQE VENHKKQMLS NQASWRKANL TCKIAIDNLE KAELLQGGDL 
LRQRKTTKES LAQTSSTITE SLMGISRMMA QQVQQSEEAM QSLVTSSRTI LDANEEFKSM 
SGTIQLGRKL ITKYNRRELT DKLLIFLALA LFLATVLYIV KKRLFPFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.