Details for: BNIP1

Gene ID: 662

Symbol: BNIP1

Ensembl ID: ENSG00000113734

Description: BCL2 interacting protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168880
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.39
    Marker Score: 2425
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17495
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71753
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47978
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2716
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4953
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.82
    Marker Score: 660
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.77
    Marker Score: 277
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2790
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.69
    Marker Score: 1456
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2847
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 460
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 970
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.64
    Marker Score: 2372
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 785
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.59
    Marker Score: 446
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 391
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.59
    Marker Score: 355
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3499
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 369
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.57
    Marker Score: 361
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 749
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.53
    Marker Score: 389
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.53
    Marker Score: 213
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1066
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.51
    Marker Score: 1400
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1170
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.49
    Marker Score: 876
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.49
    Marker Score: 138
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.49
    Marker Score: 172
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.49
    Marker Score: 489
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 291
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.48
    Marker Score: 1169
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.47
    Marker Score: 255
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1289
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.47
    Marker Score: 507
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.47
    Marker Score: 753
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.46
    Marker Score: 289
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.46
    Marker Score: 158
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.45
    Marker Score: 479
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.44
    Marker Score: 132
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.43
    Marker Score: 525
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.43
    Marker Score: 463
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 413
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.43
    Marker Score: 209
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.43
    Marker Score: 420
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.43
    Marker Score: 380
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.43
    Marker Score: 2722
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.42
    Marker Score: 195
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.42
    Marker Score: 172
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.42
    Marker Score: 104
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.42
    Marker Score: 306
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.42
    Marker Score: 691
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.41
    Marker Score: 981
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.41
    Marker Score: 430
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.41
    Marker Score: 654
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.41
    Marker Score: 90
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.41
    Marker Score: 292
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.41
    Marker Score: 198
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.41
    Marker Score: 226
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 170
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.41
    Marker Score: 384
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4
    Marker Score: 4142
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.4
    Marker Score: 266
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.39
    Marker Score: 4002
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.39
    Marker Score: 409
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.39
    Marker Score: 393
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.39
    Marker Score: 601
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.39
    Marker Score: 143
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.38
    Marker Score: 204
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.38
    Marker Score: 405
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.38
    Marker Score: 196
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 560
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.38
    Marker Score: 621
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.38
    Marker Score: 4972
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.37
    Marker Score: 205
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.37
    Marker Score: 397
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.37
    Marker Score: 245
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.37
    Marker Score: 74
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.37
    Marker Score: 1416
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.36
    Marker Score: 333

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Other Information

## Summary BNIP1 is a protein involved in the regulation of apoptosis, a process where cells die on their own. It is a key regulator of the mitochondrial outer membrane permeabilization (MOMP) pathway, a critical process that triggers apoptosis in response to mitochondrial fragmentation. ## Key characteristics * BNIP1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the BNIP family of proteins, which are involved in the regulation of apoptosis and cell cycle progression. * BNIP1 is expressed in a variety of cell types, including mural cells, germ cells, cardiac muscle myoblasts, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, intestinal crypt stem cells of colon, tuft cells of colon, and human cells. ## Pathways and functions * BNIP1 is a key regulator of the MOMP pathway. * The MOMP pathway is a critical process that triggers apoptosis in response to mitochondrial fragmentation. * BNIP1 interacts with the MOMP pathway adaptor protein Apaf-1 and facilitates its interaction with Apaf-1. * This interaction triggers the activation of the caspase cascade, leading to apoptosis. * BNIP1 also regulates the mitochondrial outer membrane permeabilization (MOMP) pathway indirectly. * By regulating the MOMP pathway, BNIP1 helps to protect cells from apoptosis in response to mitochondrial fragmentation. ## Clinical significance BNIP1 gene mutations have been linked to a number of human diseases, including cancer and neurodegenerative disorders. These mutations can lead to the activation of the MOMP pathway and the subsequent death of cells. Therefore, BNIP1 is a potential therapeutic target for cancer and neurodegenerative disorders.

Genular Protein ID: 4151554329

Symbol: SEC20_HUMAN

Name: Vesicle transport protein SEC20

UniProtKB Accession Codes:

Q12981 D3DQM3 D3DQM4 D3DQM5 D3DQM6 O75622 O75623 O75624 Q6K044 Q96FG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 10217402

Title: Novel BNIP1 variants and their interaction with BCL2 family members.

PubMed ID: 10217402

DOI: 10.1016/s0014-5793(99)00335-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15272311

Title: Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.

PubMed ID: 15272311

DOI: 10.1038/sj.emboj.7600333

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21931693

Title: RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.

PubMed ID: 21931693

DOI: 10.1371/journal.pone.0024367

PubMed ID: 23896122

Title: A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1.

PubMed ID: 23896122

DOI: 10.1016/j.cellsig.2013.07.016

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 228
  • Mass: 26132
  • Checksum: 23F4C21E7327DE3D
  • Sequence:
    • MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSAL TELNTKVKEK FQQLRHRIQD 
LEQLAKEQDK ESEKQLLLQE VENHKKQMLS NQASWRKANL TCKIAIDNLE KAELLQGGDL 
LRQRKTTKES LAQTSSTITE SLMGISRMMA QQVQQSEEAM QSLVTSSRTI LDANEEFKSM 
SGTIQLGRKL ITKYNRRELT DKLLIFLALA LFLATVLYIV KKRLFPFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.