Details for: BNIP2

Gene ID: 663

Symbol: BNIP2

Ensembl ID: ENSG00000140299

Description: BCL2 interacting protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.4427
    Cell Significance Index: -33.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.6706
    Cell Significance Index: -30.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 105.8630
    Cell Significance Index: -43.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.9430
    Cell Significance Index: -36.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.3970
    Cell Significance Index: -40.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.9097
    Cell Significance Index: -40.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.0114
    Cell Significance Index: -40.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.6491
    Cell Significance Index: -36.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.9930
    Cell Significance Index: -36.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0443
    Cell Significance Index: -32.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0278
    Cell Significance Index: -30.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7693
    Cell Significance Index: -38.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3759
    Cell Significance Index: -20.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1945
    Cell Significance Index: 40.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4659
    Cell Significance Index: 39.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4636
    Cell Significance Index: 1321.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1462
    Cell Significance Index: 140.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0534
    Cell Significance Index: 189.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0214
    Cell Significance Index: 65.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9498
    Cell Significance Index: 10.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9298
    Cell Significance Index: 48.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7922
    Cell Significance Index: 14.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7899
    Cell Significance Index: 85.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7791
    Cell Significance Index: 22.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7672
    Cell Significance Index: 90.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7420
    Cell Significance Index: 120.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7037
    Cell Significance Index: 20.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6894
    Cell Significance Index: 136.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6761
    Cell Significance Index: 92.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6539
    Cell Significance Index: 17.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6483
    Cell Significance Index: 30.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5977
    Cell Significance Index: 12.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5665
    Cell Significance Index: 35.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5437
    Cell Significance Index: 240.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5222
    Cell Significance Index: 104.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4992
    Cell Significance Index: 63.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4744
    Cell Significance Index: 28.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4576
    Cell Significance Index: 13.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4243
    Cell Significance Index: 22.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4053
    Cell Significance Index: 221.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3753
    Cell Significance Index: 17.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3509
    Cell Significance Index: 24.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2921
    Cell Significance Index: 20.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2902
    Cell Significance Index: 200.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2823
    Cell Significance Index: 27.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2765
    Cell Significance Index: 99.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2647
    Cell Significance Index: 34.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1975
    Cell Significance Index: 11.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1810
    Cell Significance Index: 4.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1351
    Cell Significance Index: 1.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1103
    Cell Significance Index: 2.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0962
    Cell Significance Index: 3.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0834
    Cell Significance Index: 15.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0588
    Cell Significance Index: 4.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0435
    Cell Significance Index: 3.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0421
    Cell Significance Index: 79.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0089
    Cell Significance Index: 16.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0131
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0218
    Cell Significance Index: -13.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0221
    Cell Significance Index: -30.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0238
    Cell Significance Index: -14.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0284
    Cell Significance Index: -21.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0288
    Cell Significance Index: -2.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0310
    Cell Significance Index: -22.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0490
    Cell Significance Index: -27.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0528
    Cell Significance Index: -23.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0938
    Cell Significance Index: -4.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1269
    Cell Significance Index: -26.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1410
    Cell Significance Index: -2.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1467
    Cell Significance Index: -4.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1631
    Cell Significance Index: -19.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1833
    Cell Significance Index: -26.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1891
    Cell Significance Index: -21.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2201
    Cell Significance Index: -7.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2674
    Cell Significance Index: -17.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2722
    Cell Significance Index: -31.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2786
    Cell Significance Index: -7.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2796
    Cell Significance Index: -4.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2990
    Cell Significance Index: -4.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3019
    Cell Significance Index: -2.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3035
    Cell Significance Index: -2.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3142
    Cell Significance Index: -15.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3292
    Cell Significance Index: -34.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3493
    Cell Significance Index: -7.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3839
    Cell Significance Index: -20.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4114
    Cell Significance Index: -13.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4186
    Cell Significance Index: -8.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4332
    Cell Significance Index: -12.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4682
    Cell Significance Index: -37.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5030
    Cell Significance Index: -12.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5493
    Cell Significance Index: -33.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5852
    Cell Significance Index: -35.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6357
    Cell Significance Index: -28.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6359
    Cell Significance Index: -13.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7157
    Cell Significance Index: -16.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7269
    Cell Significance Index: -18.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7392
    Cell Significance Index: -10.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BNIP2 is a protein that interacts with BCL2, a key regulator of apoptosis. This interaction modulates BCL2's anti-apoptotic activity, leading to either cell survival or apoptosis, depending on the cellular context. BNIP2's ability to regulate BCL2's activity is crucial in maintaining cellular homeostasis and responding to various stressors, such as oxygen-glucose deprivation. BNIP2 is also involved in myogenesis, a process of muscle cell differentiation, and developmental biology, where it regulates cellular growth and differentiation. Its expression is observed in various cell types, including CD14-positive monocytes, blood cells, and epithelial cells of the urethra. **Pathways and Functions:** BNIP2's primary function is to regulate apoptosis by modulating BCL2's activity. This interaction occurs through BCL2's binding to BNIP2, leading to either the inhibition or activation of BCL2's anti-apoptotic activity. The outcome of this interaction depends on the cellular context, with BNIP2 promoting cell survival in some cases and inducing apoptosis in others. BNIP2's involvement in myogenesis and developmental biology highlights its role in regulating cellular growth and differentiation. Its expression in CD14-positive monocytes and blood cells suggests its involvement in immune responses and cellular homeostasis. **Clinical Significance:** BNIP2's involvement in regulating apoptosis and cell survival makes it a potential therapeutic target for various diseases, including cancer and neurodegenerative disorders. Its role in myogenesis and developmental biology also suggests its potential in treating muscle-related disorders and developmental abnormalities. Furthermore, BNIP2's expression in various cell types and its involvement in immune responses make it a potential biomarker for diagnosing and monitoring diseases, such as cancer and inflammatory disorders. In conclusion, BNIP2's dual role in regulating cell survival and apoptosis highlights its significance in maintaining cellular homeostasis. Its involvement in various cellular processes, including myogenesis and developmental biology, suggests its potential in treating a range of diseases. Further research is needed to fully elucidate BNIP2's role in human health and disease, but its potential as a therapeutic target and biomarker makes it an exciting area of investigation.

Genular Protein ID: 1213419395

Symbol: BNIP2_HUMAN

Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

UniProtKB Accession Codes:

Q12982 B4DS94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 314
  • Mass: 36018
  • Checksum: 0A3CEC636569DD2F
  • Sequence:
    • MEGVELKEEW QDEDFPIPLP EDDSIEADIL AITGPEDQPG SLEVNGNKVR KKLMAPDISL 
TLDPSDGSVL SDDLDESGEI DLDGLDTPSE NSNEFEWEDD LPKPKTTEVI RKGSITEYTA 
AEEKEDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESSQ 
PNYRYLMDNL FKYVIGTLEL LVAENYMIVY LNGATTRRKM PSLGWLRKCY QQIDRRLRKN 
LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQVD 
QELNGKQDEP KNEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.