Details for: BNIP2

Gene ID: 663

Symbol: BNIP2

Ensembl ID: ENSG00000140299

Description: BCL2 interacting protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.94
    Marker Score: 108733
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.87
    Marker Score: 21724
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.75
    Marker Score: 44938
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.75
    Marker Score: 3659
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.72
    Marker Score: 4273
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.65
    Marker Score: 1302.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.63
    Marker Score: 1961.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.62
    Marker Score: 3237
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.6
    Marker Score: 1828
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.59
    Marker Score: 3100
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.56
    Marker Score: 942
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.55
    Marker Score: 1525
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.55
    Marker Score: 52636
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.52
    Marker Score: 1102
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.48
    Marker Score: 1326
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.44
    Marker Score: 511
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.44
    Marker Score: 792
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.43
    Marker Score: 2110
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.43
    Marker Score: 1428
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.41
    Marker Score: 546
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.4
    Marker Score: 3801
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.4
    Marker Score: 602
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.39
    Marker Score: 3423
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.39
    Marker Score: 2011
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.37
    Marker Score: 3349
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.36
    Marker Score: 1387
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.36
    Marker Score: 813
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.36
    Marker Score: 326
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.36
    Marker Score: 1275
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.35
    Marker Score: 1220
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.34
    Marker Score: 321
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.34
    Marker Score: 5742
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.34
    Marker Score: 1428
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.33
    Marker Score: 840
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.33
    Marker Score: 1603
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.32
    Marker Score: 2309
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.32
    Marker Score: 965
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.32
    Marker Score: 3365.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.32
    Marker Score: 13365
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.32
    Marker Score: 325
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.31
    Marker Score: 5157
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.31
    Marker Score: 69158
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.31
    Marker Score: 1148
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.3
    Marker Score: 1123
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.3
    Marker Score: 1312
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.29
    Marker Score: 860
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.29
    Marker Score: 1784
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.29
    Marker Score: 383
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.28
    Marker Score: 1376
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.27
    Marker Score: 277
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.27
    Marker Score: 1189
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.25
    Marker Score: 947
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.25
    Marker Score: 509
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.25
    Marker Score: 3932
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.24
    Marker Score: 975
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.24
    Marker Score: 309
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.24
    Marker Score: 725
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.23
    Marker Score: 426
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.23
    Marker Score: 431
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.23
    Marker Score: 510
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.23
    Marker Score: 428
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 836
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.22
    Marker Score: 2974
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.22
    Marker Score: 1573
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.21
    Marker Score: 993
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.21
    Marker Score: 604
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.21
    Marker Score: 3585
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.21
    Marker Score: 417
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.2
    Marker Score: 7317.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.2
    Marker Score: 1308
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.2
    Marker Score: 732
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.2
    Marker Score: 291
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.2
    Marker Score: 518
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.2
    Marker Score: 451
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.19
    Marker Score: 253
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.18
    Marker Score: 784
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.18
    Marker Score: 291
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.18
    Marker Score: 1138.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.17
    Marker Score: 1987
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.17
    Marker Score: 1047
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.17
    Marker Score: 262
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.17
    Marker Score: 798
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.17
    Marker Score: 1720
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.17
    Marker Score: 1553
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.16
    Marker Score: 10212
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 267
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1218.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.16
    Marker Score: 7397
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.16
    Marker Score: 317
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.15
    Marker Score: 369
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.15
    Marker Score: 11364
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.14
    Marker Score: 1619
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.14
    Marker Score: 328
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.14
    Marker Score: 650
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.14
    Marker Score: 3196
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.14
    Marker Score: 2746
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.14
    Marker Score: 4718
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 474
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.13
    Marker Score: 351
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.13
    Marker Score: 768

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Other Information

**Key characteristics:** * Gene name: BNIP2 * Ensembl ID: ENSG00000140299 * Protein name: BNIP2_HUMAN * Protein size: 130 kDa * Subcellular localization: Cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm, and cell membrane * Domain: BCL2 interacting protein 2 **Pathways and functions:** * Apoptosis process: BNIP2 is involved in the regulation of apoptosis in various cell types. It interacts with the BCL2 protein and inhibits its activity, leading to the inhibition of apoptosis. * Calcium ion binding: BNIP2 is a calcium ion sensor and can be activated by calcium ions. Activation of BNIP2 promotes the phosphorylation of BCL2, leading to the inhibition of apoptosis. * Negative regulation of apoptotic process: BNIP2 acts as a negative regulator of apoptosis by interacting with the BCL2 protein. It inhibits BCL2's ability to bind to the BCLXL1 protein, thereby blocking the activation of the intrinsic pathway of apoptosis. **Clinical significance:** BNIP2 has potential clinical significance in cancer immunotherapy. By targeting BNIP2, it is possible to inhibit apoptosis in cancer cells and enhance the efficacy of cancer immunotherapy approaches. However, further research is needed to develop therapeutic strategies that effectively target BNIP2 in humans.

Genular Protein ID: 1213419395

Symbol: BNIP2_HUMAN

Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

UniProtKB Accession Codes:

Q12982 B4DS94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 314
  • Mass: 36018
  • Checksum: 0A3CEC636569DD2F
  • Sequence:
    • MEGVELKEEW QDEDFPIPLP EDDSIEADIL AITGPEDQPG SLEVNGNKVR KKLMAPDISL 
TLDPSDGSVL SDDLDESGEI DLDGLDTPSE NSNEFEWEDD LPKPKTTEVI RKGSITEYTA 
AEEKEDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESSQ 
PNYRYLMDNL FKYVIGTLEL LVAENYMIVY LNGATTRRKM PSLGWLRKCY QQIDRRLRKN 
LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQVD 
QELNGKQDEP KNEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.