Smurf2 | ENSMUSG00000018363 | NCBI 66313

Details for: Smurf2

Gene ID: 66313

Symbol: Smurf2

Ensembl ID: ENSMUSG00000018363

Description: SMAD specific E3 ubiquitin protein ligase 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Asymmetric localization of pcp proteins
(R-MMU-4608870)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Degradation of axin
(R-MMU-4641257)
Deubiquitination
(R-MMU-5688426)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Downregulation of tgf-beta receptor signaling
(R-MMU-2173788)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hedgehog 'on' state
(R-MMU-5632684)
Immune system
(R-MMU-168256)
Metabolism of proteins
(R-MMU-392499)
Pcp/ce pathway
(R-MMU-4086400)
Post-translational protein modification
(R-MMU-597592)
Regulation of runx3 expression and activity
(R-MMU-8941858)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by bmp
(R-MMU-201451)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional regulation by runx3
(R-MMU-8878159)
Ub-specific processing proteases
(R-MMU-5689880)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of trophoblast cell migration
(GO:1901165)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Smad binding
(GO:0046332)
Transferase activity
(GO:0016740)
Transforming growth factor beta receptor binding
(GO:0005160)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase SMURF2
Q9CSE3_MOUSE

Genular Protein ID: 1771672995

Symbol: SMUF2_MOUSE

Name: E3 ubiquitin-protein ligase SMURF2

UniProtKB Accession Codes:

A2A5Z6 A2A5Z7 Q5IRE6

Database IDs:

Citations:

PubMed ID: 15820682

Title: Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.

PubMed ID: 15820682

DOI: 10.1016/j.cell.2005.01.035

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16373342

Title: Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

PubMed ID: 16373342

DOI: 10.1074/jbc.m509430200

PubMed ID: 18448069

Title: AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2.

PubMed ID: 18448069

DOI: 10.1016/j.bbrc.2008.04.099

Sequence Information:

Length: 748
Mass: 86175
Checksum: 385AFA32D289D33F
Sequence:

MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 
WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 
GPNDNDTVRG QIVVSLQSRD RIGTGGQVVD CSRLFDNDLP DGWEERRTAS GRIQYLNHIT 
RTTQWERPTR PASEYSSPGR PLSCFVDENT PITGTNGATC GHSSDPRLAE RRVRSQRHRN 
YMSRTHLHTP PDLPEGYEQR TTQQGQVYFL HTQTGVSTWH DPRVPRDLSN INCEELGPLP 
PGWEIRNTAT GRVYFVDHNN RTTQFTDPRL SANLHLVLNR QNQLKDQQQQ QVVPLCPDDT 
ECLTVPRYKR DLVQKLKILR QELSQQQPQA GHCRIEVSRE EIFEESYRQV MKMRPKDLWK 
RLMIKFRGEE GLDYGGVARE WLYLLSHEML NPYYGLFQYS RDDIYTLQIN PDSAVNPEHL 
SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND 
ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVTEENKKE YVRLYVNWRF LRGIEAQFLA 
LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVSDWKVN TRLKHCTPDS NVVKWFWKAV 
EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI 
DIPPYESYEK LYEKLLTAIE ETCGFAVE

Genular Protein ID: 230692560

Symbol: Q9CSE3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CSE3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 258
Mass: 29670
Checksum: B0BE04BCE1FCBC98
Sequence:

GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND ITGVLDHTFC 
VEHNAYGEII QHELKPNGKS IPVTEENKKE YVRLYVNWRF LRGIEAQFLA LQKGFNEVIP 
QHLLKTFDEK ELELIICGLG KIDVSDWKVN TRLKHCTPDS NVVKWFWKAV EFFDEERRAR 
LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI DIPPYESYEK 
LYEKLLTAIE ETCGFAVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smurf2

Associated with

Other Information

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. PubMed ID: 15820682

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. PubMed ID: 16373342

AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. PubMed ID: 18448069

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073