Psenen | ENSMUSG00000036835 | NCBI 66340

Details for: Psenen

Gene ID: 66340

Symbol: Psenen

Ensembl ID: ENSMUSG00000036835

Description: presenilin enhancer gamma secretase subunit

Associated with

Axon guidance
(R-MMU-422475)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Nervous system development
(R-MMU-9675108)
Noncanonical activation of notch3
(R-MMU-9017802)
Notch3 activation and transmission of signal to the nucleus
(R-MMU-9013507)
Nrif signals cell death from the nucleus
(R-MMU-205043)
Nuclear signaling by erbb4
(R-MMU-1251985)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Signaling by erbb4
(R-MMU-1236394)
Signaling by notch
(R-MMU-157118)
Signaling by notch3
(R-MMU-9012852)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Amyloid-beta formation
(GO:0034205)
Amyloid precursor protein catabolic process
(GO:0042987)
Amyloid precursor protein metabolic process
(GO:0042982)
Endopeptidase activator activity
(GO:0061133)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Gamma-secretase complex
(GO:0070765)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane protein intracellular domain proteolysis
(GO:0031293)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Plasma membrane
(GO:0005886)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of endopeptidase activity
(GO:0010950)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)

Other Information

Proteins

Gamma-secretase subunit PEN-2

Genular Protein ID: 4079843752

Symbol: PEN2_MOUSE

Name: Gamma-secretase subunit PEN-2

UniProtKB Accession Codes:

Q9CQR7

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12522139

Title: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

PubMed ID: 12522139

DOI: 10.1074/jbc.c200648200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24941111

Title: Pen-2 is essential for gamma-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

PubMed ID: 24941111

DOI: 10.1021/bi500489j

Sequence Information:

Length: 101
Mass: 11999
Checksum: 6596CA2984FBCC59
Sequence:

MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLAPAYTEQ SQIKGYVWRS 
AVGFLFWVII LATWITIFQI YRPRWGALGD YLSFTIPLGT P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psenen

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. PubMed ID: 12522139