Details for: BNIP3

Gene ID: 664

Symbol: BNIP3

Ensembl ID: ENSG00000176171

Description: BCL2 interacting protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 337.2653
    Cell Significance Index: -52.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 208.0874
    Cell Significance Index: -52.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.5250
    Cell Significance Index: -49.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.1534
    Cell Significance Index: -56.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.7273
    Cell Significance Index: -45.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.8702
    Cell Significance Index: -54.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.4220
    Cell Significance Index: -49.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.9114
    Cell Significance Index: -54.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6487
    Cell Significance Index: -38.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5287
    Cell Significance Index: -12.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.5175
    Cell Significance Index: 34.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.1163
    Cell Significance Index: 216.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.0755
    Cell Significance Index: 32.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0649
    Cell Significance Index: 142.9000
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.4093
    Cell Significance Index: 1.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3143
    Cell Significance Index: 1263.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.6640
    Cell Significance Index: 284.1400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.4866
    Cell Significance Index: 7.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4598
    Cell Significance Index: 289.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3975
    Cell Significance Index: 280.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3751
    Cell Significance Index: 37.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0790
    Cell Significance Index: 148.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9871
    Cell Significance Index: 284.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9871
    Cell Significance Index: 25.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8643
    Cell Significance Index: 40.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8485
    Cell Significance Index: 108.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8393
    Cell Significance Index: 10.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7664
    Cell Significance Index: 124.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.7260
    Cell Significance Index: 987.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6695
    Cell Significance Index: 4.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6680
    Cell Significance Index: 72.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6515
    Cell Significance Index: 17.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5523
    Cell Significance Index: 198.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4902
    Cell Significance Index: 216.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4507
    Cell Significance Index: 693.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4413
    Cell Significance Index: 12.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4144
    Cell Significance Index: 24.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3928
    Cell Significance Index: 27.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3896
    Cell Significance Index: 47.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3435
    Cell Significance Index: 8.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3260
    Cell Significance Index: 24.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2940
    Cell Significance Index: 20.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2597
    Cell Significance Index: 33.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2530
    Cell Significance Index: 45.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2411
    Cell Significance Index: 45.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1912
    Cell Significance Index: 11.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1787
    Cell Significance Index: 329.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1486
    Cell Significance Index: 279.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1435
    Cell Significance Index: 1.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1252
    Cell Significance Index: 2.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1202
    Cell Significance Index: 3.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0862
    Cell Significance Index: 1.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0812
    Cell Significance Index: 2.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0659
    Cell Significance Index: 4.4300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0590
    Cell Significance Index: 0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0395
    Cell Significance Index: 17.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0384
    Cell Significance Index: 28.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0354
    Cell Significance Index: 2.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0254
    Cell Significance Index: 19.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0217
    Cell Significance Index: 0.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0167
    Cell Significance Index: 1.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0157
    Cell Significance Index: 10.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0024
    Cell Significance Index: 1.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0119
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -18.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0551
    Cell Significance Index: -5.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0594
    Cell Significance Index: -33.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0794
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1045
    Cell Significance Index: -22.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1112
    Cell Significance Index: -5.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1127
    Cell Significance Index: -3.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1156
    Cell Significance Index: -2.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1290
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1477
    Cell Significance Index: -16.9200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1616
    Cell Significance Index: -1.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1736
    Cell Significance Index: -9.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1870
    Cell Significance Index: -1.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2007
    Cell Significance Index: -29.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2297
    Cell Significance Index: -14.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2443
    Cell Significance Index: -28.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2463
    Cell Significance Index: -19.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3194
    Cell Significance Index: -5.3800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3224
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3524
    Cell Significance Index: -40.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3686
    Cell Significance Index: -38.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3797
    Cell Significance Index: -10.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4002
    Cell Significance Index: -11.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4003
    Cell Significance Index: -6.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4502
    Cell Significance Index: -7.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5034
    Cell Significance Index: -32.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5131
    Cell Significance Index: -13.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5272
    Cell Significance Index: -4.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5602
    Cell Significance Index: -6.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5834
    Cell Significance Index: -12.6400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7032
    Cell Significance Index: -10.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7647
    Cell Significance Index: -18.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7896
    Cell Significance Index: -13.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8000
    Cell Significance Index: -41.6700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8005
    Cell Significance Index: -11.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BNIP3 is a pro-apoptotic protein that interacts with BCL2 family members, modulating the mitochondrial outer membrane permeabilization (MOMP) and the release of cytochrome c. It is also involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. BNIP3 is highly expressed in tissues that require rapid energy production, such as brown adipose tissue, cardiac muscle cells, and neurons. Its expression is induced by hypoxia, oxidative stress, and nutrient deprivation. **Pathways and Functions** BNIP3 is involved in several key pathways, including: 1. **Autophagic cell death**: BNIP3 regulates the autophagy process, which is essential for cell survival under conditions of nutrient deprivation or stress. 2. **Apoptotic signaling pathway**: BNIP3 modulates the mitochondrial outer membrane permeabilization (MOMP) and the release of cytochrome c, leading to apoptosis. 3. **Mitochondrial function**: BNIP3 regulates mitochondrial membrane permeability, calcium ion concentration, and fusion. 4. **Autophagy of mitochondria**: BNIP3 is involved in the regulation of autophagy of mitochondria, which is essential for maintaining mitochondrial function and preventing cell death. 5. **Cardiac muscle cell apoptosis**: BNIP3 regulates cardiac muscle cell apoptosis, which is critical for maintaining cardiac function and preventing heart failure. **Clinical Significance** BNIP3 dysregulation has been implicated in various diseases, including: 1. **Cancer**: BNIP3 has been shown to inhibit tumor growth and metastasis in various cancer types. 2. **Neurodegenerative disorders**: BNIP3 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders**: BNIP3 has been shown to regulate glucose and lipid metabolism, and its dysregulation has been implicated in metabolic disorders, such as type 2 diabetes. 4. **Cardiac disease**: BNIP3 has been shown to regulate cardiac function and prevent cardiac failure in models of heart disease. In conclusion, BNIP3 is a critical protein involved in various cellular processes, including autophagy, apoptosis, and mitochondrial function. Its dysregulation has been implicated in various diseases, and its study has the potential to reveal new therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 87013543

Symbol: BNIP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12983 O14620 Q96GP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 60 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 9396766

Title: The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.

PubMed ID: 9396766

DOI: 10.1084/jem.186.12.1975

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9575197

Title: Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence.

PubMed ID: 9575197

DOI: 10.1074/jbc.273.20.12415

PubMed ID: 10381623

Title: A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.

PubMed ID: 10381623

DOI: 10.1038/sj.cdd.4400493

PubMed ID: 15868100

Title: Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3.

PubMed ID: 15868100

DOI: 10.1007/s00018-005-4543-3

PubMed ID: 18371312

Title: Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines.

PubMed ID: 18371312

DOI: 10.1016/j.bbagen.2008.02.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19935772

Title: S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.

PubMed ID: 19935772

DOI: 10.1038/cr.2009.129

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22292033

Title: BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.

PubMed ID: 22292033

DOI: 10.1371/journal.pone.0030767

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 194
  • Mass: 21541
  • Checksum: 6D79E68F146D25EB
  • Sequence:
    • MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK 
SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW 
SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG 
IYIGRRLTTS TSTF

Genular Protein ID: 479690336

Symbol: Q6NVY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVY4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 244
  • Mass: 26396
  • Checksum: 1CD24F66321DE611
  • Sequence:
    • GFLRPGCGAP LSPGAQLGRG APTSAFPPPA AEAHPAARRG LRSPQLPSGA MSQNGAPGMQ 
EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS 
QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK 
EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG IYIGRRLTTS 
TSTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.