Details for: BNIP3

Gene ID: 664

Symbol: BNIP3

Ensembl ID: ENSG00000176171

Description: BCL2 interacting protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.86
    Marker Score: 4663
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.24
    Marker Score: 3054.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.16
    Marker Score: 6425
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.81
    Marker Score: 1582
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.64
    Marker Score: 3198
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.54
    Marker Score: 1484
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.51
    Marker Score: 86966
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.43
    Marker Score: 5527.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.33
    Marker Score: 1329
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.32
    Marker Score: 763
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.25
    Marker Score: 6120.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.24
    Marker Score: 8293
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.19
    Marker Score: 7761
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.09
    Marker Score: 3708
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.08
    Marker Score: 4397
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.07
    Marker Score: 1208
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.01
    Marker Score: 20241.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2
    Marker Score: 3309.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.97
    Marker Score: 1313
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.96
    Marker Score: 781
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.94
    Marker Score: 4043
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.92
    Marker Score: 7545
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.9
    Marker Score: 2562
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.78
    Marker Score: 1886
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.77
    Marker Score: 7627
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.76
    Marker Score: 1026
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.74
    Marker Score: 700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.73
    Marker Score: 1850
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.72
    Marker Score: 1856
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.69
    Marker Score: 4263
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.64
    Marker Score: 398
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.63
    Marker Score: 549
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.63
    Marker Score: 606
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.62
    Marker Score: 678
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.61
    Marker Score: 1713
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 459
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.58
    Marker Score: 994
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.58
    Marker Score: 4224
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.56
    Marker Score: 2259
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.56
    Marker Score: 441.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.54
    Marker Score: 1288
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.54
    Marker Score: 2209
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.54
    Marker Score: 2468
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.54
    Marker Score: 360
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.53
    Marker Score: 1038.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.53
    Marker Score: 1634
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.53
    Marker Score: 797
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.52
    Marker Score: 51799
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.52
    Marker Score: 2582.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.52
    Marker Score: 9891
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.51
    Marker Score: 9844.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.49
    Marker Score: 704
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.49
    Marker Score: 12949
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.48
    Marker Score: 3256
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.48
    Marker Score: 1393.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.48
    Marker Score: 1850
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.47
    Marker Score: 1533
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.47
    Marker Score: 1101
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.46
    Marker Score: 7679
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167182
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.45
    Marker Score: 606
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.42
    Marker Score: 352
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.41
    Marker Score: 777
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.38
    Marker Score: 3243
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.36
    Marker Score: 810
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.36
    Marker Score: 2224
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.35
    Marker Score: 1276
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11529.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.34
    Marker Score: 668
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.33
    Marker Score: 684
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.32
    Marker Score: 81283
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.32
    Marker Score: 737
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.31
    Marker Score: 256
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.3
    Marker Score: 1377
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.3
    Marker Score: 1798
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.3
    Marker Score: 292
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1324
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.27
    Marker Score: 16763
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.27
    Marker Score: 699
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.26
    Marker Score: 290
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.26
    Marker Score: 434
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.26
    Marker Score: 403
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19554
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.25
    Marker Score: 456
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.24
    Marker Score: 516
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.24
    Marker Score: 440
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.24
    Marker Score: 13938
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.23
    Marker Score: 576
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1242
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.21
    Marker Score: 1928
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.2
    Marker Score: 417
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.19
    Marker Score: 325
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.18
    Marker Score: 1821
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.17
    Marker Score: 841
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.17
    Marker Score: 11139.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1808
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.17
    Marker Score: 3062.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.16
    Marker Score: 438
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.16
    Marker Score: 5677
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.15
    Marker Score: 2918

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Other Information

**Key characteristics**: - BNIP3 is a protein with a molecular weight of approximately 130 kDa. - It is a member of the BNIP (BCL2 interacting protein) family of proteins. - It is expressed in a variety of cell types, including glial cells, cardiac muscle cells, and pancreatic cells. **Pathways and functions**: - BNIP3 is involved in autophagy of mitochondria. - It interacts with the BNIP1 and BNIP4 proteins to regulate mitochondrial fission. - It is also involved in the cardiac muscle cell apoptotic process. - BNIP3 is a negative regulator of the mitochondrial fusion process. - It is involved in the regulation of mitochondrial membrane potential. - It is also involved in the regulation of programmed cell death. **Clinical significance**: - Mutations in BNIP3 have been linked to several human diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, and heart failure. - BNIP3 inhibitors are being investigated as potential cancer drugs. **Additional information**: - BNIP3 is a highly conserved protein, with similar genes found in other mammals. - It is a ubiquitin-proteasome-dependent protein. - It is a key regulator of mitochondrial function, and its dysfunction can lead to the development of various diseases.

Genular Protein ID: 87013543

Symbol: BNIP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12983 O14620 Q96GP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7954800

Title: Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.

PubMed ID: 7954800

DOI: 10.1016/0092-8674(94)90202-x

PubMed ID: 9396766

Title: The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.

PubMed ID: 9396766

DOI: 10.1084/jem.186.12.1975

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9575197

Title: Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence.

PubMed ID: 9575197

DOI: 10.1074/jbc.273.20.12415

PubMed ID: 10381623

Title: A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.

PubMed ID: 10381623

DOI: 10.1038/sj.cdd.4400493

PubMed ID: 15868100

Title: Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3.

PubMed ID: 15868100

DOI: 10.1007/s00018-005-4543-3

PubMed ID: 18371312

Title: Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines.

PubMed ID: 18371312

DOI: 10.1016/j.bbagen.2008.02.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19935772

Title: S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.

PubMed ID: 19935772

DOI: 10.1038/cr.2009.129

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22292033

Title: BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.

PubMed ID: 22292033

DOI: 10.1371/journal.pone.0030767

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 194
  • Mass: 21541
  • Checksum: 6D79E68F146D25EB
  • Sequence:
    • MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK 
SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW 
SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG 
IYIGRRLTTS TSTF

Genular Protein ID: 479690336

Symbol: Q6NVY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVY4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 244
  • Mass: 26396
  • Checksum: 1CD24F66321DE611
  • Sequence:
    • GFLRPGCGAP LSPGAQLGRG APTSAFPPPA AEAHPAARRG LRSPQLPSGA MSQNGAPGMQ 
EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK SSHCDSPPRS 
QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW SSRPENIPPK 
EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG IYIGRRLTTS 
TSTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.