Nmnat1 | ENSMUSG00000028992 | NCBI 66454

Details for: Nmnat1

Gene ID: 66454

Symbol: Nmnat1

Ensembl ID: ENSMUSG00000028992

Description: nicotinamide nucleotide adenylyltransferase 1

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Nicotinate metabolism
(R-MMU-196807)
Atp generation from poly-adp-d-ribose
(GO:1990966)
Chromatin
(GO:0000785)
Identical protein binding
(GO:0042802)
Nad biosynthetic process
(GO:0009435)
Negative regulation of apoptotic dna fragmentation
(GO:1902511)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nicotinamide-nucleotide adenylyltransferase activity
(GO:0000309)
Nicotinate-nucleotide adenylyltransferase activity
(GO:0004515)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mapk cascade
(GO:0043410)
Protein adp-ribosyltransferase-substrate adaptor activity
(GO:0140768)
Response to wounding
(GO:0009611)

Other Information

Proteins

Nicotinamide mononucleotide adenylyltransferase 1

Genular Protein ID: 760303525

Symbol: NMNA1_MOUSE

Name: Nicotinamide mononucleotide adenylyltransferase 1

UniProtKB Accession Codes:

Q9EPA7 Q6B504

Database IDs:

Citations:

PubMed ID: 11027338

Title: A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse.

PubMed ID: 11027338

DOI: 10.1073/pnas.97.21.11377

PubMed ID: 15381699

Title: The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.

PubMed ID: 15381699

DOI: 10.1074/jbc.m408388200

PubMed ID: 15310905

Title: Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

PubMed ID: 15310905

DOI: 10.1126/science.1098014

PubMed ID: 16914673

Title: Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.

PubMed ID: 16914673

DOI: 10.1523/jneurosci.2320-06.2006

PubMed ID: 27735788

Title: NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

PubMed ID: 27735788

DOI: 10.7554/elife.19749

PubMed ID: 32822587

Title: Functional interplay between histone H2B ADP-ribosylation and phosphorylation controls adipogenesis.

PubMed ID: 32822587

DOI: 10.1016/j.molcel.2020.08.002

Sequence Information:

Length: 285
Mass: 32355
Checksum: 2769D42E894EB84F
Sequence:

MDSSKKTEVV LLACGSFNPI TNMHLRLFEL AKDYMHATGK YSVIKGIISP VGDAYKKKGL 
IPAHHRIIMA ELATKNSHWV EVDTWESLQK EWVETVKVLR YHQEKLATGS CSYPQSSPAL 
EKPGRKRKWA DQKQDSSPQK PQEPKPTGVP KVKLLCGADL LESFSVPNLW KMEDITQIVA 
NFGLICITRA GSDAQKFIYE SDVLWRHQSN IHLVNEWITN DISSTKIRRA LRRGQSIRYL 
VPDLVQEYIE KHELYNTESE GRNAGVTLAP LQRNAAEAKH NHSTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nmnat1

Associated with

Other Information

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. PubMed ID: 11027338

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. PubMed ID: 15381699

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. PubMed ID: 15310905

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. PubMed ID: 16914673

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion. PubMed ID: 27735788