Details for: BNIP3L

Gene ID: 665

Symbol: BNIP3L

Ensembl ID: ENSG00000104765

Description: BCL2 interacting protein 3 like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.38
    Marker Score: 4082
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.1
    Marker Score: 2927
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.97
    Marker Score: 3590
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.76
    Marker Score: 5606.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.63
    Marker Score: 11004
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16866
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.58
    Marker Score: 144531
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.55
    Marker Score: 10619
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.52
    Marker Score: 25359
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.48
    Marker Score: 3337
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.48
    Marker Score: 1448
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.42
    Marker Score: 1380
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.4
    Marker Score: 3323
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.39
    Marker Score: 2036
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.38
    Marker Score: 990
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.34
    Marker Score: 1308
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.32
    Marker Score: 3566
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.29
    Marker Score: 5023
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.28
    Marker Score: 30025
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.26
    Marker Score: 14727.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.24
    Marker Score: 708
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.24
    Marker Score: 1303
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.23
    Marker Score: 3951
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.2
    Marker Score: 644
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.19
    Marker Score: 74637
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.19
    Marker Score: 1065
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.14
    Marker Score: 4463
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.13
    Marker Score: 9200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.13
    Marker Score: 2131
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.13
    Marker Score: 2653
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.12
    Marker Score: 5783
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.08
    Marker Score: 23451
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.08
    Marker Score: 4050
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 2.06
    Marker Score: 1108
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.05
    Marker Score: 7572
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.04
    Marker Score: 2522
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.04
    Marker Score: 2147
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.02
    Marker Score: 1445
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.01
    Marker Score: 822
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.01
    Marker Score: 501
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2
    Marker Score: 501
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.99
    Marker Score: 2857
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.99
    Marker Score: 2110
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.99
    Marker Score: 3375
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.98
    Marker Score: 723
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.97
    Marker Score: 3168
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.97
    Marker Score: 2306
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.94
    Marker Score: 2745.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.93
    Marker Score: 1008
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.93
    Marker Score: 941
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.93
    Marker Score: 28795
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.92
    Marker Score: 3507
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117159
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2785
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.89
    Marker Score: 7307.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.87
    Marker Score: 692.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.87
    Marker Score: 7192
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.86
    Marker Score: 429
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.86
    Marker Score: 2142
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.85
    Marker Score: 1961
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.85
    Marker Score: 1232
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.85
    Marker Score: 975
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.85
    Marker Score: 950
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.84
    Marker Score: 440
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.84
    Marker Score: 4186
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.84
    Marker Score: 2099.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.83
    Marker Score: 1008
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.81
    Marker Score: 4742
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.79
    Marker Score: 3369
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.79
    Marker Score: 1929
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.78
    Marker Score: 10583
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.78
    Marker Score: 28640
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.78
    Marker Score: 1110
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67452
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.77
    Marker Score: 1481
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.77
    Marker Score: 61398.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.77
    Marker Score: 16663
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.77
    Marker Score: 20582
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6844
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.77
    Marker Score: 6285
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.77
    Marker Score: 1115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.76
    Marker Score: 1981
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.76
    Marker Score: 1177
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.76
    Marker Score: 436
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.76
    Marker Score: 1900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.76
    Marker Score: 2117
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.76
    Marker Score: 45067
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.76
    Marker Score: 3384
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.75
    Marker Score: 64628
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.75
    Marker Score: 2777
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16427
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.72
    Marker Score: 34214
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.72
    Marker Score: 386
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.71
    Marker Score: 13084
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.71
    Marker Score: 629
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.7
    Marker Score: 386
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.7
    Marker Score: 2782
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.69
    Marker Score: 689
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.68
    Marker Score: 2173
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.68
    Marker Score: 415

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Other Information

**Key characteristics:** * BNIP3L is a protein that is involved in the regulation of apoptosis. * It is a key regulator of the mitochondrial membrane potential. * It is also involved in the regulation of the programmed cell death pathway. * BNIP3L is expressed in a variety of cell types, including neurons, macrophages, and cancer cells. **Pathways and functions:** * BNIP3L is involved in the regulation of apoptosis. * It is a key regulator of the mitochondrial membrane potential. * It is also involved in the regulation of the programmed cell death pathway. * BNIP3L is a key regulator of the expression of genes involved in programmed cell death. **Clinical significance:** BNIP3L is a potential target for cancer therapy. Studies have shown that inhibitors of BNIP3L can inhibit apoptosis and tumor growth. This suggests that BNIP3L is a promising target for the treatment of cancer. **Additional information:** * BNIP3L is a member of the BCL2 family of proteins. * BNIP3L is a multi-domain protein that contains a BCL2 homology domain and a coiled-coil domain. * BNIP3L is a highly conserved protein that is found in mammals, birds, and fish.

Genular Protein ID: 2606533519

Symbol: BNI3L_HUMAN

Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

UniProtKB Accession Codes:

O60238 B0AZS9 Q5JW63 Q8NF87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9523198

Title: Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

PubMed ID: 9523198

DOI: 10.1002/(sici)1098-2264(199803)21:3<230::aid-gcc7>3.3.co;2-g

PubMed ID: 9867803

Title: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.

PubMed ID: 9867803

DOI: 10.1074/jbc.274.1.7

PubMed ID: 10381623

Title: A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.

PubMed ID: 10381623

DOI: 10.1038/sj.cdd.4400493

PubMed ID: 12663450

Title: The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.

PubMed ID: 12663450

DOI: 10.1182/blood-2002-11-3324

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12606722

Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

PubMed ID: 12606722

DOI: 10.1073/pnas.0530298100

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21264228

Title: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.

PubMed ID: 21264228

DOI: 10.1371/journal.pone.0016060

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31324791

Title: Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus.

PubMed ID: 31324791

DOI: 10.1038/s41467-019-11164-2

Sequence Information:

  • Length: 219
  • Mass: 23930
  • Checksum: 19372E897BC63609
  • Sequence:
    • MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV 
PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS 
EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI 
FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.