Details for: BNIP3L

Gene ID: 665

Symbol: BNIP3L

Ensembl ID: ENSG00000104765

Description: BCL2 interacting protein 3 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 447.1047
    Cell Significance Index: -69.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 310.5541
    Cell Significance Index: -78.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 214.5297
    Cell Significance Index: -88.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 197.9147
    Cell Significance Index: -93.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 191.5536
    Cell Significance Index: -77.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 167.4037
    Cell Significance Index: -86.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 139.8836
    Cell Significance Index: -93.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.6450
    Cell Significance Index: -77.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.0560
    Cell Significance Index: -56.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.8033
    Cell Significance Index: -77.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.2812
    Cell Significance Index: -77.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.9597
    Cell Significance Index: -90.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.6416
    Cell Significance Index: -23.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.7118
    Cell Significance Index: 28.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3870
    Cell Significance Index: 177.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3429
    Cell Significance Index: 321.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0736
    Cell Significance Index: 337.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6156
    Cell Significance Index: 291.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5716
    Cell Significance Index: 315.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4583
    Cell Significance Index: 523.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3409
    Cell Significance Index: 164.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3025
    Cell Significance Index: 45.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2022
    Cell Significance Index: 22.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1604
    Cell Significance Index: 126.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1598
    Cell Significance Index: 633.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1259
    Cell Significance Index: 144.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9893
    Cell Significance Index: 73.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8907
    Cell Significance Index: 41.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8245
    Cell Significance Index: 46.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7741
    Cell Significance Index: 20.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7362
    Cell Significance Index: 21.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6989
    Cell Significance Index: 1315.9900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6781
    Cell Significance Index: 4.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6072
    Cell Significance Index: 37.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6068
    Cell Significance Index: 268.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6063
    Cell Significance Index: 7.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5117
    Cell Significance Index: 353.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5019
    Cell Significance Index: 682.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4890
    Cell Significance Index: 310.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4572
    Cell Significance Index: 703.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4174
    Cell Significance Index: 28.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4157
    Cell Significance Index: 5.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3721
    Cell Significance Index: 73.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3697
    Cell Significance Index: 10.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3575
    Cell Significance Index: 24.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3406
    Cell Significance Index: 307.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3331
    Cell Significance Index: 15.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2428
    Cell Significance Index: 10.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2368
    Cell Significance Index: 436.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2206
    Cell Significance Index: 11.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1899
    Cell Significance Index: 86.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1787
    Cell Significance Index: 21.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1418
    Cell Significance Index: 1.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0849
    Cell Significance Index: 6.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0552
    Cell Significance Index: 0.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0529
    Cell Significance Index: 0.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0424
    Cell Significance Index: 1.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0387
    Cell Significance Index: 2.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0243
    Cell Significance Index: 18.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0153
    Cell Significance Index: 2.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0547
    Cell Significance Index: -34.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0781
    Cell Significance Index: -57.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1154
    Cell Significance Index: -65.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1213
    Cell Significance Index: -15.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2029
    Cell Significance Index: -9.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2029
    Cell Significance Index: -42.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.2124
    Cell Significance Index: -40.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2169
    Cell Significance Index: -4.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2399
    Cell Significance Index: -34.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2594
    Cell Significance Index: -74.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2631
    Cell Significance Index: -7.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2675
    Cell Significance Index: -6.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3145
    Cell Significance Index: -19.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3181
    Cell Significance Index: -31.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3269
    Cell Significance Index: -34.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3457
    Cell Significance Index: -24.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3622
    Cell Significance Index: -3.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4110
    Cell Significance Index: -47.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4451
    Cell Significance Index: -51.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5059
    Cell Significance Index: -13.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5534
    Cell Significance Index: -19.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5836
    Cell Significance Index: -16.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5838
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7016
    Cell Significance Index: -80.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8094
    Cell Significance Index: -13.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8097
    Cell Significance Index: -21.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8223
    Cell Significance Index: -19.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8627
    Cell Significance Index: -27.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9409
    Cell Significance Index: -74.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9689
    Cell Significance Index: -13.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0003
    Cell Significance Index: -20.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0139
    Cell Significance Index: -6.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0671
    Cell Significance Index: -31.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2160
    Cell Significance Index: -26.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2312
    Cell Significance Index: -64.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3689
    Cell Significance Index: -34.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3826
    Cell Significance Index: -17.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BNIP3L is a protein that interacts with BCL2, a family of proteins involved in regulating apoptosis. BNIP3L is specifically expressed in various cell types, including glycinergic neurons, lens epithelial cells, and granulosa cells. It is also found in immune cells, such as classical monocytes, where it may play a role in modulating the immune response. BNIP3L's expression is upregulated in response to hypoxia, a condition characterized by inadequate oxygen supply, which highlights its role in adapting to low-oxygen environments. **Pathways and Functions:** BNIP3L is involved in several cellular pathways, including: 1. **Cellular response to hypoxia**: BNIP3L is upregulated in response to hypoxia, where it helps to regulate mitochondrial function and promote adaptation to low-oxygen conditions. 2. **Apoptosis regulation**: BNIP3L interacts with BCL2 and other anti-apoptotic proteins, modulating the apoptotic process and preventing excessive cell death. 3. **Autophagy regulation**: BNIP3L is involved in regulating autophagy, a process by which cells recycle damaged or dysfunctional components, including mitochondria. 4. **Mitochondrial outer membrane permeabilization**: BNIP3L helps to regulate the permeabilization of the mitochondrial outer membrane, a critical step in apoptosis and autophagy. 5. **TP53 regulation**: BNIP3L is a transcriptional target of TP53, a tumor suppressor protein that regulates cell growth, differentiation, and apoptosis. **Clinical Significance:** BNIP3L's involvement in various cellular processes highlights its potential role in several diseases, including: 1. **Cancer**: BNIP3L's regulation of apoptosis and autophagy may influence cancer progression and treatment outcomes. 2. **Neurodegenerative diseases**: BNIP3L's expression in glycinergic neurons and other neuronal cells may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Metabolic disorders**: BNIP3L's regulation of mitochondrial function may influence metabolic disorders, such as diabetes and metabolic syndrome. 4. **Inflammatory diseases**: BNIP3L's expression in immune cells may contribute to the development of inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In conclusion, BNIP3L is a critical regulator of cellular stress responses, particularly under hypoxic conditions. Its involvement in various cellular pathways highlights its potential role in maintaining cellular homeostasis and responding to environmental stressors. Further research is needed to fully elucidate BNIP3L's functions and its relevance to human disease.

Genular Protein ID: 2606533519

Symbol: BNI3L_HUMAN

Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

UniProtKB Accession Codes:

O60238 B0AZS9 Q5JW63 Q8NF87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9523198

Title: Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

PubMed ID: 9523198

DOI: 10.1002/(sici)1098-2264(199803)21:3<230::aid-gcc7>3.3.co;2-g

PubMed ID: 9867803

Title: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.

PubMed ID: 9867803

DOI: 10.1074/jbc.274.1.7

PubMed ID: 10381623

Title: A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.

PubMed ID: 10381623

DOI: 10.1038/sj.cdd.4400493

PubMed ID: 12663450

Title: The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.

PubMed ID: 12663450

DOI: 10.1182/blood-2002-11-3324

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12606722

Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

PubMed ID: 12606722

DOI: 10.1073/pnas.0530298100

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21264228

Title: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.

PubMed ID: 21264228

DOI: 10.1371/journal.pone.0016060

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31324791

Title: Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus.

PubMed ID: 31324791

DOI: 10.1038/s41467-019-11164-2

Sequence Information:

  • Length: 219
  • Mass: 23930
  • Checksum: 19372E897BC63609
  • Sequence:
    • MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV 
PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS 
EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI 
FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.