Details for: BNIP3L

Gene ID: 665

Symbol: BNIP3L

Ensembl ID: ENSG00000104765

Description: BCL2 interacting protein 3 like

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.38
    Marker Score: 4,082
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.1
    Marker Score: 2,927
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.97
    Marker Score: 3,590
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.76
    Marker Score: 5,607
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.63
    Marker Score: 11,004
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16,866
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.58
    Marker Score: 144,531
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.55
    Marker Score: 10,619
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.52
    Marker Score: 25,359
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.48
    Marker Score: 3,337
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.48
    Marker Score: 1,448
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.42
    Marker Score: 1,380
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.4
    Marker Score: 3,323
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.39
    Marker Score: 2,036
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.38
    Marker Score: 990
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.34
    Marker Score: 1,308
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.32
    Marker Score: 3,566
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.29
    Marker Score: 5,023
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.28
    Marker Score: 30,025
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.26
    Marker Score: 14,728
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.24
    Marker Score: 708
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.24
    Marker Score: 1,303
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.23
    Marker Score: 3,951
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.2
    Marker Score: 644
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.19
    Marker Score: 74,637
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.19
    Marker Score: 1,065
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.14
    Marker Score: 4,463
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.13
    Marker Score: 9,200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.13
    Marker Score: 2,131
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.13
    Marker Score: 2,653
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.12
    Marker Score: 5,783
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.08
    Marker Score: 23,451
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.08
    Marker Score: 4,050
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 2.06
    Marker Score: 1,108
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.05
    Marker Score: 7,572
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.04
    Marker Score: 2,522
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.04
    Marker Score: 2,147
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.02
    Marker Score: 1,445
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.01
    Marker Score: 822
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.01
    Marker Score: 501
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2
    Marker Score: 501
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.99
    Marker Score: 2,857
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.99
    Marker Score: 2,110
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.99
    Marker Score: 3,375
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.98
    Marker Score: 723
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.97
    Marker Score: 3,168
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.97
    Marker Score: 2,306
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.94
    Marker Score: 2,746
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.93
    Marker Score: 1,008
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.93
    Marker Score: 941
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.93
    Marker Score: 28,795
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.92
    Marker Score: 3,507
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117,159
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2,785
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.89
    Marker Score: 7,308
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.87
    Marker Score: 693
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.87
    Marker Score: 7,192
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.86
    Marker Score: 429
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.86
    Marker Score: 2,142
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.85
    Marker Score: 1,961
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.85
    Marker Score: 1,232
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.85
    Marker Score: 975
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.85
    Marker Score: 950
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.84
    Marker Score: 440
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.84
    Marker Score: 4,186
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.84
    Marker Score: 2,100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.83
    Marker Score: 1,008
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.81
    Marker Score: 4,742
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.79
    Marker Score: 3,369
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.79
    Marker Score: 1,929
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.78
    Marker Score: 10,583
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.78
    Marker Score: 28,640
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.78
    Marker Score: 1,110
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67,452
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.77
    Marker Score: 1,481
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.77
    Marker Score: 61,399
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.77
    Marker Score: 16,663
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.77
    Marker Score: 20,582
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,844
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.77
    Marker Score: 6,285
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.77
    Marker Score: 1,115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.76
    Marker Score: 1,981
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.76
    Marker Score: 1,177
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.76
    Marker Score: 436
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.76
    Marker Score: 1,900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.76
    Marker Score: 2,117
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.76
    Marker Score: 45,067
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.76
    Marker Score: 3,384
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.75
    Marker Score: 64,628
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.75
    Marker Score: 2,777
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,427
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.72
    Marker Score: 34,214
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.72
    Marker Score: 386
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.71
    Marker Score: 13,084
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.71
    Marker Score: 629
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.7
    Marker Score: 386
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.7
    Marker Score: 2,782
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.69
    Marker Score: 689
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.68
    Marker Score: 2,173
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.68
    Marker Score: 415

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BNIP3L is a protein that interacts with BCL2, a family of proteins involved in regulating apoptosis. BNIP3L is specifically expressed in various cell types, including glycinergic neurons, lens epithelial cells, and granulosa cells. It is also found in immune cells, such as classical monocytes, where it may play a role in modulating the immune response. BNIP3L's expression is upregulated in response to hypoxia, a condition characterized by inadequate oxygen supply, which highlights its role in adapting to low-oxygen environments. **Pathways and Functions:** BNIP3L is involved in several cellular pathways, including: 1. **Cellular response to hypoxia**: BNIP3L is upregulated in response to hypoxia, where it helps to regulate mitochondrial function and promote adaptation to low-oxygen conditions. 2. **Apoptosis regulation**: BNIP3L interacts with BCL2 and other anti-apoptotic proteins, modulating the apoptotic process and preventing excessive cell death. 3. **Autophagy regulation**: BNIP3L is involved in regulating autophagy, a process by which cells recycle damaged or dysfunctional components, including mitochondria. 4. **Mitochondrial outer membrane permeabilization**: BNIP3L helps to regulate the permeabilization of the mitochondrial outer membrane, a critical step in apoptosis and autophagy. 5. **TP53 regulation**: BNIP3L is a transcriptional target of TP53, a tumor suppressor protein that regulates cell growth, differentiation, and apoptosis. **Clinical Significance:** BNIP3L's involvement in various cellular processes highlights its potential role in several diseases, including: 1. **Cancer**: BNIP3L's regulation of apoptosis and autophagy may influence cancer progression and treatment outcomes. 2. **Neurodegenerative diseases**: BNIP3L's expression in glycinergic neurons and other neuronal cells may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Metabolic disorders**: BNIP3L's regulation of mitochondrial function may influence metabolic disorders, such as diabetes and metabolic syndrome. 4. **Inflammatory diseases**: BNIP3L's expression in immune cells may contribute to the development of inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. In conclusion, BNIP3L is a critical regulator of cellular stress responses, particularly under hypoxic conditions. Its involvement in various cellular pathways highlights its potential role in maintaining cellular homeostasis and responding to environmental stressors. Further research is needed to fully elucidate BNIP3L's functions and its relevance to human disease.

Genular Protein ID: 2606533519

Symbol: BNI3L_HUMAN

Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

UniProtKB Accession Codes:

O60238 B0AZS9 Q5JW63 Q8NF87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9523198

Title: Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.

PubMed ID: 9523198

DOI: 10.1002/(sici)1098-2264(199803)21:3<230::aid-gcc7>3.3.co;2-g

PubMed ID: 9867803

Title: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.

PubMed ID: 9867803

DOI: 10.1074/jbc.274.1.7

PubMed ID: 10381623

Title: A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.

PubMed ID: 10381623

DOI: 10.1038/sj.cdd.4400493

PubMed ID: 12663450

Title: The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.

PubMed ID: 12663450

DOI: 10.1182/blood-2002-11-3324

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12606722

Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

PubMed ID: 12606722

DOI: 10.1073/pnas.0530298100

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21264228

Title: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.

PubMed ID: 21264228

DOI: 10.1371/journal.pone.0016060

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31324791

Title: Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus.

PubMed ID: 31324791

DOI: 10.1038/s41467-019-11164-2

Sequence Information:

  • Length: 219
  • Mass: 23930
  • Checksum: 19372E897BC63609
  • Sequence:
    • MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV 
PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS 
EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI 
FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.